References
- Hancock JF, Paterson H, Marshall CJ. A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 1990;63:133–9.
- Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nat Rev Cancer 2003;3:459–65.
- Fernandez-Medarde A, Santos E. Ras in cancer and developmental diseases. Genes Cancer 2011;2:344–58.
- Prior IA, Lewis PD, Mattos C. A comprehensive survey of Ras mutations in cancer. Cancer Res 2012;72:2457–67.
- Castellano E, Santos E. Functional specificity of Ras isoforms: so similar but so different. Genes Cancer 2011;2:216–31.
- Smith MJ, Neel BG, Ikura M. NMR-based functional profiling of RASopathies and oncogenic RAS mutations. Proc Natl Acad Sci USA 2013;110:4574–9.
- Clausen R, Ma B, Nussinov R, Shehu A. Mapping the conformation space of wildtype and mutant H-Ras with a memetic, cellular, and multiscale evolutionary algorithm. PLoS Comput Biol 2015;11:e1004470.
- Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell 2007;129:865–77.
- Van Hattum H, Waldmann H. Chemical biology tools for regulating RAS signaling complexity in space and time. Chem Biol 2014;21:1185–95.
- Antonoff MB, D'Cunha J. Non-small cell lung cancer: the era of targeted therapy. Lung Cancer (Auckl) 2012;3:31–41.
- Forde PM, Ettinger DS. Targeted therapy for non-small-cell lung cancer: past, present and future. Expert Rev Anticancer Ther 2013;13:745–58.
- Ostrem JM, Shokat KM. Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design. Nat Rev Drug Discov 2016;15:771–85.
- Laraia L, McKenzie G, Spring DR, et al. Overcoming chemical, biological, and computational challenges in the development of inhibitors targeting protein-protein interactions. Chem Biol 2015;22:689–703.
- Sun Q, Burke JP, Phan J, et al. Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl 2012;51:6140–3.
- Maurer T, Garrenton LS, Oh A, et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A 2012;109:5299–304.
- Shimaa F, Yoshikawaa Y, Yea M, et al. In silico discovery of small-molecule Ras Inhibitors that display antitumor activity by blocking the Ras-effector interaction. Proc Natl Acad Sci U S A 2013;110:8182–7.
- Hendricks MP, Campos MP, Cleveland GT, et al. A tunable library of substituted thiourea precursors to metal sulfide nanocrystals. Science 2015;348:1226–32.
- Perry CJ, Holding K, Tyrrell E. Simple, novel synthesis for 1-carbamoyl-lH-benzotriazole and some of its analogs. Synth Commun 2008;38:3354–65.
- Munch H, Hansen JS, Pittelkow M, et al. A new efficient synthesis of isothiocyanates from amines using di-tert-butyl dicarbonate. Tetrahedron Lett 2008;49:3117–9.
- Hroch L, Guest P, Benek O, et al. Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment. Bioorg Med Chem 2017;25:1143–52.
- Mohd Siddique MU, McCann GJ, Sonawane V, et al. Biphenyl urea derivatives as selective CYP1B1 inhibitors. Org Biomol Chem 2016;14:8931–6.
- Kapanda CN, Masquelier J, Labar G, et al. Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors. J Med Chem 2012;55:5774–83.
- Chen L, Zhuang C, Lu J, et al. Discovery of novel KRAS-PDEdelta inhibitors by fragment-based drug design. J Med Chem 2018;61:2604–10.