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Expert Opinion on Drug Safety Volume 21, 2022 - Issue 1
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Original Research

Adverse reactions related to proton pump inhibitors in pediatric population: an analysis of spontaneous reporting data

Valeria Dipasqualea Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood “G. Barresi,” University of Messina, Messina, ItalyView further author information
,
Giuseppe Cicalab Sicilian Regional Pharmacovigilance Center, University Hospital of Messina, Messina, ItalyView further author information
,
Francesca Laganàa Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood “G. Barresi,” University of Messina, Messina, ItalyView further author information
,
Paola Cutroneob Sicilian Regional Pharmacovigilance Center, University Hospital of Messina, Messina, ItalyView further author information
,
Patrizia Felicettic Italian Medicines Agency, Rome, ItalyView further author information
,
Simona Potenzac Italian Medicines Agency, Rome, ItalyView further author information
,
Giuseppe Trimarchid Department of Medicine, University of Messina, Messina, ItalyView further author information
,
Edoardo Spinab Sicilian Regional Pharmacovigilance Center, University Hospital of Messina, Messina, ItalyView further author information
&
Claudio Romanoa Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood “G. Barresi,” University of Messina, Messina, ItalyCorrespondence[email protected]
View further author information
 show all
Pages 127-132 | Received 24 Apr 2021, Accepted 07 Sep 2021, Published online: 20 Sep 2021

References

  • Levy EI, Salvatore S, Vandenplas Y, et al. Prescription of acid inhibitors in infants: an addiction hard to break. Eur J Pediatr. 2020;179(12):1957–1961.
  • Rosen R, Vandenplas Y, Singendonk M, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American society for pediatric gastroenterology, hepatology, and nutrition and the European society for pediatric gastroenterology, hepatology, and nutrition. J Pediatr Gastroenterol Nutr. 2018;66:516–554.
  • Salvatore SPF, Huysentruyt K, Bosco A, et al. Distress in infants and young children: don’t blame acid reflux. J Pediatr Gastroenterol Nutr. 2020;71(4):465–469.
  • Ward R, Kearns G. Proton pump inhibitors in pediatrics: mechanism of action, pharmacokinetics, pharmacogenetics, and pharmacodynamics. Paediatr Drugs. 2013;15(2):119–131.
  • O’Reilly D, Conway R, O’Connor L, et al. Use of anti-reflux medications in infants under 1 year of age: a retrospective drug utilization study using national prescription reimbursement data. Eur J Pediatr. 2020;179(12):1963–1967.
  • De Bruyne P, Christiaens T, Vander SR, et al. Changes in prescription patterns of acid-suppressant medications by belgian pediatricians: analysis of the national database, [1997-2009]. J Pediatr Gastroenterol Nutr. 2014;58(2):220–225.
  • Blank ML, Parkin L. National study of off-label proton pump inhibitor use among New Zealand infants in the first year of life (2005-2012). J Pediatr Gastroenterol Nutr. 2017;65(2):179–184.
  • Barron JJ, Tan H, Spalding J, et al. Proton pump inhibitor utilization patterns in infants. J Pediatr Gastroenterol Nutr. 2007;45(4):421–427.
  • Illueca M, Alemayehu B, Shoetan N, et al. Proton pump inhibitor prescribing patterns in newborns and infants. J Pediatr Pharmacol Ther. 2014;19:283–287.
  • Aznar-Lou I, Reilev M, Lødrup AB, et al. Use of proton pump inhibitors among Danish children: a 16-year register-based nationwide study. Basic Clin Pharmacol Toxicol. 2019;124(6):704–710.
  • Joret-Descout P, Dauger S, Bellaiche M, et al. Guidelines for proton pump inhibitor prescriptions in paediatric intensive care unit. Int J Clin Pharm. 2017;39(1):181–186.
  • Eghbali A, Khalilpour A, Taherahmadi H, et al. Pantoprazole reduces serum ferritin in patients with thalassemia major and intermedia: a randomized, controlled study. Therapie. 2019;74(5):507–512.
  • Malchodi L, Wagner K, Susi A, et al. Early acid suppression therapy exposure and fracture in young children. Pediatrics. 2019;144(1):e20182625.
  • Canani RB, Cirillo P, Roggero P, et al. Therapy with gastric acidity inhibitors increases the risk of acute gastroenteritis and community-acquired pneumonia in children. Pediatrics. 2006;117(5):e817–e820.
  • Mitre E, Susi A, Kropp LE, et al. Association between use of acid-suppressive medications and antibiotics during infancy and allergic diseases in early childhood. JAMA Pediatr. 2018;172(6):e180315.
  • Cheung KS, Chan EW, Wong AYS, et al. Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study. Gut. 2018;67(1):28–35.
  • Schubert ML. Proton pump inhibitors: placing putative adverse effects in proper perspective. Curr Opin Gastroenterol. 2019;35(6):509–516.
  • Lanas-Gimeno A, Hijos G, Lanas Á. Proton pump inhibitors, adverse events and increased risk of mortality. Expert Opin Drug Saf. 2019;18(11):1043–1053.
  • Yadlapati R, Kahrilas PJ. The “dangers” of chronic proton pump inhibitor use. J Allergy Clin Immunol. 2018;141(1):79–81.
  • Wang L, Li M, Cao Y, et al. Proton pump inhibitors and the risk for fracture at specific sites: data mining of the FDA adverse event reporting system. Sci Rep. 7(1):5527. 2017.
  • for the J-NEPECS (Japan Nexium Pediatrics Study) Group, Shimizu T, Nakayama Y, Ishii E, et al. Oral esomeprazole in Japanese pediatric patients with gastric acid-related disease: safety, efficacy, and pharmacokinetics. Pediatr Int. 2019;61(1):87–95.
  • Davidson G, Wenzl TG, Thomson M, et al. Efficacy and safety of once-daily esomeprazole for the treatment of gastroesophageal reflux disease in neonatal patients. J Pediatr. 2013;163(3):692–698.
  • Levy EI, Hoang DM, Vandenplas Y. The effects of proton pump inhibitors on the microbiome in young children. Acta Paediatr. 2020;109(8):1531–1538.
  • Hazell L, Shakir SA. Under-reporting of adverse drug reactions. Drug Safety. 2006;29(5):385–396.

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