Potential multifunctional agents with anti-hepatoma and anti-inflammation properties by inhibiting NF-кB activation

References

• Nelson KM, Dahlin JL, Bisson JJ, et al. The essential medicinal chemistry of curcumin. J Med Chem 2017;60:1620–37.
   PubMed Web of Science ®Google Scholar
• Begum A, Jones MG, Morihara T, et al. Curcumin structure–function, bioavailability, and efficacy in models of neuroinflammation and alzheimer's disease. J Pharmacol Exp Ther 2008;326:196–208.
   PubMed Web of Science ®Google Scholar
• Siviero A, Gallo E, Maggini V, et al. Curcumin, a golden spice with a low bioavailability. J Herb Med 2015;5:57–70.
   Web of Science ®Google Scholar
• Dimmock JR, Raghavan SK, Logan BM, et al. Antileukemic evaluation of some Mannich bases derived from 2-arylidene-1,3-diketones. Eur J Med Chem 1983;18:248–54.
   Web of Science ®Google Scholar
• Sun JF, Zhang SP, Yu C, et al. Design, synthesis and bioevaluation of novel N-substituted-3,5-bis(arylidene)-4-piperidone derivatives as cytotoxic and antitumor agents with fluorescent properties. Chem Biol Drug Des 2014;83:392–400.
   PubMed Web of Science ®Google Scholar
• Selvendiran K, Tong L, Vishwanath S, et al. EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression. J Biol Chem 2007;282:28609–18.
   PubMed Web of Science ®Google Scholar
• Yin DL, Liang YJ, Zheng TS, et al. EF24 inhibits tumor growth and metastasis via suppressing NF-κB dependent pathways in human cholangiocarcinoma. Sci Rep 2016;6:32167.
   PubMed Web of Science ®Google Scholar
• Lagisetty P, Vilekar P, Sahoo K, et al. CLEFMA – an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones. Bioorg Med Chem 2010;18:6109–20.
   PubMed Web of Science ®Google Scholar
• Gundewar C, Ansari D, Tang L, et al. Antiproliferative effects of curcumin analog L49H37 in pancreatic stellate cells: a comparative study. Ann Gastro Enterol 2015;28:1–8.
   Web of Science ®Google Scholar
• Chen L, Li Q, Weng B, et al. Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-кB pathway inhibition. Eur J Med Chem 2018;151:508–19.
   PubMed Web of Science ®Google Scholar
• Zhu HP, Xu TT, Qiu CY, et al. Synthesis and optimization of novel allylated mono-carbonyl analogs of curcumin (MACs) act as potent anti-inflammatory agents against LPS-induced acute lung injury (ALI) in rats. Eur J Med Chem 2016;121:181–93.
   PubMed Web of Science ®Google Scholar
• Li N, Xin WY, Yao BR, et al. Novel dissymmetric 3,5-bis(arylidene)-4-piperidones as potential antitumor agents with biological evaluation in vitro and in vivo. Eur J Med Chem 2018;147:21–33.
   PubMed Web of Science ®Google Scholar
• Li N, Xin WY, Yao BR, et al. N-phenylsulfonyl-3,5-bis(arylidene)-4-piperidone derivatives as activation NF-κB inhibitors in hepatic carcinoma cell lines. Eur J Med Chem 2018;155:531–44.
   PubMed Web of Science ®Google Scholar
• Yao BR, Sun Y, Chen SL, et al. Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-кB pathway activation. Eur J Med Chem 2019;167:187–99.
   PubMed Web of Science ®Google Scholar
• Sun JF, Wang SW, Li HJ, et al. Synthesis, antitumor activity evaluation of some new N-aroyl-α,β-unsaturated piperidones with fluorescence. J Enzyme Inhib Med Chem 2016;31:495–502.
   PubMed Web of Science ®Google Scholar
• Li HJ, Wang L, Zhao JJ, et al. Synthesis, structure and luminescence of novel co-crystals based on bispyridyl-substituted α,β-unsaturated ketones with coformers. J Mol Struct 2015;1079:414–22.
   Web of Science ®Google Scholar
• Liu LD, Liu SL, Liu ZX, et al. Synthesis, structure, antitumor activity of novel pharmaceutical cocrystals based on bispyridyl-substituted α,β-unsaturated ketones with gallic acid. J Mol Struct 2016;1112:1–8.
   Web of Science ®Google Scholar
• Zhang LS, Chen Q, Hou GG, et al. Hydroxyl-substituted double Schiff-base condensed 4-piperidone/cyclohexanones as potential anticancer agents with biological evaluation. J Enzyme Inhib Med Chem 2019;34:264–71.
   PubMed Web of Science ®Google Scholar
• Yao BR, Li N, Wang CH, et al. Novel asymmetric 3,5-bis(arylidene)piperidin-4-one derivatives: synthesis, crystal structures and cytotoxicity. Acta Cryst 2018;C74:659–65.
   Google Scholar
• Chen Q, Hou Y, Hou GG, et al. Design, synthesis, anticancer activity and cytotoxicity of novel 4-piperidone/cyclohexanone derivatives. Res Chem Intermediat 2016;42:8119–30.
   Web of Science ®Google Scholar
• Chen Q, Hou Y, Hou GG, et al. Synthesis, anticancer activity and cytotoxicity of novel double Schiff-base condensed α,β-unsaturated keto derivatives. J Chem Res 2016;40:400–3.
   Web of Science ®Google Scholar
• Silva CMD, Silva DLD, Modolo LV, et al. Schiff bases: a short review of their antimicrobial activities. J Adv Res 2011;2:1–8.
   Google Scholar
• Makawana JA, Sangani CB, Lin L, et al. Schiff’s base derivatives bearing nitroimidazole and quinoline nuclei: new class of anticancer agents and potential EGFR tyrosine kinase inhibitors. Bioorg Med Chem Lett 2014;24:1734–6.
   PubMed Web of Science ®Google Scholar
• Singh P, Kaur S, Sharma A, et al. TNF-α and IL-6 inhibitors: conjugates of N-substituted indole and aminophenylmorpholin-3-one as anti-inflammatory agents. Eur J Med Chem 2017;140:92–103.
   PubMed Web of Science ®Google Scholar
• Viatour P, Merville MP, Bours V, et al. Phosphorylation of NF-κB and IκB proteins: implications in cancer and inflammation. Trends Biochem Sci 2005;30:43–52.
   PubMed Web of Science ®Google Scholar
• Zhang L, Shi L, Soars SM, et al. Discovery of novel small-molecule inhibitors of NF-кB signaling with antiinflammatory and anti-cancer properties. J Med Chem 2018;61:5881–99.
   PubMed Web of Science ®Google Scholar
• Sathishkumar N, Sathiyamoorthy S, Ramya M, et al. Molecular docking studies of anti-apoptotic BCL-2, BCL-XL, and MCL-1 proteins with ginsenosides from Panax ginseng. J Enzyme Inhib Med Chem 2012;27:685–92.
   PubMed Web of Science ®Google Scholar
• Shishodia S, Majumdar S, Banerjee S, et al. Ursolic acid inhibits nuclear factor-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res 2003;63:4375–83.
   PubMed Web of Science ®Google Scholar