Omentin-1: a newly discovered warrior against metabolic related diseases

References

• Hassan M, Latif N, Yacoub M. Adipose tissue: friend or foe? Nat Rev Cardiol. 2012 Dec;9(12):689–702.
   PubMed Web of Science ®Google Scholar
• Fasshauer M, Bluher M. Adipokines in health and disease. Trends Pharmacol Sci. 2015 Jul;36(7):461–470.
   PubMed Web of Science ®Google Scholar
• Yang RZ, Lee MJ, Hu H, et al. Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1253–61.
   PubMed Web of Science ®Google Scholar
• Suzuki YA, Shin K, Lonnerdal B. Molecular cloning and functional expression of a human intestinal lactoferrin receptor. Biochemistry. 2001 Dec 25; 40(51):15771–15779.
   PubMed Web of Science ®Google Scholar
• Shin K, Wakabayashi H, Yamauchi K, et al. Recombinant human intelectin binds bovine lactoferrin and its peptides. Biol Pharm Bull. 2008 Aug;31(8):1605–1608.
   PubMed Web of Science ®Google Scholar
• Lee JK, Schnee J, Pang M, et al. Human homologs of the Xenopus oocyte cortical granule lectin XL35. Glycobiology. 2001 Jan;11(1):65–73.
   PubMed Web of Science ®Google Scholar
• Watanabe T, Watanabe-Kominato K, Takahashi Y, et al. Adipose Tissue-Derived Omentin-1 Function and Regulation. Compr Physiol. [2017 Jun 18];7(3):765–781.
   PubMed Web of Science ®Google Scholar
• Lin X, Sun Y, Yang S, et al. Omentin-1 modulates macrophage function via integrin receptors alphavbeta3 and alphavbeta5 and reverses plaque vulnerability in animal models of atherosclerosis. Front Cardiovasc Med. 2021;8:757926.
   PubMed Web of Science ®Google Scholar
• Nathan C. Points of control in inflammation. Nature. 2002Dec19-26; 420(6917):846–852.
   PubMed Web of Science ®Google Scholar
• Medzhitov R. Origin and physiological roles of inflammation. Nature. 2008 Jul 24; 454(7203):428–435.
   PubMed Web of Science ®Google Scholar
• Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol. 2014;5:614.
   PubMed Web of Science ®Google Scholar
• Watanabe K, Watanabe R, Konii H, et al. Counteractive effects of omentin-1 against atherogenesisdagger. Cardiovasc Res. 2016 May 1 110(1):118–128.
   PubMed Web of Science ®Google Scholar
• Pascual G, Fong AL, Ogawa S, et al. A sumoylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature. 2005 Sep 29 437(7059):759–763.
   PubMed Web of Science ®Google Scholar
• Lawrence T. The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651.
   PubMed Web of Science ®Google Scholar
• Rao SS, Hu Y, Xie PL, et al. Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines. Bone Res. 2018;6(1):9.
   PubMed Web of Science ®Google Scholar
• Wang J, Gao Y, Lin F, et al. Omentin-1 attenuates lipopolysaccharide (LPS)-induced U937 macrophages activation by inhibiting the TLR4/MyD88/NF-kappaB signaling. Arch Biochem Biophys. 2020 Jan 15;679:108187.
   PubMed Web of Science ®Google Scholar
• Yamawaki H, Kuramoto J, Kameshima S, et al. Omentin, a novel adipocytokine inhibits TNF-induced vascular inflammation in human endothelial cells. Biochem Biophys Res Commun. 2011 May 6 408(2):339–343.
   PubMed Web of Science ®Google Scholar
• Jiang S, Xiao H, Wu Z, et al. NLRP3 sparks the Greek fire in the war against lipid-related diseases. Obes Rev. 2020 Sep;21(9):e13045.
   PubMed Web of Science ®Google Scholar
• Yang C, Xia W, Liu X, et al. Role of TXNIP/NLRP3 in sepsis-induced myocardial dysfunction. Int J Mol Med. 2019 Aug;44(2):417–426.
   PubMed Web of Science ®Google Scholar
• Zhou H, Zhang Z, Qian G, et al. Omentin-1 attenuates adipose tissue inflammation via restoration of TXNIP/NLRP3 signaling in high-fat diet-induced obese mice. Fundam Clin Pharmacol. 2020 Dec;34(6):721–735.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Hao C, Li C, et al. Omentin-1 protects against bleomycin-induced acute lung injury. Mol Immunol. 2018 Nov;103:96–105.
   PubMed Web of Science ®Google Scholar
• van der Pol A, van Gilst Wh, Voors AA, et al. Treating oxidative stress in heart failure: past, present and future. Eur J Heart Fail. 2019 Apr;21(4):425–435.
   PubMed Web of Science ®Google Scholar
• Gu N, Wang J, Di Z, et al. The effects of intelectin-1 on antioxidant and angiogenesis in huvecs exposed to oxygen glucose deprivation. Front Neurol. 2019;10:383.
   PubMed Web of Science ®Google Scholar
• Octavia Y, Tocchetti CG, Gabrielson KL, et al. Doxorubicin-induced cardiomyopathy: from molecular mechanisms to therapeutic strategies. J Mol Cell Cardiol. 2012 Jun;52(6):1213–1225.
   PubMed Web of Science ®Google Scholar
• Kazama K, Okada M, Yamawaki H. Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species. Biochem Biophys Res Commun. 2015 Feb 20; 457(4):602–607.
   PubMed Web of Science ®Google Scholar
• Vitale G, Salvioli S, Franceschi C. Oxidative stress and the ageing endocrine system. Nat Rev Endocrinol. 2013 Apr;9(4):228–240.
   PubMed Web of Science ®Google Scholar
• Renehan AG, Booth C, Potten CS. What is apoptosis, and why is it important? BMJ. 2001 Jun 23; 322(7301):1536–1538.
   PubMed Web of Science ®Google Scholar
• Charununtakorn ST, Shinlapawittayatorn K, Chattipakorn SC, et al. Potential roles of humanin on apoptosis in the heart. Cardiovasc Ther. 2016 Apr;34(2):107–114.
   PubMed Web of Science ®Google Scholar
• Porter AG, Janicke RU. Emerging roles of caspase-3 in apoptosis. Cell Death Differ. 1999 Feb;6(2):99–104.
   PubMed Web of Science ®Google Scholar
• Lage R, Cebro-Marquez M, Rodriguez-Manero M, et al. Omentin protects H9c2 cells against docetaxel cardiotoxicity. PLoS One. 2019;14(2):e0212782.
   PubMed Web of Science ®Google Scholar
• Kataoka Y, Shibata R, Ohashi K, et al. Omentin prevents myocardial ischemic injury through AMP-activated protein kinase- and akt-dependent mechanisms. J Am Coll Cardiol. 2014 Jun 24 63(24):2722–2733.
   PubMed Web of Science ®Google Scholar
• Maruyama S, Shibata R, Kikuchi R, et al. Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism. J Biol Chem. 2012 Jan 2 287(1):408–417.
   PubMed Web of Science ®Google Scholar
• Gu N, Dong Y, Tian Y, et al. Anti-apoptotic and angiogenic effects of intelectin-1 in rat cerebral ischemia. Brain Res Bull. 2017 Apr;130:27–35.
   PubMed Web of Science ®Google Scholar
• Sotozono C, Ueta M, Nakatani E, et al. Predictive factors associated with acute ocular involvement in stevens-johnson syndrome and toxic epidermal necrolysis. Am J Ophthalmol. 2015 Aug;160(2):228–237 e2.
   PubMed Web of Science ®Google Scholar
• Yin L, Huang D, Liu X, et al. Omentin-1 effects on mesenchymal stem cells: proliferation, apoptosis, and angiogenesis in vitro. Stem Cell Res Ther. 2017 Oct 10 8(1):224.
   PubMed Web of Science ®Google Scholar
• Shi WZ, Li W, Cheng Y, et al. The cytoprotective role of omentin against oxidative stress-induced PC12 apoptosis. Artif Cells Nanomed Biotechnol. 2021 Dec;49(1):483–492.
   PubMed Web of Science ®Google Scholar
• Komiya T, Tanigawa Y, Hirohashi S. Cloning of the novel gene intelectin, which is expressed in intestinal paneth cells in mice. Biochem Biophys Res Commun. 1998 Oct 29; 251(3):759–762.
   PubMed Web of Science ®Google Scholar
• Wesener DA, Wangkanont K, McBride R, et al. Recognition of microbial glycans by human intelectin-1. Nat Struct Mol Biol. 2015 Aug;22(8):603–610.
   PubMed Web of Science ®Google Scholar
• Tsuji S, Yamashita M, Hoffman DR, et al. Capture of heat-killed Mycobacterium bovis bacillus Calmette-Guerin by intelectin-1 deposited on cell surfaces. Glycobiology. 2009 May;19(5):518–526.
   PubMed Web of Science ®Google Scholar
• Filbin M, Monje M. Developmental origins and emerging therapeutic opportunities for childhood cancer. Nat Med. 2019 Mar;25(3):367–376.
   PubMed Web of Science ®Google Scholar
• Zhang YY, Zhou LM. Omentin-1, a new adipokine, promotes apoptosis through regulating Sirt1-dependent p53 deacetylation in hepatocellular carcinoma cells. Eur J Pharmacol. 2013 Jan 5; 698(1–3):137–144.
   PubMed Web of Science ®Google Scholar
• Lorentzen A, Lewinsky RH, Bornholdt J, et al. Expression profile of the N-myc downstream regulated gene 2 (NDRG2) in human cancers with focus on breast cancer. BMC Cancer. 2011 Jan 12 11(1):14.
   PubMed Web of Science ®Google Scholar
• Hu XL, Liu XP, Lin SX, et al. NDRG2 expression and mutation in human liver and pancreatic cancers. World J Gastroenterol. 2004 Dec 1 10(23):3518–3521.
   PubMed Web of Science ®Google Scholar
• Lorentzen A, Vogel LK, Lewinsky RH, et al. Expression of NDRG2 is down-regulated in high-risk adenomas and colorectal carcinoma. BMC Cancer. 2007 Oct 12 7(1):192.
   PubMed Web of Science ®Google Scholar
• Yao L, Zhang J, Liu X. NDRG2: a Myc-repressed gene involved in cancer and cell stress. Acta Biochim Biophys Sin (Shanghai). 2008 Jul;40(7):625–635.
   PubMed Web of Science ®Google Scholar
• Li D, Mei H, Pu J, et al. Intelectin 1 suppresses the growth, invasion and metastasis of neuroblastoma cells through up-regulation of N-myc downstream regulated gene 2. Mol Cancer. 2015 Feb 21 14(1):47.
   PubMed Web of Science ®Google Scholar
• Li D, Zhao X, Xiao Y, et al. Intelectin 1 suppresses tumor progression and is associated with improved survival in gastric cancer. Oncotarget. 2015 Jun 30 6(18):16168–16182.
   PubMedGoogle Scholar
• Maeda K, Saigo C, Kito Y, et al. Expression of TMEM207 in Colorectal Cancer: relation between TMEM207 and Intelectin-1. J Cancer. 2016;7(2):207–213.
   PubMed Web of Science ®Google Scholar
• Ji H, Wan L, Zhang Q, et al. The effect of omentin-1 on the proliferation and apoptosis of colon cancer stem cells and the potential mechanism. J BUON. 2019 Jan-Feb;24(1):91–98.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhao X, Chen M. Autocrine action of adipokine omentin-1 in the SW480 colon cancer cell line. Oncol Lett. 2020 Jan;19(1):892–898.
   PubMed Web of Science ®Google Scholar
• Kiczmer P, Szydlo B, Senkowska AP, et al. Serum omentin-1 and chemerin concentrations in pancreatic cancer and chronic pancreatitis. Folia Med Cracov. 2018;58(2):77–87.
   PubMedGoogle Scholar
• Karabulut S, Afsar CU, Karabulut M, et al. Clinical significance of serum omentin-1 levels in patients with pancreatic adenocarcinoma. BBA Clinical. 2016 Dec;6:138–142.
   PubMedGoogle Scholar
• Zhou L, He W, Wang W, et al. Altered circulating levels of adipokine omentin-1 in patients with prostate cancer. Onco Targets Ther. 2019;12:3313–3319.
   PubMed Web of Science ®Google Scholar
• Shen XD, Zhang L, Che H, et al. Circulating levels of adipocytokine omentin-1 in patients with renal cell cancer. Cytokine. 2016 Jan;77:50–55.
   PubMed Web of Science ®Google Scholar
• Vijan S. Type 2 Diabetes. Ann Intern Med. 2019 Nov 5; 171(9):ITC65–ITC80.
   PubMed Web of Science ®Google Scholar
• Onyango AN. The Contribution of Singlet Oxygen to Insulin Resistance. Oxid Med Cell Longev. 2017;2017:8765972.
   PubMed Web of Science ®Google Scholar
• Reinehr T, Roth CL. Inflammation markers in type 2 diabetes and the metabolic syndrome in the pediatric population. Curr Diab Rep. 2018 Oct 18; 18(12):131.
   PubMed Web of Science ®Google Scholar
• SC M, PA M, and Raquel S. Endothelial dysfunction - a major mediator of diabetic vascular disease. Biochim Biophys Acta. 2013;1832(12):2216–2231.
   PubMed Web of Science ®Google Scholar
• Leandro A, Queiroz M, Azul L, et al. Omentin: a novel therapeutic approach for the treatment of endothelial dysfunction in type 2 diabetes. Free Radic Biol Med. 2021 Jan;162:233–242.
   PubMed Web of Science ®Google Scholar
• Liu F, Fang S, Liu X, et al. Omentin-1 protects against high glucose-induced endothelial dysfunction via the AMPK/PPARdelta signaling pathway. Biochem Pharmacol. 2020 Apr;174:113830.
   PubMed Web of Science ®Google Scholar
• Yu SM, Bonventre JV. Acute kidney injury and progression of diabetic kidney disease. Adv Chronic Kidney Dis. 2018 Mar;25(2):166–180.
   PubMed Web of Science ®Google Scholar
• Song J, Zhang H, Sun Y, et al. Omentin-1 protects renal function of mice with type 2 diabetic nephropathy via regulating miR-27a-Nrf2/Keap1 axis. Biomed Pharmacother. 2018 Nov;107:440–446.
   PubMed Web of Science ®Google Scholar
• El-Mesallamy HO, El-Derany MO, Hamdy NM. Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease. Diabet Med. 2011 Oct;28(10):1194–1200.
   PubMed Web of Science ®Google Scholar
• Greulich S, Chen WJ, Maxhera B, et al. Cardioprotective properties of omentin-1 in type 2 diabetes: evidence from clinical and in vitro studies. PLoS One. 2013;8(3):e59697.
   PubMed Web of Science ®Google Scholar
• Volmer-Thole M, Lobmann R. Neuropathy and diabetic foot syndrome. Int J Mol Sci. 2016 Jun 10; 17(6):917.
   Web of Science ®Google Scholar
• Tuttolomondo A, Del Cuore A, La Malfa A, et al. Assessment of heart rate variability (HRV) in subjects with type 2 diabetes mellitus with and without diabetic foot: correlations with endothelial dysfunction indices and markers of adipo-inflammatory dysfunction. Cardiovasc Diabetol. 2021 Jul 14 20(1):142.
   PubMed Web of Science ®Google Scholar
• Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010 Jul 10; 376(9735):124–136.
   PubMed Web of Science ®Google Scholar
• Yasir M, Senthilkumar GP, Jayashree K, et al. Association of serum omentin-1, apelin and chemerin concentrations with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients. Arch Physiol Biochem. 2019 Nov;5:1–8.
   Web of Science ®Google Scholar
• Wan W, Li Q, Zhang F, et al. Serum and Vitreous Concentrations of Omentin-1 in Diabetic Retinopathy. Dis Markers. 2015;2015:754312.
   PubMed Web of Science ®Google Scholar
• Omae T, Nagaoka T, Yoshida A. Effect of circulating omentin-1 on the retinal circulation in patients with type 2 diabetes mellitus. Invest Ophthalmol Vis Sci. 2017 Oct 1; 58(12):5086–5092.
   PubMed Web of Science ®Google Scholar
• Hayashi M, Morioka T, Hatamori M, et al. Plasma omentin levels are associated with vascular endothelial function in patients with type 2 diabetes at elevated cardiovascular risk. Diabetes Res Clin Pract. 2019 Feb;148:160–168.
   PubMed Web of Science ®Google Scholar
• Herder C, Kannenberg JM, Niersmann C, et al. Independent and opposite associations of serum levels of omentin-1 and adiponectin with increases of glycaemia and incident type 2 diabetes in an older population: KORA F4/FF4 study. Eur J Endocrinol. 2017 Oct;177(4):277–286.
   PubMed Web of Science ®Google Scholar
• Niersmann C, Carstensen-Kirberg M, Maalmi H, et al. Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes. Diabetologia. 2020 Feb;63(2):410–418.
   PubMed Web of Science ®Google Scholar
• Bentzon JF, Otsuka F, Virmani R, et al. Mechanisms of plaque formation and rupture. Circ Res. 2014 Jun 6 114(12):1852–1866.
   PubMed Web of Science ®Google Scholar
• Back M, Yurdagul A Jr., Tabas I, et al. Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities. Nat Rev Cardiol. 2019 Jul;16(7):389–406.
   PubMed Web of Science ®Google Scholar
• Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol. 2006 Jul;6(7):508–519.
   PubMed Web of Science ®Google Scholar
• Hsueh TP, Sheen JM, Pang JH, et al. The Anti-atherosclerotic effect of naringin is associated with reduced expressions of cell adhesion molecules and Chemokines through NF-kappaB Pathway. Molecules. 2016 Feb 5 21(2):195.
   Web of Science ®Google Scholar
• Zhong X, Li X, Liu F, et al. Omentin inhibits TNF-alpha-induced expression of adhesion molecules in endothelial cells via ERK/NF-kappaB pathway. Biochem Biophys Res Commun. 2012 Aug 24;425(2):401–406.
   PubMed Web of Science ®Google Scholar
• Stoger JL, Gijbels MJ, van der Velden S, et al. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis. 2012 Dec;225(2):461–468.
   PubMed Web of Science ®Google Scholar
• Di Pietro N, Formoso G, Pandolfi A. Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis. Vascul Pharmacol. 2016 Sep;84:1–7.
   PubMed Web of Science ®Google Scholar
• SenBanerjee S, Lin Z, Atkins GB, et al. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17 199(10):1305–1315.
   PubMed Web of Science ®Google Scholar
• Wang Y, Sun M, Wang Z, et al. Omentin-1 ameliorates the attachment of the leukocyte THP-1 cells to HUVECs by targeting the transcriptional factor KLF2. Biochem Biophys Res Commun. 2018 Mar 25 498(1):152–156.
   PubMed Web of Science ®Google Scholar
• Chen Y, Liu F, Han F, et al. Omentin-1 ameliorated free fatty acid-induced impairment in proliferation, migration, and inflammatory States of HUVECs. Cardiol Res Pract. 2020;2020:3054379.
   PubMed Web of Science ®Google Scholar
• Duan XY, Xie PL, Ma YL, et al. Omentin inhibits osteoblastic differentiation of calcifying vascular smooth muscle cells through the PI3K/Akt pathway. Amino Acids. 2011 Nov;41(5):1223–1231.
   PubMed Web of Science ®Google Scholar
• Dong Q, Xing W, Li K, et al. Tetrahydroxystilbene glycoside improves endothelial dysfunction and hypertension in obese rats: the role of omentin-1. Biochem Pharmacol. 2021 Apr;186:114489.
   PubMed Web of Science ®Google Scholar
• Shibata R, Takahashi R, Kataoka Y, et al. Association of a fat-derived plasma protein omentin with carotid artery intima-media thickness in apparently healthy men. Hypertens Res. 2011 Dec;34(12):1309–1312.
   PubMed Web of Science ®Google Scholar
• Liu R, Wang X, Bu P. Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome. Diabetes Res Clin Pract. 2011 Jul;93(1):21–25.
   PubMed Web of Science ®Google Scholar
• Yoo HJ, Hwang SY, Hong HC, et al. Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes. Cardiovasc Diabetol. 2011 Nov 22 10(1):103.
   PubMed Web of Science ®Google Scholar
• Yoo HJ, Hwang SY, Hong HC, et al. Implication of circulating omentin-1 level on the arterial stiffening in type 2 diabetes mellitus. Endocrine. 2013 Dec;44(3):680–687.
   PubMed Web of Science ®Google Scholar
• Kocijancic M, Cubranic Z, Vujicic B, et al. Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients. Int Urol Nephrol. 2016 Jul;48(7):1145–1154.
   PubMed Web of Science ®Google Scholar
• Yang J, Gao Y. Clinical relevance of serum omentin-1 levels as a biomarker of prognosis in patients with acute cerebral infarction. Brain Behav. 2020 Jul;10(7):e01678.
   PubMed Web of Science ®Google Scholar
• Xu T, Zuo P, Cao L, et al. Omentin-1 is associated with carotid plaque instability among ischemic stroke patients. J Atheroscler Thromb. 2018 Jun 1 25(6):505–511.
   PubMed Web of Science ®Google Scholar
• Biscetti F, Nardella E, Bonadia N, et al. Association between plasma omentin-1 levels in type 2 diabetic patients and peripheral artery disease. Cardiovasc Diabetol. 2019 Jun 5 18(1):74.
   PubMed Web of Science ®Google Scholar
• Biscetti F, Nardella E, Rando MM, et al. Outcomes of lower extremity endovascular revascularization: potential predictors and prevention strategies. Int J Mol Sci. 2021 Feb 18 22(4):2002.
   PubMed Web of Science ®Google Scholar
• Biscetti F, Nardella E, Rando MM, et al. Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: a prospective cohort study. Cardiovasc Diabetol. 2020 Oct 7 19(1):170.
   PubMed Web of Science ®Google Scholar
• Xie H, Xie PL, Luo XH, et al. Omentin-1 exerts bone-sparing effect in ovariectomized mice. Osteoporos Int. 2012 Apr;23(4):1425–1436.
   PubMed Web of Science ®Google Scholar
• Wu SS, Liang QH, Liu Y, et al. Omentin-1 stimulates human osteoblast proliferation through pi3k/akt signal pathway. Int J Endocrinol. 2013;2013:368970.
   PubMed Web of Science ®Google Scholar
• Feng SK, Chen TH, Li HM, et al. Deficiency of Omentin-1 leads to delayed fracture healing through excessive inflammation and reduced CD31(hi)Emcn(hi) vessels. Mol Cell Endocrinol. 2021 Aug 20;534:111373.
   PubMed Web of Science ®Google Scholar
• Chai B, Zheng ZH, Liao X, et al. The protective role of omentin-1 in IL-1beta-induced chondrocyte senescence. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):8–14.
   PubMed Web of Science ®Google Scholar
• Li Z, Liu B, Zhao D, et al. Omentin-1 prevents cartilage matrix destruction by regulating matrix metalloproteinases. Biomed Pharmacother. 2017 Aug;92:265–269.
   PubMed Web of Science ®Google Scholar
• Li Z, Zhang Y, Tian F, et al. Omentin-1 promotes mitochondrial biogenesis via PGC1alpha-AMPK pathway in chondrocytes. Arch Physiol Biochem. 2020;15:1–7.
   Google Scholar
• Assadi M, Salimipour H, Akbarzadeh S, et al. Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue. PLoS One. 2011;6(9):e24240.
   PubMed Web of Science ®Google Scholar
• Guo LJ, Jiang TJ, Liao L, et al. Relationship between serum omentin-1 level and bone mineral density in girls with anorexia nervosa. J Endocrinol Invest. 2013 Mar;36(3):190–194.
   PubMed Web of Science ®Google Scholar
• Wang D, Jiang TJ, Liao L, et al. Relationships between serum omentin-1 concentration and bone mineral density, and bone biochemical markers in Chinese women. Clin Chim Acta. 2013 Nov 15;426:64–67.
   PubMed Web of Science ®Google Scholar
• Menzel J, Di Giuseppe R, Biemann R, et al. Association between omentin-1, adiponectin and bone health under consideration of osteoprotegerin as possible mediator. J Endocrinol Invest. 2016 Nov;39(11):1347–1355.
   PubMed Web of Science ®Google Scholar
• Tohidi M, Akbarzadeh S, Larijani B, et al. Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women. Bone. 2012 Nov;51(5):876–881.
   PubMed Web of Science ®Google Scholar
• Dikker O, Bekpinar S, Ozdemirler G, et al. Evaluation of the relation between Omentin-1 and Vitamin d in postmenopausal women with or without osteoporosis. Exp Clin Endocrinol Diabetes. 2018 May;126(5):316–320.
   PubMed Web of Science ®Google Scholar
• de Souza Batista Cm, Yang RZ, Lee MJ, et al. Omentin plasma levels and gene expression are decreased in obesity. Diabetes. 2007 Jun;56(6):1655–1661.
   PubMed Web of Science ®Google Scholar
• Moreno-Navarrete JM, Catalan V, Ortega F, et al. Circulating omentin concentration increases after weight loss. Nutr Metab (Lond). 2010 Apr 9 7(1):27.
   PubMed Web of Science ®Google Scholar
• Saremi A, Asghari M, Ghorbani A. Effects of aerobic training on serum omentin-1 and cardiometabolic risk factors in overweight and obese men. J Sports Sci. 2010 Jul;28(9):993–998.
   PubMed Web of Science ®Google Scholar
• Shang FJ, Wang JP, Liu XT, et al. Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome. Biomarkers. 2011 Dec;16(8):657–662.
   PubMed Web of Science ®Google Scholar
• Auguet T, Quintero Y, Riesco D, et al. New adipokines vaspin and omentin. Circulating levels and gene expression in adipose tissue from morbidly obese women. BMC Med Genet. 2011 Apr 28 12(1):60.
   PubMed Web of Science ®Google Scholar
• Shibata R, Ouchi N, Takahashi R, et al. Omentin as a novel biomarker of metabolic risk factors. Diabetol Metab Syndr. 2012 Jul 26 4(1):37.
   PubMed Web of Science ®Google Scholar
• Catli G, Anik A, Abaci A, et al. Low omentin-1 levels are related with clinical and metabolic parameters in obese children. Exp Clin Endocrinol Diabetes. 2013 Nov;121(10):595–600.
   PubMed Web of Science ®Google Scholar
• Prats-Puig A, Bassols J, Bargallo E, et al. Toward an early marker of metabolic dysfunction: omentin-1 in prepubertal children. Obesity. 2011 Sep;19(9):1905–1907. (Silver Spring
   PubMed Web of Science ®Google Scholar
• Zengi S, Zengi O, Kirankaya A, et al. Serum omentin-1 levels in obese children. J Pediatr Endocrinol Metab. 2019 Mar 26 32(3):247–251.
   PubMed Web of Science ®Google Scholar
• Vu A, Sidhom MS, Bredbeck BC, et al. Evaluation of the relationship between circulating omentin-1 concentrations and components of the metabolic syndrome in adults without type 2 diabetes or cardiovascular disease. Diabetol Metab Syndr. 2014 Jan 15 6(1):4.
   PubMed Web of Science ®Google Scholar
• Jialal I, Devaraj S, Kaur H, et al. Increased chemerin and decreased omentin-1 in both adipose tissue and plasma in nascent metabolic syndrome. J Clin Endocrinol Metab. 2013 Mar;98(3):E514–7.
   PubMed Web of Science ®Google Scholar
• Rothermel J, Lass N, Barth A, et al. Link between omentin-1, obesity and insulin resistance in children: findings from a longitudinal intervention study. Pediatr Obes. 2020 May;15(5):e12605.
   PubMed Web of Science ®Google Scholar
• Komosinska-Vassev K, Olczyk P, Kuznik-Trocha K, et al. Circulating C1q/TNF-Related Protein 3, Omentin-1 and NGAL in obese patients with type 2 diabetes during Insulin therapy. J Clin Med. 2019 Jun 5 8(6):805.
   Web of Science ®Google Scholar
• Siegrist M, Heitkamp M, Braun I, et al. Changes of omentin-1 and chemerin during 4 weeks of lifestyle intervention and 1 year follow-up in children with obesity. Clin Nutr. 2021 Nov;40(11):5648–5654.
   PubMed Web of Science ®Google Scholar
• Goldberg IJ, Bornfeldt KE. Lipids and the endothelium: bidirectional interactions. Curr Atheroscler Rep. 2013 Nov;15(11):365.
   PubMed Web of Science ®Google Scholar
• Torisu K, Singh KK, Torisu T, et al. Intact endothelial autophagy is required to maintain vascular lipid homeostasis. Aging Cell. 2016 Feb;15(1):187–191.
   PubMed Web of Science ®Google Scholar
• Galkina EV, Butcher M, Keller SR, et al. Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):247–256.
   PubMed Web of Science ®Google Scholar
• Rojas E, Rodriguez-Molina D, Bolli P, et al. The role of adiponectin in endothelial dysfunction and hypertension. Curr Hypertens Rep. 2014 Aug;16(8):463.
   PubMed Web of Science ®Google Scholar
• Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J Mol Sci. 2017 Jun 21; 18(6):1321.
   Web of Science ®Google Scholar
• Cheng J, Luo X, Huang Z, et al. Apelin/APJ system: a potential therapeutic target for endothelial dysfunction-related diseases. J Cell Physiol. 2019 Aug;234(8):12149–12160.
   PubMed Web of Science ®Google Scholar
• Sainz N, Gonzalez-Navarro CJ, Martinez JA, et al. Leptin signaling as a therapeutic target of obesity. Expert Opin Ther Targets. 2015 Jul;19(7):893–909.
   PubMed Web of Science ®Google Scholar
• Castan-Laurell I, Masri B, Valet P. The apelin/APJ system as a therapeutic target in metabolic diseases. Expert Opin Ther Targets. 2019 Mar;23(3):215–225.
   PubMed Web of Science ®Google Scholar
• Weber A, Wasiliew P, Kracht M. Interleukin-1beta (IL-1beta) processing pathway. Sci Signal. 2010 Jan 19; 3(105):cm2.
   PubMed Web of Science ®Google Scholar
• Akash MSH, Rehman K, Liaqat A. Tumor necrosis factor-Alpha: role in development of insulin resistance and pathogenesis of Type 2 Diabetes mellitus. J Cell Biochem. 2018 Jan;119(1):105–110.
   PubMed Web of Science ®Google Scholar
• Nishimura M, Morioka T, Hayashi M, et al. Plasma omentin levels are inversely associated with atherosclerosis in type 2 diabetes patients with increased plasma adiponectin levels: a cross-sectional study. Cardiovasc Diabetol. 2019 Dec 5 18(1):167.
   PubMed Web of Science ®Google Scholar
• Panagiotou G, Mu L, Na B, et al. Circulating irisin, omentin-1, and lipoprotein subparticles in adults at higher cardiovascular risk. Metabolism. 2014 Oct;63(10):1265–1271.
   PubMed Web of Science ®Google Scholar
• Tan YL, Ou HX, Zhang M, et al. Tanshinone IIA promotes macrophage cholesterol efflux and attenuates atherosclerosis of apoE-/- Mice by Omentin-1/ABCA1 pathway. Curr Pharm Biotechnol. 2019;20(5):422–432.
   PubMed Web of Science ®Google Scholar