Using pharmacotherapy to address sleep disturbances in autism spectrum disorders

References

• Schroder CM, Banaschewski T, Fuentes J, et al. Pediatric prolonged-release melatonin for insomnia in children and adolescents with autism spectrum disorders. Expert Opin Pharmacother. 2021;22:2445–2454. doi: 10.1080/14656566.2021.1959549
   PubMed Web of Science ®Google Scholar
• Souders MC, Zavodny S, Eriksen W, et al. Sleep in Children with Autism Spectrum Disorder. Curr Psychiatry Rep. 2017;19(6):34. doi: 10.1007/s11920-017-0782-x
   PubMed Web of Science ®Google Scholar
• Zeidan J, Fombonne E, Scorah J, et al. Global prevalence of autism: A systematic review update. Autism Res. 2022;15(5):778–790. doi: 10.1002/aur.2696
   PubMed Web of Science ®Google Scholar
• Maenner MJ, Shaw KA, Bakian AV, et al. Prevalence and Characteristics of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2018. MMWR Surveill Summ. 2021;70(11):1–16. doi: 10.15585/mmwr.ss7011a1
   Web of Science ®Google Scholar
• Ogundele MO, Yemula C. Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians. World J Clin Pediatr. 2022;11(3):239–252. doi: 10.5409/wjcp.v11.i3.239
   PubMedGoogle Scholar
• Humphreys JS, Gringras P, Blair PS, et al. Sleep patterns in children with autistic spectrum disorders: a prospective cohort study. Arch Dis Child. 2014;99:114–118. doi: 10.1136/archdischild-2013-304083
   PubMed Web of Science ®Google Scholar
• Couturier JL, Speechley KN, Steele M, et al. Parental Perception of Sleep Problems in Children of Normal Intelligence With Pervasive Developmental Disorders: Prevalence, Severity, and Pattern. J Am Acad Child Adolesc Psychiatry. 2005;44(8):815–822. doi: 10.1097/01.chi.0000166377.22651.87
   PubMed Web of Science ®Google Scholar
• Astill RG, Van der Heijden KB, Van IJzendoorn MH, et al. Sleep, cognition, and behavioral problems in school-age children: A century of research meta-analyzed. Psychol Bull. 2012;138(6):1109–1138. doi: 10.1037/a0028204
   PubMed Web of Science ®Google Scholar
• Pandina G, Ring RH, Bangerter A, et al. Current Approaches to the Pharmacologic Treatment of Core Symptoms Across the Lifespan of Autism Spectrum Disorder. Psychiatric Clinics of North America. 2020;43(4):629–645. doi: 10.1016/j.psc.2020.08.003
   PubMed Web of Science ®Google Scholar
• Richdale AL, Schreck KA. Sleep problems in autism spectrum disorders: Prevalence, nature, & possible biopsychosocial aetiologies. Sleep Medicine Reviews. 2009;13(6):403–411. doi: 10.1016/j.smrv.2009.02.003
   PubMed Web of Science ®Google Scholar
• Glickman G. Circadian rhythms and sleep in children with autism. Neurosci Biobehav Rev. 2010;34:755–768. doi: 10.1016/j.neubiorev.2009.11.017
   PubMed Web of Science ®Google Scholar
• Guénolé F, Godbout R, Nicolas A, et al. Melatonin for disordered sleep in individuals with autism spectrum disorders: Systematic review and discussion. Sleep Med Rev. 2011;15:379–387. doi: 10.1016/j.smrv.2011.02.001
   PubMed Web of Science ®Google Scholar
• Krakowiak P, Goodlin-Jones B, Hertz-Picciotto I, et al. Sleep problems in children with autism spectrum disorders, developmental delays, and typical development: a population-based study. J Sleep Res. 2008;17(2):197–206. doi: 10.1111/j.1365-2869.2008.00650.x
   PubMed Web of Science ®Google Scholar
• Cortese S, Wang F, Angriman M, et al. Sleep Disorders in Children and Adolescents with Autism Spectrum Disorder: Diagnosis, Epidemiology, and Management. CNS Drugs. 2020;34(4):415–423. doi: 10.1007/s40263-020-00710-y
   PubMed Web of Science ®Google Scholar
• Klukowski M, Wasilewska J, Lebensztejn D. Sleep and gastrointestinal disturbances in autism spectrum disorder in children. Dev Period Med. 2015;19(2):157–161.
   PubMedGoogle Scholar
• Calhoun SL, Fernandez-Mendoza J, Vgontzas AN, et al. Behavioral Profiles Associated with Objective Sleep Duration in Young Children with Insomnia Symptoms. J Abnorm Child Psychol. 2017;45(2):337–344. doi: 10.1007/s10802-016-0166-4
   PubMed Web of Science ®Google Scholar
• Schröder CM, Broquère MA, Claustrat B, et al. Approches thérapeutiques des troubles du sommeil et des rythmes chez l’enfant avec TSA. L’Encéphale. 2022;48(3):294–303. doi: 10.1016/j.encep.2021.08.005
   PubMedGoogle Scholar
• Johnson KP, Zarrinnegar P. Autism Spectrum Disorder and Sleep. Child Adolesc Psychiatr Clin N Am. 2021;30:195–208. doi: 10.1016/j.chc.2020.08.012
   PubMed Web of Science ®Google Scholar
• Licis A. Sleep Disorders: Assessment and Treatment in Preschool-Aged Children. Child Adolesc Psychiatr Clin N Am. 2017;26:587–595. doi: 10.1016/j.chc.2017.02.009
   PubMed Web of Science ®Google Scholar
• Han GT, Trevisan DA, Abel EA, et al. Associations between sleep problems and domains relevant to daytime functioning and clinical symptomatology in autism: A meta‐analysis. Autism Res. 2022;15(7):1249–1260. doi: 10.1002/aur.2758
   PubMed Web of Science ®Google Scholar
• Henderson JA, Barry TD, Bader SH, et al. The relation among sleep, routines, and externalizing behavior in children with an autism spectrum disorder. Res Autism Spectr Disord. 2011;5:758–767. doi: 10.1016/j.rasd.2010.09.003
   Web of Science ®Google Scholar
• Goldman SE, McGrew S, Johnson KP, et al. Sleep is associated with problem behaviors in children and adolescents with Autism Spectrum Disorders. Res Autism Spectr Disord. 2011;5:1223–1229. doi: 10.1016/j.rasd.2011.01.010
   Web of Science ®Google Scholar
• Cohen S, Conduit R, Lockley SW, et al. The relationship between sleep and behavior in autism spectrum disorder (ASD): a review. J Neurodev Disord. 2014;6(1):44. doi: 10.1186/1866-1955-6-44
   PubMedGoogle Scholar
• Cuomo BM, Vaz S, Lee EAL, et al. Effectiveness of Sleep-Based Interventions for Children with Autism Spectrum Disorder: A Meta-Synthesis. Pharmacother J Human Pharmacol Drug Ther. 2017;37(5):555–578. doi: 10.1002/phar.1920
   Google Scholar
• Williams Buckley A, Hirtz D, Oskoui M, et al. Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder. Neurology. 2020;94(9):392–404. doi: 10.1212/WNL.0000000000009033
   PubMed Web of Science ®Google Scholar
• Kennaway DJ. Melatonin and development: Physiology and pharmacology. Semin Perinatol. 2000;24:258–266. doi: 10.1053/sper.2000.8594
   PubMed Web of Science ®Google Scholar
• Gobbi G, Comai S. Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep. Front Endocrinol. 2019; 10. doi: 10.3389/fendo.2019.00087
   PubMed Web of Science ®Google Scholar
• Bruni O, Alonso-Alconada D, Besag F, et al. Current role of melatonin in pediatric neurology: Clinical recommendations. Eur J Paediatr Neurol. 2015;19(2):122–133. doi: 10.1016/j.ejpn.2014.12.007
   PubMed Web of Science ®Google Scholar
• Harrington RA, Lee L-C, Crum RM, et al. Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy. Autism Res. 2013;6(3):149–168. doi: 10.1002/aur.1288
   PubMed Web of Science ®Google Scholar
• Daly E, Ecker C, Hallahan B, et al. Response inhibition and serotonin in autism: a functional MRI study using acute tryptophan depletion. Brain. 2014;137(9):2600–2610. doi: 10.1093/brain/awu178
   PubMedGoogle Scholar
• Veatch OJ, Pendergast JS, Allen MJ, et al. Genetic Variation in Melatonin Pathway Enzymes in Children with Autism Spectrum Disorder and Comorbid Sleep Onset Delay. J Autism Dev Disord. 2015;45(1):100–110. doi: 10.1007/s10803-014-2197-4
   PubMed Web of Science ®Google Scholar
• Braam W, Keijzer H, Struijker Boudier H, et al. CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder?. J Intell Dis Research. 2012;57(11):993–1000. doi: 10.1111/j.1365-2788.2012.01595.x
   PubMed Web of Science ®Google Scholar
• Tordjman S, Anderson GM, Pichard N, et al. Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. Biol Psychiatry. 2005;57(2):134–138. doi: 10.1016/j.biopsych.2004.11.003
   PubMed Web of Science ®Google Scholar
• Goldman SE, Adkins KW, Calcutt MW, et al. Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep. J Autism Dev Disord. 2014;44(10):2525–2535. doi: 10.1007/s10803-014-2123-9
   PubMed Web of Science ®Google Scholar
• Rossignol DA, Frye RE. Melatonin in autism spectrum disorders: a systematic review and meta-analysis. Dev Med Child Neurol. 2011;53:783–792. doi: 10.1111/j.1469-8749.2011.03980.x
   PubMed Web of Science ®Google Scholar
• Kimland EE, Bardage C, Collin J, et al. Pediatric use of prescribed melatonin in Sweden 2006–2017: a register based study. Eur Child Adolesc Psychiatry. 2021;30(9):1339–1350. doi: 10.1007/s00787-020-01598-1
   PubMed Web of Science ®Google Scholar
• Ayyash HF, Preece P, Morton R, et al. Melatonin for sleep disturbance in children with neurodevelopmental disorders: prospective observational naturalistic study. Expert Rev Neurother. 2015;15:711–717. doi: 10.1586/14737175.2015.1041511
   PubMed Web of Science ®Google Scholar
• Damiani JM, Sweet BV, Sohoni P. Melatonin: An option for managing sleep disorders in children with autism spectrum disorder. Am J Health Syst Pharm. 2014;71(2):95–101. doi: 10.2146/ajhp130215
   PubMed Web of Science ®Google Scholar
• Wright B, Sims D, Smart S, et al. Melatonin Versus Placebo in Children with Autism Spectrum Conditions and Severe Sleep Problems Not Amenable to Behaviour Management Strategies: A Randomised Controlled Crossover Trial. J Autism Dev Disord. 2011;41(2):175–184. doi: 10.1007/s10803-010-1036-5
   PubMed Web of Science ®Google Scholar
• Gringras P, Gamble C, Jones AP, et al. Melatonin for sleep problems in children with neurodevelopmental disorders: randomised double masked placebo controlled trial. BMJ. 2012;345(nov05 1):e6664–e6664. doi: 10.1136/bmj.e6664
   PubMed Web of Science ®Google Scholar
• Cortesi F, Giannotti F, Sebastiani T, et al. Controlled-release melatonin, singly and combined with cognitive behavioural therapy, for persistent insomnia in children with autism spectrum disorders: a randomized placebo-controlled trial. J Sleep Res. 2012;21(6):700–709. doi: 10.1111/j.1365-2869.2012.01021.x
   PubMed Web of Science ®Google Scholar
• Román Martinez M, García Aguilar E, Martin Vílchez S, et al. Bioavailability of Oniria®, a Melatonin Prolonged-Release Formulation, Versus Immediate-Release Melatonin in Healthy Volunteers. Drugs R D. 2022;22(3):235–243. doi: 10.1007/s40268-022-00394-3
   PubMed Web of Science ®Google Scholar
• Gringras P, Nir T, Breddy J, et al. Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2017;56(11):948–957.e4. doi: 10.1016/j.jaac.2017.09.414
   PubMed Web of Science ®Google Scholar
• Maras A, Schroder CM, Malow BA, et al. Long-Term Efficacy and Safety of Pediatric Prolonged-Release Melatonin for Insomnia in Children with Autism Spectrum Disorder. J Child Adolesc Psychopharmacol. 2018;28:699–710. doi: 10.1089/cap.2018.0020
   PubMed Web of Science ®Google Scholar
• Malow B, Adkins KW, McGrew SG, et al. Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes. J Autism Dev Disord. 2012;42(8):1729–1737. doi: 10.1007/s10803-011-1418-3
   PubMed Web of Science ®Google Scholar
• Paavonen EJ, Nieminen-von Wendt T, Vanhala R, et al. Effectiveness of Melatonin in the Treatment of Sleep Disturbances in Children with Asperger Disorder. J Child Adolesc Psychopharmacol. 2003;13:83–95. doi: 10.1089/104454603321666225
   PubMed Web of Science ®Google Scholar
• Giannotti F, Cortesi F, Cerquiglini A, et al. An Open-Label Study of Controlled-Release Melatonin in Treatment of Sleep Disorders in Children with Autism. J Autism Dev Disord. 2006;36(6):741–752. doi: 10.1007/s10803-006-0116-z
   PubMed Web of Science ®Google Scholar
• Malow BA, Findling RL, Schroder CM, et al. Sleep, Growth, and Puberty After 2 Years of Prolonged-Release Melatonin in Children With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry. 2021;60(2):252–261.e3. doi: 10.1016/j.jaac.2019.12.007
   PubMed Web of Science ®Google Scholar
• Andersen IM, Kaczmarska J, McGrew SG, et al. Melatonin for Insomnia in Children With Autism Spectrum Disorders. J Child Neurol. 2008;23(5):482–485. doi: 10.1177/0883073807309783
   PubMed Web of Science ®Google Scholar
• Schroder CM, Malow BA, Maras A, et al. Pediatric Prolonged-Release Melatonin for Sleep in Children with Autism Spectrum Disorder: Impact on Child Behavior and Caregiver’s Quality of Life. J Autism Dev Disord. 2019;49(8):3218–3230. doi: 10.1007/s10803-019-04046-5
   PubMed Web of Science ®Google Scholar
• Nayak BN, Singh RB, Buttar H. Role of Tryptophan in Health and Disease: Systematic Review of the Anti-Oxidant, Anti-Inflammation, and Nutritional Aspects of Tryptophan and Its Metabolites. World Heart J. 2019;11(2): 161. https://www.researchgate.net/publication/336104734_Role_of_Tryptophan_in_Health_and_Disease_Systematic_Review_of_the_Anti-Oxidant_Anti-Inflammation_and_Nutritional_Aspects_of_Tryptophan_and_Its_Metabolites
   Google Scholar
• Kałużna-Czaplińska J, Gątarek P, Chirumbolo S, et al. How important is tryptophan in human health?. Crit Rev Food Sci Nutr. 2019;59:72–88. doi: 10.1080/10408398.2017.1357534
   PubMed Web of Science ®Google Scholar
• Nakade M, Akimitsu O, Wada K, et al. Can breakfast tryptophan and vitamin B6 intake and morning exposure to sunlight promote morning-typology in young children aged 2 to 6 years?. J Physiol Anthropol. 2012;31(1):11. doi: 10.1186/1880-6805-31-11
   PubMedGoogle Scholar
• Wada K, Yata S, Akimitsu O, et al. A tryptophan-rich breakfast and exposure to light with low color temperature at night improve sleep and salivary melatonin level in Japanese students. J Circadian Rhythms. 2013;11:4. doi: 10.1186/1740-3391-11-4
   PubMedGoogle Scholar
• Sutanto CN, Loh WW, Kim JE. The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression. Nutr Rev. 2022;80:306–316. doi: 10.1093/nutrit/nuab027
   PubMed Web of Science ®Google Scholar
• Schneider-Helmert D, Spinweber Cheryl L. Evaluation of l-tryptophan for treatment of insomnia: A review. Psychopharmacol (Berl). 1986;89(1):89. doi: 10.1007/BF00175180
   PubMed Web of Science ®Google Scholar
• Bergonzi P, Capocchi G, Chiurulla C, et al. Tryptophan and sleep in subjects with neuropsychiatric syndromes. Riv Neurol. 1973;43(6):403–409.
   PubMedGoogle Scholar
• Bruni O, Ferri R, Miano S, et al. l -5-Hydroxytryptophan treatment of sleep terrors in children. Eur J Pediatr. 2004;163(7):163. doi: 10.1007/s00431-004-1444-7
   PubMed Web of Science ®Google Scholar
• van Zyl LT, Chung SA, Shahid A, et al. L-Tryptophan As Treatment for Pediatric Non-Rapid Eye Movement Parasomnia. J Child Adolesc Psychopharmacol. 2018;28(6):395–401. doi: 10.1089/cap.2017.0164
   PubMed Web of Science ®Google Scholar
• Yap IKS, Angley M, Veselkov KA, et al. Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls. J Proteome Res. 2010;9:2996–3004. doi: 10.1021/pr901188e
   PubMed Web of Science ®Google Scholar
• Gevi F, Zolla L, Gabriele S, et al. Urinary metabolomics of young Italian autistic children supports abnormal tryptophan and purine metabolism. Mol Autism. 2016;7(1):47. doi: 10.1186/s13229-016-0109-5
   PubMedGoogle Scholar
• Boccuto L, Chen C-F, Pittman AR, et al. Decreased tryptophan metabolism in patients with autism spectrum disorders. Mol Autism. 2013;4(1):16. doi: 10.1186/2040-2392-4-16
   PubMedGoogle Scholar
• Murray M. 5-HTP: The Natural Way to Overcome Depression, Obesity, and Insomnia. New York: Bantam Books; 1999.
   Google Scholar
• Nevšímalová S, Oliviero B, Nevšímalová S, et al. Sleep Disorders in Children. Cham: Springer International Publishing; 2017. doi: 10.1007/978-3-319-28640-2
   Google Scholar
• Maffei ME. 5-Hydroxytryptophan (5-HTP): Natural Occurrence, Analysis, Biosynthesis, Biotechnology, Physiology and Toxicology. Int J Mol Sci. 2020;22:181. doi: 10.3390/ijms22010181
   PubMed Web of Science ®Google Scholar
• Michelson D, Page SW, Casey R, et al. An eosinophilia-myalgia syndrome related disorder associated with exposure to L-5-hydroxytryptophan. J Rheumatol. 1994;21(12):2261–2265.
   PubMed Web of Science ®Google Scholar
• Fernstrom JD. Effects and Side Effects Associated with the Non-Nutritional Use of Tryptophan by Humans. J Nutr. 2012;142:2236S–2244S. doi: 10.3945/jn.111.157065
   PubMed Web of Science ®Google Scholar
• VKM. Risk assessment of “other substances” – L-tryptophan. Opinion of the Panel on Nutrition, dietetic products. Oslo Norway; 2016. https://vkm.no/download/18.645b840415d03a2fe8f2602c/1502802082645/Risk%20assessment%20of%20%22other%20substances%22%20%E2%80%93%20L-tryptophan.pdf
   Google Scholar
• Findling RL, Schulz SC, Reed MD, et al. The Antipsychotics. Pediatr Clin North Am. 1998;45:1205–1232. doi: 10.1016/S0031-3955(05)70070-5
   PubMed Web of Science ®Google Scholar
• McCracken JT, McGough J, Shah B, et al. Risperidone in Children with Autism and Serious Behavioral Problems. N Engl J Med. 2002;347:314–321. doi: 10.1056/NEJMoa013171
   PubMed Web of Science ®Google Scholar
• Kent JM, Hough D, Singh J, et al. An Open-Label Extension Study of the Safety and Efficacy of Risperidone in Children and Adolescents with Autistic Disorder. J Child Adolesc Psychopharmacol. 2013;23:676–686. doi: 10.1089/cap.2012.0058
   PubMed Web of Science ®Google Scholar
• Golubchik P, Sever J, Weizman A. Low-Dose Quetiapine for Adolescents With Autistic Spectrum Disorder and Aggressive Behavior. Clin Neuropharmacol. 2011;34:216–219. doi: 10.1097/WNF.0b013e31823349ac
   PubMed Web of Science ®Google Scholar
• Krystal AD, Goforth HW, Roth T. Effects of antipsychotic medications on sleep in schizophrenia. Int Clin Psychopharmacol. 2008;23:150–160. doi: 10.1097/YIC.0b013e3282f39703
   PubMed Web of Science ®Google Scholar
• Food and Drug Administration. Food and Drug Administration FDA approves the first drug to treat irritability associated with autism. Risperdal. 2006. https://www.fda.gov/files/drugs/published/20-272S065-Risperidone-Clinical-CTDL-PREA.pdf
   Google Scholar
• Food and Drug Administration. Food and Drug Administration approves Abilify (aripiprazole) for the treatment of irritability associated with autistic disorder in pediatric patients (ages 6 to 17 years). 2009.
   Google Scholar
• Blackmer AB, Feinstein JA. Management of Sleep Disorders in Children With Neurodevelopmental Disorders: A Review. Pharmacother J Human Pharmacol Drug Ther. 2016;36:84–98. doi: 10.1002/phar.1686
   Google Scholar
• Megens AAHP, Awouters FHL, Schotte A, et al. Survey on the pharmacodynamics of the new antipsychotic risperidone. Psychopharmacol (Berl). 1994;114(1):9–23. doi: 10.1007/BF02245439
   PubMed Web of Science ®Google Scholar
• NICOLSON R, AWAD G, SLOMAN L. An Open Trial of Risperidone in Young Autistic Children. J Am Acad Child Adolesc Psychiatry. 1998;37(4):372–376. doi: 10.1097/00004583-199804000-00014
   PubMed Web of Science ®Google Scholar
• Gagliano A, Germanò E, Pustorino G, et al. Risperidone Treatment of Children with Autistic Disorder: Effectiveness, Tolerability, and Pharmacokinetic Implications. J Child Adolesc Psychopharmacol. 2004;14:39–47. doi: 10.1089/104454604773840472
   PubMed Web of Science ®Google Scholar
• Shea S, Turgay A, Carroll A, et al. Risperidone in the Treatment of Disruptive Behavioral Symptoms in Children With Autistic and Other Pervasive Developmental Disorders. Pediatrics. 2004;114(5):e634–41. doi: 10.1542/peds.2003-0264-F
   PubMed Web of Science ®Google Scholar
• Aman MG, Arnold MD, McDougle LE, et al. Acute and Long-Term Safety and Tolerability of Risperidone in Children with Autism. J Child Adolesc Psychopharmacol. 2005;15(6):869–884. doi: 10.1089/cap.2005.15.869
   PubMed Web of Science ®Google Scholar
• Veatch OJ, Maxwell-Horn AC, Malow BA. Sleep in Autism Spectrum Disorders. Curr Sleep Med Rep. 2015;1(2):131–140. doi: 10.1007/s40675-015-0012-1
   PubMedGoogle Scholar
• Goel R, Hong JS, Findling RL, et al. An update on pharmacotherapy of autism spectrum disorder in children and adolescents. Int Rev Psychiatry. 2018;30(1):78–95. doi: 10.1080/09540261.2018.1458706
   PubMed Web of Science ®Google Scholar
• Saller CF, Salama AI. Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacol (Berl). 1993;112(2–3):285–292. doi: 10.1007/BF02244923
   PubMed Web of Science ®Google Scholar
• Wichniak A, Wierzbicka A, Walęcka M, et al. Effects of Antidepressants on Sleep. Curr Psychiatry Rep. 2017;19(9):63. doi: 10.1007/s11920-017-0816-4
   PubMed Web of Science ®Google Scholar
• Winokur A, Demartinis N. The effects of antidepressants on sleep: The good and the bad. Psychiatric Times. 2012;29(6).
   Google Scholar
• Holmberg G. Sedative effects of maprotiline and amitriptyline. Acta Psychiatr Scand. 1988;77(5):584–586. doi: 10.1111/j.1600-0447.1988.tb05171.x
   PubMed Web of Science ®Google Scholar
• Ware JC, Brown FW, Moorad PJ, et al. Effects on Sleep: A Double-Blind Study Comparing Trimipramine to Imipramine in Depressed Insomniac Patients. Sleep. 1989;12(6):537–549. doi: 10.1093/sleep/12.6.537
   PubMed Web of Science ®Google Scholar
• Riemann D, Voderholzer U, Cohrs S, et al. Trimipramine in Primary Insomnia: Results of a Polysomnographic Double-Blind Controlled Study. Pharmacopsychiatry. 2002;35(5):165–174. doi: 10.1055/s-2002-34119
   PubMed Web of Science ®Google Scholar
• Hollander E, Phillips A, Chaplin W, et al. A Placebo Controlled Crossover Trial of Liquid Fluoxetine on Repetitive Behaviors in Childhood and Adolescent Autism. Neuropsychopharmacology. 2005;30(3):582–589. doi: 10.1038/sj.npp.1300627
   PubMed Web of Science ®Google Scholar
• Bruni O, Angriman M, Melegari MG, et al. Pharmacotherapeutic management of sleep disorders in children with neurodevelopmental disorders. Expert Opin Pharmacother. 2019;20(18):2257–2271. doi: 10.1080/14656566.2019.1674283
   PubMed Web of Science ®Google Scholar
• Younus M, Labellarte MJ. Insomnia in Children. Pediatr Drugs. 2002;4(6):391–403. doi: 10.2165/00128072-200204060-00006
   PubMedGoogle Scholar
• Wichniak A, Wierzbicka A, Jernajczyk W. Sleep and Antidepressant Treatment. Curr Pharm Des. 2012;18(36):5802–5817. doi: 10.2174/138161212803523608
   PubMed Web of Science ®Google Scholar
• Posey DJ, Guenin KD, Kohn AE, et al. A Naturalistic Open-Label Study of Mirtazapine in Autistic and Other Pervasive Developmental Disorders. J Child Adolesc Psychopharmacol. 2001;11:267–277. doi: 10.1089/10445460152595586
   PubMed Web of Science ®Google Scholar
• Monti JM. Serotonin control of sleep-wake behavior. Sleep Med Rev. 2011;15:269–281. doi: 10.1016/j.smrv.2010.11.003
   PubMed Web of Science ®Google Scholar
• Stahl SM. Mechanism of Action of Trazodone: a Multifunctional Drug. CNS Spectr. 2009;14:536–546. doi: 10.1017/S1092852900024020
   PubMed Web of Science ®Google Scholar
• Morera AL, Abreu-Gonzalez P, Henry M, et al. Trazodone Hypnotic Effect and Nocturnal Melatonin Secretion. J Clin Psychopharmacol. 2009;29:97–99. doi: 10.1097/JCP.0b013e318192e05c
   PubMed Web of Science ®Google Scholar
• Zubieta JK, Alessi NE. Acute and chronic administration of trazodone in the treatment of disruptive behavior disorders in children. J Clin Psychopharmacol. 1992;12(5):346–351. doi: 10.1097/00004714-199210000-00010
   PubMed Web of Science ®Google Scholar
• Levi G, Sogos C. Depressive disorder in pre-adolescence: comorbidity or different clinical subtypes? (A pharmacological contribution). Isr J Psychiatry Relat Sci. 1997;34(3):187–194.
   PubMed Web of Science ®Google Scholar
• Balon R. Sleep Terror Disorder and Insomnia Treated with Trazodone: A Case Report. Ann Clin Psychiatry. 1994;6(3):161–163. doi: 10.3109/10401239409148998
   PubMedGoogle Scholar
• Owens JA, Rosen CL, Mindell JA, et al. Use of pharmacotherapy for insomnia in child psychiatry practice: A national survey. Sleep Med. 2010;11:692–700. doi: 10.1016/j.sleep.2009.11.015
   PubMed Web of Science ®Google Scholar
• Pochiero I, Gorini M, Comandini A, et al. Real-World Characteristics and Treatment Patterns of Patients With Insomnia Prescribed Trazodone in the United States. Clin Ther. 2022;44:1093–1105. doi: 10.1016/j.clinthera.2022.07.004
   PubMed Web of Science ®Google Scholar
• Jaffer KY, Chang T, Vanle B, et al. Trazodone for Insomnia: A Systematic Review. Innov Clin Neurosci. 2017;14(7–8):24–34.
   PubMedGoogle Scholar
• Broese M, Riemann D, Hein L, et al. α-Adrenergic Receptor Function, Arousal and Sleep: Mechanisms and Therapeutic Implications. Pharmacopsychiatry. 2012;45(06):209–216. doi: 10.1055/s-0031-1299728
   PubMedGoogle Scholar
• Efron D, Lycett K, Sciberras E. Use of sleep medication in children with ADHD. Sleep Med. 2014;15:472–475. doi: 10.1016/j.sleep.2013.10.018
   PubMed Web of Science ®Google Scholar
• Owens JA, Babcock D, Blumer J, et al. The use of pharmacotherapy in the treatment of pediatric insomnia in primary care: rational approaches. A consensus meeting summary. J Clin Sleep Med. 2005;1(1):49–59. doi: 10.5664/jcsm.26297
   PubMed Web of Science ®Google Scholar
• Relia S, Ekambaram V. Pharmacological Approach to Sleep Disturbances in Autism Spectrum Disorders with Psychiatric Comorbidities: A Literature Review. Med Sci. 2018;6(4):95. doi: 10.3390/medsci6040095
   Google Scholar
• Jamadarkhana S, Gopal S. Clonidine in adults as a sedative agent in the intensive care unit. J Anaesthesiol Clin Pharmacol. 2010;26(4):439–445. doi: 10.4103/0970-9185.74581
   PubMedGoogle Scholar
• Fiks AG, Mayne SL, Song L, et al. Changing Patterns of Alpha Agonist Medication Use in Children and Adolescents 2009–2011. J Child Adolesc Psychopharmacol. 2015;25:362–367. doi: 10.1089/cap.2014.0122
   PubMed Web of Science ®Google Scholar
• Khan ZP, Ferguson CN, Jones RM. Alpha-2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role. Anaesthesia. 1999;54(2):146–165. doi: 10.1046/j.1365-2044.1999.00659.x
   PubMed Web of Science ®Google Scholar
• Ming X, Brimacombe M, Chaaban J, et al. Autism Spectrum Disorders: Concurrent Clinical Disorders. J Child Neurol. 2008;23(1):6–13. doi: 10.1177/0883073807307102
   PubMed Web of Science ®Google Scholar
• Ingrassia A, Turk J. The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders. Eur Child Adolesc Psychiatry. 2005;14:34–40. doi: 10.1007/s00787-005-0424-4
   PubMed Web of Science ®Google Scholar
• Bronstein AC, Spyker DA, Cantilena LR, et al. 2007 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 25th Annual Report. Clin Toxicol. 2008;46(10):927–1057. doi: 10.1080/15563650802559632
   PubMed Web of Science ®Google Scholar
• Pelayo R, Yuen K. Pediatric Sleep Pharmacology. Child Adolesc Psychiatr Clin N Am. 2012;21:861–883. doi: 10.1016/j.chc.2012.08.001
   PubMed Web of Science ®Google Scholar
• Wang M, Ramos BP, Paspalas CD, et al. α2A-AdrenoceptorsStrengthen Working Memory Networks by Inhibiting cAMP-HCN Channel Signaling in Prefrontal Cortex. Cell. 2007;129(2):397–410. doi: 10.1016/j.cell.2007.03.015
   PubMed Web of Science ®Google Scholar
• Muzur A, Pace-Schott EF, Hobson JA. The prefrontal cortex in sleep. Trends Cogn Sci. 2002;6:475–481. doi: 10.1016/S1364-6613(02)01992-7
   PubMed Web of Science ®Google Scholar
• Spiegel R, DeVos J. Central effects of guanfacine and clonidine during wakefulness and sleep in healthy subjects. Br J Clin Pharmacol. 1980;10:165S–168S. doi: 10.1111/j.1365-2125.1980.tb04925.x
   PubMed Web of Science ®Google Scholar
• Hollway JA, Aman MG. Pharmacological treatment of sleep disturbance in developmental disabilities: A review of the literature. Res Dev Disabil. 2011;32(3):939–962. doi: 10.1016/j.ridd.2010.12.035
   PubMed Web of Science ®Google Scholar
• Politte LC, Scahill L, Figueroa J, et al. A randomized, placebo-controlled trial of extended-release guanfacine in children with autism spectrum disorder and ADHD symptoms: an analysis of secondary outcome measures. Neuropsychopharmacology. 2018;43(8):1772–1778. doi: 10.1038/s41386-018-0039-3
   PubMed Web of Science ®Google Scholar
• Rugino TA. Effect on Primary Sleep Disorders When Children With ADHD Are Administered Guanfacine Extended Release. J Atten Disord. 2018;22(1):14–24. doi: 10.1177/1087054714554932
   PubMed Web of Science ®Google Scholar
• Scahill L, McCracken JT, King BH, et al. Extended-Release Guanfacine for Hyperactivity in Children With Autism Spectrum Disorder. Am J Psychiatry. 2015;172:1197–1206. doi: 10.1176/appi.ajp.2015.15010055
   PubMed Web of Science ®Google Scholar
• Griffin CE, Kaye AM, Bueno FR, et al. Benzodiazepine pharmacology and central nervous system-mediated effects. Ochsner J. 2013;13(2):214–223.
   PubMedGoogle Scholar
• Holbrook AM, Crowther R, Lotter A, et al. Meta-analysis of benzodiazepine use in the treatment of insomnia. CMAJ. 2000;162(2):225–233.
   PubMed Web of Science ®Google Scholar
• Thirumalai SS, Shubin RA, Robinson R. Rapid Eye Movement Sleep Behavior Disorder in Children With Autism. J Child Neurol. 2002;17(3):173–178. doi: 10.1177/088307380201700304
   PubMed Web of Science ®Google Scholar
• Olsen L. Hypnotic hazards: adverse effects of zolpidem and other z-drugs. Aust Prescr. 2008;31(6):146–149. doi: 10.18773/austprescr.2008.084
   Web of Science ®Google Scholar
• Ballester P, Richdale AL, Baker EK, et al. Sleep in autism: A biomolecular approach to aetiology and treatment. Sleep Med Rev. 2020;54:101357. doi: 10.1016/j.smrv.2020.101357
   PubMed Web of Science ®Google Scholar
• Furuhashi Y. Unexpected effect of Zolpidem in a patient with attention deficit hyperactivity disorder. Asian J Psychiatr. 2019;44:68–69. doi: 10.1016/j.ajp.2019.07.012
   PubMed Web of Science ®Google Scholar
• Farzam K, Sabir S, O’Rourke MC. Antihistamines. In: StatPearls [Internet].Treasure Island (FL): StatPearls Publishing; 2023. Jan. PMID: 30844215.
   Google Scholar
• Owens JA, Rosen CL, Mindell JA. Medication Use in the Treatment of Pediatric Insomnia: Results of a Survey of Community-Based Pediatricians. Pediatrics. 2003;111(5):e628–35. doi: 10.1542/peds.111.5.e628
   PubMed Web of Science ®Google Scholar
• Stahl SM. Selective Histamine H 1 Antagonism: Novel Hypnotic and Pharmacologic Actions Challenge Classical Notions of Antihistamines. CNS Spectr. 2008;13:1027–1038. doi: 10.1017/S1092852900017089
   PubMed Web of Science ®Google Scholar
• Church MK, Maurer M, Simons FER, et al. Risk of first-generation H 1 -antihistamines: a GA 2 LEN position paper. Allergy. 2010;65(4):459–466. doi: 10.1111/j.1398-9995.2009.02325.x
   PubMed Web of Science ®Google Scholar
• Kalpaklioglu F, Baccioglu A. Efficacy and Safety of H1-Antihistamines: An Update. Antiinflamm Antiallergy Agents Med Chem. 2012;11(3):230–237. doi: 10.2174/1871523011202030230
   PubMedGoogle Scholar
• Yoshikawa T, Nakamura T, Yanai K. Histaminergic neurons in the tuberomammillary nucleus as a control centre for wakefulness. Br J Pharmacol. 2021;178:750–769. doi: 10.1111/bph.15220
   PubMed Web of Science ®Google Scholar
• Rossi PG, Posar A, Parmeggiani A. Niaprazine in the Treatment of Autistic Disorder. J Child Neurol. 1999;14(8):547–550. doi: 10.1177/088307389901400814
   PubMed Web of Science ®Google Scholar
• Vuurman EF, van Veggel LM, Uiterwijk MM, et al. Seasonal allergic rhinitis and antihistamine effects on children’s learning. Ann allergy. 1993;71(2):121–126.
   PubMedGoogle Scholar
• Devnani P, Hegde A. Autism and sleep disorders. J Pediatr Neurosci. 2015;10(4):304. doi: 10.4103/1817-1745.174438
   PubMed Web of Science ®Google Scholar
• Esposito D, Belli A, Ferri R, et al. Sleeping without Prescription: Management of Sleep Disorders in Children with Autism with Non-Pharmacological Interventions and Over-the-Counter Treatments. Brain Sci. 2020;10(7):441. doi: 10.3390/brainsci10070441
   PubMed Web of Science ®Google Scholar
• Stigler KA, Posey DJ, McDougle CJ. Ramelteon for Insomnia in Two Youths with Autistic Disorder. J Child Adolesc Psychopharmacol. 2006;16:631–636. doi: 10.1089/cap.2006.16.631
   PubMed Web of Science ®Google Scholar
• Asano M, Ishitobi M, Kosaka H, et al. Ramelteon Monotherapy for Insomnia and Impulsive Behavior in High-Functioning Autistic Disorder. J Clin Psychopharmacol. 2014;34:402–403. doi: 10.1097/JCP.0000000000000137
   PubMed Web of Science ®Google Scholar
• Sills GJ, Rogawski MA. Mechanisms of action of currently used antiseizure drugs. Neuropharmacology. 2020;168:107966. doi: 10.1016/j.neuropharm.2020.107966
   PubMed Web of Science ®Google Scholar
• Bazil CW. Effects of Antiepileptic Drugs on Sleep Structure. CNS Drugs. 2003;17(10):719–728. doi: 10.2165/00023210-200317100-00003
   PubMed Web of Science ®Google Scholar
• Miano S, Ferri R. Epidemiology and Management of Insomnia in Children with Autistic Spectrum Disorders. Pediatr Drugs. 2010;12:75–84. doi: 10.2165/11316140-000000000-00000
   PubMedGoogle Scholar
• Hellings JA, Weckbaugh M, Nickel EJ, et al. ADouble-Blind, Placebo-Controlled Study of Valproate for Aggression in Youth with Pervasive Developmental Disorders. J Child Adolesc Psychopharmacol. 2005;15:682–692. doi: 10.1089/cap.2005.15.682
   PubMed Web of Science ®Google Scholar
• Wasserman S, Iyengar R, Chaplin WF, et al. Levetiracetam versus placebo in childhood and adolescent autism: a double-blind placebo-controlled study. Int Clin Psychopharmacol. 2006;21:363–367. doi: 10.1097/01.yic.0000224787.13782.0f
   PubMed Web of Science ®Google Scholar
• Hollander E, Chaplin W, Soorya L, et al. Divalproex Sodium vs Placebo for the Treatment of Irritability in Children and Adolescents with Autism Spectrum Disorders. Neuropsychopharmacology. 2010;35(4):990–998. doi: 10.1038/npp.2009.202
   PubMed Web of Science ®Google Scholar
• Belsito KM, Law PA, Kirk KS, et al. Lamotrigine therapy for autistic disorder: a randomized double-blind, placebo-controlled trial. J Autism Dev Disord. 2001;31:175–181. doi: 10.1023/A:1010799115457
   PubMed Web of Science ®Google Scholar
• Rezaei V, Mohammadi M-R, Ghanizadeh A, et al. Double-blind, placebo-controlled trial of risperidone plus topiramate in children with autistic disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:1269–1272. doi: 10.1016/j.pnpbp.2010.07.005
   PubMed Web of Science ®Google Scholar
• Robinson AA, Malow BA. Gabapentin Shows Promise in Treating Refractory Insomnia in Children. J Child Neurol. 2013;28(12):1618–1621. doi: 10.1177/0883073812463069
   PubMed Web of Science ®Google Scholar
• Cooke JR, Loredo JS, Liu L, et al. Acetylcholinesterase Inhibitors and Sleep Architecture in Patients with Alzheimer’s Disease. Drugs & Aging. 2006;23(6):503–511. doi: 10.2165/00002512-200623060-00005
   PubMed Web of Science ®Google Scholar
• Deutsch SI, Urbano MR, Neumann SA, et al. Cholinergic Abnormalities in Autism: is there a rationale for selective nicotinic agonist interventions?. Clin Neuropharmacol. 2010;33:114–120. doi: 10.1097/WNF.0b013e3181d6f7ad
   PubMed Web of Science ®Google Scholar
• Karvat G, Kimchi T. Acetylcholine Elevation Relieves Cognitive Rigidity and Social Deficiency in a Mouse Model of Autism. Neuropsycho-pharmacology. 2014;39(4):831–840. doi: 10.1038/npp.2013.274
   PubMed Web of Science ®Google Scholar
• Buckley AW, Sassower K, Rodriguez AJ, et al. An Open Label Trial of Donepezil for Enhancement of Rapid Eye Movement Sleep in Young Children with Autism Spectrum Disorders. J Child Adolesc Psychopharmacol. 2011;21:353–357. doi: 10.1089/cap.2010.0121
   PubMed Web of Science ®Google Scholar
• Kumar A, Gupta V, Sharma S, et al. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023. Jan. PMID: 30020629.
   Google Scholar
• Honomichl RD, Goodlin‐Jones BL, Burnham MM, et al. Secretin and sleep in children with autism. Child Psychiatry Hum Dev. 2002;33:107–123. doi: 10.1023/A:1020778108068
   PubMed Web of Science ®Google Scholar
• Roberts W, Weaver L, Brian J, et al. Repeated Doses of Porcine Secretin in the Treatment of Autism: A Randomized, Placebo-Controlled Trial. Pediatrics. 2001;107(5):e71–e71. doi: 10.1542/peds.107.5.e71
   PubMed Web of Science ®Google Scholar
• Sponheim E, Oftedal G, Helverschou SB. Multiple doses of secretin in the treatment of autism: a controlled study. Acta Paediatr. 2002;91(5):540–545. doi: 10.1080/080352502753711669
   PubMed Web of Science ®Google Scholar
• Horvath K, Stefanatos G, Sokolski KN, et al. Improved social and language skills after secretin administration in patients with autistic spectrum disorders. J Assoc Acad Minor Phys. 1998;9(1):9–15.
   PubMedGoogle Scholar
• McDowell Rd E, Suite A, Phoenix AZ - Southwestern Autism Research Center: Within Our Reach: 2000 Annual Report. n.d.
   Google Scholar
• Inutsuka A, Yamanaka A. The regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin. Nagoya J Med Sci. 2013;75(1–2):29–36.
   PubMed Web of Science ®Google Scholar
• Kawabe K, Horiuchi F, Ochi M, et al. Suvorexant for the Treatment of Insomnia in Adolescents. J Child Adolesc Psychopharmacol. 2017;27:792–795. doi: 10.1089/cap.2016.0206
   PubMed Web of Science ®Google Scholar
• Bruni O, Angriman M, Calisti F, et al. Practitioner Review: Treatment of chronic insomnia in children and adolescents with neurodevelopmental disabilities. J Child Psychol Psychiatry. 2018;59(5):489–508. doi: 10.1111/jcpp.12812
   PubMed Web of Science ®Google Scholar