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Review

Pharmacotherapeutic management of macular edema in diabetic subjects undergoing cataract surgery

, , , , , , & show all
Pages 1551-1563 | Received 18 Apr 2018, Accepted 22 Aug 2018, Published online: 05 Sep 2018

References

  • Flaxman SR, Bourne RRA, Resnikoff S, et al. Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e1221–e1234.
  • Bourne RRA, Flaxman SR, Braithwaite T, et al. Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis. Lancet Glob Health. 2017;5:e888–e897.
  • Becker C, Schneider C, Aballéa S, et al. Cataract in patients with diabetes mellitus-incidence rates in the UK and risk factors. Eye (Lond). 2018;32:1028–1035.
  • Klein BE, Klein R, Moss SE. Incidence of cataract surgery in the wisconsin epidemiologic study of diabetic retinopathy. Am J Ophthalmol. 1995;119:295–300.
  • Chu CJ, Johnston RL, Buscombe C, et al. Risk factors and incidence of macular edema after cataract surgery: a database study of 81984 eyes. Ophthalmology. 2016;123:316–323. .
  • Kanthan GL, Mitchell P, Burlutsky G, et al. Fasting blood glucose levels and the long-term incidence and progression of cataract: the Blue mountains eye study. Acta Ophthalmol. 2011;89:434–438.
  • Munk MR, Jampol LM, Simader C, et al. Differentiation of diabetic macular edema from pseudophakic cystoid macular edema by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2015;56:6724–6733.
  • Hayashi K, Igarashi C, Hirata A. Changes in diabetic macular oedema after phacoemulsification surgery. Eye (Lond). 2009;23:389–396.
  • Dowler JG, Sehmi KS, Hykin PG. The natural history of macular edema after cataract surgery in diabetes. Ophthalmology. 1999;106:663–668.
  • Kwon SI, Hwang DJ, Seo JY. Evaluation of changes of macular thickness in diabetic retinopathy after cataract surgery. Korean J Ophthalmol. 2011;25:238–242.
  • Cunha-Vaz J, Bernardes R, Lobo C. Blood-retinal barrier. Eur J Ophthalmol. 2011;21:S3–S9.
  • Romero-Aroca P, Baget-Bernaldiz M, Pareja-Rios A, et al. Diabetic macular edema pathophysiology: vasogenic versus inflammatory. J Diabetes Res. 2016;2016:2156273.
  • Antonetti DA, Lieth E, Barber AJ, et al. Molecular mechanisms of vascular permeability in diabetic retinopathy. Semin Ophthalmol. 1999;14:240–248.
  • Bandello F, Battaglia Parodi M, Lanzetta P, et al. Diabetic macular edema. Dev Ophthalmol. 2010;47:73–110.
  • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med. 1994;331:1480–1487.
  • Adamis AP, Miller JW, Bernal M-T, et al. Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy. Am J Ophthalmol. 1994;118:445–450.
  • Silvestre JS, Mallat Z, Duriez M, et al. Antiangiogenic effect of interleukin-10 in ischemia-induced angiogenesis in mice hindlimb. Circ Res. 2000;87:448–452.
  • Sgadari C, Angiolillo AL, Tosato G. Inhibition of angiogenesis by interleukin-12 is mediated by the interferon inducible mprotein 10. Blood. 1996;87:3877–3882.
  • Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011;30:343–358.
  • Liu X, Ye F, Xiong H, et al. IL-1β induces IL-6 production in retinal Müller cells predominantly through the activation of p38 MAPK/NF-κB signaling pathway. Exp Cell Res. 2015;331:223–231.
  • Aveleira CA, Lin CM, Abcouwer SF, et al. TNF-α signals through PKC/NF-κB to alter the tight junction complex and increase retinal endothelial cell permeability. Diabetes. 2010;59:2872–2882.
  • Simo R, Hernandez C. Novel approaches for treating diabetic retinopathy based on recent pathogenic evidence. Prog Retin Eye Res. 2015;48:160–180.
  • van Dijk HW, Verbraak FD, Kok PH, et al. Early neurodegeneration in the retina of type 2 diabetic patients. Invest Ophthalmol Vis Sci. 2012;53:2715–2719.
  • El-Harazi SM, Feldman RM. Control of intra-ocular inflammation associated with cataract surgery. Curr Opin Ophthalmol. 2001;12:4–8.
  • Flach AJ. The incidence, pathogenesis and treatment of cystoid macular edema following cataract surgery. Trans Am Ophthalmol Soc. 1998;96:557–634.
  • Benitah NR, Arroyo JG. Pseudophakic cystoid macular edema. Int Ophthalmol Clin. 2010;50:139–153.
  • Yonekawa Y, Kim IK. Pseudophakic cystoid macular edema. Curr Opin Ophthalmol. 2012;23:26–32.
  • Loewenstein A, Zur D. Postsurgical cystoid macular edema. Dev Ophthalmol. 2010;47:148–159.
  • Henderson BA, Kim JY, Ament CS, et al. Clinical pseudophakic cystoid macular edema. Risk factors for development and duration after treatment. J Cataract Refract Surg. 2007;33:1550–1558.
  • Yang J, Cai L, Sun Z, et al. Risk factors for and diagnosis of pseudophakic cystoid macular edema after cataract surgery in diabetic patients. J Cataract Refract Surg. 2017;43:207–214.
  • Shorstein NH, Liu L, Waxman MD, et al. Comparative effectiveness of three prophylactic strategies to prevent clinical macular edema after phacoemulsification surgery. Ophthalmology. 2015;122:2450–2456.
  • McCafferty S, Harris A, Kew C, et al. Pseudophakic cystoid macular edema prevention and risk factors; prospective study with adjunctive once daily topical nepafenac 0.3% versus placebo. BMC Ophthalmol. 2017;17:16.
  • Denniston AK, Chakravarthy U, Zhu H, et al. The UK Diabetic Retinopathy Electronic Medical Record (UK DR EMR) users group, report 2: real-world data for the impact of cataract surgery on diabetic macular oedema. Br J Ophthalmol. 2017;101:1673–1678.
  • Daien V, Nguyen V, Morlet N, et al. Outcomes and predictive factors after cataract surgery in patients with neovascular age-related macular degeneration. The fight retinal blindness! Project. Am J Ophthalmol. 2018;190:50–57.
  • Ahmed AA, Hossam YA, Sherief EE, et al. Impact of topical nonsteroidal anti-inflammatory drugs in prevention of macular edema following cataract surgery in diabetic patients. Int J Ophthalmol. 2018;11:616–622.
  • Krepler K, Biowski R, Schrey S, et al. Cataract surgery in patients with diabetic retinopathy: visual outcome, progression of diabetic retinopathy, and incidence of diabetic macular oedema. Graefes Arch Clin Exp Ophthalmol. 2002;240:735–738.
  • Flesner P, Sander B, Henning V, et al. Cataract surgery on diabetic patients. a prospective evaluation of risk factors and complications. Acta Ophthalmol Scand. 2002;80:19–24.
  • Ning D, Bing X, Bingsong W, et al. Aqueous cytokines as predictors of macular edema in patients with diabetes following uncomplicated phacoemulsification cataract surgery. Biomed Res Int. 2015;2015:126984.
  • Gass JD, Norton EW. Cystoid macular edema and papilledema following cataract extraction. A fluorescein fundoscopic and angiographic study. Arch Ophthalmol. 1966;76:646–661.
  • Chen XY, Song WJ, Cai HY, et al. Macular edema after cataract surgery in diabetic eyes evaluated by optical coherence tomography. Int J Ophthalmol. 2016;9:81–85.
  • Perente I, Utine CA, Ozturker C, et al. Evaluation of macular changes after uncomplicated phacoemulsification surgery by optical coherence tomography. Curr Eye Res. 2007;32:241–247.
  • Serra R, Sellam A, Coscas F, et al. Evaluation of pseudophakic cystoid macular edema using optical coherence tomography angiography. Eur J Ophthalmol. 2018;28:234–240.
  • Agemy SA, Scripsema NK, Shah CM, et al. Retinal vascular perfusion density mapping using optical coherence tomography angiography in normals and diabetic retinopathy patients. Retina. 2015;35(11):2353–2363.
  • Shelsta HN, Jampol LM. Pharmacologic therapy of pseudophakic cystoid macular edema: 2010 update. Retina. 2011;31:4–12.
  • Wielders LH, Lambermont VA, Schouten JS. Prevention of cystoid macular edema after cataract surgery in nondiabetic and diabetic patients: a systematic review and meta-analysis. Am J Ophthalmol. 2015;160:968–981.
  • Kessel L, Tendal B, Jørgensen KJ, et al. Post-cataract prevention of inflammation and macular edema by steroid and nonsteroidal anti-inflammatory eye drops: a systematic review. Ophthalmology. 2014;121:1915–1924.
  • Endo N, Kato S, Haruyama K, et al. Efficacy of bromfenac sodium ophthalmic solution in preventing cystoid macular oedema after cataract surgery in patients with diabetes. Acta Ophthalmol. 2010;88:896–900.
  • Lim BX, Lim CH, Lim DK, et al. Prophylactic non-steroidal anti-inflammatory drugs for the prevention of macular oedema after cataract surgery. Cochrane Database Syst Rev. 2016;11:CD006683.
  • Modjtahedi BS, Paschal JF, Batech M, et al. Perioperative topical nonsteroidal anti inflammatory drugs for macular edema prophylaxis following cataract surgery. Am J Ophthalmol. 2017;176:174–182.
  • Elsawy MF, Badawi N, Khairy HA. Prophylactic postoperative ketorolac improves outcomes in diabetic patients assigned for cataract surgery. Clin Ophthalmol. 2013;7:1245–1249.
  • Medić A, Jukić T, Matas A, et al. Effect of preoperative topical diclofenac on intraocular interleukin-12 concentration and macular edema after cataract surgery in patients with diabetic retinopathy: a randomized controlled trial. Croat Med J. 2017;58:49–55.
  • Duong H-VQ, Westfield KC, Singleton IC. Treatment paradigm after uncomplicated cataract surgery: a prospective evaluation. Asia Pac J Ophthalmol. 2014;3:220–225.
  • Terada Y, Masuda A, Nejima R, et al. The anti-inflammatory effect of 0.1% bromfenac and 0.1% betamethasone combination in post-cataract surgery patients with diabetes mellitus. Nippon Ganka Gakkai Zasshi. 2014;118:645–665.
  • Jung JW, Chung BH, Kim EK, et al. The effects of two non-steroidal anti-inflammatory drugs, bromfenac 0.1% and ketorolac 0.45%, on cataract surgery. Yonsei Med J. 2015;56:1671–1677.
  • Hariprasad SM, Sanders M, Chastain J, et al. Periocular distribution of nepafenac and amfenac after topical administration of nepafenac in the rabbit. Invest Ophthalmol Vis Sci. 2009;50:5999.
  • Lindstrom R, Kim T. Ocular permeation and inhibition of retinal inflammation: an examination of data and expert opinion on the clinical utility of nepafenac. Curr Med Res Opin. 2006;22:397–404.
  • Singh R, Alpern L, Jaffe GJ. Evaluation of nepafenac in prevention of macular edema following cataract surgery in patients with diabetic retinopathy. Clin Ophthalmol. 2012;6:1259–1269.
  • Hariprasad SM, Callanan D, Gainey S, et al. Cystoid and diabetic macular edema treated with nepafenac 0.1%. J Ocul Pharmacol Ther. 2007;23:585–590.
  • Sarfraz MH, Haq RI, Mehboob MA. Effect of topical nepafenac in prevention of macular edema after cataract surgery in patients with nonproliferative diabetic retinopathy. Pak J Med Sci. 2017;33:210–214.
  • Pollack A, Staurenghi G, Sager D, et al. Prospective randomised clinical trial to evaluate the safety and efficacy of nepafenac 0.1% treatment for the prevention of macular oedema associated with cataract surgery in patients with diabetic retinopathy. Br J Ophthalmol. 2017;101:423–427.
  • Chastain JE, Sanders ME, Curtis MA, et al. Distribution of topical ocular nepafenac and its active metabolite amfenac to the posterior segment of the eye. Exp Eye Res. 2016;145:58–67.
  • Singh RP, Lehmann R, Martel J, et al. Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy: results of 2 randomized Phase 3 studies. Ophthalmology. 2017;124(6):776–785.
  • Duong HVQ, Westfield KC, Singleton IC. Comparing the efficacy of bromfenac 0.09% and nepafenac 0.1% post cataract surgery: a prospective evaluation. J Clin Exp Ophthalmol. 2011;2:8.
  • Loftsson T, Sigurdsson HH, Konrádsdóttir F, et al. Topical drug delivery to the posterior segment of the eye: anatomical and physiological considerations. Pharmazie. 2008;63:171–179.
  • Kim SJ, Schoenberger SD, Thorne JE, et al. Topical nonsteroidal anti-inflammatory drugs and cataract surgery: a report by the American academy of ophthalmology. Ophthalmology. 2015;122:2159–2168.
  • Fard MA, Yazdanei Abyane A, Malihi M,. Prophylactic intravitreal bevacizumab for diabetic macular edema (thickening) after cataract surgery: prospective randomized study. Eur J Ophthalmol. 2011;21:276–281.
  • Udaondo P, Garcia-Pous M, Garcia-Delpech S, et al. Prophylaxis of macular edema with intravitreal ranibizumab in patients with diabetic retinopathy after cataract surgery: a pilot study. J Ophthalmol. 2011;2011:159436.
  • Chae JB, Joe SG, Yang SJ, et al. Effect of combined cataract surgery and ranibizumab injection in postoperative macular edema in nonproliferative diabetic retinopathy. Retina. 2014;34:149–156.
  • Kim SY, Yang J, Lee YC, et al. Effect of a single intraoperative sub-tenon injection of triamcinolone acetonide on the progression of diabetic retinopathy and visual outcomes after cataract surgery. J Cataract Refract Surg. 2008;34:823–826.
  • Ahmadabadi HF, Mohammadi M, Beheshtnejad H, et al. Effect of intravitreal triamcinolone acetonide injection on central macular thickness in diabetic patients having phacoemulsification. J Cataract Refract Surg. 2010;36:917–922.
  • Wielders L. The PREMED study: the diabetic eye. Paper presented at: Changing Pharmaceutical Treatment in Cataract Surgery. 35th Congress of the European Society of Cataract and Refractive Surgeons (ESCRS); 2017 Oct 7–11; [Accessed 2018 Mar 24. Available from: https://escrs.conference2web.com/#resources/the-premed-study-the-diabetic-eye
  • Calvo P, Ferreras A, Al Adel F, et al. Effect of an intravitreal dexamethasone implant on diabetic macular edema after cataract surgery. Retina. 2018;38:490–496.
  • Boscia F. Current approaches to the management of diabetic retinopathy and diabetic macular oedema. Drugs. 2010;70:2171–2200.
  • Baker CW, Almukhtar T, Bressler NM, et al.; Diabetic Retinopathy Clinical Research Network Authors/Writing Committee. Macular edema after cataract surgery in eyes without preoperative central-involved diabetic macular edema. JAMA Ophthalmol. 2013;131:870–879.
  • Scott IU, Danis RP, Bressler SB, et al. Effect of focal/grid photocoagulation on visual acuity and retinal thickening in eyes with non-center involved diabetic macular edema. Retina. 2009;29:613–617.
  • Early treatment diabetic retinopathy study research group. Photocoagulation for diabetic macular edema. Early treatment diabetic retinopathy study report number 1. Arch Ophthalmol. 1985;103:1796–1806.
  • Suto C, Hori S, Kato S. Management of type 2 diabetics requiring panretinal photocoagulation and cataract surgery. J Cataract Refract Surg. 2008;34:1001–1006.
  • Chew EY, Benson WE, Remaley NA, et al. Results after lens extraction in patients with diabetic retinopathy: early treatment diabetic retinopathy study report number 25. Arch Ophthalmol. 1999;117:1600–1606.
  • Murtha T, Cavallerano J. The management of diabetic eye disease in the setting of cataract surgery. Curr Opin Ophthalmol. 2007;18:13–18.
  • Fraser-Bell S, Kaines A, Hykin PG. Update on treatments for diabetic macular edema. Curr Opin Ophthalmol. 2008;19:185–189.
  • Moshfeghi AA, Shapiro H, Lemmon LA, et al. Impact of cataract surgery during treatment with ranibizumab in patients with diabetic macular edema. Ophthalmology Retina. 2018;2:86–90.
  • Heier JS, Korobelnik JF, Brown DM, et al. Intravitreal aflibercept for diabetic macular edema: 148-week results from the VISTA and VIVID studies. Ophthalmology. 2016;123:2376–2385.
  • Boyer DS, Yoon YH, Belfort R Jr, et al. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 2014;121:1904–1914.
  • Veritti D, Sarao V, Diplotti L, et al. Fluocinolone acetonide for the treatment of diabetic macular edema. Expert Opin Pharmacother. 2017;18:1507–1516.
  • Yang Y, Bailey C, Holz FG, et al. Long-term outcomes of phakic patients with diabetic macular oedema treated with intravitreal fluocinolone acetonide (FAc) implants. Eye (Lond). 2015;29:1240.
  • Takamura Y, Kubo E, Akagi Y. Analysis of the effect of intravitreal bevacizumab injection on diabetic macular edema after cataract surgery. Ophthalmology. 2009;116:1151–1157.
  • Lanzagorta-Aresti A, Palacios-Pozo E, Menezo Rozalen JL, et al. Prevention of vision loss after cataract surgery in diabetic macular edema with intravitreal bevacizumab: a pilot study. Retina. 2009;29:530–535.
  • Chen CH, Liu YC, Wu PC. The combination of intravitreal bevacizumab and phacoemulsification surgery in patients with cataract and coexisting diabetic macular edema. J Ocul Pharmacol Ther. 2009;25:83–89.
  • Akinci A, Batman C, Ozkilic E, et al. Phacoemulsification with intravitreal bevacizumab injection in diabetic patients with macular edema and cataract. Retina. 2011;31:755–758.
  • Rauen PI, Ribeiro JA, Almeida FP, et al. Intravitreal injection of ranibizumab during cataract surgery in patients with diabetic macular edema. Retina. 2012;32:1799–1803.
  • Lam DS, Chan CK, Mohamed S, et al. Phacoemulsification with intravitreal triamcinolone in patients with cataract and coexisting diabetic macular oedema: a 6-month prospective pilot study. Eye (Lond). 2005;19:885–890.
  • Habib MS, Cannon PS, Steel DH. The combination of intravitreal triamcinolone and phacoemulsification surgery in patients with diabetic foveal oedema and cataract. BMC Ophthalmol. 2005;5:15.
  • Nunome T, Sugimoto M, Kondo M, et al. Triamcinolone acetonide combined with cataract surgery for diabetic macular edema in japan: in the era of anti-vascular endothelial growth factor therapy. Ophthalmologica. 2018. DOI:10.1159/000487548.
  • Takata C, Messias A, Folgosa MS, et al. Intravitreal injection versus subtenon infusion of triamcinolone acetonide during cataract surgery in patients with refractory diabetic macular edema. Retina. 2010;30:562–569.
  • Lim LL, Morrison JL, Constantinou M, et al. Diabetic macular edema at the time of cataract surgery trial: a prospective, randomized clinical trial of intravitreous bevacizumab versus triamcinolone in patients with diabetic macular oedema at the time of cataract surgery - preliminary 6 month results. Clin Exp Ophthalmol. 2016;44:233–242.
  • Ozgur OR, Ozkurt Y, Kulekci Z, et al. The combination of phacoemulsification surgery and intravitreal triamcinolone injection in patients with cataract and diabetic macular edema. Saudi J Ophthalmol. 2016;30:33–38.
  • Sze AM, Luk FO, Yip TP, et al. Use of intravitreal dexamethasone implant in patients with cataract and macular edema undergoing phacoemulsification. Eur J Ophthalmol. 2015;25:168–172.
  • Agarwal A, Gupta V, Ram J, et al. Dexamethasone intravitreal implant during phacoemulsification. Ophthalmology. 2013;120(211):1–5.
  • Furino C, Boscia F, Niro A, et al. Combined phacoemulsification and intravitreal dexamethasone implant (Ozurdex) in diabetic patients with coexisting cataract and diabetic macular edema. J Ophthalmol. 2017;2017:4896036.
  • Panozzo GA, Gusson E, Panozzo G, et al. Dexamethasone intravitreal implant at the time of cataract surgery in eyes with diabetic macular edema. Eur J Ophthalmol. 2017;27:433–437.

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