240
Views
1
CrossRef citations to date
0
Altmetric
Review

The prognostic and diagnostic potential of kallikrein-related peptidases in ovarian cancer

, , &
Pages 535-545 | Received 02 Mar 2021, Accepted 28 Apr 2021, Published online: 14 May 2021

References

  • Webb PM, Jordan SJ. Epidemiology of epithelial ovarian cancer. Best Pract Res Clin Obstetrics Gynaecol. 2017 May;41:3–14.
  • Lisio M-A, Fu L, Goyeneche A, et al. High-grade serous ovarian cancer: basic sciences, clinical and therapeutic standpoints. Int J Mol Sci. 2019 Feb 22;20:4.
  • Klotz DM, Wimberger P. Cells of origin of ovarian cancer: ovarian surface epithelium or fallopian tube? Arch Gynecol Obstet. 2017 Dec;296(6):1055–1062.
  • Kroeger PT, Drapkin R. Pathogenesis and heterogeneity of ovarian cancer. Curr Opin Obstet Gynecol. 2017;29(1):26–34.
  • Gee ME, Faraahi Z, McCormick A, et al. DNA damage repair in ovarian cancer: unlocking the heterogeneity. J Ovarian Res. 2018 Dec;11(1):50.
  • Hunter MV, Moncada R, Weiss JM, et al. Spatial transcriptomics reveals the architecture of the tumor/microenvironment interface [Internet]. Cancer Biology; 2020 Nov. Available from: http://biorxiv.org/lookup/doi/10.1101/2020.11.05.368753
  • Narod S. Can advanced-stage ovarian cancer be cured? Nat Rev Clin Oncol. 2016 Apr;13(4):255–261.
  • Coleman MP, Forman D, Bryant H, et al. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data. Lancet. 2011 Jan 8;377(9760):127–138.
  • Lheureux S, Gourley C, Vergote I, et al. Epithelial ovarian cancer. Lancet. 2019 Mar;393(10177):1240–1253.
  • Menon U, Karpinskyj C, Gentry-Maharaj A. Ovarian cancer prevention and screening. Obstet Gynecol. 2018;131(5):909–927.
  • Weiland F, Martin K, Oehler MK, et al. Deciphering the molecular nature of ovarian cancer biomarker CA125. IJMS. 2012 Aug 22;13(8):10568–10582.
  • Pinsky PF, Yu K, Kramer BS, et al. Extended mortality results for ovarian cancer screening in the PLCO trial with median 15years follow-up. Gynecol Oncol. 2016 Nov;143(2):270–275.
  • Skates SJ. Ovarian cancer screening: development of the risk of ovarian cancer algorithm (ROCA) and ROCA screening trials. Int J Gynecol Cancer. 2012 May;22(Suppl 1):S24–26.
  • Jacobs IJ, Menon U, Ryan A, et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2016 Mar 5;387(10022):945–956.
  • Elias KM, Guo J, Bast RC. Early detection of ovarian cancer. Hematol Oncol Clin North Am. 2018 Dec;32(6):903–914.
  • Kobayashi H, Yamada Y, Sado T, et al. A randomized study of screening for ovarian cancer: a multicenter study in Japan. Int J Gynecol Cancer. 2008 May;18(3):414–420.
  • Glubb DM, Thompson DJ, Aben KK, et al. Cross-cancer genome-wide association study of endometrial cancer and epithelial ovarian cancer identifies genetic risk regions associated with risk of both cancers. Cancer Epidemiol Biomarkers Prev.2020;Nov:Vol. 3; cebp.0739.2020.
  • Ratner E, Lu L, Boeke M, et al. A KRAS-variant in ovarian cancer acts as a genetic marker of cancer risk. Cancer Res. 2010 Aug 15;70(16):6509–6515.
  • Asante D-B, Calapre L, Ziman M, et al. Liquid biopsy in ovarian cancer using circulating tumor DNA and cells: ready for prime time? Cancer Lett. 2020;468:59–71.
  • Weigelt B, Comino-Méndez I, De Bruijn I, et al. Diverse BRCA1 and BRCA2 reversion mutations in circulating cell-free DNA of therapy-resistant breast or ovarian cancer. Clin Cancer Res. 2017 Nov 1;23(21):6708–6720.
  • Clements J, Hooper J, Dong Y, et al. The expanded human kallikrein (KLK) gene family: genomic organisation, tissue-specific expression and potential funtions. Biol Chem. 382(1)Internet]. 2001 Jan 6 [2021 Feb 24]; Available from: https://www.degruyter.com/view/j/bchm.2001.382.issue-1/bc.2001.002/bc.2001.002.xml
  • Loessner D, Goettig P, Preis S, et al. Kallikrein-related peptidases represent attractive therapeutic targets for ovarian cancer. Expert Opin Ther Targets. 2018 Sep 2;22(9):745–763.
  • Filippou PS, Karagiannis GS, Musrap N, et al. Kallikrein-related peptidases (KLKs) and the hallmarks of cancer. Crit Rev Clin Lab Sci. 2016 Jul 3;53(4):277–291.
  • Yu Y, Prassas I, Diamandis EP. Putative kallikrein substrates and their (patho)biological functions. Biol Chem. 2014 Sep 1;395(9):931–943.
  • Bronger H, Magdolen V, Goettig P, et al. Proteolytic chemokine cleavage as a regulator of lymphocytic infiltration in solid tumors. Cancer Metastasis Rev. 2019 Sep;38(3):417–430.
  • Stefanini ACB, Da Cunha BR, Henrique T, et al. Involvement of kallikrein-related peptidases in normal and pathologic processes. Dis Markers. 2015;2015:1–17.
  • Prassas I, Eissa A, Poda G, et al. Unleashing the therapeutic potential of human kallikrein-related serine proteases. Nat Rev Drug Discov. 2015 Mar;14(3):183–202.
  • Shaw JL, Diamandis EP. Distribution of 15 human kallikreins in tissues and biological fluids. Clin Chem. 2007 Aug 1;53(8):1423–1432.
  • Schmitt M, Magdolen V, Yang F, et al. Emerging clinical importance of the cancer biomarkers kallikrein-related peptidases (KLK) in female and male reproductive organ malignancies. Radiol Oncol. 2013 Dec 1;47(4):319–329.
  • Obiezu CV, Scorilas A, Katsaros D, et al. Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients. Clin Cancer Res. 2001 Aug;7(8):2380–2386.
  • Gong W, Liu Y, Seidl C, et al. Characterization of kallikrein-related peptidase 4 (KLK4) mRNA expression in tumor tissue of advanced high-grade serous ovarian cancer patients. Ulrich H, editor. PLoS ONE. 2019;Feb 27 14(2):e0212968.
  • Dong Y, Kaushal A, Bui L, et al. Human kallikrein 4 (KLK4) is highly expressed in serous ovarian carcinomas. Clin Cancer Res. 2001 Aug;7(8):2363–2371.
  • Xi Z, Kærn J, Davidson B, et al. Kallikrein 4 is associated with paclitaxel resistance in ovarian cancer. Gynecol Oncol. 2004 Jul;94(1):80–85.
  • Caubet C, Jonca N, Brattsand M, et al. Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J Invest Dermatol. 2004 May;122(5):1235–1244.
  • Kim H, Scorilas A, Katsaros D, et al. Human kallikrein gene 5 (KLK5) expression is an indicator of poor prognosis in ovarian cancer. Br J Cancer. 2001 Mar 2;84(5):643–650.
  • Gong W, Liu Y, Seidl C, et al. Quantitative assessment and clinical relevance of kallikrein-related peptidase 5 mRNA expression in advanced high-grade serous ovarian cancer. BMC Cancer. 2019 Dec;19(1):696.
  • Dong Y, Kaushal A, Brattsand M, et al. Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. Clin Cancer Res. 2003 May;9(5):1710–1720.
  • Diamandis EP, Borgoño CA, Scorilas A, et al. Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis. Tumor Biol. 2003;24(6):299–309.
  • Dorn J, Bronger H, Kates R, et al. OVSCORE - a validated score to identify ovarian cancer patients not suitable for primary surgery. Oncol Lett. 2015 Jan;9(1):418–424.
  • Yousef GM, Polymeris M-E, Grass L, et al. Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer. Cancer Res. 2003 Jul 15;63(14):3958–3965.
  • Bandiera E, Zanotti L, Bignotti E, et al. Human kallikrein 5: an interesting novel biomarker in ovarian cancer patients that elicits humoral response. Int J Gynecol Cancer. 2009 Jul;19(6):1015–1021.
  • Dorn J, Magdolen V, Gkazepis A, et al. Circulating biomarker tissue kallikrein-related peptidase KLK5 impacts ovarian cancer patients’ survival. Ann Oncol. 2011 Aug;22(8):1783–1790.
  • Oikonomopoulou K, Li L, Zheng Y, et al. Prediction of ovarian cancer prognosis and response to chemotherapy by a serum-based multiparametric biomarker panel. Br J Cancer. 2008 Oct;99(7):1103–1113.
  • Kuk C, Kulasingam V, Gunawardana CG, et al. Mining the ovarian cancer ascites proteome for potential ovarian cancer biomarkers. Mol Cell Proteomics. 2009 Apr;8(4):661–669.
  • Ni X, Zhang W, Huang K-C, et al. Characterisation of human kallikrein 6/protease M expression in ovarian cancer. Br J Cancer. 2004 Aug 16;91(4):725–731.
  • Seiz L, Dorn J, Kotzsch M, et al. Stromal cell-associated expression of kallikrein-related peptidase 6 (KLK6) indicates poor prognosis of ovarian cancer patients. Biol Chem. 2012 May 1;393(5):391–401.
  • Kountourakis P, Psyrri A, Scorilas A, et al. Expression and prognostic significance of kallikrein-related peptidase 8 protein levels in advanced ovarian cancer by using automated quantitative analysis. Thromb Haemost. 2009 Mar;101(3):541–546.
  • Ahmed N, Dorn J, Napieralski R, et al. Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer. Biol Chem. 2016 Dec 1;397(12):1265–1276.
  • Hu C-J, Zhang F, Chen Y-J, et al. [Correlation of hK6 expression with clinicopathological features and prognosis in epithelial ovarian cancer]. Zhonghua Zhong Liu Za Zhi. 2009 Jul;31(7):520–523.
  • Tamir A, Jag U, Sarojini S, et al. Kallikrein family proteases KLK6 and KLK7 are potential early detection and diagnostic biomarkers for serous and papillary serous ovarian cancer subtypes. J Ovarian Res. 2014 Dec;7(1):109.
  • White NMA, Mathews M, Yousef GM, et al. KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. Br J Cancer. 2009 Oct;101(7):1107–1113.
  • Yang F, Hu Z-D, Chen Y, et al. Diagnostic value of KLK6 as an ovarian cancer biomarker: a meta-analysis. Biomed Rep. 2016 Jun;4(6):681–686.
  • Diamandis EP, Scorilas A, Fracchioli S, et al. Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma. JCO. 2003 Mar 15;21(6):1035–1043.
  • Koh SCL, Huak CY, Lutan D, et al. Combined panel of serum human tissue kallikreins and CA-125 for the detection of epithelial ovarian cancer. J Gynecol Oncol. 2012 Jul;23(3):175–181.
  • Bandiera E, Zanotti L, Fabricio ASC, et al. Cancer antigen 125, human epididymis 4, kallikrein 6, osteopontin and soluble mesothelin-related peptide immunocomplexed with immunoglobulin M in epithelial ovarian cancer diagnosis. Clin Chem Lab Med. 51(9)Internet]. 2013 Jan 1 [2021 Feb 24]; Available from: https://www.degruyter.com/doi/10.1515/cclm-2013-0151
  • Rosen DG, Wang L, Atkinson JN, et al. Potential markers that complement expression of CA125 in epithelial ovarian cancer. Gynecol Oncol. 2005 Nov;99(2):267–277.
  • Mah ES, Sallam MM, Shaban EAK, et al. Diagnostic value of serum kallikrein-related peptidases 6 and 10 versus CA125 in ovarian cancer. Int J Gynecol Cancer. 2011 Apr;21(4):625–632.
  • Leung F, Bernardini MQ, Brown MD, et al. Validation of a novel biomarker panel for the detection of ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2016 Sep;25(9):1333–1340.
  • Chen E, Zhu H, Yang Y, et al. Analysis of expression and prognosis of KLK7 in ovarian cancer. Open Med (Wars). 2020;15(1):932–939.
  • Shan SJC, Scorilas A, Katsaros D, et al. Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols. Clin Chem. 2006 Oct 1;52(10):1879–1886.
  • Psyrri A, Kountourakis P, Scorilas A, et al. Human tissue kallikrein 7, a novel biomarker for advanced ovarian carcinoma using a novel in situ quantitative method of protein expression. Ann Oncol. 2008 Jul;19(7):1271–1277.
  • Kyriakopoulou LG, Yousef GM, Scorilas A, et al. Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer. Clin Biochem. 2003 Mar;36(2):135–143.
  • Gong W, Liu Y, Diamandis EP, et al. Prognostic value of kallikrein-related peptidase 7 (KLK7) mRNA expression in advanced high-grade serous ovarian cancer. J Ovarian Res. 2020 Oct 21;13(1):125.
  • Dorn J, Gkazepis A, Kotzsch M, et al. Clinical value of protein expression of kallikrein-related peptidase 7 (KLK7) in ovarian cancer. Biol Chem. 2014 Jan;395(1):95–107.
  • Magklara A, Scorilas A, Katsaros D, et al. The human KLK8 (neuropsin/ovasin) gene: identification of two novel splice variants and its prognostic value in ovarian cancer. Clin Cancer Res. 2001 Apr;7(4):806–811.
  • Borgoño CA, Kishi T, Scorilas A, et al. Human kallikrein 8 protein Is a favorable prognostic marker in ovarian cancer. Clin Cancer Res. 2006 Mar 1;12(5):1487–1493.
  • Kishi T, Grass L, Soosaipillai A, et al. Human kallikrein 8, a novel biomarker for ovarian carcinoma. Cancer Res. 2003 Jun 1;63(11):2771–2774.
  • Shih I-M, Salani R, Fiegl M, et al. Ovarian cancer specific kallikrein profile in effusions. Gynecol Oncol. 2007 May;105(2):501–507.
  • Shigemasa K, Tian X, Gu L, et al. Human kallikrein 8 (hK8/TADG-14) expression is associated with an early clinical stage and favorable prognosis in ovarian cancer. Oncol Rep. 2004 Jun 1 2021 Jan 10. Available from: http://www.spandidos-publications.com/10.3892/or.11.6.1153
  • Gilks CB, Vanderhyden BC, Zhu S, et al. Distinction between serous tumors of low malignant potential and serous carcinomas based on global mRNA expression profiling. Gynecol Oncol. 2005 Mar;96(3):684–694.
  • Konstantinopoulos PA, Ceccaldi R, Shapiro GI, et al. Homologous recombination deficiency: exploiting the fundamental vulnerability of ovarian cancer. Cancer Discov. 2015 Nov;5(11):1137–1154.
  • Shvartsman HS, Lu KH, Lee J, et al. Overexpression of kallikrein 10 in epithelial ovarian carcinomas. Gynecol Oncol. 2003 Jul;90(1):44–50.
  • Luo L-Y, Katsaros D, Scorilas A, et al. The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis. Cancer Res. 2003 Feb 15;63(4):807–811.
  • Dorn J, Harbeck N, Kates R, et al. Impact of expression differences of kallikrein-related peptidases and of uPA and PAI-1 between primary tumor and omentum metastasis in advanced ovarian cancer. Ann Oncol. 2011 Apr;22(4):877–883.
  • Geng X, Liu Y, Dreyer T, et al. Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients. Am J Cancer Res. 2018;8(9):1856–1864.
  • Planque C, Aïnciburu M, Heuzé-Vourc’h N, et al. Expression of the human kallikrein genes 10 (KLK10) and 11 (KLK11) in cancerous and non-cancerous lung tissues. Biol Chem. 2006 Jun;387(6):783–788.
  • Lawrence MG, Lai J, Clements JA. Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus. Endocr Rev. 2010 Aug 1;31(4):407–446.
  • Meinhold-Heerlein I, Bauerschlag D, Zhou Y, et al. An integrated clinical-genomics approach identifies a candidate multi-analyte blood test for serous ovarian carcinoma. Clin Cancer Res. 2007 Jan 15;13(2):458–466.
  • Geng X, Liu Y, Diersch S, et al. Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer. Ulrich H, editor. PLoS ONE. 2017;Nov 2 12(11):e0186847.
  • Shigemasa K, Gu L, Tanimoto H, et al. Human kallikrein gene 11 (KLK11) mRNA overexpression is associated with poor prognosis in patients with epithelial ovarian cancer. Clin Cancer Res. 2004 Apr 15;10(8):2766–2770.
  • Zheng Y, Katsaros D, Shan SJC, et al. A multiparametric panel for ovarian cancer diagnosis, prognosis, and response to chemotherapy. Clin Cancer Res. 2007 Dec 1;13(23):6984–6992.
  • McIntosh MW, Liu Y, Drescher C, et al. Validation and characterization of human kallikrein 11 as a serum marker for diagnosis of ovarian carcinoma. Clin Cancer Res. 2007 Aug 1;13(15):4422–4428.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.