Advanced search
Publication Cover
Expert Review of Molecular Diagnostics Volume 21, 2021 - Issue 2
Submit an article Journal homepage
1,220
Views
0
CrossRef citations to date
0
Altmetric
Editorial

Are T cell repertoires useful as diagnostics for SARS- CoV- 2 infection?

Tim HarrisRepertoire Immune Medicines, Cambridge, MA, USACorrespondence[email protected]
View further author information
&
Karsten SauerRepertoire Immune Medicines, Cambridge, MA, USAView further author information
Pages 137-139 | Received 08 Dec 2020, Accepted 25 Jan 2021, Published online: 17 Feb 2021

References

  • Kilic T, Weissleder R, Lee H. Molecular and immunological diagnostic tests of COVID-19: current status and challenges. iScience. 2020;23(8):101406.
  • Krammer F. SARS-CoV-2 vaccines in development. Nature. 2020;586(7830):516–527.
  • Dan JM, Mateus J, Kato Y, et al. Immunological memory to SARS-CoV 2 assessed for greater than eight months after infection. Science. 2021. DOI:10.1126/science.abf4063.
  • Wajnberg A, Amanat F, Firpo A, et al. Robust neutralizing antibodies to SARS-CoV-2 infection persist for months. Science. 2020;370(6521):1227–1230. .
  • Sauer K, Harris T. An effective COVID-19 vaccine needs to engage T cells. Front Immunol. 2020;11:581807.
  • Sekine T, Perez-Potti A, Rivera-Ballesteros O, et al. Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19. Cell. 2020;183(1):158–168 e114. .
  • Chen Z, John Wherry E. T cell responses in patients with COVID-19. Nat Rev Immunol. 2020;20(9):529–536.
  • Canete PF, Vinuesa CG. COVID-19 makes B cells forget, but T cells remember. Cell. 2020;183(1):13–15.
  • Li CK, Wu H, Yan H, et al. T cell responses to whole SARS coronavirus in humans. J Immunol. 2008;181(8):5490–5500.
  • Kisielow J, Obermair FJ, Deciphering KM. CD4(+) T cell specificity using novel MHC-TCR chimeric receptors. Nat Immunol. 2019;20(5):652–662.
  • Snyder TM, Gittelman RM, Klinger M, et al. Magnitude and dynamics of the T-cell response to SARS-CoV-2 infection at both individual and population levels. medRxiv. 2020;2020.2007.2031.20165647.
  • Schulien I, Kemming J, Oberhardt V, et al. Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells. Nat Med. 2020;27:78–85.
  • Braun J, Loyal L, Frentsch M, et al. SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature. 2020;587(7833):270–274. .
  • Knierman MD, Lannan MB, Spindler LJ, et al. The human leukocyte antigen class II immunopeptidome of the SARS-CoV-2 spike glycoprotein. Cell Rep. 2020;33(9):108454.
  • Widge AT, Rouphael NG, Jackson LA, et al. Durability of responses after SARS-CoV-2 mRNA-1273 vaccination. N Engl J Med. 20211;384: 80-82.
  • Sette A, Crotty S. Adaptive immunity to SARS-CoV-2 and COVD 19. Cell. 2021. DOI:10.1016/jcell.2021.01.007

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.