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Drug Evaluation

Intramuscular Midazolam for treatment of Status Epilepticus

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Pages 37-44 | Received 29 Apr 2020, Accepted 11 Aug 2020, Published online: 25 Aug 2020

References

  • Nelson SE, Varelas PN. Status Epilepticus, Refractory Status Epilepticus, and Super-refractory Status Epilepticus. Continuum (Minneap Minn). 2018 Dec;24(6):1683–1707.
  • Trinka E, Cock H, Hesdorffer D, et al. A definition and classification of status epilepticus - report of the ILAE task force on classification of Status Epilepticus. Epilepsia. 2015 Oct;56(10):1515–1523.
  • Capovilla G, Beccaria F, Beghi E, et al. Treatment of convulsive status epilepticus in childhood: recommendations of the Italian League Against Epilepsy. Epilepsia. 2013 Oct;54 Suppl 7:23–34
  • Sculier C, Gaínza-Lein M, Sánchez Fernández I, et al. Long-term outcomes of status epilepticus: a critical assessment. Epilepsia. 2018 Oct;59(Suppl 2 (SupplSuppl 2)):155–169.
  • Gaínza-Lein M, Fernández IS, Ulate-Campos A, et al. Timing in the treatment of status epilepticus: from basics to the clinic. Seizure. 2019 May;68:22–30.
  • Abend NS, Loddenkemper T. Pediatric status epilepticus management. Curr Opin Pediatr. 2014;26:668–674.
  • Trinka E, Höfler J, Leitinger M, et al. Pharmacotherapy for Status Epilepticus. Drugs. 2015 Sep;75(13):1499–1521.
  • Sofou K, Kristjánsdóttir R, Papachatzakis NE, et al. Management of prolonged seizures and status epilepticus in childhood: A systematic review. J Child Neurol. 2009 Aug;24(8):918–926.
  • Arya R, Kothari H, Zhang Z, et al. Efficacy of nonvenous medications for acute convulsive seizures: a network meta-analysis. Neurology. 2015 Nov;85(21):1859–1868. .
  • Arnautova EN, Nesmeianova TN. A proposed international classification of Epileptic seizures. Epilepsia. 1964 Dec;5:297–306.
  • Sánchez Fernández I, Loddenkemper T. Therapeutic choices in convulsive status epilepticus. Expert Opin Pharmacother. 2015 Mar;16(4):487–500.
  • Brophy GM, Bell R, Claassen J, et al. Guidelines for the evaluation and management of Status Epilepticus. Neurocrit Care. 2012;17:3–23.
  • Grover EH, Nazzal Y, Hirsch LJ. Treatment of Convulsive Status Epilepticus. Curr Treat Options Neurol. 2016;18:11.
  • Cascino GD. Nonconvulsive Status Epilepticus in Adults and Children. Epilepsia. 1993;34(Suppl. 1):S21–S28.
  • Leitinger M, Beniczky S, Rohracher A, et al. Salzburg consensus criteria for non-convulsive Status Epilepticus—approach to clinical application. Epilepsy Behav. 2015 Aug;49:158–163.
  • Dupont S. Non-convulsive status epilepticus in the elderly. Geriatr Psychol Neuropsychiatr Vieil. 2019 Mar 1;17(S1):25–30.
  • Rossetti AO, Lowenstein DH. Management of refractory status epilepticus in adults: still more questions than answers. Lancet Neurol. 2011;10:922–930.
  • Strzelczyk A, Ansorge S, Hapfelmeier J, et al. Costs, length of stay, and mortality of super-refractory status epilepticus: A population-based study from Germany. Epilepsia. 2017 Sep;58(9):1533–1541. .
  • Gaspard N, Hirsch LJ, Sculier C, et al. New-onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES): state of the art and perspectives. Epilepsia. 2018;59(4):745-752.
  • Cuero MR, Varelas PN. Super-Refractory Status Epilepticus. Curr Neurol Neurosci Rep. 2015;15:74.
  • Prasad M, Krishnan PR, Sequeira R, et al. Anticonvulsant therapy for status epilepticus. Cochrane Database Syst Rev. 2014 Sep;10(9):CD003723.
  • Leitinger M, Trinka E, Giovannini G, et al. Epidemiology of status epilepticus in adults: A population-based study on incidence, causes, and outcomes. Epilepsia. 2019 Jan;60(1):53–62.
  • Betjemmann JP, Lowestein DH. Status epilepticus in adults. Lancet Neurol. 2015 Jun;14(6):615–624.
  • Lagae L. Clinical practice: the treatment of acute convulsive seizures in children. Eur J Pediatr. 2011 Apr;170(4):413–418.
  • Neligan A, Shorvon SD. Prognostic factors, morbidity and mortality in tonic—clonic status epilepticus: A review. Epilepsy Res. 2011 Jan;93(1):1–10.
  • Ostrowsky K, Arzimanoglou A. Outcome and prognosis of Status Epilepticus in Children. Semin Pediatr Neurol. 2010 Sep;17(3):195–200.
  • Verrotti A, Mazzocchetti C. Epilepsy: timely treatment of refractory convulsive status epilepticus. Nat Rev Neurol. 2018 May;14(5):256–258.
  • Glauser T, Shinnar S, Gloss D, et al. Evidence-based guideline: treatment of convulsive Status Epilepticus in Children and Adults: report of the guideline committee of the American Epilepsy society. Epilepsy Curr. 2016 Jan-Feb;16(1):48–61. .
  • Sánchez Fernández I, Goodkin HP, Scott RC. Pathophysiology of convulsive status epilepticus. Seizure. 2019 May;68:16–21.
  • Maglalang PD, Rautiola D, Siegel RA, et al. Rescue therapies for seizure emergencies: new modes of administration. Epilepsia. 2018;59 Suppl 2:207-215.
  • Scott RC, Besag FM, Neville BG, et al. Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: a randomised trial. Lancet. 1999 Feb 20;353(9153):623–626.
  • Detyniecki K, Van Ess PJ, Sequeira DJ, et al. Safety and efficacy of midazolam nasal spray in the outpatient treatment of patients with seizure clusters-a randomized, double-blind, placebo-controlled trial. Epilepsia. 2019 Sep;60(9):1797–1808.
  • Alldredge BK, Gelb AM, Isaacs SM, et al. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med. 2001 Dec 20;345(25):1860.
  • Kapur J, Elm J, Chamberlain JM, et al. Randomized trial of three anticonvulsant medications for Status Epilepticus. N Engl J Med. 2019 Nov 28;381(22):2103–2113.
  • Kellinghaus C, Rossetti AO, Trinka E, et al. Factors predicting cessation of status epilepticus in clinical practice: data from a prospective observational registry (SENSE). Ann Neurol. 2019 Mar;85(3):421–432.
  • Chamberlain JM, Kapur J, Shinnar S, et al. Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomized controlled trial. Lancet. 2020 Apr 11;395(10231):1217–1224.
  • Crawshaw AA, Cock HR. Medical management of status epilepticus: emergency room to intensive care unit. Seizure. 2020 Feb;75:145–152.
  • Dalziel SR, Borland ML, Furyk J, et al. Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial. Lancet. 2019 May 25;393(10186):2135–2145.
  • Lyttle MD, Rainford NEA, Gamble C, et al. Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicenter, open-label, randomised trial. Lancet. 2019 May 25;393(10186):2125–2134.
  • Kanto JH. Midazolam: the first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anesthesia. Pharmacotherapy. 1985 May-June;5(3):138–155.
  • Reves JG, Fragen RJ, Vinik HR, et al. Midazolam: pharmacology and uses. Anesthesiology. 1985 Mar;62(3):310–324.
  • Verrotti A, Ambrosi M, Pavone P, et al. Pediatric status epilepticus: improved management with new drug therapies? Expert Opin Pharmacother. 2017 Jun;18(8):789–798.
  • Pellock JM. Use of midazolam for refractory status epilepticus in pediatric patients. J Child Neurol. 1998 dec;13812):581–587.
  • Olkkola KT, Ahonen J. Midazolam and other benzodiazepines. Handb Exp Pharmacol. 2008;(182):335–360.
  • Towne AR, DeLorenzo RJ. Use of intramuscular midazolam for status epilepticus. J Emerg Med. 1999;17(2):323–328.
  • Hung OR, Dyck JB, Varvel J, et al. Comparative absorption kinetics of intramuscular midazolam and diazepam. Can J Anaesth. 1996 May;43(5 Pt 1):450–455.
  • Maglalang PD, Rautiola D, Siegel RA, et al. Rescue therapies for seizure emergencies: new modes of administration. Epilepsia. 2018 Oct;59(S2):207–215.
  • Bell DM, Richards G, Dhillon S, et al. A comparative pharmacokinetic study of intravenous and intramuscular midazolam in patients with epilepsy. Epilepsy Res. 1991 Nov-Dec;10(2–4):183–190.
  • Holazo AA, Winkler MB, Patel IH. Effects of age, gender and oral contraceptives on intramuscular midazolam pharmacokinetics. J Clin Pharmacol. 1998 Nov;28(11):1040–1045.
  • Nordt SP, Clark RF. Midazolam: a review of therapeutic uses and toxicity. J Emerg Med. 1197 May-Jun;15(3):357–365.
  • Momen AA, Azizi Malamiri R, Nikkhah A, et al. Efficacy and safety of intramuscular midazolam versus rectal diazepam in controlling status epilepticus in children. Eur J Paediatr Neurol. 2015 Mar;19(2):149–154.
  • Silbergleit R, Durkalski V, Lowenstein D, et al. Intramuscular versus intravenous therapy for prehospital status epilepticus. N Engl J Med. 2012 Feb;366(7):591–600.
  • Chamberlain JM, ALTIERI MA, FUTTERMAN C, et al. A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. Pediatr Emerg Care. 1997 Apr;13(2):92–94.
  • Verrotti A, Ambrosi M, Pavone P, Striano P. Pediatric status epilepticus: improved management with new drug therapies? Expert Opin Pharmacother. 2017 Jun;18(8):789–798.
  • Welch RD, Nicholas K, Durkalski-Mauldin VL, et al. Intramuscular midazolam versus intravenous lorazepam for the prehospital treatment of status epilepticus in the pediatric population. Epilepsia. 2015;56(Feb):(2);254–62.
  • Shah I, Deshmukh CT, et al. Intramuscular midazolam vs intravenous diazepam for acute seizures. Indian J Pediatr. 2005 Aug;72(8):667–670.
  • Vohra TT, Miller JB, Nicholas KS, et al. Endotracheal intubation in patients treated for prehospital Status Epilepticus. Neurocrit Care. 2015 Aug;23(1):33–43.
  • Alansari K, Barkat M, Mohamed AH, et al. Intramuscular versus Buccal Midazolam for Pediatric seizures: a randomized double-blinded trial. Pediatr Neurol. 2020 Mar 16;S0887-8994(20):30090–30094.
  • Kay L, Merkel N, von Blomberg A, et al. Intranasal midazolam as first-line inhospital treatment for status epilepticus: a pharmaco-EEG cohort study. Ann Clin Transl Neurol. 2019 Dec;6(12):2413–2425.
  • Kutlu NO, Dogrul M, Yakinci C, et al. Buccal midazolam for treatment of prolonged seizures in children. Brain Dev. 2003 Jun;25(4):275–278.
  • McTague A, Martland T, Appleton R. Drug management for acute tonic-clonic convulsions including convulsive status epilepticus in children. Cochrane Database Syst Rev. 2018;1;Jan:CD001905.
  • Portela JL, Garcia PCR, Piva JP, et al. Intramuscular midazolam versus intravenous diazepam for treatment of seizures in the pediatric emergency department: a randomized clinical trial. Med Intensiva. 2015 Apr;39(3):160–166.
  • Frölich MA, Arabshahi A, Katholi C, et al. Hemodynamic characteristics of midazolam, propofol, and dexmedetomidine in healthy volunteers. J Clin Anesth. 2011 May;23(3):218–223.
  • Matson AM, Thurlow AC. Hypotension and neurological sequelae following intramuscular midazolam. Anaesthesia. 1988 Oct;43(10):896.
  • Sánchez Fernández I, Gaínza-Lein M, Loddenkemper T. Nonintravenous rescue medications for pediatric status epilepticus: A cost-effectiveness analysis. Epilepsia. 2017 Aug;58(8):1349–1359.
  • Von Blomberg, Kay L, Knake S, et al. Efficacy, tolerability, and safety of concentrated intranasal Midazolam spray as emergency medication in Epilepsy patients during video-EEG monitoring. CNS Drugs. 2020 May;34(5):545–553.

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