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Original Research

Dual agonist–antagonist effect of ulipristal acetate in human endometrium and myometrium

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Pages 851-857 | Received 23 Nov 2020, Accepted 09 Jun 2021, Published online: 24 Jun 2021

References

  • Bulun SE. Uterine fibroids. The New England j medicine. 2013;369(14):1344–1355.
  • Laganà AS, Vergara D, Favilli A, et al. Epigenetic and genetic landscape of uterine leiomyomas: a current view over a common gynecological disease. Arch Gynecol Obstet. 2017;296:855–867.
  • Yang Q, Mas A, Diamond MP, et al. The mechanism and function of epigenetics in uterine leiomyoma development. Reprod Sci. 2017;23(2):163–175.
  • Bulun SE, Moravek MB, Yin P, et al. Uterine leiomyoma stem cells: linking progesterone to growth. Semin Reprod Med. 2015;33:357–365.
  • Donnez J, Dolmans MM. Hormone therapy for intramural myoma-related infertility from ulipristal acetate to GnRH antagonist: a review. Reprod Biomed Online 2020;431–442.
  • Meunier L, Meszaros M, Pageaux GP, et al., Acute liver failure requiring transplantation caused by ulipristal acetate. Clin Res Hepatol Gastroenterol. 44(3): e45–e49. 2020.
  • European Medicines Agency . Suspension of ulipristal acetate for uterine fibroids during ongoing EMA review of liver injury risk. (2020). https://www.ema.europa.eu/en/medicines/human/EPAR/ulipristal-acetate-gedeon-richter.
  • Geiss GK, Bumgarner RE, Birditt B, et al. Direct multiplexed measurement of gene expression with color-coded probe pairs. Nature Biotechnol. 2008;26(3):317–325.
  • Veldman-Jones MH, Brant R, Rooney C, et al., Evaluating robustness and sensitivity of the NanoString technologies ncounter platform to enable multiplexed gene expression analysis of clinical samples. Cancer Res. 75(13): 2587–2593. 2015.
  • Ali M, Al-Hendy A. Selective progesterone receptor modulators for fertility preservation in women with symptomatic uterine fibroids. Biolo Reprod. 2017;97:337–352.
  • Salas A, López J, Reyes R, et al. Organotypic culture as a research and preclinical model to study uterine leiomyomas. Sci Rep. 2020;10:5212.
  • Almeida TA, Quispe-Ricalde A, Montes De Oca F, et al. A high-throughput open-array qPCR gene panel to identify housekeeping genes suitable for myometrium and leiomyoma expression analysis. Gynecol Oncol. 2014;134(1):138–143.
  • Rider V, Carlone DL, Foster RT. Oestrogen and progesterone control basic fibroblast growth factor mRNA in the rat uterus. J endocrinol. 1997;154(1):75–84.
  • Xu Q, Ohara N, Chen W, et al. Progesterone receptor modulator CDB-2914 down-regulates vascular endothelial growth factor, adrenomedullin and their receptors and modulates progesterone receptor content in cultured human uterine leiomyoma cells. Hum Reprod. 2006;21:2408–2416.
  • Hyder SM, Huang J-C, Nawaz Z, et al. Regulation of vascular endothelial growth factor expression by estrogens and progestins. Environmental Health Perspectives. 2000;108:785–790.
  • Dou Q. Differential expression of matrix metalloproteinases and their tissue inhibitors in leiomyomata: a mechanism for gonadotrophin releasing hormone agonist-induced tumour regression. Mol Hum Reprod. 2007;3:1005–1014.
  • Marbaix E, Donnez J, Courtoy PJ, et al. Progesterone regulates the activity of collagenase and related gelatinases A and B in human endometrial explants. Proc Natl Acad Sci U S A. 1992;89(24):11789–11793.
  • Patel B, Elguero S, Thakore S, et al. Role of nuclear progesterone receptor isoforms in uterine pathophysiology. Hum Reprod Update. 2015;21:155–173.
  • Donnez J, Tatarchuk TF, Bouchard P, et al. Ulipristal acetate versus placebo for fibroid treatment before surgery. N Engl J Med. 2012;366(5):409–420.
  • Gashaw I, Stiller S, Boing C, et al. Premenstrual regulation of the pro-angiogenic factor CYR61 in human endometrium. Endocrinology 2008;149(5):2261–2269.
  • Maybin JA, Barcroft J, Thiruchelvam U, et al. The presence and regulation of connective tissue growth factor in the human endometrium. Hum Reprod. 2012;27(4):1112–1121.
  • Sampath D, Winneker RC, Zhang Z. The angiogenic factor Cyr61 is induced by the progestin R5020 and is necessary for mammary adenocarcinoma cell growth. Endocrine 2002;18:147–159.
  • Rageh MAE, Moussad EE-DA, Wilson AK. et al. Steroidal regulation of connective tissue growth factor (CCN2; CTGF) synthesis in the mouse uterus. J Clin Pathol: Mol Pathol. 2001;54(5):338–346.
  • Yu HN, Li XM, Kong LL, et al. Connective tissue growth factor gene expression in goat endometrium during estrous cycle and early pregnancy. Theriogenology 2020;153:85–90.
  • Hall-Glenn F, Lyons M. K. Roles for CCN2 in normal physiological processes. Cell Mol Life Sci. 2011;68(19):3209–3217.
  • Mo F-E, Muntean AG, Chen -C-C, et al. CYR61 (CCN1) Is Essential for Placental Development and Vascular Integrity. Molecular and Cellular Biology. 1997;3(24):1005–1014.
  • Absenger Y, Hess-Stumpp H, Kreft B, et al. Cyr61, a deregulated gene in endometriosis. Molecular Human Reproduction. 2004;10(6):399–407.
  • Gashaw I, Hastings JM, Jackson KS, et al. Induced Endometriosis in the Baboon (Papio anubis) Increases the Expression of the Proangiogenic Factor CYR61 (CCN1) in Eutopic and Ectopic Endometria1. Biology of Reproduction. 2006;74:1060–1066.
  • MacLaughlan SD, Palomino WA, Mo B, et al. Endometrial Expression of Cyr61. Obstetrics & Gynecology. 2007;110(1):146–154.
  • Paradis V, Dargere D, Vidaud M, et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology. 1999;30(4):968–976.
  • Rachfal AW. Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatology Research. 2003;26(1):1–9.
  • George J, Tsutsumi M. siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats. Genet Ther. 2007;14(10):790–803.
  • Sedlaczek N, Jia J-D, Bauer M, et al. Proliferating bile duct epithelial cells are a major source of connective tissue growth factor in rat biliary fibrosis. Am J Pathol. 2001;158(4):1239–1244.
  • Bassiouny AR, Zaky AZ, Abdulmalek SA. et al. Modulation of AP-endonuclease1 levels associated with hepatic cirrhosis in rat model treated with human umbilical cord blood mononuclear stem cells. Int J Clin Exp Pathol. 2011;4(7):692–707.
  • Hernández-Aquino E, Quezada-Ramírez MA, Silva-Olivares A, et al. Curcumin downregulates Smad pathways and reduces hepatic stellate cells activation in experimental fibrosis. Annals of Hepatology. 2020;19(5):497–506.
  • Li X, Chen R, Kemper S, et al. Dynamic Changes in Function and Proteomic Composition of Extracellular Vesicles from Hepatic Stellate Cells during Cellular Activation. Cells. 2020;9(2):290.
  • Tamatani T, Kobayashi H, Tezuka K, et al. Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Biochemical and Biophysical Research Communications. 1998;251(3):748–752.
  • Williams EJ, Gaça MDA, Brigstock DR, et al. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol. 2000;32(5):754–761.
  • Kanzler S, Baumann M, Schirmacher P, et al. Prediction of progressive liver fibrosis in hepatitis C infection by serum and tissue levels of transforming growth factor-beta. Journal of Viral Hepatitis. 2001;8(6):430–437.
  • Li Z-Q, Ding W, Sun S-J, et al. Cyr61/CCN1 Is Regulated by Wnt/β-Catenin Signaling and Plays an Important Role in the Progression of Hepatocellular Carcinoma. PLoS One. 2012;7(4):e35754.
  • Li Z-Q, Wu W-R, Zhao C, et al. CCN1/Cyr61 enhances the function of hepatic stellate cells in promoting the progression of hepatocellular carcinoma. International journal of molecular medicine. 2018;41(3):1518–1528.
  • Borkham-Kamphorst E, Schaffrath C, Van de Leur E, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-β signaling. Biochim Biophys Acta. 1843;902–14:2014.
  • Dendooven A, Gerritsen KG, Nguyen TQ, et al. Connective tissue growth factor (CTGF/CCN2) ELISA: a novel tool for monitoring fibrosis. Biomarkers 2011;16(4):289–301.
  • Derbala Y, Elazzamy H, Bilal M, et al. Mast cell–induced immunopathology in recurrent pregnancy losses. American Journal of Reproductive Immunol. 2019;82(1):1–10.
  • Zierau O, Zenclussen AC, Jensen F. Role of female sex hormones, estradiol and progesterone, in mast cell behavior. Front. Immunol. 2010–13;3:2012.
  • Jensen F, Woudwyk M, Teles A, et al. Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation. PLoS ONE. 2010;5(12):1–12.
  • Lombardo J, Broadwater D, Collins R, et al. Hepatic mast cell concentration directly correlates to stage of fibrosis in NASH. Human Pathology. 2019;86:129–135.
  • Weiskirchen R, Meurer SK, Liedtke C, et al. Mast Cells in Liver Fibrogenesis. Cells 2019;8(11):1–33.
  • Shimizu Y, Takeuchi T, Mita S, et al. Krüppel-like factor 4 mediates anti-proliferative effects of progesterone with G0/G1 arrest in human endometrial epithelial cells. Journal of Endocrinological Investigation. 2010;33(10):745–750.
  • Danková Z, Braný D, Dvorská D, et al. Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions. International journal of molecular medicine. 2018;42(6):3318–3328.

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