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Perspective

Can NSAIDs and Acetaminophen Effectively Replace Opioid Treatment Options for Acute Pain?

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Pages 1119-1126 | Received 23 Aug 2020, Accepted 08 Mar 2021, Published online: 14 Jun 2021

References

  • Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain–United States, 2016. Jama. 2016 Apr 19;315(15):1624–1645.
  • Dowell D, Haegerich T, Chou R. No shortcuts to safer opioid prescribing. N Engl J Med. 2019;380(24):2285–2287.
  • Pergolizzi JV Jr., Rosenblatt M, LeQuang JA. Three years down the road: the aftermath of the CDC guideline for prescribing opioids for chronic pain. Adv Ther. 2019 Jun;36(6):1235–1240.
  • Imani F, Varrassi G. Ketamine as adjuvant for acute pain management. Anesth Pain Med. 2019;9(6):e100178.
  • Daniels SE, Playne R, Stanescu I, et al. Efficacy and Safety of an intravenous acetaminophen/ibuprofen fixed-dose combination after bunionectomy: a Randomized, Double-blind, Factorial, Placebo-controlled Trial. Clin Ther. 2019 Oct;41(10):1982–95.e8.
  • Eloy JD, Anthony C, Amin S, et al. Gabapentin Does Not appear to improve postoperative pain and sleep patterns in patients who concomitantly receive regional anesthesia for lower extremity orthopedic surgery: a Randomized Control Trial. Pain Res Manag. 2017;13:2310382.
  • Sivakumar W, Jensen M, Martinez J, et al. Intravenous acetaminophen for postoperative supratentorial craniotomy pain: a prospective, randomized, double-blinded, placebo-controlled trial. J Neurosurg. 2018 Apr 20;130(3):722–766.
  • Thybo KH, Hägi-Pedersen D, Dahl JB, et al. Effect of Combination of paracetamol (acetaminophen) and ibuprofen vs either alone on patient-controlled morphine consumption in the first 24 hours after total hip arthroplasty: the PANSAID Randomized Clinical Trial. Jama. 2019 Feb 12;321(6):562–571.
  • Bugada D, Lavand’homme P, Ambrosoli AL, et al. Effect of postoperative analgesia on acute and persistent postherniotomy pain: a randomized study. J Clin Anesth. 2015 Dec;27(8):658–664. .
  • Moore RA, McQuay HJ, Tomaszewski J, et al. Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy. BMC Anesthesiol. 2016 Jan 22;16(1):9.
  • Oh JH, Seo HJ, Lee YH, et al. do selective cox-2 inhibitors affect pain control and healing after arthroscopic rotator cuff repair? A Preliminary Study. Am J Sports Med. 2018 Mar;46(3):679–686.
  • Pathan SA, Mitra B, Straney LD, et al. Delivering safe and effective analgesia for management of renal colic in the emergency department: a double-blind, multigroup, randomised controlled trial. Lancet. 2016 May 14;387(10032):1999–2007.
  • Pergolizzi JV, Magnusson P, LeQuang JA, et al. The pharmacological management of dental pain. Expert Opin Pharmacother. 2020 Apr;21(5):591–601.
  • Hersh EV, Moore PA, Grosser T, et al. Nonsteroidal Anti-Inflammatory Drugs and Opioids in Postsurgical Dental Pain. J Dent Res. 2020 Jul;99(7):777–786.
  • Christensen SE, Cooper SA, Mack RJ, et al. A Randomized double-blind controlled trial of intravenous meloxicam in the treatment of pain following dental impaction surgery. J Clin Pharmacol. 2018 May;58(5):593–605.
  • Cooper SA, Desjardins P, Brain P, et al. Longer analgesic effect with naproxen sodium than ibuprofen in post-surgical dental pain: a randomized, double-blind, placebo-controlled, single-dose trial. Curr Med Res Opin. 2019;1–10.
  • Daniels SE, Atkinson HC, Stanescu I, et al. Analgesic efficacy of an acetaminophen/ibuprofen fixed-dose combination in moderate to severe postoperative dental pain: a Randomized, Double-blind, Parallel-group, Placebo-controlled Trial. Clin Ther. 2018 October;40(10):1765–1776e5.
  • Weiser T, Richter E, Hegewisch A, et al. Efficacy and safety of a fixed-dose combination of ibuprofen and caffeine in the management of moderate to severe dental pain after third molar extraction. Eur J Pain. 2018 Jan;22(1):28–38.
  • Chang AK, Bijur PE, Esses D, et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a Randomized Clinical Trial. Jama. 2017 Nov 7;318(17):1661–1667.
  • Gong J, Colligan M, Kirkpatrick C, et al. Oral paracetamol versus combination oral analgesics for acute musculoskeletal injuries. Ann Emerg Med. 2019 Oct;74(4):521–529.
  • Barnaby DP, Chertoff AE, Restivo AJ, et al. Randomized controlled trial of intravenous acetaminophen versus intravenous hydromorphone for the treatment of acute pain in the emergency department. Ann Emerg Med. 2019 Feb;73(2):133–140. .
  • Demirozogul E, Yilmaz A, Ozen M, et al. Intravenous dexketoprofen versus paracetamol in non-traumatic musculoskeletal pain in the emergency department: a randomized clinical trial. Am J Emerg Med. 2019 Dec;37(12):2136–2142.
  • Ridderikhof ML, Lirk P, Goddijn H, et al. acetaminophen or nonsteroidal anti-inflammatory drugs in acute musculoskeletal trauma: a Multicenter, Double-Blind, Randomized, Clinical Trial. Ann Emerg Med. 2018 Mar;71(3):357–68.e8. .
  • Yilmaz A, Sabirli R, Ozen M, et al. Intravenous paracetamol versus dexketoprofen in acute musculoskeletal trauma in the emergency department: a randomised clinical trial. Am J Emerg Med. 2019 May;37(5):902–908. .
  • Friedman BW, Dym AA, Davitt M, et al. Naproxen with cyclobenzaprine, oxycodone/ acetaminophen,or placebo for treating acute low back pain: a Randomized Clinical Trial. Jama. 2015 Oct 20;314(15):1572–1580.
  • Friedman BW, Irizarry E, Solorzano C, et al. A randomized, placebo-controlled trial of ibuprofen plus metaxalone, tizanidine, or baclofen for acute low back pain. Ann Emerg Med. 2019 Oct;74(4):512–520. .
  • Andolfatto G, Innes K, Dick W, et al. Prehospital Analgesia with intranasal ketamine (PAIN-K): a Randomized Double-Blind Trial in Adults. Ann Emerg Med. 2019 Aug;74(2):241–250.
  • Hung KKC, Graham CA, Lo RSL, et al. Oral paracetamol and/or ibuprofen for treating pain after soft tissue injuries: single centre double-blind, randomised controlled clinical trial. PLoS One. 2018;13(2):e0192043. .
  • Motov S, Masoudi A, Drapkin J, et al. Comparison of oral ibuprofen at three single-dose regimens for treating acute pain in the emergency department: a Randomized Controlled Trial. Ann Emerg Med. 2019 Oct;74(4):530–537. .
  • Rao AS, Gelaye B, Kurth T, et al. A randomized trial of ketorolac vs. sumatripan vs. placebo nasal spray (KSPN) for acute migraine. Headache. 2016 Feb;56(2):331–340.
  • Roddy E, Clarkson K, Blagojevic-Bucknall M, et al. Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care. Ann Rheum Dis. 2020 Feb;79(2):276–284. .
  • Benyamin R, Trescot AM, Datta S, et al. Opioid complications and side effects. Pain Physician. 2008 Mar;11(2 Suppl):S105–20.
  • Viscusi ER. Clinical overview and considerations for the management of opioid-induced constipation in patients with chronic noncancer pain. Clin J Pain. 2019;35(2):174–188.
  • Centers for Disease Control and Prevention. Understanding the epidemic. Opioid basics 2019 [ cited 2019 November 4]; [cited 2021 May 3]. Available from: https://www.cdc.gov/drugoverdose/epidemic/index.html
  • Kim B, Nolan S, Beaulieu T, et al. Inappropriate opioid prescribing practices: a narrative review. Am J Health-system Pharm. 2019 Aug 1;76(16):1231–1237.
  • McDonald DC, Carlson K, Izrael D. Geographic variation in opioid prescribing in the U.S. J Pain. 2012;13(10):988–996.
  • Moody L, Satterwhite E, Bickel WK. Substance use in rural Central Appalachia: current status and treatment considerations. Journal of Rural Mental Health. 2017;41(2):123–135.
  • Bohnert ASB, Valenstein M, Bair MJ, et al. Association between opioid prescribing patterns and opioid overdose-related deaths. Jama. 2011;305(13):1315–1321. .
  • Webster LR. Risk Factors for Opioid-use disorder and overdose. Anesth Analg. 2017 Nov;125(5):1741–1748.
  • Pergolizzi JV Jr., Gharibo C, Passik S, et al. Dynamic risk factors in the misuse of opioid analgesics. J Psychosom Res. 2012 Jun;72(6):443–451. .
  • Matthias MS, Johnson NL, Shields CG, et al. “I’m not gonna pull the rug out from under you”: patient-provider communication about opioid tapering. J Pain. 2017 Nov;18(11):1365–1373. .
  • Park BK, Dear JW, Antoine DJ. Paracetamol (acetaminophen) poisoning. BMJ Clin Evid. 2015 Oct;2015.
  • Lee WM. Acetaminophen (APAP) hepatotoxicity-Isn’t it time for APAP to go away? J Hepatol. 2017 Dec;67(6):1324–1331.
  • Rowden AK, Norvell J, Eldridge DL, et al. Acetaminophen poisoning. Clin Lab Med. 2006 Mar;26(1):49–65, viii.
  • Salgia AD, Kosnik SD. When acetaminophen use becomes toxic. Treating acute accidental and intentional overdose. Postgrad Med. 1999 Apr;105(4):81–4, 87, 90.
  • Harirforoosh S, Asghar W, Jamali F. Adverse effects of nonsteroidal antiinflammatory drugs: an update of gastrointestinal, cardiovascular and renal complications. J Pharm Pharm Sci. 2013;16(5):821–847.
  • Pepine CJ, Gurbel PA. Cardiovascular safety of NSAIDs: additional insights after PRECISION and point of view. Clin Cardiol. 2017 Dec;40(12):1352–1356.
  • Radi ZA, Khan KN. Cardio-renal safety of non-steroidal anti-inflammatory drugs. J Toxicol Sci. 2019;44(6):373–391.
  • Moore N, Scheiman JM. Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics. Postgrad Med. 2018 Mar;130(2):188–199.

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