Thalamic neuromodulation in epilepsy: A primer for emerging circuit-based therapies

References

• Collaborators GBDE. Global, regional, and national burden of epilepsy, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 Apr;18(4):357–375.
   PubMed Web of Science ®Google Scholar
• Begley CE, Durgin TL. The direct cost of epilepsy in the United States: a systematic review of estimates. Epilepsia. 2015 Sep;56(9):1376–1387.
   PubMed Web of Science ®Google Scholar
• Kramer MA, Cash SS. Epilepsy as a Disorder of Cortical Network Organization. Neuroscientist. 2012;18(4):360–372.
   PubMed Web of Science ®Google Scholar
• Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med. 2000 Feb 3;342(5):314–319.
   PubMed Web of Science ®Google Scholar
• Chen Z, Brodie MJ, Liew D, et al. Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs: a 30-Year Longitudinal Cohort Study. JAMA Neurol. [2018 Mar 1];75(3):279–286.
   PubMed Web of Science ®Google Scholar
• Perucca E, Brodie MJ, Kwan P, et al. 30 years of second-generation antiseizure medications: impact and future perspectives. Lancet Neurol. 2020 Jun;19(6):544–556.
   PubMed Web of Science ®Google Scholar
• Spencer SS. Neural Networks in Human Epilepsy: evidence of and Implications for Treatment. Epilepsia. 2002;43(3):219–227.
   PubMed Web of Science ®Google Scholar
• van Diessen E, Wjem Z, Jansen FE, et al. Brain Network Organization in Focal Epilepsy: a Systematic Review and Meta-Analysis. PLOS ONE. 2014;9(12):e114606.
   PubMed Web of Science ®Google Scholar
• Pittau F, Megevand P, Sheybani L, et al. Mapping epileptic activity: sources or networks for the clinicians? Front Neurol. 2014;5:218.
   PubMed Web of Science ®Google Scholar
• Amorim-Leite R, Remick M, Welch W, et al. History of the Network Approach in Epilepsy Surgery. Neurosurg Clin N Am. 2020 Jul;31(3):301–308.
   PubMed Web of Science ®Google Scholar
• Zhu J, Xu C, Zhang X, et al. The thalamus-precentral gyrus functional connectivity changes in epilepsy patients following vagal nerve stimulation. Neurosci Lett. 2021 Apr 23;751:135815.
   PubMed Web of Science ®Google Scholar
• Ryvlin P, Rheims S, Hirsch LJ, et al. Neuromodulation in epilepsy: state-of-the-art approved therapies. Lancet Neurol. 2021 Dec;20(12):1038–1047.
   PubMed Web of Science ®Google Scholar
• Carron R, Roncon P, Lagarde S, et al. Latest Views on the Mechanisms of Action of Surgically Implanted Cervical Vagal Nerve Stimulation in Epilepsy. Neuromodulation. 2022 Sep 1. Advance online publication.
   Web of Science ®Google Scholar
• Yu T, Wang X, Li Y, et al. High-frequency stimulation of anterior nucleus of thalamus desynchronizes epileptic network in humans. Brain. [2018 Sep 1];141(9):2631–2643.
   PubMedGoogle Scholar
• Fisher RS, Velasco AL. Electrical brain stimulation for epilepsy. Nat Rev Neurol. 2014 [2014 may 01];10(5):261–270.
   PubMed Web of Science ®Google Scholar
• Tripoliti E, Limousin P, Foltynie T, et al. Predictive factors of speech intelligibility following subthalamic nucleus stimulation in consecutive patients with Parkinson’s disease. Mov Disord. 2014 Apr;29(4):532–538.
   PubMed Web of Science ®Google Scholar
• Lizarraga KJ, Gnanamanogaran B, Al-Ozzi TM, et al. Lateralized Subthalamic Stimulation for Axial Dysfunction in Parkinson’s Disease: a Randomized Trial. Mov Disord. 2022 May;37(5):1079–1087.
   PubMed Web of Science ®Google Scholar
• Jones EG. The thalamus. Second ed. Cambridge UK New York: Cambridge University Press; 2007. p. 2007.
   Google Scholar
• Mendoza JE, Foundas AL. The Thalamus. Clinical Neuroanatomy: a Neurobehavioral Approach. New York NY: Springer New York; 2008. p. 195–211.
   Google Scholar
• Zhou H, Schafer RJ, Desimone R. Pulvinar-Cortex Interactions in Vision and Attention. Neuron. 2016 Jan 6;89(1):209–220.
   PubMed Web of Science ®Google Scholar
• Benarroch EE. Pulvinar: associative role in cortical function and clinical correlations. Neurology. 2015 Feb 17;84(7):738–747.
   PubMed Web of Science ®Google Scholar
• Bertini C, Pietrelli M, Braghittoni D, et al. Pulvinar Lesions Disrupt Fear-Related Implicit Visual Processing in Hemianopic Patients. Front Psychol. 2018;9:2329.
   PubMed Web of Science ®Google Scholar
• Jaramillo J, Mejias JF, Wang XJ. Engagement of Pulvino-cortical Feedforward and Feedback Pathways in Cognitive Computations. Neuron. 2019 Jan 16;101(2):321–336 e9.
   PubMed Web of Science ®Google Scholar
• Homman-Ludiye J, Bourne JA. The medial pulvinar: function, origin and association with neurodevelopmental disorders. J Anat. 2019 Sep;235(3):507–520.
   PubMed Web of Science ®Google Scholar
• Homman-Ludiye J, Mundinano IC, Kwan WC, et al. Extensive Connectivity Between the Medial Pulvinar and the Cortex Revealed in the Marmoset Monkey. Cereb Cortex. [2020 Mar 14];30(3):1797–1812.
   PubMed Web of Science ®Google Scholar
• Rikhye RV, Wimmer RD, Halassa MM. Toward an Integrative Theory of Thalamic Function. Annu Rev Neurosci. 2018;41(1):163–183.
   PubMedGoogle Scholar
• Jones EG. The thalamic matrix and thalamocortical synchrony. Trends Neurosci. 2001;24(10):595–601.
   PubMed Web of Science ®Google Scholar
• Sherman SM. Thalamus plays a central role in ongoing cortical functioning. Nat Neurosci. 2016 Apr;19(4):533–541.
   PubMed Web of Science ®Google Scholar
• Halassa MM, Sherman SM. Thalamocortical Circuit Motifs: a General Framework. Neuron. 2019;103(5):762–770. .
   PubMed Web of Science ®Google Scholar
• Muller EJ, Munn B, Hearne LJ, et al. Core and matrix thalamic sub-populations relate to spatio-temporal cortical connectivity gradients. Neuroimage. 2020 Nov 15;222:117224.
   PubMed Web of Science ®Google Scholar
• Cappe C, Morel A, Barone P, et al. The thalamocortical projection systems in primate: an anatomical support for multisensory and sensorimotor interplay. Cereb Cortex. 2009 Sep;19(9):2025–2037.
   PubMed Web of Science ®Google Scholar
• Georgescu IA, Popa D, Zagrean L. The Anatomical and Functional Heterogeneity of the Mediodorsal Thalamus. Brain Sci. 2020 Sep 9. 10(9):624.
   PubMed Web of Science ®Google Scholar
• Campi KL, Bales KL, Grunewald R, et al. Connections of auditory and visual cortex in the prairie vole (Microtus ochrogaster): evidence for multisensory processing in primary sensory areas. Cereb Cortex. 2010 Jan;20(1):89–108.
   PubMed Web of Science ®Google Scholar
• Tyll S, Budinger E, Noesselt T. Thalamic influences on multisensory integration. Commun Integr Biol. 2011 Jul;4(4):378–381.
   PubMedGoogle Scholar
• Antunes FM, Malmierca MS. Corticothalamic Pathways in Auditory Processing: recent Advances and Insights From Other Sensory Systems. Front Neural Circuits. 2021;15:721186.
   PubMed Web of Science ®Google Scholar
• der Werf Yd V, Witter MP, Groenewegen HJ. The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness. Brain Res Rev. 2002;39(2–3):107–140.
   PubMedGoogle Scholar
• Llinas R, Ribary U, Contreras D, et al. The neuronal basis for consciousness. Philos Trans R Soc Lond B Biol Sci. 1998 [Nov 29];353:1841–1849.
   PubMed Web of Science ®Google Scholar
• Baker R, Gent TC, Yang Q, et al. Altered activity in the central medial thalamus precedes changes in the neocortex during transitions into both sleep and propofol anesthesia. J Neurosci. [2014 Oct 1];34(40):13326–13335.
   PubMed Web of Science ®Google Scholar
• Redinbaugh MJ, Phillips JM, Kambi NA, et al. Thalamus Modulates Consciousness via Layer-Specific Control of Cortex. Neuron. [2020 Apr 8];106(1):66–75 e12.
   PubMed Web of Science ®Google Scholar
• Pouchelon G, Gambino F, Bellone C, et al. Modality-specific thalamocortical inputs instruct the identity of postsynaptic L4 neurons. Nature. [2014 Jul 24];511(7510):471–474.
   PubMed Web of Science ®Google Scholar
• Alzu’bi A, Homman-Ludiye J, Bourne JA, et al. Thalamocortical Afferents Innervate the Cortical Subplate much Earlier in Development in Primate than in Rodent. Cereb Cortex. [2019 Apr 1];29(4):1706–1718.
   PubMed Web of Science ®Google Scholar
• Beierlein M, Connors BW. Short-term dynamics of thalamocortical and intracortical synapses onto layer 6 neurons in neocortex. J Neurophysiol. 2002 Oct;88(4):1924–1932.
   PubMed Web of Science ®Google Scholar
• Zarrinpar A, Callaway EM. Local connections to specific types of layer 6 neurons in the rat visual cortex. J Neurophysiol. 2006 Mar;95(3):1751–1761.
   PubMed Web of Science ®Google Scholar
• Crandall SR, Patrick SL, Cruikshank SJ, et al. Infrabarrels Are Layer 6 Circuit Modules in the Barrel Cortex that Link Long-Range Inputs and Outputs. Cell Rep. [2017 Dec 12];21(11):3065–3078.
   PubMed Web of Science ®Google Scholar
• Sherman SM, Guillery RW. The role of the thalamus in the flow of information to the cortex. Philos Trans R Soc Lond B Biol Sci. 2002 [Dec 29];357:1695–1708.
   PubMed Web of Science ®Google Scholar
• Thomson AM. Neocortical layer 6, a review. Front Neuroanat. 2010;4:13.
   PubMed Web of Science ®Google Scholar
• Prasad JA, Carroll BJ, Sherman SM. Layer 5 Corticofugal Projections from Diverse Cortical Areas: variations on a Pattern of Thalamic and Extrathalamic Targets. J Neurosci. 2020 Jul 22;40(30):5785–5796.
   PubMed Web of Science ®Google Scholar
• Guillery RW, Sherman SM. Thalamic relay functions and their role in corticocortical communication: generalizations from the visual system. Neuron. 2002 Jan 17;33(2):163–175.
   PubMed Web of Science ®Google Scholar
• Kinomura S, Larsson J, Gulyas B, et al. Activation by attention of the human reticular formation and thalamic intralaminar nuclei. Science. [1996 Jan 26];271(5248):512–515.
   PubMed Web of Science ®Google Scholar
• Poulet JF, Fernandez LM, Crochet S, et al. Thalamic control of cortical states. Nat Neurosci. [2012 Jan 22];15(3):370–372.
   PubMed Web of Science ®Google Scholar
• Nakajima M, Halassa MM. Thalamic control of functional cortical connectivity. Curr Opin Neurobiol. 2017 Jun;44:127–131.
   PubMed Web of Science ®Google Scholar
• Schmitt LI, Wimmer RD, Nakajima M, et al. Thalamic amplification of cortical connectivity sustains attentional control. Nature. 2017 [2017 may 01];545(7653):219–223.
   PubMed Web of Science ®Google Scholar
• Honjoh S, Sasai S, Schiereck SS, et al. Regulation of cortical activity and arousal by the matrix cells of the ventromedial thalamic nucleus. Nat Commun. [2018 May 29];9(1):2100.
   PubMedGoogle Scholar
• Phillips JM, Kambi NA, Redinbaugh MJ, et al. Disentangling the influences of multiple thalamic nuclei on prefrontal cortex and cognitive control. Neurosci Biobehav Rev. 2021;128:487–510.
   PubMed Web of Science ®Google Scholar
• Reinhold K, Lien AD, Scanziani M. Distinct recurrent versus afferent dynamics in cortical visual processing. Nat Neurosci. 2015 Dec;18(12):1789–1797.
   PubMed Web of Science ®Google Scholar
• Theyel BB, Llano DA, Sherman SM. The corticothalamocortical circuit drives higher-order cortex in the mouse. Nat Neurosci. 2010 Jan;13(1):84–88.
   PubMed Web of Science ®Google Scholar
• Fries P. A mechanism for cognitive dynamics: neuronal communication through neuronal coherence. Trends Cogn Sci. 2005 Oct;9(10):474–480.
   PubMed Web of Science ®Google Scholar
• Saalmann YB, Pinsk MA, Wang L, et al. The pulvinar regulates information transmission between cortical areas based on attention demands. Science. [2012 Aug 10];337(6095):753–756.
   PubMed Web of Science ®Google Scholar
• Halassa MM, Kastner S. Thalamic functions in distributed cognitive control. Nat Neurosci. 2017 Dec;20(12):1669–1679.
   PubMed Web of Science ®Google Scholar
• Weyand TG. The multifunctional lateral geniculate nucleus. Rev Neurosci. 2016 Feb;27(2):135–157.
   PubMed Web of Science ®Google Scholar
• Halassa MM, Chen Z, Wimmer RD, et al. State-dependent architecture of thalamic reticular subnetworks. Cell. [2014 Aug 14];158(4):808–821.
   PubMed Web of Science ®Google Scholar
• Durkin JM, Aton SJ. How Sleep Shapes Thalamocortical Circuit Function in the Visual System. Annu Rev Vis Sci. 2019 Sep 15;5:295–315.
   PubMed Web of Science ®Google Scholar
• McAlonan K, Brown VJ, Bowman EM. Thalamic reticular nucleus activation reflects attentional gating during classical conditioning. J Neurosci. 2000 Dec 1;20(23):8897–8901.
   PubMed Web of Science ®Google Scholar
• Castro-Alamancos MA. Role of thalamocortical sensory suppression during arousal: focusing sensory inputs in neocortex. J Neurosci. 2002 Nov 15;22(22):9651–9655.
   PubMed Web of Science ®Google Scholar
• Lewis LD, Voigts J, Flores FJ, et al. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13;4:e08760.
   PubMed Web of Science ®Google Scholar
• Matyas F, Komlosi G, Babiczky A, et al. A highly collateralized thalamic cell type with arousal-predicting activity serves as a key hub for graded state transitions in the forebrain. Nat Neurosci. 2018 Nov;21(11):1551–1562.
   PubMed Web of Science ®Google Scholar
• Murata Y, Colonnese MT. Thalamus Controls Development and Expression of Arousal States in Visual Cortex. J Neurosci. 2018 Oct 10;38(41):8772–8786.
   PubMed Web of Science ®Google Scholar
• Martinez-Garcia RI, Voelcker B, Zaltsman JB, et al. Two dynamically distinct circuits drive inhibition in the sensory thalamus. Nature. 2020 Jul;583(7818):813–818.
   PubMed Web of Science ®Google Scholar
• Molnar B, Sere P, Borde S, et al. Cell Type-Specific Arousal-Dependent Modulation of Thalamic Activity in the Lateral Geniculate Nucleus. Cereb Cortex Commun. 2021;2(2):tgab020.
   PubMedGoogle Scholar
• Hay YA, Deperrois N, Fuchsberger T, et al. Thalamus mediates neocortical Down state transition via GABAB-receptor-targeting interneurons. Neuron. [2021 Sep 1];109(17):2682–2690 e5.
   PubMed Web of Science ®Google Scholar
• Erro E, Lanciego JL, Gimenez-Amaya JM. Relationships between thalamostriatal neurons and pedunculopontine projections to the thalamus: a neuroanatomical tract-tracing study in the rat. Exp Brain Res. 1999 Jul;127(2):162–170.
   PubMed Web of Science ®Google Scholar
• Krout KE, Belzer RE, Loewy AD. Brainstem projections to midline and intralaminar thalamic nuclei of the rat. J Comp Neurol. 2002 Jun 17;448(1):53–101.
   PubMed Web of Science ®Google Scholar
• Fuller PM, Sherman D, Pedersen NP, et al. Reassessment of the structural basis of the ascending arousal system. J Comp Neurol. [2011 Apr 1];519(5):933–956.
   PubMed Web of Science ®Google Scholar
• Houser CR, Vaughn JE, Barber RP, et al. GABA neurons are the major cell type of the nucleus reticularis thalami. Brain Res. [1980 Nov 3];200(2):341–354.
   PubMed Web of Science ®Google Scholar
• Halassa MM, Acsady L. Thalamic Inhibition: diverse Sources, Diverse Scales. Trends Neurosci. 2016 Oct;39(10):680–693.
   PubMed Web of Science ®Google Scholar
• Lam YW, Sherman SM. Functional organization of the thalamic input to the thalamic reticular nucleus. J Neurosci. 2011 May 4;31(18):6791–6799.
   PubMed Web of Science ®Google Scholar
• Huguenard JR, Prince DA. A novel T-type current underlies prolonged Ca(2+)-dependent burst firing in GABAergic neurons of rat thalamic reticular nucleus. J Neurosci. 1992 Oct;12(10):3804–3817.
   PubMed Web of Science ®Google Scholar
• Ulrich D, Huguenard JR. Gamma-aminobutyric acid type B receptor-dependent burst-firing in thalamic neurons: a dynamic clamp study. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13245–13249.
   PubMed Web of Science ®Google Scholar
• Jones EG. Thalamic circuitry and thalamocortical synchrony. Philos Trans R Soc Lond B Biol Sci. 2002 [Dec 29];357:1659–1673.
   PubMed Web of Science ®Google Scholar
• DA M, Pape H-C. Properties of a hyperpolarization‐activated cation current and its role in rhythmic oscillation in thalamic relay neurones. J Physiol. 1990;431(1):291–318.
   PubMedGoogle Scholar
• Nun A, Amzica F, Steriade M. Intrinsic and synaptically generated delta (1–4 Hz) rhythms in dorsal lateral geniculate neurons and their modulation by light-induced fast (30–70 Hz) events. Neuroscience. 1992;51(2):269–284.
   PubMed Web of Science ®Google Scholar
• Soltesz I, Lightowler S, Leresche N, et al. Two inward currents and the transformation of low‐frequency oscillations of rat and cat thalamocortical cells. J Physiol. 1991;441(1):175–197.
   PubMedGoogle Scholar
• Morison R, Bassett D. Electrical activity of the thalamus and basal ganglia in decorticate cats. J Neurophysiol. 1945;8(5):309–314.
   Web of Science ®Google Scholar
• Steriade M, Deschenes M, Domich L, et al. Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami. J Neurophysiol. 1985;54(6):1473–1497.
   PubMed Web of Science ®Google Scholar
• Huguenard JR, McCormick DA. Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci. 2007 Jul;30(7):350–356.
   PubMed Web of Science ®Google Scholar
• Rogala J, Waleszczyk WJ, Leski S, et al. Reciprocal inhibition and slow calcium decay in perigeniculate interneurons explain changes of spontaneous firing of thalamic cells caused by cortical inactivation. J Comput Neurosci. 2013 Jun;34(3):461–476.
   PubMed Web of Science ®Google Scholar
• Paz JT, Huguenard JR. Microcircuits and their interactions in epilepsy: is the focus out of focus? Nat Neurosci. 2015 Mar;18(3):351–359.
   PubMed Web of Science ®Google Scholar
• Ali I, Gandrathi A, Zheng T, et al. Neuropeptide Y affects thalamic reticular nucleus neuronal firing and network synchronization associated with suppression of spike-wave discharges. Epilepsia. 2018 Jul;59(7):1444–1454.
   PubMed Web of Science ®Google Scholar
• Wilson JR. Synaptic organization of individual neurons in the macaque lateral geniculate nucleus. J Neurosci. 1989 Aug;9(8):2931–2953.
   PubMed Web of Science ®Google Scholar
• Arcelli P, Frassoni C, Regondi MC, et al. GABAergic neurons in mammalian thalamus: a marker of thalamic complexity? Brain Res Bull. 1997;42(1):27–37.
   PubMed Web of Science ®Google Scholar
• Sherman SM. Interneurons and triadic circuitry of the thalamus. Trends Neurosci. 2004 Nov;27(11):670–675.
   PubMed Web of Science ®Google Scholar
• Govindaiah CCL. Synaptic activation of metabotropic glutamate receptors regulates dendritic outputs of thalamic interneurons. Neuron. 2004 Feb 19;41(4):611–623.
   PubMed Web of Science ®Google Scholar
• Simko J, Markram H. Morphology, physiology and synaptic connectivity of local interneurons in the mouse somatosensory thalamus. J Physiol. 2021 Nov;599(22):5085–5101.
   PubMed Web of Science ®Google Scholar
• Charalambakis NE, Govindaiah G, Campbell PW, et al. Developmental Remodeling of Thalamic Interneurons Requires Retinal Signaling. J Neurosci. [2019 May 15];39(20):3856–3866.
   PubMed Web of Science ®Google Scholar
• Sherman SM. Functioning of Circuits Connecting Thalamus and Cortex. Compr Physiol. 2017 Mar 16;7(2):713–739.
   PubMed Web of Science ®Google Scholar
• Zimmermann E, Ghio M, Pergola G, et al. Separate and overlapping functional roles for efference copies in the human thalamus. Neuropsychologia. 2020;147:107558.
   PubMed Web of Science ®Google Scholar
• Bolkan SS, Stujenske JM, Parnaudeau S, et al. Thalamic projections sustain prefrontal activity during working memory maintenance. Nat Neurosci. 2017 [2017 july 01];20(7):987–996.
   PubMed Web of Science ®Google Scholar
• Guo ZV, Inagaki HK, Daie K, et al. Maintenance of persistent activity in a frontal thalamocortical loop. Nature. 2017 [2017 may 01];545(7653):181–186.
   PubMed Web of Science ®Google Scholar
• Rikhye RV, Gilra A, Halassa MM. Thalamic regulation of switching between cortical representations enables cognitive flexibility. Nat Neurosci. 2018 [2018 dec 01];21(12):1753–1763.
   PubMed Web of Science ®Google Scholar
• Ouhaz Z, Fleming H, Mitchell AS. Cognitive Functions and Neurodevelopmental Disorders Involving the Prefrontal Cortex and Mediodorsal Thalamus. Front Neurosci. 2018;12:33.
   PubMed Web of Science ®Google Scholar
• Sorokin JM, Davidson TJ, Frechette E, et al. Bidirectional Control of Generalized Epilepsy Networks via Rapid Real-Time Switching of Firing Mode. Neuron. 2017;93(1):194–210.
   PubMed Web of Science ®Google Scholar
• Wicker E, Forcelli PA. Optogenetic activation of the reticular nucleus of the thalamus attenuates limbic seizures via inhibition of the midline thalamus. Epilepsia. 2021 Sep;62(9):2283–2296.
   PubMed Web of Science ®Google Scholar
• Cruikshank SJ, Lewis TJ, Connors BW. Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex. Nat Neurosci. 2007 Apr;10(4):462–468.
   PubMed Web of Science ®Google Scholar
• Gabernet L, Jadhav SP, Feldman DE, et al. Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition. Neuron. [2005 Oct 20];48(2):315–327.
   PubMed Web of Science ®Google Scholar
• Bruno RM, Sakmann B. Cortex is driven by weak but synchronously active thalamocortical synapses. Science. 2006 Jun 16;312(5780):1622–1627.
   PubMed Web of Science ®Google Scholar
• Goldberg EM, Coulter DA. Mechanisms of epileptogenesis: a convergence on neural circuit dysfunction. Nat Rev Neurosci. 2013 May;14(5):337–349.
   PubMed Web of Science ®Google Scholar
• Gil Z, Amitai Y. Properties of convergent thalamocortical and intracortical synaptic potentials in single neurons of neocortex. J Neurosci. 1996 Oct 15;16(20):6567–6578.
   PubMed Web of Science ®Google Scholar
• Astori S, Luthi A. Synaptic plasticity at intrathalamic connections via CaV3.3 T-type Ca2+ channels and GluN2B-containing NMDA receptors. J Neurosci. 2013 Jan 9;33(2):624–630.
   PubMed Web of Science ®Google Scholar
• Fernandez LMJ, Pellegrini C, Vantomme G, et al. Cortical afferents onto the nucleus Reticularis thalami promote plasticity of low-threshold excitability through GluN2C-NMDARs. Sci Rep. [2017 Sep 25];7(1):12271.
   PubMedGoogle Scholar
• Jasper HH, Droogleever-Fortuyn J. Experimental studies on the functional anatomy of petit mal epilepsy. Res Publ Ass nerv ment Dis. 1947;26:272–298.
   Google Scholar
• Spiegel EA, Wycis HT. Thalamic recordings in man with special reference to seizure discharges. Electroencephalogr Clin Neurophysiol. 1950 [1950 jan 01];2(1):23–27.
   Google Scholar
• Williams D. A study of thalamic and cortical rhythms in petit mal. Brain. 1953 Mar;76(1):50–69.
   PubMed Web of Science ®Google Scholar
• Blumenfeld H. The thalamus and seizures. Arch Neurol. 2002 Jan;59(1):135–137.
   PubMedGoogle Scholar
• Natsume J, Bernasconi N, Andermann F, et al. MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy. Neurology. [2003 Apr 22];60(8):1296–1300.
   PubMed Web of Science ®Google Scholar
• Caciagli L, Allen LA, He X, et al. Thalamus and focal to bilateral seizures: a multiscale cognitive imaging study. Neurology. [2020 Oct 27];95(17):e2427–e2441.
   PubMedGoogle Scholar
• Kuzniecky R, Bilir E, Gilliam F, et al. Quantitative MRI in temporal lobe epilepsy: evidence for fornix atrophy. Neurology. [1999 Aug 11];53(3):496–501.
   PubMed Web of Science ®Google Scholar
• Keller SS, Glenn GR, Weber B, et al. Preoperative automated fibre quantification predicts postoperative seizure outcome in temporal lobe epilepsy. Brain. 2017 Jan;140(1):68–82.
   PubMedGoogle Scholar
• Concha L, Beaulieu C, Collins DL, et al. White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis. J Neurol Neurosurg Psychiatry. 2009 Mar;80(3):312–319.
   PubMed Web of Science ®Google Scholar
• Keller SS, Richardson MP, O’Muircheartaigh J, et al. Morphometric MRI alterations and postoperative seizure control in refractory temporal lobe epilepsy. Hum Brain Mapp. 2015 May;36(5):1637–1647.
   PubMed Web of Science ®Google Scholar
• Barron DS, Fox PT, Pardoe H, et al. Thalamic functional connectivity predicts seizure laterality in individual TLE patients: application of a biomarker development strategy. Neuroimage Clin. 2015;7:273–280.
   PubMed Web of Science ®Google Scholar
• Gonzalez HFJ, Chakravorti S, Goodale SE, et al. Thalamic arousal network disturbances in temporal lobe epilepsy and improvement after surgery. J Neurol Neurosurg Psychiatry. 2019 Oct;90(10):1109–1116.
   PubMed Web of Science ®Google Scholar
• Mirski MA, Ferrendelli JA. Interruption of the mammillothalamic tract prevents seizures in Guinea pigs. Science. 1984 Oct 5;226(4670):72–74.
   PubMed Web of Science ®Google Scholar
• Mirski MA, Ferrendelli JA. Interruption of the connections of the mammillary bodies protects against generalized pentylenetetrazol seizures in Guinea pigs. J Neurosci. 1987 Mar;7(3):662–670.
   PubMed Web of Science ®Google Scholar
• Feng L, Motelow JE, Ma C, et al. Seizures and Sleep in the Thalamus: focal Limbic Seizures Show Divergent Activity Patterns in Different Thalamic Nuclei. J Neurosci. [2017 Nov 22];37(47):11441–11454.
   PubMed Web of Science ®Google Scholar
• Yang AC, Meng DW, Liu HG, et al. The ability of anterior thalamic signals to predict seizures in temporal lobe epilepsy in kainate-treated rats. Epilepsia. 2016 Sep;57(9):1369–1376.
   PubMed Web of Science ®Google Scholar
• Rosenberg DS, Mauguiere F, Demarquay G, et al. Involvement of medial pulvinar thalamic nucleus in human temporal lobe seizures. Epilepsia. 2006 Jan;47(1):98–107.
   PubMed Web of Science ®Google Scholar
• Burton H, Jones EG . The posterior thalamic region and its cortical projection in New World and Old World monkeys. J Comp Neurol. 1976 Jul;168(2):249–301.
   PubMed Web of Science ®Google Scholar
• Mauguiere F, Baleydier C. Topographical organization of medial pulvinar neurons sending fibres to Brodman’s areas 7, 21 and 22 in the monkey. Exp Brain Res. 1978 Apr 14;31(4):605–607.
   PubMed Web of Science ®Google Scholar
• Baleydier C, Morel A. Segregated thalamocortical pathways to inferior parietal and inferotemporal cortex in macaque monkey. Vis Neurosci. 1992 May;8(5):391–405.
   PubMed Web of Science ®Google Scholar
• Velasco M, Velasco F, Velasco AL, et al. Epileptiform EEG activities of the centromedian thalamic nuclei in patients with intractable partial motor, complex partial, and generalized seizures. Epilepsia. 1989 May-Jun;30(3):295–306.
   PubMed Web of Science ®Google Scholar
• Velasco M, Velasco F, Alcala H, et al. Epileptiform EEG activity of the centromedian thalamic nuclei in children with intractable generalized seizures of the Lennox-Gastaut syndrome. Epilepsia. 1991 May-Jun;32(3):310–321.
   PubMed Web of Science ®Google Scholar
• Dalic LJ, Warren AEL, Young JC, et al. Cortex leads the thalamic centromedian nucleus in generalized epileptic discharges in Lennox-Gastaut syndrome. Epilepsia. 2020 Oct;61(10):2214–2223.
   PubMed Web of Science ®Google Scholar
• Martín-López D, Jiménez-Jiménez D, Cabañés-Martínez L, et al. The Role of Thalamus Versus Cortex in Epilepsy: evidence from Human Ictal Centromedian Recordings in Patients Assessed for Deep Brain Stimulation. Int J Neural Syst. 2017 Nov;27(7):1750010.
   PubMed Web of Science ®Google Scholar
• Westmijse I, Ossenblok P, Gunning B, et al. Onset and propagation of spike and slow wave discharges in human absence epilepsy: a MEG study. Epilepsia. 2009;50(12):2538–2548.
   PubMed Web of Science ®Google Scholar
• Maheshwari A, Noebels JL. Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits. Prog Brain Res. 2014;213:223–252.
   PubMed Web of Science ®Google Scholar
• Gloor P, Fariello RG. Generalized epilepsy: some of its cellular mechanisms differ from those of focal epilepsy. Trends Neurosci. 1988 Feb;11(2):63–68.
   PubMed Web of Science ®Google Scholar
• Wallace RH, Marini C, Petrou S, et al. Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nat Genet. 2001 May;28(1):49–52.
   PubMed Web of Science ®Google Scholar
• Crunelli V, Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks. Nat Rev Neurosci. 2002;3(5):371–382.
   PubMed Web of Science ®Google Scholar
• Polack PO, Guillemain I, Hu E, et al. Deep layer somatosensory cortical neurons initiate spike-and-wave discharges in a genetic model of absence seizures. J Neurosci. [2007 Jun 13];27(24):6590–6599.
   PubMed Web of Science ®Google Scholar
• Noebels J, Avoli M, Rogawski M, et al. Jasper’s basic mechanisms of the epilepsies. 2012.
   Google Scholar
• Tenney JR, Fujiwara H, Horn PS, et al. Focal corticothalamic sources during generalized absence seizures: a MEG study. Epilepsy Res. 2013;106(1–2):113–122.
   PubMed Web of Science ®Google Scholar
• Sorokin JM, Williams A, Ganguli S, et al. Thalamic activity patterns unfolding over multiple time scales predict seizure onset in absence epilepsy. bioRxiv. 2020.
   Google Scholar
• Steriade M, McCormick D, Sejnowski T. Thalamocortical oscillations in the sleeping and aroused brain. Science. 1993;262(5134):679–685.
   PubMed Web of Science ®Google Scholar
• Paz JT, Bryant AS, Peng K, et al. A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Nat Neurosci. [2011 Aug 21];14(9):1167–1173.
   PubMed Web of Science ®Google Scholar
• David F, Çarçak N, Furdan S, et al. Suppression of hyperpolarization-activated cyclic nucleotide-gated channel function in thalamocortical neurons prevents genetically determined and pharmacologically induced absence seizures. J Neurosci. 2018;38(30):6615–6627.
   PubMed Web of Science ®Google Scholar
• Makinson CD, Tanaka BS, Sorokin JM, et al. Regulation of thalamic and cortical network synchrony by Scn8a. Neuron. 2017;93(5):1165–1179. e6.
   PubMed Web of Science ®Google Scholar
• Tung JK, Berglund K, Gross RE. Optogenetic Approaches for Controlling Seizure Activity. Brain Stimul. 2016 Nov-Dec;9(6):801–810.
   PubMed Web of Science ®Google Scholar
• Paz JT, Davidson TJ, Frechette ES, et al. Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury. Nat Neurosci. 2013 Jan;16(1):64–70.
   PubMed Web of Science ®Google Scholar
• Malpass K. Epilepsy: shining a light on seizure control-optogenetic approach shows promise for treatment and prevention of epilepsies. Nat Rev Neurol. 2013 Jan;9(1):1.
   PubMedGoogle Scholar
• Mirski MA, Rossell LA, Terry JB, et al. Anticonvulsant effect of anterior thalamic high frequency electrical stimulation in the rat. Epilepsy Res. 1997 Sep;28(2):89–100.
   PubMed Web of Science ®Google Scholar
• Sherdil A, Chabardès S, David O, et al. Coherence between the hippocampus and anterior thalamic nucleus as a tool to improve the effect of neurostimulation in temporal lobe epilepsy: an experimental study. Brain Stimul. 2020;13(6):1678–1686.
   PubMed Web of Science ®Google Scholar
• Hamani C, Ewerton FI, Bonilha SM, et al. Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticus. Neurosurgery. 2004 Jan; 54(1):191–195. discussion 195-7
   PubMed Web of Science ®Google Scholar
• Hamani C, Hodaie M, Chiang J, et al. Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticus. Epilepsy Res. 2008 Feb;78(2–3):117–123.
   PubMed Web of Science ®Google Scholar
• Takebayashi S, Hashizume K, Tanaka T, et al. Anti-convulsant effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal limbic seizure in rats. Epilepsy Res. 2007 May;74(2–3):163–170.
   PubMed Web of Science ®Google Scholar
• Takebayashi S, Hashizume K, Tanaka T, et al. The effect of electrical stimulation and lesioning of the anterior thalamic nucleus on kainic acid-induced focal cortical seizure status in rats. Epilepsia. 2007 Feb;48(2):348–358.
   PubMedGoogle Scholar
• Herrington TM, Cheng JJ, Eskandar EN. Mechanisms of deep brain stimulation. J Neurophysiol. 2016 Jan 1;115(1):19–38.
   PubMed Web of Science ®Google Scholar
• Dostrovsky JO, Levy R, Wu JP, et al. Microstimulation-induced inhibition of neuronal firing in human globus pallidus. J Neurophysiol. 2000 Jul;84(1):570–574.
   PubMed Web of Science ®Google Scholar
• Kumar R, Lozano AM, Kim YJ, et al. Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson’s disease. Neurology. 1998 Sep;51(3):850–855.
   PubMed Web of Science ®Google Scholar
• Benabid AL, Pollak P, Gao D, et al. Chronic electrical stimulation of the ventralis intermedius nucleus of the thalamus as a treatment of movement disorders. J Neurosurg. 1996 Feb;84(2):203–214.
   PubMed Web of Science ®Google Scholar
• Chang WJ, Chang WP, Shyu BC. Suppression of cortical seizures by optic stimulation of the reticular thalamus in PV-mhChR2-YFP BAC transgenic mice. Mol Brain. 2017 Sep 2;10(1):42.
   PubMedGoogle Scholar
• Liu J, Lee HJ, Weitz AJ, et al. Frequency-selective control of cortical and subcortical networks by central thalamus. Elife. 2015;4:e09215.
   PubMed Web of Science ®Google Scholar
• Bastos AM, Donoghue JA, Brincat SL, et al. Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation. bioRxiv. 2020.
   Google Scholar
• Gummadavelli A, Kundishora AJ, Willie JT, et al. Neurostimulation to improve level of consciousness in patients with epilepsy. Neurosurgical Focus FOC. 01 Jun. 2015 2015;38(6):E10.
   PubMed Web of Science ®Google Scholar
• Fisher R, Salanova V, Witt T, et al. Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy. Epilepsia. 2010;51(5):899–908.
   PubMed Web of Science ®Google Scholar
• Mch L, Cook MJ. Deep brain stimulation for drug-resistant epilepsy. Epilepsia. 2018 Feb;59(2):273–290.
   PubMed Web of Science ®Google Scholar
• Laxpati NG, Kasoff WS, Gross RE. Deep Brain Stimulation for the Treatment of Epilepsy: circuits, Targets, and Trials. Neurotherapeutics. 2014 [2014 july 01];11(3):508–526.
   PubMed Web of Science ®Google Scholar
• Tellez-Zenteno JF, McLachlan RS, Parrent A, et al. Hippocampal electrical stimulation in mesial temporal lobe epilepsy. Neurology. [2006 May 23];66(10):1490–1494.
   PubMed Web of Science ®Google Scholar
• Fisher RS, Uematsu S, Krauss GL, et al. Placebo-controlled pilot study of centromedian thalamic stimulation in treatment of intractable seizures. Epilepsia. 1992 Sep-Oct;33(5):841–851.
   PubMed Web of Science ®Google Scholar
• Wright GD, McLellan DL, Brice JG. A double-blind trial of chronic cerebellar stimulation in twelve patients with severe epilepsy. J Neurol Neurosurg Psychiatry. 1984 Aug;47(8):769–774.
   PubMed Web of Science ®Google Scholar
• Salanova V, Witt T, Worth R, et al. Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy. Neurology. 2015;84(10):1017–1025.
   PubMed Web of Science ®Google Scholar
• Morrell MJ. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011;77(13):1295–1304.
   PubMed Web of Science ®Google Scholar
• Skarpaas TL, Morrell MJ. Intracranial stimulation therapy for epilepsy. Neurotherapeutics. 2009 Apr;6(2):238–243.
   PubMed Web of Science ®Google Scholar
• Skarpaas TL, Jarosiewicz B, Morrell MJ. Brain-responsive neurostimulation for epilepsy (RNS((R)) System). Epilepsy Res. 2019 Jul;153:68–70.
   PubMed Web of Science ®Google Scholar
• Morrell MJ; Group RNSSiES. Responsive cortical stimulation for the treatment of medically intractable partial epilepsy. Neurology. 2011 Sep 27;77(13):1295–1304.
   PubMed Web of Science ®Google Scholar
• Nair DR, Laxer KD, Weber PB, et al. Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy. Neurology. 2020;95(9):e1244–e1256.
   PubMed Web of Science ®Google Scholar
• Blair RD. Temporal lobe epilepsy semiology. Epilepsy Res Treat. 2012;2012:751510.
   PubMedGoogle Scholar
• Sherdil A, Coizet V, Pernet-Gallay K, et al. Implication of Anterior Nucleus of the Thalamus in Mesial Temporal Lobe Seizures. Neuroscience. 2019 [2019 oct 15];418:279–290.
   PubMed Web of Science ®Google Scholar
• Heath RG. Electrical self-stimulation of the brain in man. Am J Psychiatry. 1963;120(6):571–577.
   PubMed Web of Science ®Google Scholar
• Upton AR, Cooper IS, Springman M, et al. Suppression of seizures and psychosis of limbic system origin by chronic stimulation of anterior nucleus of the thalamus. Int J Neurol. 1985;19-20:223–230.
   PubMedGoogle Scholar
• Hodaie M, Wennberg RA, Dostrovsky JO, et al. Chronic anterior thalamus stimulation for intractable epilepsy. Epilepsia. 2002 Jun;43(6):603–608.
   PubMed Web of Science ®Google Scholar
• Kerrigan JF, Litt B, Fisher RS, et al. Electrical stimulation of the anterior nucleus of the thalamus for the treatment of intractable epilepsy. Epilepsia. 2004 Apr;45(4):346–354.
   PubMed Web of Science ®Google Scholar
• Lim SN, Lee ST, Tsai YT, et al. Electrical stimulation of the anterior nucleus of the thalamus for intractable epilepsy: a long-term follow-up study. Epilepsia. 2007 Feb;48(2):342–347.
   PubMed Web of Science ®Google Scholar
• Osorio I, Overman J, Giftakis J, et al. High frequency thalamic stimulation for inoperable mesial temporal epilepsy. Epilepsia. 2007 Aug;48(8):1561–1571.
   PubMed Web of Science ®Google Scholar
• Elder C, Friedman D, Devinsky O, et al. Responsive neurostimulation targeting the anterior nucleus of the thalamus in 3 patients with treatment‐resistant multifocal epilepsy. Epilepsia Open. 2019;4(1):187–192.
   PubMedGoogle Scholar
• Herlopian A, Cash SS, Eskandar EM, et al. Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy. Ann Clin Transl Neurol. 2019 Oct;6(10):2104–2109.
   PubMed Web of Science ®Google Scholar
• Kokoszka MA, Panov F, La Vega-Talbott M, et al. Treatment of medically refractory seizures with responsive neurostimulation: 2 pediatric cases. J Neurosurg Pediatr. 2018 Apr;21(4):421–427.
   PubMed Web of Science ®Google Scholar
• Singhal NS, Numis AL, Lee MB, et al. Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy. Epilepsy Behav Case Rep. 2018;10:21–24.
   PubMed Web of Science ®Google Scholar
• Welch WP, Hect JL, Abel TJ. Case Report: responsive Neurostimulation of the Centromedian Thalamic Nucleus for the Detection and Treatment of Seizures in Pediatric Primary Generalized Epilepsy. Front Neurol. 2021;12:656585.
   PubMed Web of Science ®Google Scholar
• Rosenberg DS, Mauguière F, Catenoix H, et al. Reciprocal thalamocortical connectivity of the medial pulvinar: a depth stimulation and evoked potential study in human brain. Cereb Cortex. 2009 Jun;19(6):1462–1473.
   PubMed Web of Science ®Google Scholar
• Filipescu C, Lagarde S, Lambert I, et al. The effect of medial pulvinar stimulation on temporal lobe seizures. Epilepsia. 2019 Apr;60(4):e25–e30.
   PubMed Web of Science ®Google Scholar
• Arthuis M, Valton L, Régis J, et al. Impaired consciousness during temporal lobe seizures is related to increased long-distance cortical-subcortical synchronization. Brain. 2009 Aug;132(Pt 8):2091–2101.
   PubMedGoogle Scholar
• Chatzikonstantinou A, Gass A, Forster A, et al. Features of acute DWI abnormalities related to status epilepticus. Epilepsy Res. 2011 Nov;97(1–2):45–51.
   PubMed Web of Science ®Google Scholar
• Capecchi F, Mothersill I, Imbach LL. The medial pulvinar as a subcortical relay in temporal lobe status epilepticus. Seizure. 2020 Oct;81:276–279.
   PubMed Web of Science ®Google Scholar
• Burdette DE, Haykal MA, Jarosiewicz B, et al. Brain-responsive corticothalamic stimulation in the centromedian nucleus for the treatment of regional neocortical epilepsy. Epilepsy Behav. 2020;112:107354.
   PubMed Web of Science ®Google Scholar
• Mullan S, Vailati G, Karasick J, et al. Thalamic lesions for the control of epilepsy. A study of nine cases. Arch Neurol. 1967 Mar;16(3):277–285.
   PubMedGoogle Scholar
• Sitnikov AR, Grigoryan YA, Mishnyakova LP. Bilateral stereotactic lesions and chronic stimulation of the anterior thalamic nuclei for treatment of pharmacoresistant epilepsy. Surg Neurol Int. 2018;9:137.
   PubMedGoogle Scholar
• Andrade DM, Zumsteg D, Hamani C, et al. Long-term follow-up of patients with thalamic deep brain stimulation for epilepsy. Neurology. [2006 May 23];66(10):1571–1573.
   PubMed Web of Science ®Google Scholar
• Krishna V, King NK, Sammartino F, et al. Anterior Nucleus Deep Brain Stimulation for Refractory Epilepsy: insights Into Patterns of Seizure Control and Efficacious Target. Neurosurgery. 2016 Jun;78(6):802–811.
   PubMed Web of Science ®Google Scholar
• Velasco M, Velasco F, Velasco AL, et al. Acute and chronic electrical stimulation of the centromedian thalamic nucleus: modulation of reticulo-cortical systems and predictor factors for generalized seizure control. Arch Med Res. 2000 May-Jun;31(3):304–315.
   PubMed Web of Science ®Google Scholar
• Velasco F, Velasco M, Ogarrio C, et al. Electrical stimulation of the centromedian thalamic nucleus in the treatment of convulsive seizures: a preliminary report. Epilepsia. 1987 Jul-Aug;28(4):421–430.
   PubMed Web of Science ®Google Scholar
• Velasco F, Velasco M, Velasco AL, et al. Electrical stimulation of the centromedian thalamic nucleus in control of seizures: long-term studies. Epilepsia. 1995 Jan;36(1):63–71.
   PubMed Web of Science ®Google Scholar
• Valentín A, García Navarrete E, Chelvarajah R, et al. Deep brain stimulation of the centromedian thalamic nucleus for the treatment of generalized and frontal epilepsies. Epilepsia. 2013 Oct;54(10):1823–1833.
   PubMed Web of Science ®Google Scholar
• Velasco AL, Velasco F, Jimenez F, et al. Neuromodulation of the centromedian thalamic nuclei in the treatment of generalized seizures and the improvement of the quality of life in patients with Lennox-Gastaut syndrome. Epilepsia. 2006 Jul;47(7):1203–1212.
   PubMed Web of Science ®Google Scholar
• Dalic LJ, Warren AEL, Bulluss KJ, et al. DBS of Thalamic Centromedian Nucleus for Lennox-Gastaut Syndrome (ESTEL Trial). Ann Neurol. 2022 Feb;91(2):253–267 .
   PubMed Web of Science ®Google Scholar
• Bagla R, Skidmore CT. Frontal lobe seizures. Neurologist. 2011 May;17(3):125–135.
   PubMed Web of Science ®Google Scholar
• Huang W, Lu G, Zhang Z, et al. Gray-matter volume reduction in the thalamus and frontal lobe in epileptic patients with generalized tonic-clonic seizures. J Neuroradiol. 2011 Dec;38(5):298–303.
   PubMed Web of Science ®Google Scholar
• Law N, Smith ML, Widjaja E. Thalamocortical connections and executive function in pediatric temporal and frontal lobe Epilepsy. AJNR Am J Neuroradiol. 2018 Aug;39(8):1523–1529.
   PubMed Web of Science ®Google Scholar
• Phillips RK, Aghagoli G, Blum AS, et al. Bilateral thalamic responsive neurostimulation for multifocal, bilateral frontotemporal epilepsy: illustrative case. J Neuro: Case Lessons. 2022;3(12).
   PubMedGoogle Scholar
• Pizzo F, Roehri N, Giusiano B, et al. The Ictal Signature of Thalamus and Basal Ganglia in Focal Epilepsy: a SEEG Study. Neurology. [2021 Jan 12];96(2):e280–e293.
   PubMed Web of Science ®Google Scholar
• Gummadavelli A, Zaveri HP, Spencer DD, et al. Expanding brain–computer interfaces for controlling epilepsy networks: novel thalamic responsive neurostimulation in refractory epilepsy [hypothesis and theory]. Front Neurosci. 2018 2018-July-31;12:474 .
   PubMed Web of Science ®Google Scholar
• Devinsky O, Spruill T, Thurman D, et al. Recognizing and preventing epilepsy-related mortality: a call for action. Neurology. [2016 Feb 23];86(8):779–786.
   PubMed Web of Science ®Google Scholar
• Blumenfeld H. Epilepsy and the consciousness system: transient vegetative state? Neurol Clin. 2011 Nov;29(4):801–823.
   PubMed Web of Science ®Google Scholar
• Kokkinos V, Sisterson ND, Wozny TA, et al. Association of closed-loop brain stimulation neurophysiological features with seizure control among patients with focal Epilepsy. JAMA Neurol. 2019;76(7):800–808.
   PubMed Web of Science ®Google Scholar
• Scheid BH, Bernabei JM, Khambhati AN, et al. Synchronizability predicts effective responsive neurostimulation for epilepsy prior to treatment. medRxiv. 2021.
   Google Scholar
• Klinger N, Mittal S. Deep brain stimulation for seizure control in drug-resistant epilepsy. Neurosurg Focus. 2018 Aug;45(2):E4.
   PubMed Web of Science ®Google Scholar
• Vertes RP, Linley SB, Hoover WB. Limbic circuitry of the midline thalamus. Neurosci Biobehav Rev. 2015 Jul;54:89–107.
   PubMed Web of Science ®Google Scholar
• Taber KH, Wen C, Khan A, et al. The limbic thalamus. J Neuropsychiatry Clin Neurosci. 2004 Spring;16(2):127–132.
   PubMed Web of Science ®Google Scholar
• Schiff ND, Giacino JT, Kalmar K, et al. Behavioural improvements with thalamic stimulation after severe traumatic brain injury. Nature. [2007 Aug 2];448(7153):600–603.
   PubMed Web of Science ®Google Scholar
• Xu J, Galardi MM, Pok B, et al. Thalamic stimulation improves postictal cortical arousal and behavior. J Neurosci. [2020 Sep 16];40(38):7343–7354.
   PubMed Web of Science ®Google Scholar
• Bertram EH, Mangan PS, Zhang D, et al. The midline thalamus: alterations and a potential role in limbic epilepsy. Epilepsia. 2001 Aug;42(8):967–978.
   PubMed Web of Science ®Google Scholar
• Dolleman-van D, Weel MJ, Witter MP. The thalamic midline nucleus reuniens: potential relevance for schizophrenia and epilepsy. Neurosci Biobehav Rev. 2020 Dec;119:422–439.
   PubMed Web of Science ®Google Scholar
• Sloan DM, Zhang D, Bertram EH 3rd. Excitatory amplification through divergent-convergent circuits: the role of the midline thalamus in limbic seizures. Neurobiol Dis. 2011 Aug;43(2):435–445.
   PubMed Web of Science ®Google Scholar
• Romeo A, Issa Roach AT, Toth E, et al. Early ictal recruitment of midline thalamus in mesial temporal lobe epilepsy. Ann Clin Transl Neurol. 2019 Aug;6(8):1552–1558.
   PubMed Web of Science ®Google Scholar
• Pergola G, Danet L, Pitel AL, et al. The regulatory role of the human mediodorsal thalamus. Trends Cogn Sci. 2018 Nov;22(11):1011–1025.
   PubMed Web of Science ®Google Scholar
• Wang Z, Zhang Z, Jiao Q, et al. Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI. PLoS One. 2012;7(7):e39701.
   PubMed Web of Science ®Google Scholar
• Zhang CH, Sha Z, Mundahl J, et al. Thalamocortical relationship in epileptic patients with generalized spike and wave discharges–A multimodal neuroimaging study. Neuroimage Clin. 2015;9:117–127.
   PubMed Web of Science ®Google Scholar
• Nail-Boucherie K, Le-Pham BT, Gobaille S, et al. Evidence for a role of the parafascicular nucleus of the thalamus in the control of epileptic seizures by the superior colliculus. Epilepsia. 2005 Jan;46(1):141–145.
   PubMed Web of Science ®Google Scholar
• Chen B, Xu C, Wang Y, et al. A disinhibitory nigra-parafascicular pathway amplifies seizure in temporal lobe epilepsy. Nat Commun. [2020 Feb 17];11(1):923.
   PubMed Web of Science ®Google Scholar
• Fisher RS. The new classification of seizures by the international league against epilepsy 2017. Curr Neurol Neurosci Rep. 2017 Jun;17(6):48.
   PubMed Web of Science ®Google Scholar
• Zillgitt AJ, Haykal MA, Chehab A, et al. Centromedian thalamic neuromodulation for the treatment of idiopathic generalized epilepsy. Front Hum Neurosci. 2022;16:907716.
   PubMed Web of Science ®Google Scholar
• Sisterson ND, Kokkinos V, Urban A, et al. Responsive neurostimulation of the thalamus improves seizure control in idiopathic generalised epilepsy: initial case series. J Neurol Neurosurg Psychiatry. 2022 May;93(5):491–498.
   PubMed Web of Science ®Google Scholar
• Mormann F, Andrzejak RG, Elger CE, et al. Seizure prediction: the long and winding road. Brain. 2007;130(2):314–333.
   PubMedGoogle Scholar
• Kuhlmann L, Lehnertz K, Richardson MP, et al. Seizure prediction — ready for a new era. Nat Rev Neurol. 2018 [2018 oct 01];14(10):618–630.
   PubMed Web of Science ®Google Scholar
• Sirica D, Hewitt AL, Tarolli CG, et al. Neurophysiological biomarkers to optimize deep brain stimulation in movement disorders. Neurodegener Dis Manag. 2021 Aug;11(4):315–328.
   PubMedGoogle Scholar
• Rowland NC, De Hemptinne C, Swann NC, et al. Task-related activity in sensorimotor cortex in Parkinson’s disease and essential tremor: changes in beta and gamma bands. Front Hum Neurosci. 2015;9:512.
   PubMed Web of Science ®Google Scholar
• Cole SR, van der Meij R, Peterson EJ, et al. Nonsinusoidal beta oscillations reflect cortical pathophysiology in Parkinson’s disease. J Neurosci. [2017 May 3];37(18):4830–4840.
   PubMed Web of Science ®Google Scholar
• Ahn M, Lee S, Lauro PM, et al. Rapid motor fluctuations reveal short-timescale neurophysiological biomarkers of Parkinson’s disease. J Neural Eng. [2020 Aug 27];17(4):046042.
   PubMed Web of Science ®Google Scholar
• Lauro PM, Lee S, Amaya DE, et al. Decoding dynamically shifting states of parkinson’s disease: tremor, bradykinesia, and effective motor control. bioRxiv. 2022.
   Google Scholar
• Scherer M, Milosevic L, Guggenberger R, et al. Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy. NeuroImage. 2020 [2020 sep 01];218:116967.
   PubMed Web of Science ®Google Scholar
• Gadot R, Korst G, Shofty B, et al. Thalamic stereoelectroencephalography in epilepsy surgery: a scoping literature review. J Neurosurg. 2022;11:1–16.
   Google Scholar