A nanobody-derived mimotope against VEGF inhibits cancer angiogenesis

References

• Makni L, Stayoussef M, Ghazouani E, et al. Distinct association of VEGF-A polymorphisms with laryngeal and nasopharyngeal cancer. Meta Gene 2016;10:90–4.
   Web of Science ®Google Scholar
• Otrock ZK, Makarem JA, Shamseddine AI. Vascular endothelial growth factor family of ligands and receptors. Blood Cells Mol Dis 2007;38:258–68.
   PubMed Web of Science ®Google Scholar
• Folkman J. Opinion: Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273–86.
   PubMed Web of Science ®Google Scholar
• Reichert JM, Valge-Archer VE. Development trends for monoclonal antibody cancer therapeutics. Nat Rev Drug Discov 2007;6:349–56.
   PubMed Web of Science ®Google Scholar
• Kazemi-Lomedasht F, Behdani M, Bagheri KP, et al. Inhibition of angiogenesis in human endothelial cell using VEGF specific nanobody. Mol Immunol 2015;65:58–67.
   PubMed Web of Science ®Google Scholar
• Kolkman JA, Law DA. Nanobodies–from llamas to therapeutic proteins. Drug Discov Today 2010;7:e139–e146.
   Google Scholar
• Klettner A, Roider J. Comparison of bevacizumab, ranibizumab, and pegaptanib in vitro: efficiency and possible additional pathways. Investig Ophthalmol Vis Scie 2008;49:4523–7.
   PubMed Web of Science ®Google Scholar
• Kazemi-Lomedasht F, Behdani M, Pooshang Bagheri K, et al. Expression and purification of functional human vascular endothelial growth factor-a121; the most important angiogenesis factor. Adv Pharm Bull 2014;4:323–8.
   PubMedGoogle Scholar
• Sadeghi A, Behdani M, Muyldermans S, et al. Development of a mono‐specific anti‐VEGF bivalent nanobody with extended plasma half‐life for treatment of pathologic neovascularization. Drug Test Anal 2020;12:92–100.
   PubMed Web of Science ®Google Scholar
• Dolk E, van der Vaart M, Lutje Hulsik D, et al. Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo. Appl Environ Microbiol 2005;71:442–50.
   PubMed Web of Science ®Google Scholar
• Olichon A, Schweizer D, Muyldermans S, et al. Heating as a rapid purification method for recovering correctly-folded thermotolerant VH and VHH domains. BMC Biotechnol 2007;7:7.
   PubMed Web of Science ®Google Scholar
• Fazlalipour M, Baniasadi V, Pouriayevali MH, et al. A case of methotrexate intoxication misdiagnosed as crimean-congo hemorrhagic fever. J Med Microbiol and Infect Dis 2016;4:37–8.
   Google Scholar
• Khodabakhsh F, Behdani M, Rami A, et al. Single-domain antibodies or nanobodies: a class of next-generation antibodies. Int Rev Immunol 2018;37:316–22.
   PubMed Web of Science ®Google Scholar
• Alirahimi E, Kazemi-Lomedasht F, Shahbazzadeh D, et al. Nanobodies as novel therapeutic agents in envenomation. Biochimica et Biophysica Acta (BBA)-General Subjects 2018;1862:2955–65.
   PubMed Web of Science ®Google Scholar
• Homayouni V, Ganjalikhani-Hakemi M, Rezaei A, et al. Preparation and characterization of a novel nanobody against T-cell immunoglobulin and mucin-3 (TIM-3). Iran J Basic Med Sci 2016;19:1201.
   PubMed Web of Science ®Google Scholar
• Muruganandam A, Tanha J, Narang S, et al. Selection of phage-displayed llama single-domain antibodies that transmigrate across human blood–brain barrier endothelium. FASEB J 2002;16:1–242.
   PubMedGoogle Scholar
• Arbabi-Ghahroudi M, Tanha J, MacKenzie R. Prokaryotic expression of antibodies. Cancer Metastasis Rev 2005;24:501–19.
   PubMed Web of Science ®Google Scholar
• Jana S, Deb J. Retracted article: Strategies for efficient production of heterologous proteins in Escherichia coli. Appl Microbiol Biotechnol 2005;67:289–98.
   PubMed Web of Science ®Google Scholar
• Muyldermans S, Baral TN, Retamozzo VC, et al. Camelid immunoglobulins and nanobody technology. Vet Immunol Immunopathol 2009;128:178–83.
   PubMed Web of Science ®Google Scholar
• Desmyter A, Decanniere K, Muyldermans S, et al. Antigen specificity and high affinity binding provided by one single loop of a camel single-domain antibody. J Biol Chem 2001;276:26285–90.
   PubMed Web of Science ®Google Scholar
• Bond CJ, Marsters JC, Jr, Sidhu SS. Contributions of CDR3 to VHH domain stability and the design of monobody scaffolds for naive antibody libraries. J Mol Biol 2003;332:643–55.
   PubMed Web of Science ®Google Scholar
• Ohrnberger J, Singh S, Arthurs J, et al. Methods and compositions for detecting cancer, US Patent App. 16/182,854; 2019.
   Google Scholar
• Vicari D, Foy KC, Liotta EM, et al. Engineered conformation-dependent VEGF peptide mimics are effective in inhibiting VEGF signaling pathways. J Biol Chem 2011;286:13612–25.
   PubMed Web of Science ®Google Scholar
• Pourhashem Z, Mehrpouya M, Yardehnavi N, et al. An in-silico approach to find a peptidomimetic targeting extracellular domain of HER3 from a HER3 Nanobody. Computational Biol Chem 2017;68:39–42.
   PubMed Web of Science ®Google Scholar
• Knittelfelder R, Riemer AB, Jensen-Jarolim E. Mimotope vaccination–from allergy to cancer. Expert Opin Biol Ther 2009;9:493–506.
   PubMed Web of Science ®Google Scholar
• Riemer AB, Jensen-Jarolim E. Mimotope vaccines: epitope mimics induce anti-cancer antibodies. Immunol Lett 2007;113:1–5.
   PubMed Web of Science ®Google Scholar
• Kazemi-Lomedasht F, Behdani M, Rahimpour A, et al. Selection and characterization of specific Nanobody against human immunoglobulin G. Monoclon Antib Immunodiagn Immunother 2015;34:201–5.
   PubMedGoogle Scholar
• Kazemi-Lomedasht F, Pooshang-Bagheri K, Habibi-Anbouhi M, et al. In vivo immunotherapy of lung cancer using cross-species reactive vascular endothelial growth factor nanobodies. Iran J Basic Med Sci 2017;20:489–96.
   PubMed Web of Science ®Google Scholar
• Robinson J, Waller MJ, Parham P, et al. IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res 2003;31:311 – 4.
   Google Scholar
• Yang J, Zhang Y. Protein structure and function prediction using I‐TASSER. Curr Protoc Bioinformatics 2015;52:5.8.1–15.
   PubMedGoogle Scholar
• Zhang Y. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics 2008;9:40.
   PubMed Web of Science ®Google Scholar
• Schwede T. SWISS-MODEL: an automated protein homology-modeling server. Nucleic Acids Res 2003;31:3381–5.
   PubMed Web of Science ®Google Scholar
• Macindoe G, Mavridis L, Venkatraman V, et al. HexServer: an FFT-based protein docking server powered by graphics processors. Nucleic Acids Res 2010;38:W445–W449.
   PubMed Web of Science ®Google Scholar
• Beatty JD, Beatty BG, Vlahos WG. Measurement of Monoclonal-antibody affinity by noncompetitive enzyme-immunoassay. J Immunol Methods 1987;100:173–9.
   PubMed Web of Science ®Google Scholar
• Chacon E, Acosta D, Lemasters JJ. Primary cultures of cardiac myocytes as in vitro models for pharmacological and toxicological assessments. In: Castell JV, Gómez-Lechón, MJ, eds. In vitro methods in pharmaceutical research. Academic Press; 1997: 209–23.
   Google Scholar
• Auerbach R, Lewis R, Shinners B, et al. Angiogenesis assays: a critical overview. Clin Chem 2003;49:32–40.
   PubMed Web of Science ®Google Scholar
• Hoeben A, Landuyt B, Highley MS, et al. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev 2004;56:549–80.
   PubMed Web of Science ®Google Scholar
• Shimizu T, Hoshino Y, Miyazaki H, et al. Angiogenesis and microvasculature in the female reproductive organs: physiological and pathological implications. Curr Pharmaceut Des 2012;18:303–9.
   PubMed Web of Science ®Google Scholar
• Fuh G, Wu P, Liang W-C, et al. Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin™ Fab. J Biol Chem 2006;281:6625–31.
   PubMed Web of Science ®Google Scholar
• Andris-Widhopf J, Steinberger P, Fuller R, et al. Generation of human Fab antibody libraries: PCR amplification and assembly of light-and heavy-chain coding sequences. Cold Spring Harbor Protocols 2011;2011:pdb.prot065565.
   PubMedGoogle Scholar
• Rahbarizadeh F, Rasaee MJ, Forouzandeh Moghadam M, et al. Production of novel recombinant single-domain antibodies against tandem repeat region of MUC1 mucin. Hybridoma Hybridomics 2004;23:151–9.
   PubMedGoogle Scholar
• Kazemi-Lomedasht F, Behdani M, Habibi-Anbouhi M, et al. Production and characterization of novel camel single domain antibody targeting mouse vascular endothelial growth factor. Monocl Antib Immunodiagn Immunother 2016;35:167–71.
   PubMedGoogle Scholar
• Alvarez-Rueda N, Behar G, Ferré V, et al. Generation of llama single-domain antibodies against methotrexate, a prototypical hapten. Mol Immunol 2007;44:1680–90.
   PubMed Web of Science ®Google Scholar
• Akram ON, DeGraff DJ, Sheehan JH, et al. Tailoring peptidomimetics for targeting protein–protein interactions. Mol Cancer Res 2014;12:967–78.
   PubMed Web of Science ®Google Scholar
• Kazemi-Lomedasht F, Muyldermans S, Habibi-Anbouhi M, et al. Design of a humanized anti vascular endothelial growth factor nanobody and evaluation of its in vitro function. Iran J Basic Med Sci 2018;21:260–6.
   PubMed Web of Science ®Google Scholar
• Arnaoutova I, Kleinman HK. In vitro angiogenesis: endothelial cell tube formation on gelled basement membrane extract. Nat Protocols 2010;5:628–35.
   PubMed Web of Science ®Google Scholar
• Li W, Ran Y, Li M, et al. Mimotope vaccination for epitope-specific induction of anti-VEGF antibodies. BMC Biotechnol 2013;13:77.
   PubMed Web of Science ®Google Scholar
• Javanmardi M, Rasaee MJ, Modjtahedi H, et al. Triple tandem mimotope peptide of Epidermal Growth Factor Receptor displaying on the surface of M13 phage induces anti-tumor response in mice tumor model. Iran J Biotechnol 2014;12:9–17.
   Web of Science ®Google Scholar
• Yang L, Xing R, Li C, et al. Active immunization with Tocilizumab mimotopes induces specific immune responses. BMC Biotechnol 2015;15:46.
   PubMed Web of Science ®Google Scholar