Advanced search
Publication Cover
Amyotrophic Lateral Sclerosis Volume 6, 2005 - Issue 2
Journal homepage
190
Views
96
CrossRef citations to date
0
Altmetric
Original article

Autonomic dysfunction in ALS: A preliminary study on the effects of intrathecal BDNF

Marcus Beck Department of Neurology, ALS Study Group, Julius‐Maximilians‐University WuerzburgCorrespondence[email protected]‐wuerzburg.de
,
Peter Flachenecker Department of Neurology, Saarland University Hospital, Homburg/Saar, Germany
,
Tim Magnus Department of Neurology, ALS Study Group, Julius‐Maximilians‐University Wuerzburg
,
Ralf Giess Department of Neurology, Saarland University Hospital, Homburg/Saar, Germany
,
Karlheinz Reiners Department of Neurology, ALS Study Group, Julius‐Maximilians‐University Wuerzburg
,
Klaus V. Toyka Department of Neurology, Saarland University Hospital, Homburg/Saar, Germany
&
Markus Naumann Department of Neurology, ALS Study Group, Julius‐Maximilians‐University Wuerzburg
 show all
Pages 100-103 | Received 01 Mar 2004, Accepted 17 Dec 2004, Published online: 10 Jul 2009

References

  • Pisano F, Miscio G, Mazzero G, Lanfranchi P, Colombo R, Pinelli P. Decreased heart rate variability in amyotrophic lateral sclerosis. Muscle Nerve. 1995;18:1225–31.
  • Giess R, Werner E, Beck M, Reiners C, Toyka KV, Naumann M. Impaired salivary function reveals autonomic dysfunction in amyotrophic lateral sclerosis. J Neurol. 2002;249:1246–9.
  • Druschky A, Spitzer A, Platsch G, Claus D, Feistel H, Druschky K, et al. Cardiac sympathetic denervation in early stages of amyotrophic lateral sclerosis demonstrated by 123I- MIBG-Spect. Acta Neurol Scand. 1999;99:308–14.
  • Masur H, Schulte-Oversohl U, Papke K, Oberwittler C, Voller J. Sympathetic skin response in patients with amyo- trophic lateral sclerosis. Funct Neurol. 1995;1:131–5.
  • Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde YA. Brain-derived neurotrophic factor prevents the death of motor neurons in newborn rats after nerve section. Nature. 1992;360:757–9.
  • Roosen A, Schober A, Strelau J, Bottner M, Faulhaber J, Bendner G, et al. Lack of neurotrophin-4 causes structural and chemical deficits in sympathetic ganglia and their preganglionic innervation. J Neurosci. 2001;21:3073–84.
  • Dittrich F, Ochs G, Grosse-Wilde A, Berweiler U, Yan Q, Miller JA, et al. Pharmakokinetics of intrathecally applied BDNF and effects on spinal motor neurons. Exp Neurol. 1996;141:225–39.
  • Ochs G, Penn RD, York M, Giess R, Beck M, Tonn J, et al. A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1:201–6.
  • Flachenecker P, Hartung HP, Reiners K. Quantitative assessment of cardiovascular autonomic function in Guillain-Barre´ syndrome. Ann Neurol. 1997;42:171–9.
  • Schmidt RE, Dorsey DA, Selznick LA, DiStefano PS, Carroll SL, Beaudet LN, Roth KA. Neurotrophin sensitivity of prevertebral and paravertebral rat sympathetic autonomic ganglia. J Neuropathol Exp Neurol. 1998;57:158–67.
  • Flachenecker P, Schneider C, Cursiefen S, Ricker K, Toyka KV, Reiners K. Assessment of cardiovascular auto- nomic function in myotonic dystrophy type 2 (DM2/ PROMM). Neuromusc Disord. 2003;13:289–93.
  • Oey PL, Vos PE, Wieneke GH, Wokke JHJ, Blankestijn PJ, Karemaker JM. Subtle involvement of the sympathetic nervous system in amyotrophic lateral sclerosis. Muscle Nerve. 2002;25:402–8.
  • Geracioti TD. Jr, Baker DG, Ekhator NN, West SA, Hill KK, Bruce AB, et al. CSF norepinephrine concentrations in post-traumatic stress disorder. Am J Psychiatry. 2001;158:1227–30.
  • Shimizu T, Hayashi H, Kato S, Hayashi M, Tanabe H, Oda M. Circulatory collapse and sudden death in respiratory- dependent amyotrophic lateral sclerosis. J Neurol Sci. 1994;124:45–55.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.