Current and emerging pharmacotherapy for pediatric allergic rhinitis

References

• Kim S-K, Jo M-W, Kim S-H. Health-related quality of life by allergy symptoms in elementary school students. Health Qual Life Outcomes. 2018;16:93.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Bedbrook A, Czarlewski W, et al. Guidance to 2018 good practice: ARIA digitally-enabled, integrated, person-centred care for rhinitis and asthma. Clin Transl Allergy. 2019;9:16.
   PubMed Web of Science ®Google Scholar
• Knipping K, Knippels LMJ, Dupont C, et al. Serum biomarkers for allergy in children. Pediatr Allergy Immunol. 2017;28:114–123.
   PubMed Web of Science ®Google Scholar
• Sanchez J, Sánchez A, Cardona R. Clinical differences between children with asthma and rhinitis in rural and urban areas. Colomb Med. 2018;49:169–174.
   PubMed Web of Science ®Google Scholar
• Zhou H, Li XI, Kim JH, et al. Effect of inhaled allergens and air pollutants on childhood rhinitis development. Ann Allergy Asthma Immunol. 2018;120:212–214.
   PubMed Web of Science ®Google Scholar
• Gough H, Grabenhenrich L, Reich A, et al. Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth cohort MAS. Pediatr Allergy Immunol. 2015;26:431–437.
   PubMed Web of Science ®Google Scholar
• Anto JM, Bousquet J, Akdis M, et al. Mechanisms of the Development of Allergy (MeDALL): introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol. 2017;139:388–399.
   PubMed Web of Science ®Google Scholar
• Alduraywish SA, Standl M, Lodge CJ, et al. Is there a march from early food sensitization to later childhood allergic airway disease? Results from two prospective birth cohort studies. Pediatr Allergy Immunol. 2017;28:30–37.
   PubMed Web of Science ®Google Scholar
• Ballardini N, Bergström A, Wahlgren C-F, et al. IgE antibodies in relation to prevalence and multimorbidity of eczema, asthma, and rhinitis from birth to adolescence. Allergy. 2016;71:342–349.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Anto JM, Wickman M, et al. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis. Allergy. 2015;70:1062–1078.
   PubMed Web of Science ®Google Scholar
• Westman M, Lupinek C, Bousquet J, et al. Early childhood IgE reactivity to pathogenesis-related class 10 proteins predicts allergic rhinitis in adolescence. J Allergy Clin Immunol. 2015;135:1199–206.e1-11.
   Web of Science ®Google Scholar
• Cingi C, Bayar Muluk N, Scadding GK. Will every child have allergic rhinitis soon? Int J Pediatr Otorhinolaryngol. 2019;118:53–58.
   PubMed Web of Science ®Google Scholar
• Zajac AE, Adams AS, Turner JH. A systematic review and meta-analysis of probiotics for the treatment of allergic rhinitis. Int Forum Allergy Rhinol. 2015;5:524–532.
   PubMed Web of Science ®Google Scholar
• Krzych-Fałta E, Furmańczyk K, Tomaszewska A, et al. Probiotics: myths or facts about their role in allergy prevention. Adv Clin Exp Med. 2018;27:119–124.
   PubMed Web of Science ®Google Scholar
• Wickens K, Barthow C, Mitchell EA, et al. Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years. Pediatr Allergy Immunol. 2018;29:808–814.
   PubMed Web of Science ®Google Scholar
• Simpson MR, Dotterud CK, Storrø O, et al. Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial. BMC Dermatol. 2015;15:13.
   PubMed Web of Science ®Google Scholar
• Wahn U. Preventing new sensitization and asthma onset by allergen immunotherapy: the current evidence. Curr Opin Allergy Clin Immunol. 2017;17:443–446.
   PubMed Web of Science ®Google Scholar
• Halken S, Larenas-Linnemann D, Roberts G, et al. EAACI guidelines on allergen immunotherapy: prevention of allergy. Pediatr Allergy Immunol. 2017;28:728–745.
   PubMed Web of Science ®Google Scholar
• Di Lorenzo G, Leto-Barone MS, La Piana S, et al. The effect of allergen immunotherapy in the onset of new sensitizations: a meta-analysis. Int Forum Allergy Rhinol. 2017;7:660–669.
   PubMed Web of Science ®Google Scholar
• Lim JH, Kim JY, Han DH, et al. Sublingual immunotherapy (SLIT) for house dust mites does not prevent new allergen sensitization and bronchial hyper-responsiveness in allergic rhinitis children. PLoS ONE. 2017;12:e0182295.
   PubMed Web of Science ®Google Scholar
• Valovirta E, Petersen TH, Piotrowska T, et al. Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy. J Allergy Clin Immunol. 2018;141:529–538.e13.
   PubMed Web of Science ®Google Scholar
• Zolkipli Z, Roberts G, Cornelius V, et al. Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood. J Allergy Clin Immunol. 2015;136:1541–1547.
   PubMedGoogle Scholar
• Liu K, Li S, Qian ZM, et al. Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: new insights from the Seven Northeastern Cities study in China. Environ Pollut. 2020;256:113434.
   PubMed Web of Science ®Google Scholar
• Dulny G, Sybilski AJ, Zalewska M, et al. The Effect of Preventive Immunization on the Incidence of Allergic Conditions. Iran J Allergy Asthma Immunol. 2015;14:402–409.
   PubMed Web of Science ®Google Scholar
• Roberts G, Xatzipsalti M, Borrego LM, et al. Paediatric rhinitis: position paper of the European academy of allergy and clinical immunology. Allergy. 2013;68:1102–1116.
   PubMed Web of Science ®Google Scholar
• Scadding GK. Optimal management of allergic rhinitis. Arch Dis Child. 2015;100:576–582.
   PubMed Web of Science ®Google Scholar
• Khattiyawittayakun L, Seresirikachorn K, Chitsuthipakorn W, et al. Effects of double-dose intranasal corticosteroid for allergic rhinitis: a systematic review and meta-analysis. Int Forum Allergy Rhinol. 2019;9:72–78.
   PubMed Web of Science ®Google Scholar
• Berger W, Bousquet J, Fox AT, et al. MP-AzeFlu is more effective than fluticasone propionate for the treatment of allergic rhinitis in children. Allergy. 2016;71:1219–1222.
   PubMed Web of Science ®Google Scholar
• Berger W, Meltzer EO, Amar N, et al. Efficacy of MP-AzeFlu in children with seasonal allergic rhinitis: importance of paediatric symptom assessment. Pediatr Allergy Immunol. 2016;27:126–133.
   PubMed Web of Science ®Google Scholar
• Gross GN, Berman G, Amar NJ, et al. Efficacy and safety of olopatadine-mometasone combination nasal spray for the treatment of seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2019;122:630–638.e3).
   PubMed Web of Science ®Google Scholar
• Head K, Snidvongs K, Glew S, et al. Saline irrigation for allergic rhinitis. Cochrane Database Syst Rev. 2018;6:CD012597.
   PubMedGoogle Scholar
• Madison S, Brown EA, Franklin R, et al. Clinical question: nasal saline or intranasal corticosteroids to treat allergic rhinitis in children. J Okla State Med Assoc. 2016;109:152–153.
   PubMedGoogle Scholar
• Gutiérrez-Cardona N, Sands P, Roberts G, et al. The acceptability and tolerability of nasal douching in children with allergic rhinitis: a systematic review. Int J Pediatr Otorhinolaryngol. 2017;98:126–135.
   PubMed Web of Science ®Google Scholar
• Li C-L, Lin H-C, Lin C-Y, et al. Effectiveness of hypertonic saline nasal irrigation for alleviating allergic rhinitis in children: a systematic review and meta-analysis. J Clin Med. 2019:8. DOI:10.3390/jcm8010064.
   Web of Science ®Google Scholar
• Malizia V, Fasola S, Ferrante G, et al. Efficacy of buffered hypertonic saline nasal irrigation for nasal symptoms in children with seasonal allergic rhinitis: a randomized controlled trial. Int Arch Allergy Immunol. 2017;174:97–103.
   PubMed Web of Science ®Google Scholar
• Meltzer, published by Dove Press. IJGM_8184_treatment-of-congestion-in-upper-respiratory-diseases.
   Google Scholar
• Yazid S, Sinniah A, Solito E, et al. Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. PLoS ONE. 2013;8:e58963.
   PubMed Web of Science ®Google Scholar
• Watts AM, Cripps AW, West NP, et al. Modulation of allergic inflammation in the nasal mucosa of allergic rhinitis sufferers with topical pharmaceutical agents. Front Pharmacol. 2019;10:294.
   PubMed Web of Science ®Google Scholar
• Berings M, Jult A, Vermeulen H, et al. Probiotics-impregnated bedding covers for house dust mite allergic rhinitis: a pilot randomized clinical trial. Clin Exp Allergy. 2017;47:1092–1096.
   PubMed Web of Science ®Google Scholar
• Moustafa Y, El Nady HG, Saber MM, et al. Assessment of allergic rhinitis among children after low-level laser therapy. Open Access Maced J Med Sci. 2019;7:1968–1973.
   PubMedGoogle Scholar
• Hox V, Lourijsen E, Jordens A, et al. Benefits and harm of systemic steroids for short- and long-term use in rhinitis and rhinosinusitis: an EAACI position paper. Clin Transl Allergy. 2020;10:1.
   PubMed Web of Science ®Google Scholar
• Aasbjerg K, Torp-Pedersen C, Vaag A, et al. Treating allergic rhinitis with depot-steroid injections increase risk of osteoporosis and diabetes. Respir Med. 2013;107:1852–1858.
   PubMed Web of Science ®Google Scholar
• Parisi GF, Licari A, Papale M, et al. Antihistamines: ABC for the pediatricians. Pediatr Allergy Immunol. [Internet]. 2020;31 Suppl 24: 34–36. Available from: https://onlinelibrary-1wiley-1com-10013b58s5658.han.medunigraz.at/doi/full/10.1111/pai.13152
   PubMedGoogle Scholar
• Nayak AS, Berger WE, LaForce CF, et al. Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc. 2017;38:222–230.
   PubMed Web of Science ®Google Scholar
• Parisi GF, Leonardi S, Ciprandi G, et al. Cetirizine use in childhood: an update of a friendly 30-year drug. Clin Mol Allergy CMA. 2020;18:2.
   PubMedGoogle Scholar
• Hunto ST, Kim HG, Baek K-S, et al. Loratadine, an antihistamine drug, exhibits anti-inflammatory activity through suppression of the NF-(k)B pathway. Biochem Pharmacol. 2020;177:113949.
   PubMed Web of Science ®Google Scholar
• Cingi C, Muluk NB, Ipci K, et al. Antileukotrienes in upper airway inflammatory diseases. Curr Allergy Asthma Rep. 2015;15:64.
   PubMed Web of Science ®Google Scholar
• Yilmaz O, Altintas D, Rondon C, et al. Effectiveness of montelukast in pediatric patients with allergic rhinitis. Int J Pediatr Otorhinolaryngol. 2013;77:1922–1924.
   PubMed Web of Science ®Google Scholar
• Hashiguchi K, Okubo K, Inoue Y, et al. Evaluation of montelukast for the treatment of children with japanese cedar pollinosis using an artificial exposure chamber (OHIO Chamber). Allergy Rhinol (Providence). 2018;9:2152656718783599.
   Web of Science ®Google Scholar
• Arnold DH, Bowman N, Reiss TF, et al. Adverse events are rare after single-dose montelukast exposures in children. Clin Toxicol (Phila). 2018;56:25–29.
   PubMed Web of Science ®Google Scholar
• Brożek JL, Bousquet J, Agache I, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol. 2017;140:950–958.
   PubMed Web of Science ®Google Scholar
• Marseglia G, Licari A, Leonardi S, et al. A polycentric, randomized, parallel-group, study on Lertal®, a multicomponent nutraceutical, as preventive treatment in children with allergic rhinoconjunctivitis: phase II. Ital J Pediatr. 2019;45:84.
   PubMed Web of Science ®Google Scholar
• Miraglia Del Giudice M, Indolfi C, Capasso M, et al. Bifidobacterium mixture (B longum BB536, B infantis M-63, B breve M-16V) treatment in children with seasonal allergic rhinitis and intermittent asthma. Ital J Pediatr. 2017;43:25.
   PubMed Web of Science ®Google Scholar
• Zheng Z, Sun Z, Zhou X, et al. Efficacy of Chinese herbal medicine in treatment of allergic rhinitis in children: a meta-analysis of 19 randomized controlled trials. J Int Med Res. 2018;46:4006–4018.
   PubMed Web of Science ®Google Scholar
• Arasi S, Corsello G, Villani A, et al. The future outlook on allergen immunotherapy in children: 2018 and beyond. Ital J Pediatr. 2018;44:80.
   PubMed Web of Science ®Google Scholar
• Halken S, Roberts G, Valovirta E, et al. Safety of timothy grass sublingual immunotherapy tablet in children: pooled analyses of clinical trials. J Allergy Clin Immunol Pract. 2020;8:1387–1393.e2.
   PubMed Web of Science ®Google Scholar
• Rodríguez Del Río P, Vidal C, Just J, et al. The European survey on adverse systemic reactions in allergen immunotherapy (EASSI): a paediatric assessment. Pediatr Allergy Immunol. 2017;28:60–70.
   PubMed Web of Science ®Google Scholar
• Tortajada-Girbés M, Mesa Del Castillo M, Larramona H, et al. Decision-making for pediatric allergy immunotherapy for aeroallergens: a narrative review. Eur J Pediatr. 2019;178:1801–1812.
   PubMed Web of Science ®Google Scholar
• Roberts G, Pfaar O, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis. Allergy. 2018;73:765–798.
   PubMed Web of Science ®Google Scholar
• Esposito S, Isidori C, Pacitto A, et al. Epicutaneous immunotherapy in rhino-conjunctivitis and food allergies: a review of the literature. J Transl Med. 2018;16:329.
   PubMed Web of Science ®Google Scholar
• Fleischer DM, Greenhawt M, Sussman G, et al. Effect of epicutaneous immunotherapy vs placebo on reaction to peanut protein ingestion among children with peanut allergy: the PEPITES randomized clinical trial. JAMA. 2019;321:946–955.
   PubMed Web of Science ®Google Scholar
• Vieira-Hernández A, Capriles-Hulett A, Sánchez-Borges M, et al. Inmunoterapia intradérmica con alérgenos de ácaros a bajas dosis en pacientes con rinitis alérgica: un estudio conceptual [Intradermal immunotherapy with low-dose house dust mite allergens in patients with allergic rhinitis: a proof-of-concept study]. Rev Alerg Mex. 2018;65:41–51.
   PubMedGoogle Scholar
• Feng B, Wu J, Chen B, et al. Efficacy and safety of sublingual immunotherapy for allergic rhinitis in pediatric patients: a meta-analysis of randomized controlled trials. Am J Rhinol Allergy. 2017;31:27–35.
   PubMed Web of Science ®Google Scholar
• Kiotseridis H, Arvidsson P, Backer V, et al. Adherence and quality of life in adults and children during 3-years of SLIT treatment with Grazax-a real life study. NPJ Prim Care Respir Med. 2018;28:4.
   PubMed Web of Science ®Google Scholar
• Gerstlauer M, Szepfalusi Z, Golden D, et al. Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis. Ann Allergy Asthma Immunol. 2019;123:70–80.
   PubMed Web of Science ®Google Scholar
• Radulovic S, Wilson D, Calderon M, et al. Systematic reviews of sublingual immunotherapy (SLIT). Allergy. 2011;66:740–752.
   PubMed Web of Science ®Google Scholar
• Mäkelä MJ, Gyllfors P, Valovirta E, et al. Immunotherapy with the SQ tree SLIT-tablet in adults and adolescents with allergic rhinoconjunctivitis. Clin Ther. 2018;40:574–586.e4.
   PubMed Web of Science ®Google Scholar
• Shah-Hosseini K, Mioc K, Hadler M, et al. Optimum treatment strategies for polyallergic patients - analysis of a large observational trial. Curr Med Res Opin. 2015;31:2249–2259.
   PubMed Web of Science ®Google Scholar
• Masuyama K, Okamoto Y, Okamiya K, et al. Efficacy and safety of SQ house dust mite sublingual immunotherapy-tablet in Japanese children. Allergy. 2018;73:2352–2363.
   PubMed Web of Science ®Google Scholar
• Okamoto Y, Fujieda S, Okano M, et al. Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: a randomized trial in a pediatric population. Pediatr Allergy Immunol. 2019;30:66–73.
   PubMed Web of Science ®Google Scholar
• Zhang Y-Z, Luo J, Wang Z-H, et al. Efficacy and safety of sublingual dust mite drops in children with mono- or polysensitized allergic rhinitis. Am J Otolaryngol. 2019;40:755–760.
   PubMed Web of Science ®Google Scholar
• Pajno GB, Bernardini R, Peroni D, et al. Clinical practice recommendations for allergen-specific immunotherapy in children: the Italian consensus report. Ital J Pediatr. 2017;43:13.
   PubMed Web of Science ®Google Scholar
• Albuhairi S, Sare T, Lakin P, et al. Systemic reactions in pediatric patients receiving standardized allergen subcutaneous immunotherapy with and without seasonal dose adjustment. J Allergy Clin Immunol Pract. 2018;6:1711–1716.e4.
   PubMed Web of Science ®Google Scholar
• Toprak-Kanık E, Yılmaz Ö, Yangın-Ergon E, et al. Safety of subcutaneous allergen immunotherapy in children: a retrospective review and bird eye to literature. Turk J Pediatr. 2018;60:684–690.
   PubMed Web of Science ®Google Scholar
• Breiteneder H, Diamant Z, Eiwegger T, et al. Future research trends in understanding the mechanisms underlying allergic diseases for improved patient care. Allergy. 2019;74:2293–2311.
   PubMed Web of Science ®Google Scholar
• Zissler UM, Esser-von Bieren J, Jakwerth CA, et al. Current and future biomarkers in allergic asthma. Allergy. [Internet]. 2016;71:475–494. Available from: https://onlinelibrary.wiley.com/doi/pdf/10.1111/all.12828
   PubMed Web of Science ®Google Scholar
• Patterson AM, Bonny AE, Shiels WE, et al. Three-injection intralymphatic immunotherapy in adolescents and young adults with grass pollen rhinoconjunctivitis. Ann Allergy Asthma Immunol. 2016;116:168–170.
   PubMed Web of Science ®Google Scholar
• Di Fraia M, Tripodi S, Arasi S, et al. Adherence to prescribed E-diary recording by patients with seasonal allergic rhinitis: observational study. J Med Internet Res. 2020;22:e16642.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Devillier P, Arnavielhe S, et al. Treatment of allergic rhinitis using mobile technology with real-world data: the MASK observational pilot study. Allergy. 2018;73:1763–1774.
   PubMed Web of Science ®Google Scholar
• Raciborski F, Samoliński B, Krzych-Fałta E, et al. The nationwide program of allergic disease prevention as an implementation of GARD guidelines in Poland. J Thorac Dis. 2018;10:5595–5604.
   PubMed Web of Science ®Google Scholar
• Giallongo A, Parisi GF, Licari A, et al. Novel therapeutic targets for allergic airway disease in children. Drugs Context. 2019;8:212590.
   PubMedGoogle Scholar
• Okayama Y, Matsumoto H, Odajima H, et al. Roles of omalizumab in various allergic diseases. Allergol Int. 2020;69:167–177.
   PubMed Web of Science ®Google Scholar
• Busse WW, Maspero JF, Lu Y, et al. Efficacy of dupilumab on clinical outcomes in patients with asthma and perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2020;S1081-1206:30389-96.
   Web of Science ®Google Scholar
• Ciprandi G, Marseglia GL, Castagnoli R, et al. From IgE to clinical trials of allergic rhinitis. Expert Rev Clin Immunol. 2015;11:1321–1333.
   PubMed Web of Science ®Google Scholar