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Review

An update on anesthetics and impact on the brain

, , , , , & show all
Pages 997-1008 | Received 03 Apr 2017, Accepted 03 Jul 2017, Published online: 18 Jul 2017

References

  • Fodale V, Ritchie K, Rasmussen LS, et al. Anesthetics and Alzheimer’s disease: background and research. Preface. J Alzheimers Dis. 2010;22(Suppl 3):1–3.
  • Uhrig L, Dehaene S, Jarraya B. Cerebral mechanisms of general anesthesia. Ann Fr Anesth Reanim. 2014;33:72–82.
  • Mandal PK, Fodale V. Anesthetics and Alzheimer’s disease. Editorial. J Alzheimers Dis. 2010;22(Suppl 3):135–136.
  • Vutskits L, Xie Z. Lasting impact of general anaesthesia on the brain: mechanisms and relevance. Nat Rev Neurosci. 2016;17:705–717.
  • Mandal PK, Saharan S, Penna O, et al. Anesthesia issues in central nervous system disorders. Curr Aging Sci. 2016;9:116–143.
  • Vlisides P, Xie Z. Neurotoxicity of general anesthetics: an update. Curr Pharm Des. 2012;18:6232–6240.
  • Mandal PK, Fodale V. Editorial: smaller molecular-sized anaesthetics oligomerize Aβ peptide simulating Alzheimer’s disease: a relevant issue. Eur J Anaesthesiol. 2009;26:805–806.
  • Mandal PK, Schifilliti D, Mafrica F, et al. Inhaled anesthesia and cognitive performance. Drugs of Today. 2009;45:55–62.
  • Mandal PK, Schifilliti D, Mafrica F, et al. Inhaled anesthesia and cognitive performance. Drugs Today (Barc). 2009;45:47–54.
  • Zurek AA, Yu J, Wang DS, et al. Sustained increase in alpha5GABAA receptor function impairs memory after anesthesia. J Clin Invest. 2014;124:5437–5441.
  • Paredes S, Cortinez L, Contreras V, et al. Post-operative cognitive dysfunction at 3 months in adults after non-cardiac surgery: a qualitative systematic review. Acta Anaesthesiol Scand. 2016;60:1043–1058.
  • Fodale V, Santamaria LB, Schifilliti D, et al. Anaesthetics and postoperative cognitive dysfunction: a pathological mechanism mimicking Alzheimer’s disease. Anaesthesia. 2010;65:388–395.
  • Oomens MA, Booij LH, Baart JA. [The risk of general anaesthesia and sedation in the older people]. Ned Tijdschr Tandheelkd. 2015;122:674–679.
  • Rasmussen LS, Steinmetz J. Ambulatory anaesthesia and cognitive dysfunction. Curr Opin Anaesthesiol. 2015;28:631–635.
  • Zhang C, Li C, Xu Z, et al. The effect of surgical and psychological stress on learning and memory function in aged C57BL/6 mice. Neuroscience. 2016;320:210–220.
  • Pratico C, Quattrone D, Lucanto T, et al. Drugs of anesthesia acting on central cholinergic system may cause post-operative cognitive dysfunction and delirium. Med Hypotheses. 2005;65:972–982.
  • Fodale V, Santamaria LB. Drugs of anesthesia, central nicotinic receptors and post-operative cognitive dysfunction. Acta Anaesthesiol Scand. 2003;47:1180;author reply 1.
  • Fodale V, Santamaria LB. The inhibition of central nicotinic nAch receptors is the possible cause of prolonged cognitive impairment after anesthesia. Anesth Analg. 2003;97:1207; author reply.
  • Ozer AB, Demirel I, Erhan OL, et al. Effect of different anesthesia techniques on the serum brain-derived neurotrophic factor (BDNF) levels. Eur Rev Med Pharmacol Sci. 2015;19:3886–3894.
  • Zhu Y, Wang Y, Yao R, et al. Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period. J Neuroinflammation. 2017;14:6.
  • Li Y, Pan K, Chen L, et al. Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. J Neuroinflammation. 2016;13:268.
  • Zheng B, Lai R, Li J, et al. Critical role of P2X7 receptors in the neuroinflammation and cognitive dysfunction after surgery. Brain Behav Immun. 2017;61:365–374.
  • Moller JT, Cluitmans P, Rasmussen LS, et al. Long-term postoperative cognitive dysfunction in the elderly ISPOCD1 study. ISPOCD investigators. International Study of Post-Operative Cognitive Dysfunction. Lancet. 1998;351:857–861.
  • Yang L, Xin X, Zhang J, et al. Inflammatory pain may induce cognitive impairment through an interlukin-6-dependent and postsynaptic density-95-associated mechanism. Anesth Analg. 2014;119:471–480.
  • Hughes CG, Patel MB, Jackson JC, et al.; Mind-Icu B-ICUi. Surgery and anesthesia exposure is not a risk factor for cognitive impairment after major noncardiac surgery and critical illness. Ann Surg. 2017;265:1126–1133.
  • Zhang TZ, Zhou J, Jin Q, et al. Protective effects of remifentanil preconditioning on cerebral injury during pump-assisted coronary artery bypass graft. Genet Mol Res. 2014;13:7658–7665.
  • Salazar D, Hazel A, Tauchen AJ, et al. Neurocognitive deficits and cerebral desaturation during shoulder arthroscopy with patient in beach-chair position: a review of the current literature. Am J Orthop (Belle Mead NJ). 2016;45:E63–8.
  • Aceto P, Perilli V, Lai C, et al. Postoperative cognitive dysfunction after liver transplantation. Gen Hosp Psychiatry. 2015;37:109–115.
  • Spires-Jones TL, De Calignon A, Meyer-Luehmann M, et al. Monitoring protein aggregation and toxicity in Alzheimer’s disease mouse models using in vivo imaging. Methods. 2011;53:201–207.
  • Mandal PK, Ritchie K, Fodale V. Anesthetics and its impact on the brain and Alzheimer’s disease. J Alzheimer’s Dis. 2014;39:223–225.
  • Schenning KJ, Murchison CF, Mattek NC, et al. Surgery is associated with ventricular enlargement as well as cognitive and functional decline. Alzheimers Dement. 2016;12:590–597.
  • Schifilliti D, Santamaria LB, Rosa G, et al. Cholinergic central system, Alzheimer’s disease, and anesthetics liaison: a vicious circle? J Alzheimers Dis. 2010;22(Suppl 3):35–41.
  • Fodale V, Quattrone D, Trecroci C, et al. Alzheimer’s disease and anaesthesia: implications for the central cholinergic system. Br J Anaesth. 2006;97:445–452.
  • Mafrica F, Fodale V. Thyroid function, Alzheimer’s disease and postoperative cognitive dysfunction: a tale of dangerous liaisons? J Alzheimers Dis. 2008;14:95–105.
  • Mandal PK, Simplaceanu V, Fodale V. Intravenous anesthetic diazepam does not induce amyloid-beta peptide oligomerization but diazepam co-administered with halothane oligomerizes amyloid-beta peptide: an NMR study. J Alzheimers Dis. 2010;20:127–134.
  • Mandal PK, Bhavesh NS, Chauhan VS, et al. NMR investigations of amyloid-beta peptide interactions with propofol at clinically relevant concentrations with and without aqueous halothane solution. J Alzheimers Dis. 2010;21:1303–1309.
  • Mandal PK, Fodale V. Isoflurane and desflurane at clinically relevant concentrations induce amyloid beta-peptide oligomerization: an NMR study. Biochem Biophys Res Commun. 2009;379:716–720.
  • Tang JX, Eckenhoff MF, Eckenhoff RG. Anesthetic modulation of neuroinflammation in Alzheimer’s disease. Curr Opin Anaesthesiol. 2011;24:389–394.
  • Heneka MT, Carson MJ, El Khoury J, et al. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015;14:388–405.
  • Zhou R, Bickler P. Interaction of isoflurane, tumor necrosis factor-alpha and beta-amyloid on long-term potentiation in rat hippocampal slices. Anesth Analg. 2017;124:582–587.
  • Zhang L, Zhang J, Dong Y, et al. The potential dual effects of sevoflurane on AKT/GSK3beta signaling pathway. Med Gas Res. 2014;4:5.
  • Avramescu S, Wang DS, Lecker I, et al. Inflammation increases neuronal sensitivity to general anesthetics. Anesthesiology. 2016;124:417–427.
  • Hovens IB, Van Leeuwen BL, Nyakas C, et al. Prior infection exacerbates postoperative cognitive dysfunction in aged rats. Am J Physiol Regul Integr Comp Physiol. 2015;309:R148–59.
  • Qian XL, Zhang W, Liu MZ, et al. Dexmedetomidine improves early postoperative cognitive dysfunction in aged mice. Eur J Pharmacol. 2015;746:206–212.
  • Ni C, Li C, Dong Y, et al. Anesthetic isoflurane induces DNA damage through oxidative stress and p53 pathway. Mol Neurobiol. 2017;54;3591–3605.
  • Feng C, Liu Y, Yuan Y, et al. Isoflurane anesthesia exacerbates learning and memory impairment in zinc-deficient APP/PS1 transgenic mice. Neuropharmacology. 2016;111:119–129.
  • Acharya NK, Goldwaser EL, Forsberg MM, et al. Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: possible link to postoperative delirium and cognitive decline. Brain Res. 2015;1620:29–41.
  • Lee JH, Zhang J, Wei L, et al. Neurodevelopmental implications of the general anesthesia in neonate and infants. Exp Neurol. 2015;272:50–60.
  • Woloszczuk-Gebicka B. Why is neonatal anaesthesia such a challenge? Dev Period Med. 2015;19:319–323.
  • Nasr VG, Davis JM. Anesthetic use in newborn infants: the urgent need for rigorous evaluation. Pediatr Res. 2015;78:2–6.
  • Jevtovic-Todorovic V. Functional implications of an early exposure to general anesthesia: are we changing the behavior of our children? Mol Neurobiol. 2013;48:288–293.
  • Jevtovic-Todorovic V. General Anesthetics and neurotoxicity: how much do we know? Anesthesiol Clin. 2016;34:439–451.
  • Zhang X, Liu F, Slikker W Jr, et al. Minimally invasive biomarkers of general anesthetic-induced developmental neurotoxicity. Neurotoxicol Teratol. 2017;60:95–101.
  • Rappaport B, Mellon RD, Simone A, et al. Defining safe use of anesthesia in children. N Engl J Med. 2011;364:1387–1390.
  • Zhou L, Wang Z, Zhou H, et al. Neonatal exposure to sevoflurane may not cause learning and memory deficits and behavioral abnormality in the childhood of Cynomolgus monkeys. Sci Rep. 2015;5:11145.
  • Zhang X, Liu S, Newport GD, et al. In vivo monitoring of sevoflurane-induced adverse effects in neonatal nonhuman primates using small-animal positron emission tomography. Anesthesiology. 2016;125:133–146.
  • Makaryus R, Lee H, Feng T, et al. Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia. Anesthesiology. 2015;123:557–568.
  • Liu F, Rainosek SW, Frisch-Daiello JL, et al. Potential adverse effects of prolonged sevoflurane exposure on developing monkey brain: from abnormal lipid metabolism to neuronal damage. Toxicol Sci. 2015;147:562–572.
  • Yang B, Liang G, Khojasteh S, et al. Comparison of neurodegeneration and cognitive impairment in neonatal mice exposed to propofol or isoflurane. PLoS One. 2014;9:e99171.
  • Mesa Suarez P, Santotoribio JD, Ramos Ramos V, et al. Brain damage after general anesthesia. Med Clin (Barc). 2016;146:384–388.
  • Li L, Yu Q, Liang W. Molecular pathways of mitochondrial dysfunctions: possible cause of cell death in anesthesia-induced developmental neurotoxicity. Brain Res Bull. 2015;110:14–19.
  • Levy RJ. Carbon monoxide and anesthesia-induced neurotoxicity. Neurotoxicol Teratol. 2017;60:50–58.
  • Backeljauw B, Holland SK, Altaye M, et al. Cognition and brain structure following early childhood surgery with anesthesia. Pediatrics. 2015;136:e1–12.
  • Graham MR, Brownell M, Chateau DG, et al. Neurodevelopmental assessment in kindergarten in children exposed to general anesthesia before the age of 4 years: a retrospective matched cohort study. Anesthesiology. 2016;125:667–677.
  • Davidson AJ, Disma N, de Graaff JC, et al.; Consortium GAS. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet. 2016;387:239–250.
  • Warner DO, Flick RP. Anaesthetics, infants, and neurodevelopment: case closed? Lancet. 2016;387:202–204.
  • Pandharipande P, Ely EW, Maze M. Alpha-2 agonists: can they modify the outcomes in the Postanesthesia Care Unit? Curr Drug Targets. 2005;6:749–754.
  • Ghoneim MM, O’Hara MW. Depression and postoperative complications: an overview. BMC Surg. 2016;16:5.
  • Santos LJ, Garcia JB, Pacheco JS, et al. Quality of life, pain, anxiety and depression in patients surgically treated with cancer of rectum. Arq Bras Cir Dig. 2014;27:96–100.
  • Goebel S, Steinert A, Vierheilig C, et al. Correlation between depressive symptoms and perioperative pain: a prospective cohort study of patients undergoing orthopedic surgeries. Clin J Pain. 2013;29:392–399.
  • Kim YS, Do H, Lee JW, et al. Patient reporting pain intensity immediately after surgery can be associated with underlying depression in women with breast cancer. Psychooncology. 2016;25:308–315.
  • Kaufmann FN, Costa AP, Ghisleni G, et al. Nlrp3 inflammasome-driven pathways in depression: clinical and preclinical findings. Brain Behav Immun. 2017;64:367–383.
  • Tatebe M, Iwatsuki K, Hirata H, et al. Effects of depression and inflammatory factors on chronic conditions of the wrist. Bone Joint J. 2016;98-B:961–968.
  • Ozyurtkan MO, Yildizeli B, Kuscu K, et al. Postoperative psychiatric disorders in general thoracic surgery: incidence, risk factors and outcomes. Eur J Cardiothorac Surg. 2010;37:1152–1157.
  • Zhang L, Huang Z, Wu H, et al. Effect of swallowing training on dysphagia and depression in postoperative tongue cancer patients. Eur J Oncol Nurs. 2014;18:626–629.
  • Schutt PE, Kung S, Clark MM, et al. Comparing the Beck Depression Inventory-II (BDI-II) and Patient Health Questionnaire (PHQ-9) depression measures in an outpatient bariatric clinic. Obes Surg. 2016;26:1274–1278.
  • Vlassakova BG, Emmanouil DE. Perioperative considerations in children with autism spectrum disorder. Curr Opin Anaesthesiol. 2016;29:359–366.
  • Li C, Schaefer M, Gray C, et al. Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/c mutant mouse model. Neurotoxicol Teratol. 2017;60;69–74.
  • Creagh O, Torres H, Rivera K, et al. Previous exposure to anesthesia and autism spectrum disorder (ASD): a Puerto Rican Population-Based Sibling Cohort Study. Bol Asoc Med P R. 2015;107:29–37.
  • Chung W, Park S, Hong J, et al. Sevoflurane exposure during the neonatal period induces long-term memory impairment but not autism-like behaviors. Paediatr Anaesth. 2015;25:1033–1045.
  • Ko WR, Huang JY, Chiang YC, et al. Risk of autistic disorder after exposure to general anaesthesia and surgery: a nationwide, retrospective matched cohort study. Eur J Anaesthesiol. 2015;32:303–310.
  • Fluegge K. Does environmental exposure to the greenhouse gas, N2O, contribute to etiological factors in neurodevelopmental disorders? A mini-review of the evidence. Environ Toxicol Pharmacol. 2016;47:6–18.
  • Chien LN, Lin HC, Shao YH, et al. Risk of autism associated with general anesthesia during cesarean delivery: a population-based birth-cohort analysis. J Autism Dev Disord. 2015;45:932–942.
  • Schifilliti D, Grasso G, Conti A, et al. Anaesthetic-related neuroprotection: intravenous or inhalational agents? CNS Drugs. 2010;24:893–907.
  • Di Nino G, Adversi M, Samolsky Dekel BG, et al. Peri-operative risk management in patients with Alzheimer’s disease. J Alzheimers Dis. 2010;22(Suppl 3):121–127.
  • Bilotta F, Doronzio A, Stazi E, et al. Postoperative cognitive dysfunction: toward the Alzheimer’s disease pathomechanism hypothesis. J Alzheimers Dis. 2010;22(Suppl 3):81–89.
  • Bedford PD. Adverse cerebral effects of anaesthesia on old people. Lancet. 1955;269:259–263.

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