791
Views
12
CrossRef citations to date
0
Altmetric
Review

Pharmacological treatment for insomnia in patients with major depressive disorder

, , &
Pages 1341-1349 | Received 23 Jan 2019, Accepted 30 Apr 2019, Published online: 16 May 2019

References

  • Taylor SS, Hughes JM, Coffman CJ, et al. Prevalence of and characteristics associated with insomnia and obstructive sleep apnea among veterans with knee and hip osteoarthritis. BMC Musculoskelet Disord. 2018 Mar 9;19(1):79.
  • Jordan P, Shedden-Mora MC, Löwe B. Predicting suicidal ideation in primary care: an approach to identify easily assessable key variables. Gen Hosp Psychiatry. 2018;51:106–111. Mar,Apr.
  • Shochat T, Cohen-Zion M, Tzischinsky O. Functional consequences of inadequate sleep in adolescents: a systematic review. Sleep Med Rev. 2014 Feb;18(1):75–87.
  • Chung KF, Yeung WF, Ho FY, et al. Predictors of daytime consequences of insomnia: the roles of quantitative criteria and nonrestorative sleep. Psychopathology. 2018;51(4):262–268.
  • Shekleton JA, Flynn-Evans EE, Miller B, et al. Neurobehavioral performance impairment in insomnia: relationships with self-reported sleep and daytime functioning. Sleep. 2014 Jan 1;37(1):107–116.
  • Soehner AM, Kaplan KA, Harvey AG. Prevalence and clinical correlates of co-occurring insomnia and hypersomnia symptoms in depression. J Affect Disord. 2014;167:93–97.
  • Seow LS, Subramaniam M, Abdin E, et al. Sleep disturbance among people with major depressive disorders (MDD) in Singapore. J Ment Health. 2016 Dec;25(6):492–499.
  • Sivertsen B, Vedaa Ø, Harvey AG, et al. Sleep patterns and insomnia in young adults: a national survey of Norwegian university students. J Sleep Res. 2018 Dec;4:e12790.
  • Pigeon WR, Bishop TM, Krueger KM. Insomnia as a precipitating factor in new onset mental illness: a systematic review of recent findings. Curr Psychiatry Rep. 2017 Aug;19(8):44.
  • Geoffroy PA, Hoertel N, Etain B, et al. Insomnia and hypersomnia in major depressive episode: prevalence, sociodemographic characteristics and psychiatric comorbidity in a population-based study. J Affect Disord. 2018 Jan;15(226):132–141.
  • Rumble ME, White KH, Benca RM. Sleep disturbances in mood disorders. Psychiatr Clin North Am. 2015 Dec;38(4):743–759.
  • Tempaku P, Hirotsu C, Mazzotti D, et al. Long sleep duration, insomnia, and insomnia with short objective sleep duration are independently associated with short telomere length. J Clin Sleep Med. 2018 Nov 29;14:jc-18–00113.
  • Grigolon RB, Trevizol AP, Cerqueira RO, et al. Hypersomnia and bipolar disorder: a systematic review and proportion meta-analysis. J Affect Disord. 2019 Mar 1;246:659–666.
  • Sanyal C, Asbridge M, Kisely S, et al. The utilization of antidepressants and benzodiazepines among people with major depression in Canada. Can J Psychiatry. 2011 Nov;56(11):667–676.
  • Manthey L1, Lohbeck M, Giltay EJ, et al. Correlates of benzodiazepine dependence in the Netherlands study of depression and anxiety. Addiction. 2012 Dec;107(12):2173–2182.
  • Kurko TA, Saastamoinen LK, Tähkäpää S, et al. Long-term use of benzodiazepines: definitions, prevalence and usage patterns - a systematic review of register-based studies. Eur Psychiatry. 2015 Nov;30(8):1037–1047.
  • O’Brien EM, Chelminski I, Young D, et al. Severe insomnia is associated with more severe presentation and greater functional deficits in depression. J Psychiatr Res. 2011 Aug;45(8):1101–1105.
  • Xiao L, Feng L, Zhu XQ, et al. Comparison of residual depressive symptoms and functional impairment between fully and partially remitted patients with major depressive disorder: a multicenter study. Psychiatry Res. 2018 Mar;261:547–553.
  • Chokroverty S. Overview of normal sleep. In: Chokroverty S, editor. Sleep disorders. New York, NY: Springer; 2017. p. 5–21.
  • Woody ML, Gibb BE. Integrating NIMH research domain criteria (RDoC) into depression research. Curr Opin Psychol. 2015 Aug;4:6–12.
  • Sakurai H, Suzuki T, Yoshimura K, et al. Predicting relapse with individual residual symptoms in major depressive disorder: a reanalysis of the STAR*D data. Psychopharmacology (Berl). 2017 Aug;234(16):2453–2461.
  • Suri R, Stowe ZN, Cohen LS, et al. Prospective longitudinal study of predictors of postpartum-onset depression in women with a history of major depressive disorder. J Clin Psychiatry. 2017 Sep/Oct;78(8):1110–1116.
  • Nunes ML, Bruni O. Insomnia in childhood and adolescence: clinical aspects, diagnosis, and therapeutic approach. J Pediatr. 2015 Nov-Dec;91(6 Suppl 1):S26–35.
  • Gulia KK, Kumar VM. Sleep disorders in the elderly: a growing challenge. Psychogeriatrics. 2018;18(3):155–165.
  • Pan Z, Park C, Brietzke E, et al. Cognitive impairment in major depressive disorder. CNS Spectr. 2019 Feb;24(1):22–29.
  • Nishida M, Nakashima Y, Nishikawa T. Slow sleep spindle and procedural memory consolidation in patients with major depressive disorder. Nat Sci Sleep. 2016 Jan;28(8):63–72.
  • McKinnon AC, Hickie IB, Scott J, et al. Current sleep disturbance in older people with a lifetime history of depression is associated with increased connectivity in the default mode network. J Affect Disord. 2018 Mar;15(229):85–94.
  • Fang X1, Zhang C2, Wu Z1, et al. The association between somatic symptoms and suicidal ideation in Chinese first-episode major depressive disorder. J Affect Disord. 2018 Oct;17(245):17–21.
  • Don RJ, King L, St CK, et al. Depression and the relationship between sleep disturbances, nightmares, and suicidal ideation in treatment-seeking Canadian armed forces members and veterans. BMC Psychiatry. 2018 Jun 19;18(1):204.
  • Eikelenboom M, Beekman ATF, Penninx BWJH, et al. A 6 year longitudinal study of predictors for suicide attempts in major depressive disorder. Psychol Med. 2018.
  • Michaels MS, Balthrop T, Nadorff MR, et al. Total sleep time as a predictor of suicidal behaviour. J Sleep Res. 2017 Dec;26(6):732–738.
  • Breslau N, Roth T, Rosenthal L, et al. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996 Mar 15;39(6):411–418.
  • Wu JC, Bunney WE. The biological basis of an antidepressant response to sleep deprivation and relapse: review and hypothesis. Am J Psychiatry. 1990 Jan;147(1):14–21.
  • Boland EM, Rao H, Dinges DF, et al. Meta-analysis of the antidepressant effects of acute sleep deprivation. J Clin Psychiatry. 2017 Sep/Oct;78(8):e1020–e1034.
  • Bunney BG, Li JZ, Walsh DM, et al. Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder. Mol Psychiatry. 2015 Feb;20(1):48–55.
  • Charrier A, Olliac B, Roubertoux P, et al. Clock genes and altered sleep-wake rhythms: their role in the development of psychiatric disorders. Int J Mol Sci. 2017 Apr 29;18(5):E938.
  • Orozco-Solis R, Montellier E, Aguilar-Arnal L, et al. A circadian genomic signature common to ketamine and sleep deprivation in the anterior cingulate cortex. Biol Psychiatry. 2017 Sep 1;82(5):351–360.
  • Sun X, Zheng B, Lv J, et al., China Kadoorie Biobank (CKB) Collaborative Group. Sleep behavior and depression: findings from the China Kadoorie biobank of 0.5 million Chinese adults. J Affect Disord. 2018 Mar; 15(229):120–124.
  • Lang CJ, Appleton SL, Vakulin A, et al. Co-morbid OSA and insomnia increases depression prevalence and severity in men. Respirology. 2017 Oct;22(7):1407–1415.
  • Stubbs B, Vancampfort D, Veronese N, et al. The prevalence and predictors of obstructive sleep apnea in major depressive disorder, bipolar disorder and schizophrenia: A systematic review and meta-analysis. J Affect Disord. 2016 Jun;197:259–267.
  • Chen YH, Keller JK, Kang JH, et al. Obstructive sleep apnea and the subsequent risk of depressive disorder: a population-based follow-up study. J Clin Sleep Med. 2013 May 15;9(5):417–423.
  • Lichstein KL, Justin Thomas S, Woosley JA, et al. Co-occurring insomnia and obstructive sleep apnea. Sleep Med. 2013 Sep;14(9):824–829.
  • Bishop TM, Ashrafioun L, Pigeon WR. The association between sleep apnea and suicidal thought and behavior: an analysis of national survey data. J Clin Psychiatry. 2018 Jan/Feb;79(1):pii: 17m11480.
  • Hobzova M, Prasko J, Vanek J, et al. Depression and obstructive sleep apnea. Neuro Endocrinol Lett. 2017 Oct;38(5):343–352.
  • Chung F, Abdullah HR, Liao P. STOP-bang questionnaire: a practical approach to screen for obstructive sleep apnea. Chest. 2016 Mar;149(3):631–638.
  • Nagappa M, Liao P, Wong J, et al. Validation of the STOP-bang questionnaire as a screening tool for obstructive sleep apnea among different populations: a systematic review and meta-analysis. PLoS One. 2015 Dec 14;10(12):e0143697.
  • Venkateshiah SB, Ioachimescu OC. Restless legs syndrome. Crit Care Clin. 2015 Jul;31(3):459–472.
  • Koo BB, Blackwell T, Lee HB, et al., Osteoporotic Fractures in Men (MrOS) Study Group. Restless legs syndrome and depression: effect mediation by disturbed sleep and periodic limb movements. Am J Geriatr Psychiatry. 2016 Nov; 24(11):1105–1116.
  • Sarberg M, Bladh M, Svanborg E, et al. Postpartum depressive symptoms and its association to daytime sleepiness and restless legs during pregnancy. BMC Pregnancy Childbirth. 2016 Jun 6;16(1):137.
  • Auvinen P, Mäntyselkä P, Koponen H, et al. Prevalence of restless legs symptoms according to depressive symptoms and depression type: a cross-sectional study. Nord J Psychiatry. 2018a Jan;72(1):51–56.
  • Auvinen P, Mäntyselkä P, Koponen H, et al. Elevation of tumor necrosis factor alpha levels is associated with restless legs symptoms in clinically depressed patients. J Psychosom Res. 2018b Dec;115:1–5.
  • Becker PM, Sharon D. Mood disorders in restless legs syndrome (Willis-Ekbom disease). J Clin Psychiatry. 2014 Jul;75(7):e679–94.
  • Soares CN, Murray BJ. Sleep disorders in women: clinical evidence and treatment strategies. Psychiatr Clin North Am. 2006;29(4):1095–1113.
  • Joffe H, Soares CN, Thurston RC, et al. Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptoms. Menopause. 2009;16(4):671–679.
  • Soares CN, Joffe H, Rubens R, et al. Eszopiclone in patients with insomnia during perimenopause and early postmenopause: a randomized controlled trial. Obstet Gynecol. 2006;108(6):1402–1410.
  • Joffe H, Crawford SL, Freeman MP, et al. Independent contributions of nocturnal hot flashes and sleep disturbance to depression in estrogen-deprived women. J Clin Endocrinol Metab. 2016;101(10):3847–3855.
  • Kim SJ, Han KT, Jang SY, et al. The association between migraine and types of sleep disorder. Int J Environ Res Public Health. 2018 Nov 26;15:12.
  • Buse DC, Rains JC, Pavlovic JM, et al. Sleep disorders among people with migraine: results from the chronic migraine epidemiology and outcomes (CaMEO) study. Headache. 2019 Jan;59(1):32–45.
  • Almoznino G, Haviv Y, Sharav Y, et al. An update of management of insomnia in patients with chronic orofacial pain. Oral Dis. 2017 Nov;23(8):1043–1051.
  • Generaal E, Vogelzangs N, Penninx BW, et al. Insomnia, sleep duration, depressive symptoms, and the onset of chronic multisite musculoskeletal pain. Sleep. 2017. 1. 40(1):Jan.
  • Frange C, Hachul H, Hirotsu C, et al. Temporal analysis of chronic musculoskeletal pain and sleep in postmenopausal women. J Clin Sleep Med. 2019 Feb 15;15(2):223–234.
  • Alföldi P, Dragioti E, Wiklund T, et al. Spreading of pain and insomnia in patients with chronic pain: results from a national quality registry (SQRP). J Rehabil Med. 2017 Jan 19;49(1):63–70.
  • Zhuang J, Zhan Y, Zhang F, et al. Self-reported insomnia and coronary heart disease in the elderly. Clin Exp Hypertens. 2016;38(1):51–55.
  • Tan X, van Egmond L, Chapman CD, et al. Aiding sleep in type 2 diabetes: therapeutic considerations. Lancet Diabetes Endocrinol. 2018 Jan;6(1):60–68.
  • Sen A, Opdahl S, Strand LB, et al. Insomnia and the risk of breast cancer: the HUNT study. Psychosom Med. 2017 May;79(4):461–468.
  • Shi L, Wang J, Xu S, et al. Efficacy and tolerability of vilazodone for major depressive disorder: evidence from phase III/IV randomized controlled trials. Drug Des Devel Ther. 2016 Nov 25;10:3899–3907.
  • Fabbri C, Marsano A, Balestri M, et al. Clinical features and drug induced side effects in early versus late antidepressant responders. J Psychiatr Res. 2013 Oct;47(10):1309–1318.
  • Kikuchi T, Suzuki T, Uchida H, et al. Coping strategies for antidepressant side effects: an internet survey. J Affect Disord. 2012 Dec 20;143(1–3):89–94.
  • Liu Y, Xu X, Dong M, et al. Treatment of insomnia with tricyclic antidepressants: a meta-analysis of polysomnographic randomized controlled trials. Sleep Med. 2017 Jun;34:126–133.
  • Uher R, Farmer A, Henigsberg N, et al. Adverse reactions to antidepressants. Br J Psychiatry. 2009 Sep;195(3):202–210.
  • Asnis GM, Chakraburtty A, DuBoff EA, et al. Zolpidem for persistent insomnia in SSRI-treated depressed patients. J Clin Psychiatry. 1999 Oct;60(10):668–676.
  • Wichniak A, Wierzbicka A, Walęcka M, et al. Effects of antidepressants on sleep. Curr Psychiatry Rep. 2017 Aug 9;19(9):63.
  • Wichniak A, Wierzbicka A, Jernajczyk W. Sleep as a biomarker for depression. Int Rev Psychiatry. 2013 Oct;25(5):632–645.
  • Delaplace R, Garny de La Rivière S, Bon Saint Come M, et al. Sleep and disruptive mood dysregulation disorder: A pilot actigraphy study. Arch Pediatr. 2018 Jun 14;25:S0929-693X(18)30109-X.
  • Averill IR, Crowe M, Frampton CM, et al. Clinical response to treatment in inpatients with depression correlates with changes in activity levels and psychomotor speed. Aust N Z J Psychiatry. 2018 Jul;52(7):652–659.
  • van Diermen L, Schrijvers D, Cools O, et al. Distinguishing subgroups based on psychomotor functioning among patients with major depressive disorder. Neuropsychobiology. 2017;76(4):199–208.
  • DiNapoli EA, Gebara MA, Kho T, et al. Subjective-objective sleep discrepancy in older adults with MCI and subsyndromal depression. Geriatr Psychiatry Neurol. 2017 Nov;30(6):316–323.
  • Krane-Gartiser K, Vaaler AE, Fasmer OB, et al. Variability of activity patterns across mood disorders and time of day. BMC Psychiatry. 2017 Dec 19;17(1):404.
  • Bernert RA, Luckenbaugh DA, Duncan WC, et al. Sleep architecture parameters as a putative biomarker of suicidal ideation in treatment-resistant depression. J Affect Disord. 2017 Jan 15;208:309–315.
  • Bourla A, Ferreri F, Ogorzelec L, et al. Assessment of mood disorders by passive data gathering: the concept of digital phenotype versus psychiatrist’s professional culture. Encephale. 2018 Apr;44(2):168–175.
  • Lorenz CP1, Williams AJ. Sleep apps: what role do they play in clinical medicine? Curr Opin Pulm Med. 2017 Nov;23(6):512–516.
  • Paré G, Leaver C, Bourget C. Diffusion of the digital health self-tracking movement in Canada: results of a national survey. J Med Internet Res. 2018 May 2;20(5):e177.
  • Sung SC, Wisniewski SR, Luther JF, et al., COMED Study Team. Pre-treatment insomnia as a predictor of single and combination antidepressant outcomes: a CO-MED report. J Affect Disord. 2015 Mar; 15(174):157–164.
  • Srinivasan V, Brzezinski A, Pandi-Perumal SR, et al. Melatonin agonists in primary insomnia and depression-associated insomnia: are they superior to sedative-hypnotics? Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):913–923.
  • Urade CS, Mahakalkar SM, Tiple PG. A comparative study of the clinical efficacy and safety of agomelatine with escitalopram in major depressive disorder patients: A randomized, parallel-group, phase IV study. J Pharmacol Pharmacother. 2015 Oct–Dec;6(4):198–203.
  • Alberti S, Chiesa A, Andrisano C, et al. Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depression: a meta-analysis. J Clin Psychopharmacol. 2015 Jun;35(3):296–303.
  • Burrows GD, Kremer CM. Mirtazapine: clinical advantages in the treatment of depression. J Clin Psychopharmacol. 1997;17:34S–39S.
  • Karsten J, Hagenauw LA, Kamphuis J, et al. Low doses of mirtazapine or quetiapine for transient insomnia: a randomised, double-blind, cross-over, placebo-controlled trial. J Psychopharmacol. 2017 Mar;31(3):327–337.
  • Rothschild-Fuentes B, Roche A, Jiménez-Genchi A, et al. Effects of mirtazapine on the sleep wake rhythm of geriatric patients with major depression: an exploratory study with actigraphy. Pharmacopsychiatry. 2013 Mar;46(2):59–62.
  • Shen J, Moller HJ, Wang X, et al. Mirtazapine, a sedating antidepressant, and improved driving safety in patients with major depressive disorder: a prospective, randomized trial of 28 patients. J Clin Psychiatry. 2009 Mar;70(3):370–377.
  • Bertisch SM, Herzig SJ, Winkelman JW, et al. National use of prescription medications for insomnia: NHANES 1999-2010. Sleep. 2014;37:343–349.
  • Liguori C, Ferini-Strambi L, Izzi F, et al. Preliminary evidence that vortioxetine may improve sleep quality in depressed patients with insomnia: a retrospective questionnaire analysis. Br J Clin Pharmacol. 2019 Jan;85(1):240–244.
  • Krystal AD, Mittoux A, Meisels P, et al. Effects of adjunctive brexpiprazole on sleep disturbances in patients with major depressive disorder: an open-label, flexible-dose, exploratory study. Prim Care Companion CNS Disord. 2016 Sep 8;18(5).
  • Peyron C, Kilduff TS. Mapping the hypocretin/orexin neuronal system: an unexpectedly productive journey. J Neurosci. 2017 Mar 1;37(9):2268–2272.
  • Mieda M. The roles of orexins in sleep/wake regulation. Neurosci Res. 2017 May;118:56–65.
  • Schwartz MD, Kilduff TS. The neurobiology of sleep and wakefulness. Psychiatr Clin North Am. 2015 Dec;38(4):615–644.
  • Coleman PJ, Gotter AL, Herring WJ, et al. The discovery of suvorexant, the first orexin receptor drug for insomnia. Annu Rev Pharmacol Toxicol. 2017 Jan;6(57):509–533.
  • Winrow CJ, Renger JJ. Discovery and development of orexin receptor antagonists as therapeutics for insomnia. Br J Pharmacol. 2014 Jan;171(2):283–293.
  • Nollet M, Leman S. Role of orexin in the pathophysiology of depression: potential for pharmacological intervention. CNS Drugs. 2013 Jun;27(6):411–422.
  • Murillo-Rodriguez E, Poot-Ake A, Arias-Carrion O, et al. The emerging role of the endocannabinoid system in the sleep-wake cycle modulation. Cent Nerv Syst Agents Med Chem. 2011 Sep 1;11(3):189–196.
  • Babson KA, Sottile J, Morabito D. Cannabis, cannabinoids, and sleep: a review of the literature. Curr Psychiatry Rep. 2017 Apr;19(4):23.
  • Hsiao YT, Yi PL, Li CL, et al. Effect of cannabidiol on sleep disruption induced by the repeated combination tests consisting of open field and elevated plus-maze in rats. Neuropharmacology. 2012 Jan;62(1):373–384.
  • Irwin MR, Piber D. Insomnia and inflammation: a two hit model of depression risk and prevention. World Psychiatry. 2018 Oct;17(3):359–361.
  • Shariq AS, Brietzke E, Rosenblat JD, et al. Targeting cytokines in reduction of depressive symptoms: A comprehensive review. Prog Neuropsychopharmacol Biol Psychiatry. 2018 Apr;20(83):86–91.
  • Maes M, Noto C, Brietzke E. Omics-based depression and inflammation research. Braz J Psychiatry. 2015;37(1):1–2. Jan–Mar.
  • Noto C, Rizzo LB, Mansur RB, et al. Targeting the inflammatory pathway as a therapeutic tool for major depression. Neuroimmunomodulation. 2014;21(2–3):131–139.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.