Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder

References

• Catala-Lopez F, Genova-Maleras R, Vieta E, et al. The increasing burden of mental and neurological disorders. Eur Neuropsychopharmacol. 2013 Nov;23(11):1337–1339.
   PubMed Web of Science ®Google Scholar
• McEwen BS, Bowles NP, Gray JD, et al. Mechanisms of stress in the brain. Nat Neurosci. 2015 Oct;18(10):1353–1363.
   PubMed Web of Science ®Google Scholar
• Schramm E, Klein DN, Elsaesser M, et al. Review of dysthymia and persistent depressive disorder: history, correlates, and clinical implications. Lancet Psychiatry. 2020 Sep;7(9):801–812.
   PubMed Web of Science ®Google Scholar
• World Health OFM. Depression and other common mental disorders. World Health Org. 2017. p. 2–2.
   PubMedGoogle Scholar
• Global Burden of Disease Cancer C, Fitzmaurice C, Akinyemiju TF, et al. Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study. JAMA Oncol. 2018 Nov 1;4(11):1553-1568.
   Google Scholar
• Dean J, Keshavan M. The neurobiology of depression: an integrated view. Asian J Psychiatr. 2017 Jun;27:101–111. doi: 10.1016/j.ajp.2017.01.025
   PubMed Web of Science ®Google Scholar
• Burgess N, Maguire EA, O’Keefe J. The human hippocampus and spatial and episodic memory. Neuron. 2002 Aug 15;35(4):625–641. doi: 10.1016/S0896-6273(02)00830-9
   PubMed Web of Science ®Google Scholar
• Davidson RJ, Lewis DA, Alloy LB, et al. Neural and behavioral substrates of mood and mood regulation. Biol Psychiatry. 2002 Sep 15;52(6):478–502. doi: 10.1016/S0006-3223(02)01458-0
   PubMed Web of Science ®Google Scholar
• Sahay A, Hen R. Adult hippocampal neurogenesis in depression. Nat Neurosci. 2007 Sep;10(9):1110–1115. doi: 10.1038/nn1969
   PubMed Web of Science ®Google Scholar
• Videbech P, Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. Am J Psychiatry. 2004 Nov;161(11):1957–1966. doi: 10.1176/appi.ajp.161.11.1957
   PubMed Web of Science ®Google Scholar
• MacQueen GM, Campbell S, McEwen BS, et al. Course of illness, hippocampal function, and hippocampal volume in major depression. Proc Natl Acad Sci USA. 2003 Feb 4;100(3):1387–1392. doi: 10.1073/pnas.0337481100
   PubMed Web of Science ®Google Scholar
• Warner-Schmidt JL, Duman RS. Hippocampal neurogenesis: opposing effects of stress and antidepressant treatment. Hippocampus. 2006;16(3):239–249. doi: 10.1002/hipo.20156
   PubMed Web of Science ®Google Scholar
• Boldrini M, Santiago AN, Hen R, et al. Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression. Neuropsychopharmacology. 2013 May;38(6):1068–1077.
   PubMed Web of Science ®Google Scholar
• Kang E, Wen Z, Song H, et al. Adult neurogenesis and psychiatric disorders. Cold Spring Harb Perspect Biol. 2016 Sep 1;8(9):a019026. doi: 10.1101/cshperspect.a019026
   PubMed Web of Science ®Google Scholar
• Snyder JS, Choe JS, Clifford MA, et al. Adult-born hippocampal neurons are more numerous, faster maturing, and more involved in behavior in rats than in mice. J Neurosci. 2009 Nov 18;29(46):14484–14495. doi: 10.1523/JNEUROSCI.1768-09.2009
   PubMed Web of Science ®Google Scholar
• Encinas JM, Sierra A. Neural stem cell deforestation as the main force driving the age-related decline in adult hippocampal neurogenesis. Behav Brain Res. 2012 Feb 14;227(2):433–439. doi: 10.1016/j.bbr.2011.10.010
   PubMed Web of Science ®Google Scholar
• Schmidt-Hieber C, Jonas P, Bischofberger J. Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus. Nature. 2004 May 13;429(6988):184–187. doi: 10.1038/nature02553
   PubMed Web of Science ®Google Scholar
• Bruel-Jungerman E, Laroche S, Rampon C. New neurons in the dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment. Eur J Neurosci. 2005 Jan;21(2):513–521. doi: 10.1111/j.1460-9568.2005.03875.x
   PubMed Web of Science ®Google Scholar
• Hill AS, Sahay A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors. Neuropsychopharmacology. 2015 Sep;40(10):2368–2378. doi: 10.1038/npp.2015.85
   PubMed Web of Science ®Google Scholar
• Snyder JS, Soumier A, Brewer M, et al. Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature. 2011 Aug 3;476(7361):458–461. doi: 10.1038/nature10287
   PubMed Web of Science ®Google Scholar
• Saral S, Topcu A, Alkanat M, et al. Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF/TrkB signaling in rat hippocampus. J Chem Neuroanat. 2023 Jul;130:102269. doi: 10.1016/j.jchemneu.2023.102269
   PubMed Web of Science ®Google Scholar
• Hong N, Kim HJ, Kang K, et al. Photobiomodulation improves the synapses and cognitive function and ameliorates epileptic seizure by inhibiting downregulation of Nlgn3. Cell Biosci. 2023 Jan 12;13(1):8. doi: 10.1186/s13578-022-00949-6
   PubMed Web of Science ®Google Scholar
• Fanselow MS, Dong HW. Are the dorsal and ventral hippocampus functionally distinct structures? Neuron. 2010 Jan 14;65(1):7–19. doi: 10.1016/j.neuron.2009.11.031
   PubMed Web of Science ®Google Scholar
• Kheirbek MA, Drew LJ, Burghardt NS, et al. Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus. Neuron. 2013 Mar 6;77(5):955–968. doi: 10.1016/j.neuron.2012.12.038
   PubMed Web of Science ®Google Scholar
• Tanti A, Belzung C. Neurogenesis along the septo-temporal axis of the hippocampus: are depression and the action of antidepressants region-specific? Neuroscience. 2013 Nov 12;252:234–252. doi: 10.1016/j.neuroscience.2013.08.017
   PubMed Web of Science ®Google Scholar
• Drew LJ, Fusi S, Hen R. Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus? Learn Mem. 2013 Nov 19;20(12):710–729. doi: 10.1101/lm.026542.112
   PubMed Web of Science ®Google Scholar
• Baptista P, Andrade JP. Adult hippocampal neurogenesis: regulation and possible functional and clinical correlates. Front Neuroanat. 2018;12:44. doi: 10.3389/fnana.2018.00044
   PubMed Web of Science ®Google Scholar
• Moreno-Jimenez EP, Flor-Garcia M, Terreros-Roncal J, et al. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat Med. 2019 Apr;25(4):554–560.
   PubMed Web of Science ®Google Scholar
• Boldrini M, Fulmore CA, Tartt AN, et al. Human hippocampal neurogenesis persists throughout aging. Cell Stem Cell. 2018 Apr 5;22(4):589–599 e5. doi: 10.1016/j.stem.2018.03.015
   PubMed Web of Science ®Google Scholar
• Terreros-Roncal J, Moreno-Jimenez EP, Flor-Garcia M, et al. Response to comment on “impact of neurodegenerative diseases on human adult hippocampal neurogenesis”. Science. 2022 Apr 15;376(6590):eabo0920. doi: 10.1126/science.abo0920
   PubMedGoogle Scholar
• Boldrini M, Hen R, Underwood MD, et al. Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression. Biol Psychiatry. 2012 Oct 1;72(7):562–571. doi: 10.1016/j.biopsych.2012.04.024
   PubMed Web of Science ®Google Scholar
• Anacker C, Zunszain PA, Cattaneo A, et al. Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry. 2011 Jul;16(7):738–750.
   PubMed Web of Science ®Google Scholar
• Santarelli L, Saxe M, Gross C, et al. Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science. 2003 Aug 8;301(5634):805–809. doi: 10.1126/science.1083328
   PubMed Web of Science ®Google Scholar
• Eliwa H, Belzung C, Surget A. Adult hippocampal neurogenesis: is it the alpha and omega of antidepressant action? Biochem Pharmacol. 2017 Oct 1;141:86–99. doi: 10.1016/j.bcp.2017.08.005
   PubMed Web of Science ®Google Scholar
• Wong CH, Siah KW, Lo AW. Estimation of clinical trial success rates and related parameters. Biostatistics. 2019 Apr 1;20(2):273–286. doi: 10.1093/biostatistics/kxx069
   PubMed Web of Science ®Google Scholar
• Mahar I, Bambico FR, Mechawar N, et al. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav Rev. 2014 Jan;38:173–192. doi: 10.1016/j.neubiorev.2013.11.009
   PubMed Web of Science ®Google Scholar
• Haroon E, Miller AH, Sanacora G. Inflammation, glutamate, and glia: a trio of trouble in mood disorders. Neuropsychopharmacology. 2017 Jan;42(1):193–215. doi: 10.1038/npp.2016.199
   PubMed Web of Science ®Google Scholar
• Thorsell A, Mathe AA. Neuropeptide Y in alcohol addiction and affective disorders. Front Endocrinol. 2017;8:178. doi: 10.3389/fendo.2017.00178
   PubMed Web of Science ®Google Scholar
• Kask A, Harro J, von Horsten S, et al. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci Biobehav Rev. 2002 May;26(3):259–283.
   PubMed Web of Science ®Google Scholar
• Kormos V, Gaszner B. Role of neuropeptides in anxiety, stress, and depression: from animals to humans. Neuropeptides. 2013 Dec;47(6):401–419. doi: 10.1016/j.npep.2013.10.014
   PubMed Web of Science ®Google Scholar
• Zaben MJ, Gray WP. Neuropeptides and hippocampal neurogenesis. Neuropeptides. 2013 Dec;47(6):431–438. doi: 10.1016/j.npep.2013.10.002
   PubMed Web of Science ®Google Scholar
• Reichmann F, Holzer PNY. Neuropeptide Y: A stressful review. Neuropeptides. 2016 Feb;55:99–109. doi: 10.1016/j.npep.2015.09.008
   PubMed Web of Science ®Google Scholar
• Jimenez-Vasquez PA, Diaz-Cabiale Z, Caberlotto L, et al. Electroconvulsive stimuli selectively affect behavior and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of flinders sensitive line rat model of depression. Eur Neuropsychopharmacol. 2007 Mar;17(4):298–308.
   PubMed Web of Science ®Google Scholar
• Redrobe JP, Dumont Y, Fournier A, et al. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology. 2002 May;26(5):615–624.
   PubMed Web of Science ®Google Scholar
• Goyal SN, Upadhya MA, Kokare DM, et al. Neuropeptide Y modulates the antidepressant activity of imipramine in olfactory bulbectomized rats: involvement of NPY Y1 receptors. Brain Res. 2009 Apr 17;1266:45–53. doi: 10.1016/j.brainres.2009.02.033
   PubMed Web of Science ®Google Scholar
• Corvino V, Marchese E, Podda MV, et al. The neurogenic effects of exogenous neuropeptide Y: early molecular events and long-lasting effects in the hippocampus of trimethyltin-treated rats. PLOS ONE. 2014;9(2):e88294. doi: 10.1371/journal.pone.0088294
   PubMed Web of Science ®Google Scholar
• Cohen H, Liu T, Kozlovsky N, et al. The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder. Neuropsychopharmacology. 2012 Jan;37(2):350–363.
   PubMed Web of Science ®Google Scholar
• Cohen H, Vainer E, Zeev K, et al. Neuropeptide S in the basolateral amygdala mediates an adaptive behavioral stress response in a rat model of posttraumatic stress disorder by increasing the expression of BDNF and the neuropeptide YY1 receptor. Eur Neuropsychopharmacol. 2018 Jan;28(1):159–170.
   PubMed Web of Science ®Google Scholar
• Katsetos CD, Del Valle L, Geddes JF, et al. Aberrant localization of the neuronal class III beta-tubulin in astrocytomas. Arch Pathol Lab Med. 2001 May;125(5):613–624.
   PubMed Web of Science ®Google Scholar
• O’Donnell D, Ahmad S, Wahlestedt C, et al. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. J Comp Neurol. 1999 Jul 5;409(3):469–481. doi: 10.1002/(SICI)1096-9861(19990705)409:3<469:AID-CNE10>3.0.CO;2-Q
   PubMed Web of Science ®Google Scholar
• Lu X, Mazarati A, Sanna P, et al. Distribution and differential regulation of galanin receptor subtypes in rat brain: effects of seizure activity. Neuropeptides. 2005 Jun;39(3):147–152.
   PubMed Web of Science ®Google Scholar
• Barr AM, Kinney JW, Hill MN, et al. A novel, systemically active, selective galanin receptor type-3 ligand exhibits antidepressant-like activity in preclinical tests. Neurosci Lett. 2006 Sep 11;405(1–2):111–115. doi: 10.1016/j.neulet.2006.06.033
   PubMed Web of Science ®Google Scholar
• Kuteeva E, Wardi T, Hokfelt T, et al. Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat. Eur Neuropsychopharmacol. 2007 Jan;17(1):64–69.
   PubMed Web of Science ®Google Scholar
• Kuteeva E, Wardi T, Lundstrom L, et al. Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body level. Neuropsychopharmacology. 2008 Oct;33(11):2573–2585.
   PubMed Web of Science ®Google Scholar
• Luo H, Liu Z, Liu B, et al. Virus-mediated overexpression of ETS-1 in the ventral hippocampus counteracts depression-like behaviors in rats. Neurosci Bull. 2019 Dec;35(6):1035–1044.
   PubMed Web of Science ®Google Scholar
• Lu X, Ross B, Sanchez-Alavez M, et al. Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests. Neuropeptides. 2008 Aug;42(4):387–397.
   PubMed Web of Science ®Google Scholar
• Yun S, Reyes-Alcaraz A, Lee YN, et al. Spexin-based galanin receptor type 2 agonist for comorbid mood disorders and abnormal body weight. Front Neurosci. 2019;13:391. doi: 10.3389/fnins.2019.00391
   PubMed Web of Science ®Google Scholar
• Sharma A, Ren X, Zhang H, et al. Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: a postmortem study. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jan 10;112:110428. doi: 10.1016/j.pnpbp.2021.110428
   PubMed Web of Science ®Google Scholar
• Juhasz G, Hullam G, Eszlari N, et al. Brain galanin system genes interact with life stresses in depression-related phenotypes. Proc Natl Acad Sci USA. 2014 Apr 22;111(16):E1666–73. doi: 10.1073/pnas.1403649111
   PubMed Web of Science ®Google Scholar
• Narvaez M, Millon C, Borroto-Escuela D, et al. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the amygdala lead to increased anxiolytic actions. Brain Struct Funct. 2015 Jul;220(4):2289–2301.
   PubMed Web of Science ®Google Scholar
• Narvaez M, Borroto-Escuela DO, Millon C, et al. Galanin receptor 2-neuropeptide Y Y1 receptor interactions in the dentate gyrus are related with antidepressant-like effects. Brain Struct Funct. 2016 Nov;221(8):4129–4139.
   PubMed Web of Science ®Google Scholar
• Narvaez M, Borroto-Escuela DO, Santin L, et al. A novel integrative mechanism in anxiolytic behavior induced by galanin 2/Neuropeptide Y Y1 receptor interactions on medial paracapsular intercalated amygdala in rats. Front Cell Neurosci. 2018;12:119. doi: 10.3389/fncel.2018.00119
   PubMed Web of Science ®Google Scholar
• Mirchandani-Duque M, Barbancho MA, Lopez-Salas A, et al. Galanin and neuropeptide y interaction enhances proliferation of granule precursor cells and expression of neuroprotective factors in the rat hippocampus with consequent augmented spatial memory. Biomedicines. 2022 Jun 1;10(6):1297. doi: 10.3390/biomedicines10061297
   PubMed Web of Science ®Google Scholar
• Borroto-Escuela DO, Pita-Rodriguez M, Fores-Pons R, et al. Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus. J Cell Physiol. 2021 May;236(5):3565–3578.
   PubMed Web of Science ®Google Scholar
• Borroto-Escuela DO, Fores R, Pita M, et al. Intranasal delivery of galanin 2 and neuropeptide Y1 agonists enhanced spatial memory performance and neuronal precursor cells proliferation in the dorsal hippocampus in rats. Front Pharmacol. 2022;13:820210. doi: 10.3389/fphar.2022.820210
   PubMed Web of Science ®Google Scholar
• Diaz-Sanchez E, Lopez-Salas A, Mirchandani-Duque M, et al. Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion. Biomed Pharmacother. 2023 May;161:114433. doi: 10.1016/j.biopha.2023.114433
   PubMed Web of Science ®Google Scholar
• Fuzesi T, Wittmann G, Liposits Z, et al. Contribution of noradrenergic and adrenergic cell groups of the brainstem and agouti-related protein-synthesizing neurons of the arcuate nucleus to neuropeptide-y innervation of corticotropin-releasing hormone neurons in hypothalamic paraventricular nucleus of the rat. Endocrinology. 2007 Nov;148(11):5442–5450.
   PubMed Web of Science ®Google Scholar
• Gelfo F, Tirassa P, De Bartolo P, et al. NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus. CNS Neurosci Ther. 2012 Jun;18(6):487–492.
   PubMed Web of Science ®Google Scholar
• Decressac M, Wright B, David B, et al. Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis. Hippocampus. 2011 Mar;21(3):233–238.
   PubMed Web of Science ®Google Scholar
• Nahvi RJ, Tanelian A, Nwokafor C, et al. Intranasal neuropeptide Y as a potential therapeutic for depressive behavior in the rodent single prolonged stress model in females. Front Behav Neurosci. 2021;15:705579. doi: 10.3389/fnbeh.2021.705579
   PubMed Web of Science ®Google Scholar
• Silveira Villarroel H, Bompolaki M, Mackay JP, et al. NPY induces stress resilience via downregulation of I(h) in principal neurons of rat basolateral amygdala. J Neurosci. 2018 May 9;38(19):4505–4520. doi: 10.1523/JNEUROSCI.3528-17.2018
   PubMed Web of Science ®Google Scholar
• Morales-Medina JC, Juarez I, Venancio-Garcia E, et al. Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat. Neuroscience. 2013 Apr 16;236:233–243. doi: 10.1016/j.neuroscience.2013.01.037
   PubMed Web of Science ®Google Scholar
• Mechawar N, Saghatelyan A, Grailhe R, et al. Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulb. Proc Natl Acad Sci USA. 2004 Jun 29;101(26):9822–9826. doi: 10.1073/pnas.0403361101
   PubMed Web of Science ®Google Scholar
• Cohen H, Zohar J, Kaplan Z, et al. Adjunctive treatment with brexpiprazole and escitalopram reduces behavioral stress responses and increase hypothalamic NPY immunoreactivity in a rat model of PTSD-like symptoms. Eur Neuropsychopharmacol. 2018 Jan;28(1):63–74.
   PubMed Web of Science ®Google Scholar
• Rapp A, Brandl N, Volpi N, et al. Evaluation of chondroitin sulfate bioactivity in hippocampal neurones and the astrocyte cell line U373: influence of position of sulfate groups and charge density. Basic Clin Pharmacol Toxicol. 2005 Jan;96(1):37–43.
   PubMed Web of Science ®Google Scholar
• Narvaez M, Andrade-Talavera Y, Valladolid-Acebes I, et al. Existence of FGFR1-5-HT1AR heteroreceptor complexes in hippocampal astrocytes. Putative link to 5-HT and FGF2 modulation of hippocampal gamma oscillations. Neuropharmacology. 2020 Jun 15;170:108070. doi: 10.1016/j.neuropharm.2020.108070
   PubMed Web of Science ®Google Scholar
• Alvarez-Contino JE, Diaz-Sanchez E, Mirchandani-Duque M, et al. GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions. J Cell Physiol. 2023 Feb;238(2):459–474.
   PubMed Web of Science ®Google Scholar
• Porsolt RD, Le Pichon M, Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature. 1977 Apr 21;266(5604):730–732. doi: 10.1038/266730a0
   PubMed Web of Science ®Google Scholar
• Planchez B, Surget A, Belzung C. Animal models of major depression: drawbacks and challenges. J Neural Transm (Vienna). 2019 Nov;126(11):1383–1408. doi: 10.1007/s00702-019-02084-y
   PubMed Web of Science ®Google Scholar
• Yankelevitch-Yahav R, Franko M, Huly A, et al. The forced swim test as a model of depressive-like behavior. J Vis Exp. 2015 Mar 2;(97). doi: 10.3791/52587.
   Web of Science ®Google Scholar
• Kalynchuk LE, Gregus A, Boudreau D, et al. Corticosterone increases depression-like behavior, with some effects on predator odor-induced defensive behavior, in male and female rats. Behav Neurosci. 2004 Dec;118(6):1365–1377.
   PubMed Web of Science ®Google Scholar
• Morales-Medina JC, Dumont Y, Benoit CE, et al. Role of neuropeptide Y Y(1) and Y(2) receptors on behavioral despair in a rat model of depression with co-morbid anxiety. Neuropharmacology. 2012 Jan;62(1):200–208.
   PubMed Web of Science ®Google Scholar
• Ribeiro ACR, Zhu J, Kronfol MM, et al. Molecular mechanisms for the antidepressant-like effects of a low-dose ketamine treatment in a DFP-based rat model for gulf war illness. Neurotoxicology. 2020 Sep;80:52–59. doi: 10.1016/j.neuro.2020.06.011
   PubMed Web of Science ®Google Scholar
• Cryan JF, Page ME, Lucki I. Differential behavioral effects of the antidepressants reboxetine, fluoxetine, and moclobemide in a modified forced swim test following chronic treatment. Psychopharmacol (Berl). 2005 Nov;182(3):335–344. doi: 10.1007/s00213-005-0093-5
   PubMed Web of Science ®Google Scholar
• Paxinos G, Watson C. The rat brain in stereotaxic coordinates: hard cover edition. Elsevier; 2006.
   Google Scholar
• Kim KK, Adelstein RS, Kawamoto S. Identification of neuronal nuclei (NeuN) as fox-3, a new member of the fox-1 gene family of splicing factors. J Biol Chem. 2009 Nov 6;284(45):31052–31061. doi: 10.1074/jbc.M109.052969
   PubMed Web of Science ®Google Scholar
• Yagi S, Splinter JEJ, Tai D, et al. Sex differences in maturation and attrition of adult neurogenesis in the hippocampus. eNeuro. 2020 Jul;7(4):ENEURO.0468–19.2020.
   PubMedGoogle Scholar
• Planchez B, Lagunas N, Le Guisquet AM, et al. Increasing adult hippocampal neurogenesis promotes resilience in a mouse model of depression. Cells. 2021 Apr 21;10(5):972. doi: 10.3390/cells10050972
   PubMed Web of Science ®Google Scholar
• Walker AK, Rivera PD, Wang Q, et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20(4):500–508.
   PubMed Web of Science ®Google Scholar
• Bauman MD, Schumann CM, Carlson EL, et al. Neuroprotective efficacy of P7C3 compounds in primate hippocampus. Transl Psychiatry. 2018 Sep 26;8(1):202. doi: 10.1038/s41398-018-0244-1
   PubMedGoogle Scholar
• Colucci-D’Amato L, Speranza L, Volpicelli F. Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer. Int J Mol Sci. 2020 Oct 21;21(20):7777. doi: 10.3390/ijms21207777
   PubMed Web of Science ®Google Scholar
• Miranda M, Morici JF, Zanoni MB, et al. Brain-derived neurotrophic factor: a key molecule for memory in the healthy and the pathological brain. Front Cell Neurosci. 2019;13:363. doi: 10.3389/fncel.2019.00363
   PubMed Web of Science ®Google Scholar
• Castren E, Kojima M. Brain-derived neurotrophic factor in mood disorders and antidepressant treatments. Neurobiol Dis. 2017 Jan;97(Pt B):119–126. doi: 10.1016/j.nbd.2016.07.010
   PubMedGoogle Scholar
• Murawska-Cialowicz E, Wiatr M, Cialowicz M, et al. BDNF impact on biological markers of depression—role of physical exercise and training. Int J Environ Res Public Health. 2021 Jul 15;18(14):7553. doi: 10.3390/ijerph18147553
   PubMed Web of Science ®Google Scholar
• Dwivedi Y. Brain-derived neurotrophic factor in suicide pathophysiology. In: Dwivedi Y, editor. The neurobiological basis of suicide. Boca Raton (FL): CRC Press/Taylor & Francis; 2012. Chapter 8.
   Google Scholar
• Pandey GN, Ren X, Rizavi HS, et al. Brain-derived neurotrophic factor and tyrosine kinase B receptor signalling in post-mortem brain of teenage suicide victims. Int J Neuropsychopharmacol. 2008 Dec;11(8):1047–1061.
   PubMed Web of Science ®Google Scholar
• Hoshaw BA, Malberg JE, Lucki I. Central administration of IGF-I and BDNF leads to long-lasting antidepressant-like effects. Brain Res. 2005 Mar 10;1037(1–2):204–208. doi: 10.1016/j.brainres.2005.01.007
   PubMed Web of Science ®Google Scholar
• Corvino V, Marchese E, Giannetti S, et al. The neuroprotective and neurogenic effects of neuropeptide Y administration in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy induced by trimethyltin. J Neurochem. 2012 Jul;122(2):415–426.
   PubMed Web of Science ®Google Scholar
• Croce N, Dinallo V, Ricci V, et al. Neuroprotective effect of neuropeptide Y against beta-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production. Neurodegener Dis. 2011;8(5):300–309. doi: 10.1159/000323468
   PubMed Web of Science ®Google Scholar
• Park SW, Nhu le H, Cho HY, et al. p11 mediates the BDNF-protective effects in dendritic outgrowth and spine formation in B27-deprived primary hippocampal cells. J Affect Disord. 2016 May 15;196:1–10. doi: 10.1016/j.jad.2016.02.010
   PubMed Web of Science ®Google Scholar
• Kim HI, Lim J, Choi HJ, et al. ERRγ ligand regulates adult neurogenesis and depression-like behavior in a LRRK2-G2019S-associated young female mouse model of parkinson’s disease. Neurotherapeutics. 2022 May 25;19(4):1298–1312. doi: 10.1007/s13311-022-01244-5
   PubMed Web of Science ®Google Scholar
• Sabban EL, Serova LI. Potential of intranasal neuropeptide Y (NPY) and/or melanocortin 4 receptor (MC4R) antagonists for preventing or treating PTSD. Mil Med. 2018 Mar 1;183(suppl_1):408–412. doi: 10.1093/milmed/usx228
   PubMedGoogle Scholar
• Serova L, Mulhall H, Sabban E. NPY1 receptor agonist modulates development of depressive-like behavior and gene expression in hypothalamus in SPS rodent PTSD model. Front Neurosci. 2017;11:203. doi: 10.3389/fnins.2017.00203
   PubMed Web of Science ®Google Scholar
• Mathe AA, Michaneck M, Berg E, et al. A randomized controlled trial of intranasal neuropeptide y in patients with major depressive disorder. Int J Neuropsychopharmacol. 2020 Dec 29;23(12):783–790. doi: 10.1093/ijnp/pyaa054
   PubMed Web of Science ®Google Scholar
• Detke MJ, Rickels M, Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacol (Berl). 1995 Sep;121(1):66–72. doi: 10.1007/BF02245592
   PubMed Web of Science ®Google Scholar
• Polis AJ, Fitzgerald PJ, Hale PJ, et al. Rodent ketamine depression-related research: finding patterns in a literature of variability. Behav Brain Res. 2019 Dec 30;376:112153. doi: 10.1016/j.bbr.2019.112153
   PubMed Web of Science ®Google Scholar
• Kuipers A, Balasko M, Petervari E, et al. Intranasal delivery of a methyllanthionine-stabilized galanin receptor-2-selective agonist reduces acute food intake. Neurotherapeutics. 2021 Oct;18(4):2737–2752.
   PubMed Web of Science ®Google Scholar
• Heilig M, Soderpalm B, Engel JA, et al. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacol (Berl). 1989;98(4):524–529. doi: 10.1007/BF00441953
   PubMed Web of Science ®Google Scholar
• Redrobe JP, Dumont Y, Fournier A, et al. Role of serotonin (5-HT) in the antidepressant-like properties of neuropeptide Y (NPY) in the mouse forced swim test. Peptides. 2005 Aug;26(8):1394–1400.
   PubMed Web of Science ®Google Scholar