Advanced search
Publication Cover
Expert Opinion on Pharmacotherapy Volume 20, 2019 - Issue 13
Submit an article Journal homepage
2,945
Views
8
CrossRef citations to date
0
Altmetric
Editorial

How does one choose the correct pharmacotherapy for a pediatric patient with restless legs syndrome and periodic limb movement disorder?: Expert Guidance

Thomas J. DyeDivision of Pulmonary and sleep medicine, Cincinnati, OH, USA;Division of neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, USA;Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USAView further author information
,
Neepa GurbaniDivision of Pulmonary and sleep medicine, Cincinnati, OH, USA;Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USAView further author information
&
Narong SimakajornboonDivision of Pulmonary and sleep medicine, Cincinnati, OH, USA;Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH, USACorrespondence[email protected]
View further author information
Pages 1535-1538 | Received 26 Apr 2019, Accepted 05 Jun 2019, Published online: 26 Jun 2019

References

  • Simakajornboon N, Dye TJ, Walters AS. Restless legs syndrome/Willis-Ekbom disease and growing pains in children and adolescents. Sleep Med Clin. 2015 Sep;10(3):311–22, xiv.
  • PicchiettiD, AllenRP, WaltersAS, et al. Restless legs syndrome: prevalence and impact in children and adolescents–the Peds REST study. Pediatrics. 2007;120(2):253–266.
  • Picchietti DL, Bruni O, de Weerd A, et al. Pediatric restless legs syndrome diagnostic criteria: an update by the international restless legs syndrome study group. Sleep Med. 2013 Dec;14(12):1253–1259.
  • Walter LM, Foster AM, Patterson RR, et al. Cardiovascular variability during periodic leg movements in sleep in children. Sleep. 2009;32(8):1093–1099.
  • Wing YK, Zhang J, Ho CKW, et al. Periodic limb movement during sleep is associated with nocturnal hypertension in children. Sleep. 2010;33(6):759–765.
  • Rulong G, Dye T, Simakajornboon N. Pharmacological management of restless legs syndrome and periodic limb movement disorder in children. Paediatr Drugs. 2018 Feb;20(1):9–17.
  • Allen RP, Picchietti DL, Auerbach M, et al. Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report. Sleep Med. 2018;41:27–44.
  • Simakajornboon N, Gozal D, Vlasic V, et al. Periodic limb movements in sleep and iron status in children. Sleep. 2003;26(6):735–738.
  • Mohri I, Kato-Nishimura K, Kagitani-Shimono K, et al. Evaluation of oral iron treatment in pediatric restless legs syndrome (RLS). Sleep Med. 2012 Apr;13(4):429–432.
  • Amos LB, Grekowicz ML, Kuhn EM, et al. Treatment of pediatric restless legs syndrome. Clin Pediatr (Phila). 2014 Apr;53(4):331–336.
  • Furudate N, Komada Y, Kobayashi M, et al. Daytime dysfunction in children with restless legs syndrome. J Neurol Sci. 2014 Jan 15;336(1–2):232–236.
  • Dye TJ, Jain SV, Simakajornboon N. Outcomes of long-term iron supplementation in pediatric restless legs syndrome/periodic limb movement disorder (RLS/PLMD). Sleep Med. 2017 Apr;32:213–219.
  • Tilma J, Tilma K, Norregaard O, et al. Early childhood-onset restless legs syndrome: symptoms and effect of oral iron treatment. Acta Paediatr. 2013 May;102(5):e221–6.
  • Grim K, Lee B, Sung AY, et al. Treatment of childhood-onset restless legs syndrome and periodic limb movement disorder using intravenous iron sucrose. Sleep Med. 2013 Nov;14(11):1100–1104.
  • Ferré S, Earley C, Gulyani S, et al. In search of alternatives to dopaminergic ligands for the treatment of restless legs syndrome: iron, glutamate, and adenosine. Sleep Med. 2017;31:86–92.
  • Robinson AA, Malow BA. Gabapentin shows promise in treating refractory insomnia in children. J Child Neurol. 2013;28(12):1618–1621.
  • Vondracek P, Oslejskova H, Kepak T, et al. Efficacy of pregabalin in neuropathic pain in paediatric oncological patients. Eur J Paediatr Neurol. 2009 7;13(4):332–336.
  • Khurana DS, Riviello J, Helmers S, et al. Efficacy of gabapentin therapy in children with refractory partial seizures. J Pediatr. 1996;128(6):829–833.
  • Jan MMS, Zuberi SA, Alsaihati BA. Pregabalin: preliminary experience in intractable childhood epilepsy. Pediatr Neurol. 2009 5;40(5):347–350.
  • Walters AS, Mandelbaum DE, Lewin DS, et al. Dopaminergic therapy in children with restless legs/periodic limb movements in sleep and ADHD. Pediatr Neurol. 2000;22(3):182–186.
  • Guilleminault C, Palombini L, Pelayo R, et al. Sleepwalking and sleep terrors in prepubertal children: what triggers them? Pediatrics. 2003;111(1):e17–25.
  • England SJ, Picchietti DL, Couvadelli BV, et al. L-Dopa improves restless legs syndrome and periodic limb movements in sleep but not attention-deficit-hyperactivity disorder in a double-blind trial in children. Sleep Med. 2011 May;12(5):471–477.
  • JP HJ E, Picchietti DL, Ridel K, et al. Pharmacokinetics of rotigotine transdermal system in adolescents with idiopathic restless legs syndrome (Willis-Ekborn disease). Sleep Med. 2017;32:48–55.
  • Gingras JL, Gaultney JF, Picchietti DL. Pediatric periodic limb movement disorder: sleep symptom and polysomnographic correlates compared to obstructive sleep apnea. J Clin Sleep Med. 2011 Dec 15;7(6):603–9A.
  • Garcia-Borreguero D, Silber MH, Winkelman JW, et al. Guidelines for the first-line treatment of restless legs syndrome/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med. 2016;21:1–11.
  • Picchietti MA, Picchietti DL. Restless legs syndrome and periodic limb movement disorder in children and adolescents. Semin Pediatr Neurol. 2008;15(2):91–99.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.