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Perspective

Is there a link between talcum powder, oxidative stress, and ovarian cancer risk?

Received 29 Nov 2023, Accepted 03 May 2024, Published online: 08 May 2024

References

  • Arora T, Mullangi S, Lekkala MR. Ovarian cancer. In: Editorial Board, editor. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC; 2024. https://www.ncbi.nlm.nih.gov/books/NBK431128/
  • Jelovac D, Armstrong DK. Recent progress in the diagnosis and treatment of ovarian cancer. CA Cancer J Clin. 2011 May;61(3):183–203. doi: 10.3322/caac.20113
  • Romero I, Leskelä S, Mies BP, et al. Morphological and molecular heterogeneity of epithelial ovarian cancer: therapeutic implications. EJC Supplements. 2020 Aug;15:1–15. doi: 10.1016/j.ejcsup.2020.02.001
  • Huang Y, Ming X, Li B, et al. Histological characteristics and Early-Stage Diagnosis Are Associated with Better Survival in young patients with epithelial ovarian cancer: a retrospective analysis based on surveillance epidemiology and end results database. Front Oncol. 2020;10:595789. doi: 10.3389/fonc.2020.595789
  • Prat J, Ribé A, Gallardo A. Hereditary ovarian cancer. Hum Pathol. 2005 Aug;36(8):861–870. doi: 10.1016/j.humpath.2005.06.006
  • Ramus SJ, Vierkant RA, Johnatty SE, et al. Consortium analysis of 7 candidate SNPs for ovarian cancer. Int J Cancer. [2008 Jul 15];123(2):380–388. doi: 10.1002/ijc.23448
  • Reuter S, Gupta SC, Chaturvedi MM, et al. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med. [2010 Dec 1];49(11):1603–1616. doi: 10.1016/j.freeradbiomed.2010.09.006
  • Lei XG, Zhu JH, Cheng WH, et al. Paradoxical roles of antioxidant enzymes: basic mechanisms and health implications. Physiol Rev. 2016 Jan;96(1):307–364. doi: 10.1152/physrev.00010.2014
  • Saed GM, Diamond MP, Fletcher NM. Updates of the role of oxidative stress in the pathogenesis of ovarian cancer. Gynecol Oncol. 2017 Jun;145(3):595–602. doi: 10.1016/j.ygyno.2017.02.033
  • Klaunig JE, Kamendulis LM, Hocevar BA. Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol. 2010 Jan;38(1):96–109. doi: 10.1177/0192623309356453
  • Coussens LM, Werb Z. Inflammation and cancer. Nature. [2002 Dec 19–26];420(6917):860–867. doi: 10.1038/nature01322
  • Fruehauf JP, Meyskens FL Jr. Reactive oxygen species: a breath of life or death? Clin Cancer Res. [2007 Feb 1];13(3):789–794. doi: 10.1158/1078-0432.CCR-06-2082
  • Circu ML, Aw TY. Glutathione and modulation of cell apoptosis. Biochim Biophys Acta. 2012 Oct;1823(10):1767–1777. doi: 10.1016/j.bbamcr.2012.06.019
  • Ishikawa T, Ali-Osman F. Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. J Biol Chem. [1993 Sep 25];268(27):20116–20125. doi: 10.1016/S0021-9258(20)80702-9
  • Tossetta G, Fantone S, Goteri G, et al. The Role of NQO1 in ovarian cancer. Int J Mol Sci. [2023 Apr 25];24(9):7839. doi: 10.3390/ijms24097839
  • Tossetta G, Fantone S, Montanari E, et al. Role of NRF2 in ovarian cancer. Antioxidants (Basel). [2022 Mar 30];11(4):663. doi: 10.3390/antiox11040663
  • Tossetta G, Marzioni D. Natural and synthetic compounds in ovarian cancer: a focus on NRF2/KEAP1 pathway. Pharmacol Res. 2022 Sep;183:106365. doi: 10.1016/j.phrs.2022.106365
  • Saed GM, Fletcher NM, Jiang ZL, et al. Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress. Reprod Sci. 2011 Dec;18(12):1253–1261. doi: 10.1177/1933719111411731
  • Ding D-N, Xie L-Z, Shen Y, et al. Insights into the role of oxidative stress in ovarian cancer. Oxid Med Cell Longevity. 2021 Oct 07;2021:1–20. doi: 10.1155/2021/8388258
  • Jiang Z, Fletcher NM, Ali-Fehmi R, et al. Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells. Gynecol Oncol. 2011 Aug;122(2):418–423. doi: 10.1016/j.ygyno.2011.04.051
  • Saed GM, Ali-Fehmi R, Jiang ZL, et al. Myeloperoxidase serves as a redox switch that regulates apoptosis in epithelial ovarian cancer. Gynecol Oncol. 2010 Feb;116(2):276–281. doi: 10.1016/j.ygyno.2009.11.004
  • Pacher P, Beckman JS, Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 2007 Jan;87(1):315–424. doi: 10.1152/physrev.00029.2006
  • Malone JM, Saed GM, Diamond MP, et al. The effects of the inhibition of inducible nitric oxide synthase on angiogenesis of epithelial ovarian cancer. Am J Obstet Gynecol. 2006 Apr;194(4):1110–1116; discussion 1116-8. doi: 10.1016/j.ajog.2005.12.019
  • Abu-Soud HM, Hazen SL. Nitric oxide is a physiological substrate for mammalian peroxidases. J Biol Chem. [2000 Dec 1];275(48):37524–37532. doi: 10.1074/jbc.275.48.37524
  • Abu-Soud HM, Hazen SL. Nitric oxide modulates the catalytic activity of myeloperoxidase. J Biol Chem. [2000 Feb 25];275(8):5425–5430. doi: 10.1074/jbc.275.8.5425
  • Hileman EO, Liu J, Albitar M, et al. Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity. Cancer Chemother Pharmacol. 2004 Mar;53(3):209–219. doi: 10.1007/s00280-003-0726-5
  • Fletcher NM, Jiang Z, Ali-Fehmi R, et al. Myeloperoxidase and free iron levels: potential biomarkers for early detection and prognosis of ovarian cancer. Cancer Biomark. 2011;10(6):267–275. doi: 10.3233/CBM-2012-0255
  • Erichsen HC, Chanock SJ. SNPs in cancer research and treatment. Br J Cancer. [2004 Feb 23];90(4):747–751. doi: 10.1038/sj.bjc.6601574
  • Fletcher NM, Belotte J, Saed MG, et al. Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer. Free Radic Biol Med. 2017 Jan;102:122–132. doi: 10.1016/j.freeradbiomed.2016.11.028
  • Forsberg L, Lyrenäs L, de Faire U, et al. A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels. Free Radic Biol Med. [2001 Mar 1];30(5):500–505. doi: 10.1016/S0891-5849(00)00487-1
  • Goode EL, Fridley BL, Vierkant RA, et al. Candidate gene analysis using imputed genotypes: cell cycle single-nucleotide polymorphisms and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18(3):935–944. doi: 10.1158/1055-9965.EPI-08-0860
  • Notaridou M, Quaye L, Dafou D, et al. Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. Int J Cancer. [2011 May 1];128(9):2063–2074. doi: 10.1002/ijc.25554
  • Notaridou M, Quaye L, Dafou D, et al. Common alleles in candidate susceptibility genes associated with risk and development of epithelial ovarian cancer. Int J Cancer. 2011;128(9):2063–2074. doi: 10.1002/ijc.25554
  • Quick SK, Shields PG, Nie J, et al. Effect modification by Catalase Genotype suggests a role for oxidative stress in the association of hormone replacement therapy with postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2008;17(5):1082–1087. doi: 10.1158/1055-9965.EPI-07-2755
  • Belotte J, Fletcher NM, Saed MG, et al. A single nucleotide polymorphism in catalase is strongly associated with ovarian cancer Survival. PLoS One. 2015;10(8):e0135739. doi: 10.1371/journal.pone.0135739
  • Didžiapetrienė J, Bublevič J, Smailytė G, et al. Significance of blood serum catalase activity and malondialdehyde level for survival prognosis of ovarian cancer patients. Medicina (Kaunas). 2014;50(4):204–208. doi: 10.1016/j.medici.2014.09.001
  • Castillo-Tong DC, Pils D, Heinze G, et al. Association of myeloperoxidase with ovarian cancer. Tumour Biol. 2014 Jan;35(1):141–148. doi: 10.1007/s13277-013-1017-3
  • Sellers TA, Huang Y, Cunningham J, et al. Association of single nucleotide polymorphisms in glycosylation genes with risk of epithelial ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):397–404. doi: 10.1158/1055-9965.EPI-07-0565
  • Cramer DW, Welch WR, Scully RE, et al. Ovarian cancer and talc: a case-control study. Cancer. [1982 Jul 15];50(2):372–376. doi: 10.1002/1097-0142(19820715)50:2<372:AID-CNCR2820500235>3.0.CO;2-S
  • Chang C-J, Tu Y-K, Chen P-C, et al. Talc exposure and risk of stomach cancer: systematic review and meta-analysis of occupational cohort studies. J Formosan Med Assoc. 2020 Apr 01;119(4):781–792. doi: 10.1016/j.jfma.2018.07.015
  • Lynch HN, Lauer DJ, Thompson WJ, et al. Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc. Front Public Health. 2022;10:989111. doi: 10.3389/fpubh.2022.989111
  • Woolen SA, Lazar AA, Smith-Bindman R. Association between the frequent use of perineal talcum powder products and ovarian cancer: a systematic review and meta-analysis. J Gen Intern Med. 2022;37(10):2526–2532. doi: 10.1007/s11606-022-07414-7
  • Terry KL, Karageorgi S, Shvetsov YB, et al. Genital powder use and risk of ovarian cancer: a pooled analysis of 8,525 cases and 9,859 controls. Cancer Prev Res (Phila). 2013 Aug;6(8):811–821. doi: 10.1158/1940-6207.CAPR-13-0037
  • Penninkilampi R, Eslick GD. Perineal talc use and ovarian cancer: a systematic review and meta-analysis. Epidemiology. 2018 Jan;29(1):41–49. doi: 10.1097/EDE.0000000000000745
  • Reid BM, Permuth JB, Sellers TA. Epidemiology of ovarian cancer: a review. Cancer Biol Med. 2017 Feb;14(1):9–32. doi: 10.20892/j.issn.2095-3941.2016.0084
  • Cramer DW, Liberman RF, Titus-Ernstoff L, et al. Genital talc exposure and risk of ovarian cancer. Int J Cancer. [1999 May 5];81(3):351–356. doi: 10.1002/(SICI)1097-0215(19990505)81:3<351:AID-IJC7>3.0.CO;2-M
  • Shukla A, MacPherson MB, Hillegass J, et al. Alterations in gene expression in human mesothelial cells correlate with mineral pathogenicity. Am J Respir Cell Mol Biol. 2009 Jul;41(1):114–123. doi: 10.1165/rcmb.2008-0146OC
  • Fletcher NM, Harper AK, Memaj I, et al. Molecular Basis Supporting the Association of Talcum powder use with increased risk of ovarian cancer. Reprod Sci. 2019 Dec;26(12):1603–1612. doi: 10.1177/1933719119831773
  • Lynch HN, Lauer DJ, Leleck OM, et al. Systematic review of the association between talc and female reproductive tract cancers. Front Toxicol. 2023;5:1157761. doi: 10.3389/ftox.2023.1157761
  • Harper AK, Wang X, Fan R, et al. Talcum powder induces malignant transformation in normal human primary ovarian epithelial cells. Minerva Obstet Gynecol. 2023 Apr;75(2):150–157. doi: 10.23736/S2724-606X.21.04989-7
  • Rosenblatt KA, Weiss NS, Cushing-Haugen KL, et al. Genital powder exposure and the risk of epithelial ovarian cancer. Cancer Causes & Control. 2011 May 01;22(5):737–742. doi: 10.1007/s10552-011-9746-3
  • Wentzensen N, O’Brien KM. Talc, body powder, and ovarian cancer: a summary of the epidemiologic evidence. Gynecol Oncol. 2021 Oct 01;163(1):199–208. doi: 10.1016/j.ygyno.2021.07.032

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