Advanced search
Publication Cover
Expert Review of Neurotherapeutics Volume 21, 2021 - Issue 8
Submit an article Journal homepage
3,403
Views
4
CrossRef citations to date
0
Altmetric
Editorial

Chronic active lesions: a new MRI biomarker to monitor treatment effect in multiple sclerosis?

Paolo Preziosaa Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy;b Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, ItalyView further author information
,
Massimo Filippia Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy;b Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;c Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;d Neurophysiology Service, IRCCS San Raffaele Scientific Institute, Milan, Italy;e Vita-Salute San Raffaele University, Milan, ItalyView further author information
&
Maria A. Roccaa Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy;b Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;e Vita-Salute San Raffaele University, Milan, ItalyCorrespondence[email protected]
View further author information
Pages 837-841 | Received 26 Apr 2021, Accepted 07 Jul 2021, Published online: 19 Jul 2021

References

  • Frischer JM, Weigand SD, Guo Y, et al. Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann Neurol. 2015;78(5):710–721.
  • Luchetti S, Fransen NL, Van Eden CG, et al. Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis. Acta Neuropathol. 2018;135(4):511–528.
  • Dal-Bianco A, Grabner G, Kronnerwetter C, et al. Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging. Acta Neuropathol. 2017;133(1):25–42.
  • Dal-Bianco A, Grabner G, Kronnerwetter C, et al. Long-term evolution of multiple sclerosis iron rim lesions in 7 T MRI. Brain. 2021;144(3):833–847.
  • Filippi M, Bruck W, Chard D, et al. Association between pathological and MRI findings in multiple sclerosis. Lancet Neurol. 2019;18(2):198–210.
  • Absinta M, Sati P, Masuzzo F, et al. Association of chronic active multiple sclerosis lesions with disability in vivo. JAMA Neurol. 2019;76(12):1474–1483.
  • Absinta M, Sati P, Gaitan MI, et al. Seven-tesla phase imaging of acute multiple sclerosis lesions: a new window into the inflammatory process. Ann Neurol. 2013;74(5):669–678.
  • Absinta M, Sati P, Schindler M, et al. Persistent 7-tesla phase rim predicts poor outcome in new multiple sclerosis patient lesions. J Clin Invest. 2016;126(7):2597–2609.
  • Filippi M, Preziosa P, Barkhof F, et al. Diagnosis of progressive multiple sclerosis from the imaging perspective: a review. JAMA Neurol. 2021;78(3):351–364.
  • Chawla S, Kister I, Sinnecker T, et al. Longitudinal study of multiple sclerosis lesions using ultra-high field (7T) multiparametric MR imaging. PLoS One. 2018;13(9):e0202918.
  • Kaunzner UW, Kang Y, Zhang S, et al. Quantitative susceptibility mapping identifies inflammation in a subset of chronic multiple sclerosis lesions. Brain. 2019;142(1):133–145.
  • Tolaymat B, Zheng W, Chen H, et al. Sex-specific differences in rim appearance of multiple sclerosis lesions on quantitative susceptibility mapping. Mult Scler Relat Disord. 2020;45(102317).
  • Elliott C, Belachew S, Wolinsky JS, et al. Chronic white matter lesion activity predicts clinical progression in primary progressive multiple sclerosis. Brain. 2019;142(9):2787–2799.
  • Elliott C, Wolinsky JS, Hauser SL, et al. Slowly expanding/evolving lesions as a magnetic resonance imaging marker of chronic active multiple sclerosis lesions. Mult Scler. 2019;25(14):1915–1925.
  • Preziosa P, Pagani E, Moiola L, et al. Occurrence and microstructural features of slowly expanding lesions on fingolimod or natalizumab treatment in multiple sclerosis. Mult Scler. 2020;1352458520969105.
  • Kaunzner UW, Kang Y, Monohan E, et al. Reduction of PK11195 uptake observed in multiple sclerosis lesions after natalizumab initiation. Mult Scler Relat Disord. 2017;15:27–33.
  • Sucksdorff M, Rissanen E, Tuisku J, et al. Evaluation of the effect of fingolimod treatment on microglial activation using serial PET imaging in multiple sclerosis. J Nucl Med. 2017;58(10):1646–1651.
  • Sucksdorff M, Tuisku J, Matilainen M, et al. Natalizumab treatment reduces microglial activation in the white matter of the MS brain. Neurol Neuroimmunol Neuroinflamm. 2019;6(4):e574. DOI: https://doi.org/10.1177/1352458520969105.
  • Eisele P, Kraemer M, Dabringhaus A, et al. Characterization of chronic active multiple sclerosis lesions with sodium ((23) Na) MRI - preliminary observations. Eur J Neurol. 2021;28(7):2392–2395.
  • Tolebrutinib, a brain-penetrant bruton s tyrosine kinase inhibitor, for the modulation of chronically inflamed white matter lesions in multiple sclerosis. Available at https://clinicaltrials.gov/ct2/show/study/NCT04742400. Access date 2021 Apr 20th.
  • Hogel H, Rissanen E, Vuorimaa A, et al. Positron emission tomography imaging in evaluation of MS pathology in vivo. Mult Scler. 2018;24(11):1399–1412.
  • Elliott C, Arnold DL, Chen H, et al. Patterning chronic active demyelination in slowly expanding/evolving white matter MS lesions. AJNR Am J Neuroradiol. 2020;41(9):1584–1591.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.