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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 24, 2009 - Issue 1
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Research Article

New diterpenoid alkaloids from Aconitum heterophyllum Wall: Selective butyrylcholinestrase inhibitors

Muhammad Nisar Institute of Chemical Sciences and Department of Pharmacy, University of Peshawar, Peshawar 25120, PakistanCorrespondence[email protected]
,
Obaidullah Institute of Chemical Sciences and Department of Pharmacy, University of Peshawar, Peshawar 25120, Pakistan
,
Manzoor Ahmad H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
,
Noreen Wadood Department of Biochemistry, Kabir Medical College, Peshawar, Pakistan
,
Muhammad Arif Lodhi H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
,
Farzana Shaheen H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
&
M. Iqbal Choudhary H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
 show all
Pages 47-51 | Received 10 Oct 2007, Accepted 07 Nov 2007, Published online: 20 Oct 2008

References

  • Atta-ur-Rahman, A Nasreen, F Akhtar, MS Shekhani, J Clardy, M Parvez, and MI Choudhary. (1997). Antifungal diterpenoid alkaloids from Delphinium denudatum. J Nat Prod 60:472–474.
  • MH Benn, and JM. Jacuno In: SW Pelletier. editor. Alkaloids: Chemical and biological perspectives. Vol. 1. Chapter 4. New York: Wiley; (1984). p 153–209.
  • MG Hertog, EJ Feskens, PC Hollman, MB Katan, and D Kromhout. (1993). Dietary antioxidant flavonoids and risk of coronary heart disease: The Zutphen elderly study. Lancet 342:1007–1011.
  • JM Jacyno, JS Harwood, N-H Lin, JE Campbell, JP Sullivan, and MW Holladay. (1996). J Nat Prod 59:707.
  • NG Bisset. (1981). Arrow poisons in China. Part II. Aconitum-botany, chemistry, and pharmacology. J Ethnopharmacol 4:247–336.
  • KS Mhaskar, E Blatter, and JF Caius. (2000). Ind Med Plants 1:28.
  • T Baytop. Theraphy with medicinal plants in Turkey (past and present). Istanbul University; Publication No. 3255. (1984). p 187.
  • SW Pelletier, R Aneja, and KW Gopinath. (1968). 635The alkaloids of aconitum heterophyllum wall: Isolation and characterization. Phytochemsitry 7:625–629.
  • SW Pelletier, MMA Abdel, FM Janet, VM Naresh, and CS Lee. (1982). Atisenol, a new entatisene diterpenoid lactone from aconitum heterophyllum. J Nat Prod 45 (6):779–781.
  • WA Jacobs, and LC Craig. (1942). The aconite alkaloids. IX. The isolation of two new alkaloids from aconitum heterophyllum, heteratisine and hetisine. J Biol Chem 143:605–609.
  • WA Jacobs, and LC Craig. (1943). The aconite alkaloids. xii. Benzoyl heteratisine, a new alkaloid from aconitum heterophyllum. J Biol Chem 147:571–572.
  • V Tougu. (2001). Acetylcholinesterase: Mechanism of catalysis and inhibition. Curr Med Chem 1:155–170.
  • EK Perry. (1986). The cholinergic hypothesis—ten years on. Br Med Bull 42:63–69.
  • SQ Yu, HW Holloway, T Utsuki, A Brossi, and NH Greig. (1999). Synthesis of novel phenserine based selective inhibitors of butyrylcholinesterase for Alzheimer's disease. J Med Chem 42:1855–1861.
  • Atta-ur-Rahman, Zaheer-ul-Haq, F Feroz, A Khalid, SA Nawaz, MR Khan, and MI Choudhary. (2004). Pregnane-type steroidal alkaloids of sarcococca saligna: A new class of cholinesterases inhibitors. Helv Chem Acta 87:439.
  • Atta-ur-Rahman, F Feroz, SA Nawaz, MR Khan, and MI Choudhary. (2004). 735New pregnane-type steroidal alkaloids from sarcococca saligna and their cholinesterase inhibitory activity. Steroids 69:735–741. Prod 1982; 45(6): 779–781
  • GL Ellman, KD Courtney, V Andres, and RM Featherstone. (1961). New and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88–95.
  • EZ-Fit Enzyme Kinetics program. Perrella Scientific Inc., Amherst, MA, USA.
  • SW Pelletier. (1965). The diterpene alkaloids. The structure of atidine. J Am Chem Soc 87:799.
  • Q Jiang, and SW Pelletier. (1988). Conformation et reactivite de systemes (4.n.0) bicycliques a jonction trans—XIX: Synthese, conformation et configuration de methyl-4 et halogeno-4 bicyclo (4.2.0) octanols-3 et octanones-3 trans. Equilibres d'epimerisation des bicyclo (4.2.0) octanones α-substituees. Tetrahedron Lett 29:1865–1875.
  • MG Reinecke, WH Watson, C Chen De, and WM Yan. (1987). The case of the troubling doubling. Isoatisine and 19-Epiisoatisine from the Chinese Herb Guan-Bai-Fu (Aconitum koreanum). J Org Chem 52:5051.

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