Does high-dose benzodiazepine abuse really produce liver toxicity? Results from a series of 201 benzodiazepine monoabusers

References

• Lader M. Benzodiazepines revisited – will we ever learn? Addiction. 2011;106:2086–2109.
   PubMed Web of Science ®Google Scholar
• Soyka M. Treatment of benzodiazepine dependence. N Engl J Med. 2017;376:2399–2400.
   PubMed Web of Science ®Google Scholar
• Moore N, Pariente A, Bégaud B. Why are benzodiazepines not yet controlled substances? JAMA Psychiatry. 2015;72:110–111.
   PubMed Web of Science ®Google Scholar
• Lugoboni F, Quaglio G. Exploring the dark side of the moon: the treatment of benzodiazepine tolerance. Br J Clin Pharmacol. 2014;77:239–241.
   PubMed Web of Science ®Google Scholar
• Ashton H. The diagnosis and management of benzodiazepine dependence. Curr Opin Psychiatry. 2005;18:249–255.
   PubMed Web of Science ®Google Scholar
• Baldwin DS, Aitchison K, Bateson A, et al. Benzodiazepines: risks and benefits. A reconsideration. J Psychopharmacol. 2013;27:967–971.
   PubMed Web of Science ®Google Scholar
• Lugoboni F, Mirijello A, Faccini M, et al. Quality of life in a cohort of high-dose benzodiazepine dependent patients. Drug Alcohol Depend. 2014;142:105–109.
   PubMed Web of Science ®Google Scholar
• Janhsen K, Roser P, Hoffmann K. The problems of long-term treatment with benzodiazepines and related substances. Dtsch Arztebl Int. 2015;112:1–7.
   PubMed Web of Science ®Google Scholar
• Fang SY, Chen CY, Chang IS, et al. Predictors of the incidence and discontinuation of long-term use of benzodiazepines: a population-based study. Drug Alcohol Depend. 2009;104:140–146.
   PubMed Web of Science ®Google Scholar
• Petitjean S, Ladewig D, Meier CR, et al. Benzodiazepine prescribing to the Swiss adult population: results from a national survey of community pharmacies. Int Clin Psychopharmacol. 2007;22:292–298.
   PubMed Web of Science ®Google Scholar
• OSMED. 2015. Available from: http://www.aifa.gov.it/sites/default/files/Rapporto_OsMed_2015__AIFA.pdf
   Google Scholar
• Ohayon MM, Lader MH. Use of psychotropic medication in the general population of France, Germany, Italy, and the United Kingdom. J Clin Psychiatry. 2002;63:817–825.
   PubMed Web of Science ®Google Scholar
• O’brien CP. Benzodiazepine use, abuse, and dependence. J Clin Psychiatry. 2005;6(Suppl 2):28–33.
   Google Scholar
• Cloos JM Benzodiazepines and addiction: long term use and withdrawal. www.PsychiatricTimes.com. Available from: http://www.ama.lu/docs/PsyTimes_part2.pdf
   Google Scholar
• Ge PS, Runyon BA. Treatment of patients with cirrhosis. N Engl J Med. 2016;375:767–777.
   PubMed Web of Science ®Google Scholar
• Bellentani S, Tiribelli C, Saccoccio G, et al. Prevalence of chronic liver disease in the general population of northern Italy: the Dionysos Study. Hepatology. 1994;20:1442–1449.
   PubMed Web of Science ®Google Scholar
• Bénichou C. Criteria of drug-induced liver disorders. Report of an international consensus meeting. J Hepatol. 1990;11:272–276.
   PubMed Web of Science ®Google Scholar
• Björnsson ES. Drug-induced liver injury: an overview over the most critical compounds. Arch Toxicol. 2015;89:327–334.
   PubMed Web of Science ®Google Scholar
• Yuan L, Kaplowitz N. Mechanisms of drug-induced liver injury. Clin Liver Dis. 2013;17:507–518.
   PubMed Web of Science ®Google Scholar
• Lammert C, Einarsson S, Saha C, et al. Relationship between daily dose of oral medications and idiosyncratic drug-induced liver injury: search for signals. Hepatology. 2008;47:2003–2009.
   PubMed Web of Science ®Google Scholar
• Howie AF, Spencer E, Beckett GJ. Aspartate aminotransferase, alanine aminotransferase, and glutathione transferase in plasma during and after sedation by low-dose isoflurane or midazolam. Clin Chem. 1992;38:476–479.
   PubMed Web of Science ®Google Scholar
• Faccini M, Leone R, Opri S, et al. Slow subcutaneous infusion of flumazenil for the treatment of long-term, high-dose benzodiazepine users: a review of 214 cases. J Psychopharmacol. 2016;30:1047–1053.
   PubMed Web of Science ®Google Scholar
• Quaglio G, Pattaro C, Gerra G, et al. High dose benzodiazepine dependence: description of 29 patients treated with flumazenil infusion and stabilised with clonazepam. Psychiatry Res. 2012;198:457–462.
   PubMed Web of Science ®Google Scholar
• Hood SD, Norman A, Hince DA, et al. Benzodiazepine dependence and its treatment with low dose flumazenil. Br J Clin Pharmacol. 2014;77:285–294.
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders. 4th ed. Washington (DC): American Psychiatric Press; 2000 (text revision).
   Google Scholar
• Liebrenz M, Boesch L, Stohler R, et al. Agonist substitution – a treatment alternative for high-dose benzodiazepine-dependent patients? Addiction. 2010;105:1870–1874.
   PubMed Web of Science ®Google Scholar
• Kim WR, Flamm SL, Di Bisceglie AM, et al. Serum activity of alanine aminotransferase (ALT) as an indicator of health and disease. Hepatology. 2008;47:1363–1370.
   PubMed Web of Science ®Google Scholar
• Aithal GP, Watkins PB, Andrade RJ, et al. Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther. 2011;89:806–815.
   PubMed Web of Science ®Google Scholar
• Galanter M, Kleber HD. The American Psychiatric publishing textbook of substance abuse treatment. 4th ed. Washington, DC; American Psychiatric Publishing; 2008.
   Google Scholar
• Pendino GM, Mariano A, Surace P, et al. Prevalence and etiology of altered liver tests: a population-based survey in a Mediterranean town. Hepatology. 2005;41:1151–1159.
   PubMed Web of Science ®Google Scholar
• Younossi ZM, Stepanova M, Afendy M, et al. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol. 2011;9:524–530.e1.
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Chatterjee J, Chaudhuri K, et al. Hepatotoxicity of diazepam. Structural and trace metal studies in rat. Biol Trace Elem Res. 1997;57:239–250.
   PubMed Web of Science ®Google Scholar
• Buchanan N, Cane RD. Liver function tests and the prolonged use of high-dose diazepam, with special reference to tetanus. S Afr Med J. 1978;54:768.
   PubMed Web of Science ®Google Scholar
• Fors B, Nilsson F. Hepatitis probably induced by diazepam medication. Lakartidningen. 1968;65:4528–4531.
   PubMedGoogle Scholar
• Tedesco FJ, Mills LR. Diazepam (Valium) hepatitis. Dig Dis Sci. 1982;27:470–472.
   PubMed Web of Science ®Google Scholar
• Roy-Byrne P, Vittone BJ, Uhde TW. Alprazolam-related hepatotoxicity. Lancet. 1983;2:786–787.
   PubMed Web of Science ®Google Scholar
• Björnsson ES, Hoofnagle JH. Categorization of drugs implicated in causing liver injury: critical assessment based on published case reports. Hepatology. 2016;63:590–603.
   PubMed Web of Science ®Google Scholar
• Islam MM, Iqbal U, Walther B, et al. Benzodiazepine use and risk of Dementia in the elderly population: a systematic review and meta-analysis. Neuroepidemiology. 2016;47:181–191.
   PubMed Web of Science ®Google Scholar
• Mirijello A, D’Angelo C, Ferrulli A, et al. Identification and management of alcohol withdrawal syndrome. Drugs. 2015;75:353–365.
   PubMed Web of Science ®Google Scholar
• Nutt DJ, King LA, Phillips LD, et al. Drug harms in the UK: a multicriteria decision analysis. Lancet. 2010;376:1558–1565.
   PubMed Web of Science ®Google Scholar