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Review

Pharmacotherapeutic options in the treatment of nocturia: an update on the current oral drug therapies

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Pages 405-411 | Received 26 Sep 2021, Accepted 07 Dec 2021, Published online: 15 Dec 2021

References

  • Hashim H, Blanker MH, Drake MJ, et al. International Continence Society (ICS) report on the terminology for nocturia and nocturnal lower urinary tract function. Neurourol Urodyn. 2019;38(2):499–508.
  • Drangsholt S, Ruiz MJA, Peyronnet B, et al. Diagnosis and management of nocturia in current clinical practice: who are nocturia patients, and how do we treat them? World J Urol. 2019 July;37(7):1389–1394.
  • Robinson D, Suman S. Managing nocturia: the multidisciplinary approach. Maturitas. 2018;116:123–129.
  • Everaert K, Hervé F, Bower W, et al. How can we develop a more clinically useful and robust algorithm for diagnosing and treating nocturia? ICI-RS 2017. Neurourol Urodyn. 2018;37(S4):S46–S59.
  • Kowalik CG, Cohn JA, Delpe S, et al. Nocturia: evaluation and current management strategies. Rev Urol. 2018;20(1):1–6.
  • Zhou J, Xia S, Li T, et al. Association between obstructive sleep apnea syndrome and nocturia: a meta-analysis. Sleep Breath. 2020;24(4):1293–1298.
  • Fitzgerald MP, Lemack G, Wheeler T, et al. Urinary incontinence treatment network. Nocturia, nocturnal incontinence prevalence, and response to anticholinergic and behavioral therapy. Int Urogynecol J Pelvic Floor Dysfunct. 2008 November;19(11):1545–1550.
  • Khizer Z, Sadia A, Sharma R, et al. Drug delivery approaches for managing overactive bladder (OAB): a systematic review. Pharmaceuticals (Basel). 2021;14(5):409.
  • Gordon DJ, Emeruwa CJ, Weiss JP. Management strategies for nocturia. Curr Urol Rep. 2019;20(11):75.
  • Andersson KE, Van Kerrebroeck P. Pharmacotherapy for nocturia. Curr Urol Rep. 2018;19(1):8.
  • Andersson KE, Cardozo L, Cruz F, et al. Pharmacological treatment of urinary incontinence. In: Abrams P, Cardozo L, Wagg A, et al., editors. Incontinence. 6th international consultation on incontinence, September2016. Tokyo: The International Continence Society (ICS)and the International Consultation on Urological Diseases (ICUD); 2017. p. 805–957.
  • Ebell MH, Radke T, Gardner J. A systematic review of the efficacy and safety of desmopressin for nocturia in adults. J Urol. 2014;192(3):829–835.
  • Weiss JP, Juul KV, Wein AJ. Management of nocturia: the role of antidiuretic pharmacotherapy. Neurourol Urodyn. 2014;33(Suppl 1):S19–S24.
  • Chung E. Desmopressin and nocturnal voiding dysfunction: clinical evidence and safety profile in the treatment of nocturia. Exper Opin Pharmacol. 2018;19(3):291–298.
  • Zong H, Yang C, Peng X, et al. Efficacy and safety of desmopressin for treatment of nocturia: a systematic review and meta-analysis of double-blinded trials. Int Urol Nephrol. 2012;44(2):377–384.
  • Cai X, Tian Y, Nie M, et al. Efficacy and safety of desmopressin in women with nocturia: a systematic review and meta-analysis of randomized controlled trials. Int Urol Nephrol. 2019;51(11):1913–1923.
  • Cornu JN, Abrams P, Chapple CR, et al. A contemporary assessment of nocturia: definition, epidemiology, pathophysiology, and management- a systematic review and meta-analysis. Eur Urol. 2012;62(5):877–890.
  • Han J, Jung JH, Bakker CJ, et al. Desmopressin for treating nocturia in men. Cochrane Database Syst Rev. 2017;10:CD012059.
  • Kim JC, Cho KJ, Lee JG, et al. Efficacy and safety of desmopressin add-on therapy for men with persistent nocturia on α-blocker monotherapy for lower urinary tract symptoms: a randomized, double-blind placebo controlled study. J Urol. 2017;197(2):459–464.
  • Rovner ES, Raymond K, Andruczyk E, et al. Low-dose desmopressin and tolterodine combination therapy for treating nocturia in women with overactive bladder: a double-blind, randomized, controlled study. Low Urin Tract Symptoms. 2018;10(3):221–230.
  • Yamaguichi O, Nishizawa O, Juul KV, et al. Gender difference in efficacy and dose response in Japanese patients with nocturia treated with four different doses of desmopressin orally disintegrating tablet in a randomized, placebo-controlled trial. BJU Int. 2013;111(3):474–484.
  • Lose G, Mattiasson A, Walter S, et al. Clinical experiences with desmopressin for long-term treatment of nocturia. J Urol. 2014;172:1021–1025.
  • Juul KV, Klein BM, Noorgaard JP. Long-term durability of the response to desmopressin in female and male nocturia patients. Neurourol Urodyn. 2013;32:363–370.
  • Juul KV, Klein BM, Sandström R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011;300(5):F1116–F1122.
  • Juul KV, Malmberg A, van der Meulen E, et al. Low-dose desmopressin combined with serum sodium monitoring can prevent clinically significant hyponatraemia in patients treated for nocturia. BJU Int. 2017;119(5):776–784.
  • McElwaine-Johnn H, Schutz R, Yea C, et al. The antidiuretic effect of fedovapagon can be effectively controlled by dose. Abstr ICS Florence. 2017.
  • Golor G, McElwaine-Johnn H, Handy R, et al. Administration of fedovapagon causes a dose-responsive reduction in nocturnal polyuria index. J Urol. 2013;189(4 Suppl.1):e930–931.
  • Cheng CJ, Rodan AR, Huang CL. Emerging targets of diuretic therapy. Clin Pharmacol Ther. 2017;102(3):420–435.
  • Reynard JM, Cannon A, Yang Q, et al. A novel therapy for nocturnal polyuria: a double-blind randomized trial of frusemide against placebo. Br J Urol. 1998;81(2):215–218.
  • Fu FG, Lavery HJ, Wu DL. Reducing nocturia in the elderly: a randomized placebo-controlled trial of staggered furosemide and desmopressin. Neurourol Urodyn. 2011;30:437–452.
  • Pedersen PA, Johansen B. Prophylactic treatment of adult nocturia with bumetanide. Br J Urol. 1988;62(2):145–147.
  • Rackley R, Weiss JP, Rovner ES, et al. Nighttime dosing with tolterodine reduces overactive bladder-related nocturnal micturitions in patients with overactive bladder and nocturia. Urology. 2006;67(4):731–736.
  • Weiss JP, Jumadilova Z, Johnson TM 2nd, et al. Efficacy and safety of flexible dose fesoterodine in men and women with overactive bladder symptoms including nocturnal urinary urgency. J Urol. 2013;189(4):1396–1401.
  • Rudy D, Cline K, Harris R, et al. Multicenter phase III trial studying trospium chloride in patients with overactive bladder. Urology. 2006;67(2):275–280.
  • Khusid JA, Weiss JP, Carlsson MO, et al. Fesoterodine for the treatment of nocturnal urgency in patients with overactiveb ladder syndrome: an analysis of responders and nonresponders. J Urol. 2017;198(5):1119–1123.
  • Dmochowski RR, Peters KM, Morrow JD, et al. Randomized, double-blind, placebo-controlled trial of flexible-dose fesoterodine in subjects with overactive bladder. Urology. 2010;75(1):62–68.
  • Yokoyama O, Yamaguchi O, Kakizaki H, et al. Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary. J Urol. 2011;186(1):170–174.
  • Kwon T, Oh TH, Choi S, et al. Influence of daytime or nightime dosing with solifenacin for overactive bladder with nocturia: impact on nocturia and sleep quality. J Korean Med Sci. 2017;32(9):1491–1495.
  • Brubaker L, FitzGerald M. Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms. Int Urogynecol J Pelvic Floor Dysfunct. 2007;18(7):737–741.
  • Chapple CR, Dvorak V, Radziszewski P, et al. A phase II dose-ranging study of mirabegron in patients with overactive bladder. Int Urogynecol J. 2013;24(9):1447–1458.
  • Petrossian RA, Dynda D, Delfino K, et al. Mirabegron improves sleep measures, nocturia, and lower urinary tract symptoms in those with urinary symptoms associated with disordered sleep. Can J Urol. 2020;27(1):10106–10117.
  • Lee CL, Ong HL, Kuo HC. Therapeutic efficacy of mirabegron 25mg monotherapy in patients with nocturia-predominant hypersensitive bladder. Ci Ji Yi Xue Za Zhi. 2019;32(1):30–35.
  • Suzuki T, Minagawa T, Saito T, et al. Effect of oxybutynin patch versus mirabegron on nocturia-related quality of life in female overactive bladder patients: a multicenter randomized trial. Int J Urol. 2021;28(9):944–949.
  • Roehrborn CG, Cruz F, Fusco F. α1-Blockers in men with lower urinary tract symptoms suggestive of benign prostatic obstruction: is silodosin different? Adv Ther. 2017;33(12):2110–2121.
  • Andersson KE, Gratzke C. Pharmacology of alpha1-adrenoceptor antagonists in the lower urinary tract and central nervous system. Nat Clin Pract Urol. 2007;4(7):368–378.
  • Kim BH, Kim KH, Ko YH, et al. The prostatic urethral angle can predict the response to alpha adrenoceptor antagonist monotherapy for treating nocturia in men with lower urinary tract symptom: a multicenter study. Prostate Int. 2016;4(1):30–35.
  • Kim YW, Park J, Chung H, et al. The effectiveness of silodosin for nocturnal polyuria in elderly men with benign prostatic hyperplasia: a multicenter study. Int Neurourol J. 2015;19(3):190–196.
  • Eisenhardt A, Schneider T, Cruz F, et al. Consistent and significant improvement of nighttime voiding frequency (nocturia) with silodosin in men with LUTS suggestive of BPH: pooled analysis of three randomized, placebo-controlled, double-blind phase III studies. World J Urol. 2014;32(5):1119–1125.
  • Chapple CR, Montorsi F, Tammela TL, et al. European Silodosin Study Group Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: results of an international, randomized, double-blind, placebo- and active-controlled clinical trial performed in Europe. Eur Urol. 2011;59(3):342–352.
  • Kim SO, Choi HS, Kwon D. The α1 adrenoceptor antagonist tamsulosin for the treatment of voiding symptoms improves nocturia and sleep quality in women. Urol J. 2014;11(3):1636–1641.
  • Füllhase C, Chapple C, Cornu JN, et al. Systematic review of combination drug therapy for non-neurogenic male lower urinary tract symptoms. Eur Urol. 2013;64(2):228–243.
  • Chapple C, Herschorn S, Abrams P, et al. Tolterodine treatment improves storage symptoms suggestive of overactive bladder in men treated with α-blockers. Eur Urol. 2009;56(3):534–543.
  • Johnson TM 2nd, Jones K, Williford WO, et al. Changes in nocturia from medical treatment of benign prostatic hyperplasia: secondary analysis of the department of veterans affairs cooperative study trial. J Urol. 2003;170(1):145–148.
  • Johnson ITM, Burrows PK, Kusek JW, et al. The effect of doxazosin, finasteride, and combination therapy on nocturia in men with benign prostatic hyperplasia. J Urol. 2007;178(5):2045–2051.
  • Oelke M, Roehrborn CG, D’Ancona C, et al. Impact of dutasteride on nocturia in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH): a pooled analysis of three phase III studies. World J Urol. 2014;32(5):1141–1147.
  • Kuhlman PK, Fischer SC, Howard LE, et al. Dutasteride improves nocturia but does not lead to better sleep: results from the REDUCE clinical trial. J Urol. 2021;205(6):1733–1739.
  • Giuliano F, Uckert S, Maggi M, et al. The mechanism of action of phosphodiesterase type 5 inhibitors in the treatment of lower urinary tract symptoms related to benign prostatic hyperplasia. Eur Urol. 2013;63(3):506–516.
  • Oelke M, Weiss JP, Mamoulakis C, et al. Effects of tadalafil on nighttime voiding (nocturia) in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: a post hoc analysis of pooled data from four randomized, placebo-controlled clinical studies. World J Urol. 2014;32(5):1127–1132.
  • Takahashi R, Sumino Y, Miyazato M, et al. Tadalafil improves nocturia and nocturia-related quality of life in patients with benign prostatic hyperplasia (KYU-PRO study). Urol Int. 2020;104(7–8):587–593.
  • Wilson S, Argyropoulos S. Antidepressants and sleep: a qualitative review of the literature. Drugs. 2005;65(7):927–947.
  • Asplund R, Johansson S, Henriksson S, et al. Nocturia, depression and antidepressant medications. BJU Int. 2005;95(6):820–823.
  • Witkin JM, Smith JL, Golani LK, et al. Involvement of muscarinic receptor mechanisms in antidepressant drug action. Adv Pharmacol. 2020;89:311–356.
  • You SH, Jeong HJ. The clinical effects of amitriptyline on the nocturia of patients with benign prostatic hyperplasia. Korean J Urol. 2008;49(4):343–349.
  • Pevet P, Challet E, Felder-Schmittbuhl MP. Melatonin and the circadian system: keys for health with a focus on sleep. Handb Clin Neurol. 2021;179:331–343.
  • Drake MJ, Mills IW, Noble JG. Melatonin pharmacotherapy for nocturia in men with benign prostatic enlargement. J Urol. 2004;171(3):1199–1202.
  • Drake MJ, Canham L, Cotterill N, et al. Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of nocturia in adults with multiple sclerosis (MeNiMS. BMC Neurol. 2018;18(1):107.
  • Batla A, Simeoni S, Uchiyama T, et al. Exploratory pilot of exogenous sustained-release melatonin on nocturia in Parkinson’s disease. Eur J Neurol. 2021;28(6):1884–1892.
  • Sugaya K, Nishijima S, Miyazato M, et al. Effects of melatonin and rilmazafone on nocturia in the elderly. J Int Med Res. 2007;35(5):685–691.

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