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Drug Profile

Profile of respiratory syncytial virus prefusogenic fusion protein nanoparticle vaccine

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Pages 351-364 | Received 21 Dec 2020, Accepted 12 Mar 2021, Published online: 02 May 2021

References

  • Shi T, McAllister DA, O’Brien KL, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017;390(10098):946–958. PMID: 28689664 PMCID: PMC5592248.
  • Shi T, Arnott A, Semogas I, et al. The etiological role of common respiratory viruses in acute respiratory infections in older adults: a systematic review and meta-analysis. J Infect Dis. 2020;222(7):S577-S583 PMID: 30849176 PMCID: PMC7107439.
  • Shi T, Denouel A, Tietjen AK, et al. Global disease burden estimates of respiratory syncytial virus-associated acute respiratory infection in older adults in 2015: a systematic review and meta-analysis. J Infect Dis. 2020;222(Supplement_7):S563-S569 PMID: 30880339.
  • Branche AR, Falsey AR. Respiratory syncytial virus infection in older adults: an under-recognized problem. Drugs Aging. 2015;32(4):261–269. PMID: 30880339.
  • Nair H, Nokes DJ, Gessner BD, et al. Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet. 2010;375(9725):1545–1555. PMID: 20399493; PMCID: PMC2864404.
  • Haynes AK, Prill MM, Iwane MK, et al. Centers for Disease Control and Prevention (CDC). Respiratory syncytial virus–United States. Jul 2012-Jun 2014. MMWR Morb Mortal Wkly Rep. 2014. 63(48):1133–1136. Erratum in: MMWR Morb Mortal Wkly Rep. 2014Dec12. 63( 49): 1181. PMID: 25474034; PMCID: PMC4584603.
  • Hall CB, Weinberg GA, Iwane MK et al., The burden of respiratory syncytial virus infection in young children. N Engl J Med PMID: 19196675; PMCID: PMC4829966. 2009;360(6): 588–598.
  • Stein RT, Sherrill D, Morgan WJ, et al. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years. Lancet. 1999;354(9178):541–545. PMID: 10470697.
  • Mejias A, Wu B, Tandon N, et al. Risk of childhood wheeze and asthma after respiratory syncytial virus infection in full-term infants. Pediatr Allergy Immunol. 2020. 31(1):47–56. Epub 2019Oct23. PMID: 31566811.
  • Martinez FD.Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthma. Pediatr Infect Dis J. 2003. 22. 2 Suppl): S76-82. PMID: 12671456.
  • Walsh EE, Falsey AR. Respiratory syncytial virus infection in adult populations. Infect Disord Drug Targets. 2012;12(2):98–102. PMID:22335500.
  • Rhe IMpact-RSV study group. Palivizumab, a humanized respiratory syncytial virus monoclonal antibody, reduces hospitalization from respiratory syncytial virus infection in high-risk infants. Pediatrics. 1998. 102(3 Pt 1):531–537. PMID: 9738173.
  • Lieberthal AS, Meer HC. AAP updates guidance on use of palivizumab for RSV prophylaxis. AAP News. 2014; 35(8) :1 10.1542/aapnews.2014358-1.
  • Kim HW, Canchola JG, Brandt CD, et al. Respiratory syncytial virus disease in infants despite prior administration of antigenic inactivated vaccine. Am J Epidemiol. 1969;89(4):422–434. PMID: 4305198.
  • Murphy BR, Sotnikov AV, Lawrence LA, et al. Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin-inactivated respiratory syncytial virus (RSV) or purified F glycoprotein and challenged with RSV 3-6 months after immunization. Vaccine. 1990;8(5):497–502. PMID: 2251875.
  • Waris ME, Tsou C, Erdman DD, et al. Respiratory synctial virus infection in BALB/c mice previously immunized with formalin-inactivated virus induces enhanced pulmonary inflammatory response with a predominant Th2-like cytokine pattern. J Virol. 1996;70(5):2852–2860. PMID:8627759; PMCID: PMC190142.
  • Connors M, Giese NA, Kulkarni AB et al., Enhanced pulmonary histopathology induced by respiratory syncytial virus (RSV) challenge of formalin-inactivated RSV-immunized BALB/c mice is abrogated by depletion of interleukin-4 (IL-4) and IL-10. J Virol PMID: 8035532; PMCID: PMC236482. 1994;68(8): 5321–5325.
  • Polack FP, Teng MN, Collins PL, et al. A role for immune complexes in enhanced respiratory syncytial virus disease. J Exp Med. 2002;196(6):859–865. PMID: 12235218 PMCID: PMC2194058.
  • Dreizin RS, Vyshnevetskaia LO, Bagdamian EE, et al. Experimental RS virus infection of cotton rats. A viral and immunofluorescent study. Vopr Virusol. 1971;16(6):670–676. PMID: 5141611.
  • Prince GA, Jenson AB, Horswood RL, et al. The pathogenesis of respiratory syncytial virus infection in cotton rats. Am J Pathol. 1978;93(3):771–791. PMID: 362946 PMCID: PMC2018360.
  • Collins PL, Hill MG, Camargo EN, et al. Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5ʹproximal open reading frame of the M2 mRNA in gene expression and provides a capability for vaccine development. Proc Nat Acad Sci. 1995;92(25):11563–11567. PMID: 8524804 PMCID: PMC40442.
  • Englund JA, Glezen WP, Piedra PA. Maternal immunization against viral disease. PMID: 9711788 Vaccine. 1998;1614:1456–1463.
  • Swamy GK, Heine RP. Vaccinations for pregnant women. Obstet Gynecol. 2015 Jan;125(1):212–226. PMID: 25560127; PMCID: PMC4286306.
  • Hause AM, Avadhanula V, Maccato ML et al., A cross-sectional surveillance study of the frequency and etiology of acute respiratory illness among pregnant women. J Infect Dis PMID: 29741642 PMCID: PMC7107407. 2018;218(4): 528–535.
  • Munoz FM, Piedra PA, Glezen WP. Safety and immunogenicity of respiratory syncytial virus purified fusion protein-2 vaccine in pregnant women. Vaccine. 2003 Jul 28;21(24):3465–3467. PMID: 12850361.
  • WHO Vaccine Pipeline Tracker. [(accessed on 2020)] Dec 15; Available online: https://docs.google.com/spreadsheets/d/19otvINcayJURCMg76xWO4KvuyedYbMZDcXqbyJGdcZM/pubhtml#.
  • Biagi C, Dondi A, Scarpini S, et al. Current state and challenges in developing respiratory syncytial virus vaccines. Vaccines (Basel). PMID:33187337; PMCID: PMC7711987. 2020;8(4):672.
  • Karron RA, Luongo C, Mateo JS et al., Safety and immunogenicity of the respiratory syncytial virus vaccine RSV/ΔNS2/Δ1313/I1314L in RSV-seronegative children. J Infect Dis PMID: 31605113; PMCID: PMC7199783. 2020;222(1): 82–91. :.
  • Samy N, Reichhardt D, Schmidt D, et al. Safety and immunogenicity of novel modified vaccinia ankara-vectored RSV vaccine: a randomized phase I clinical trial. Vaccine. 2020;38(11):2608–2619. PMID: 32057576.
  • Van Der Fits L, Bolder R. Heemskerk-van der meer m. et al. Adenovector 26 encoded prefusion conformation stabilized rsv-f protein induces long-lasting th1-biased immunity in neonatal mice. npj. Vaccines (Basel). 2020;5(49). PMID: 32566260 PMCID: PMC7293210.
  • Williams K, Bastian AR, Feldman RA, et al. Phase 1 safety and immunogenicity study of a respiratory syncytial virus vaccine with an adenovirus 26 vector encoding prefusion f (ad26.rsv.pref) in adults aged ≥60 years. J Infect Dis. 2020;222(6):979–988. PMID: 32320465.
  • Malkin E, Yogev R, Abughali N et al., Safety and immunogenicity of a live attenuated RSV vaccine in healthy RSV-seronegative children 5 to 24 months of age. PLoS One PMID: 24204744; PMCID: PMC3812203. 2013;8(10): e77104.
  • Sadoff J, De Paepe E, DeVincenzo J, et al. Prevention of respiratory syncytial virus infection in healthy adults by a single immunization of ad26.rsv.pref in a human challenge study. J Infect Dis. 2021Jan5. jiab003. Epub ahead of print. PMID: 33400792.
  • Eaf S, Forleo-Neto E, Geba GP, et al. Suptavumab for the prevention of medically attended respiratory syncytial virus infection in preterm infants. Clin Infect Dis. 2020. ciaa951. Epub ahead of print. PMID: 32897368.
  • PATH.org. [(accessed on 2020)] Dec 15; Available online: https://www.path.org/resources/rsv-vaccine-and-mab-snapshot/
  • Afonso CL, Amarasinghe GK, Bányai K, et al.Taxonomy of the order Mononegavirales: update. 2016. Arch Virol. 2016 Aug. 161(8):2351–2360. Epub 2016 May 23. PMID: 27216929; PMCID: PMC4947412. .
  • Liljeroos L, Krzyzaniak MA, Helenius A, et al. Architecture of respiratory syncytial virus revealed by electron cryotomography. Proc Natl Acad Sci U S A. 2013Jul2. 110(27):11133–11138. Epub 2013 Jun 17. PMID: 23776214; PMCID: PMC3703984.
  • Nam HH, Ison MG. Respiratory syncytial virus infection in adults. BMJ. 2019 Sep 10;366. l5021.PMID: 31506273.
  • Melero JA, Mas V, McLellan JS. Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development. Vaccine. 201711. 35(3):461–468. Epub 2016 Sep 28. PMID: 27692522; PMCID: PMC5189713.
  • Hause AM, Henke DM, Avadhanula V, et al. Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B. PloS One. 2017;12(4): e0175792 PMID: 28414749 PMCID: PMC5393888.
  • Tapia LI, Shaw CA, Aideyan LO et al., Gene sequence variability of the three surface proteins of human respiratory syncytial virus (HRSV) in Texas. PloS One PMID: 24625544 PMCID: PMC3953119. 2014;9(3): e90786.
  • Re D, Rn H, Ma N, et al. Paramyxovirus fusion (F) protein: a conformational change on cleavage activation. Virology. 2001. Mar1. 281. 1):138–150 PMID: 11222104.
  • Zimmer G, Budz L, Herrler G. Proteolytic activation of respiratory syncytial virus fusion protein. Cleavage at two furin consensus sequences. J Biol Chem. Epub 2001 Jun 19. PMID: 11418598. 2001;276(34):31642–31650.
  • Gilman MSA, Furmanova-Hollenstein P, Pascual G, et al. Transient opening of trimeric prefusion RSV F proteins. Nat Commun. 209. 10, 2105. PMID: 31068578 PMCID: PMC6506550.
  • Mousa JJ, Kose N, Matta P et al., A novel pre-fusion conformation-specific neutralizing epitope on the respiratory syncytial virus fusion protein. Nat Microbiol PMID: 28134924 PMCID: PMC5463187. 2017;2(4): 16271.
  • Mousa JJ, Binshtein E, Human S, et al. Human antibody recognition of antigenic site IV on pneumovirus fusion proteins. Subbarao K, ed. PLOS Pathog. 2018;14(2):e1006837. PMID: 29470533 PMCID: PMC5823459.
  • McLellan JS, Chen M, Leung S, et al. Structure of RSV fusion glycoprotein trimer bound to a prefusion-specific neutralizing antibody. Science. 2013May31. 340(6136)1113–1117. Epub 2013 Apr 25. PMID: 23618766; PMCID: PMC4459498.
  • Ngwuta JO, Chen M, Modjarrad K, et al. Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera. Sci Transl Med. 2015Oct14. 7(309):309ra162. PMID: 26468324; PMCID: PMC4672383.
  • Ye X, Iwuchukwu OP, Avadhanula V, et al. Antigenic site-specific competitive antibody responses to the fusion protein of respiratory syncytial virus were associated with viral clearance in hematopoietic cell transplantation adults. Front Immunol. PMID: 30984206; PMCID: PMC6449644 2019;10:706.
  • Ye X, Iwuchukwu OP, Avadhanula V, et al. Comparison of palivizumab-like antibody binding to different conformations of the rsv f protein in rsv-infected adult hematopoietic cell transplant recipients. J Infect Dis. 2018;217(8):1247–1256. PMID: 29365155.
  • Melero JA, Mas V, McLellan JS. Structural, antigenic and immunogenic features of respiratory syncytial virus glycoproteins relevant for vaccine development. Vaccine. PMID: 27692522 PMCID: PMC5189713. 2017;35(3):461–468.
  • Karch CP, Burkhard P. Vaccine technologies: from whole organisms to rationally designed protein assemblies. Biochem Pharmacol PMID: 27157411 PMCID: PMC5079805. 2016;120:1–14.
  • Moser M, Leo O. Key concepts in immunology. Vaccine. 2010;28:2–13.
  • Pati R, Shevtsov M, Sonawane A. Nanoparticle vaccines against infectious diseases. Front Immunol. Internet]. 2018 [cited 2020 Sep 28];9:2224. Available from: www.frontiersin.org. PMID: 30337923 PMCID: PMC6180194.
  • Simons K, Helenius A, Leonard K. Formation of protein micelles from amphiphilic membrane proteins. Proc Natl Acad Sci. PMID: 214782 PMCID: PMC392951. 1978;75(11):5306–5310.
  • Coleman CM, Liu YV, Mu H et al., Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice. Vaccine PMID: 24736006 PMCID: PMC4058772. 2014;32(26): 3169–3174.
  • Al-Halifa S, Gauthier L, Arpin D, et al. Nanoparticle-based vaccines against respiratory viruses. Front Immunol. 2019. 10. JAN. 1-11. PMID: 30733717 PMCID: PMC6353795.
  • Smith G, Raghunandan R, Wu Y, et al. Respiratory syncytial virus fusion glycoprotein expressed in insect cells form protein nanoparticles that induce protective immunity in cotton rats. PLoS One. Varga SM, ed. 2012;7(11):e50852. PMID: 23226404 PMCID: PMC3511306.
  • Patel N, Massare MJ, Tian JH, et al. Respiratory syncytial virus prefusogenic fusion (F) protein nanoparticle vaccine: structure, antigenic profile, immunogenicity, and protection. Vaccine. 2019Sep24. 37(41):6112–6124. Epub 2019 Aug 12. PMID: 31416644.
  • Calder LJ, González-Reyes L, García-Barreno B, et al. Electron microscopy of the human respiratory syncytial virus fusion protein and complexes that it forms with monoclonal antibodies. Virology. 2000;271(1):122–131. PMID: 10814577.
  • Krueger S, Curtis JE, Scott DR et al., Structural characterization and modeling of a respiratory syncytial virus fusion glycoprotein nanoparticle vaccine in solution. Mol Pharm Epub 2020 Dec 15. PMID: 33322901. 2021;18(1): 359–376.
  • Fuentes S, Coyle EM, Beeler J et al., Antigenic fingerprinting following primary rsv infection in young children identifies novel antigenic sites and reveals unlinked evolution of human antibody repertoires to fusion and attachment glycoproteins. PLoS Pathog PMID: 27100289 PMCID: PMC4839671. 2016;12(4): 1–24.
  • Patel N, Tian JH, Flores R, et al. Flexible RSV prefusogenic fusion glycoprotein exposes multiple neutralizing epitopes that may collectively contribute to protective immunity. Vaccines (Basel). PMID: 33066540; PMCID: PMC7711572. 2020;8(4):607.
  • Goritzka M, Makris S, Kausar F, et al. Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes. J Exp Med. 2015. 212(5):699–714. Epub 2015 Apr 20. PMID: 25897172; PMCID: PMC4419339.
  • Bhoj VG, Sun Q, Bhoj EJ, et al. MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus. Proc Natl Acad Sci U S A. 2008. 105(37):14046–14051. Epub 2008 Sep 9. PMID: 18780793; PMCID: PMC2532974.
  • Demoor T, Petersen BC, Morris S, et al. IPS-1 signaling has a nonredundant role in mediating antiviral responses and the clearance of respiratory syncytial virus. J Immunol. 2012. 189(12):5942–5953. Epub 2012 Nov 7. PMID: 23136205; PMCID: PMC3888965.
  • Marr N, Turvey SE, Grandvaux N. Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: a host and cell type perspective. Trends Microbiol. 2013. 21(11):568–574. Epub 2013 Oct 9. PMID: 24119913; PMCID: PMC4848032.
  • Borchers AT, Chang C, Gershwin ME, et al. Respiratory syncytial virus–a comprehensive review. Clin Rev Allergy Immunol. 2013;45(3):331–379. PMID: 23575961; PMCID: PMC7090643.
  • Topham NJ, Hewitt EW. Natural killer cell cytotoxicity: how do they pull the trigger? Immunology. PMID: 19689731; PMCID: PMC2747134. 2009;128(1):7–15.
  • Kaiko GE, Phipps S, Angkasekwinai P et al., NK cell deficiency predisposes to viral-induced Th2-type allergic inflammation via epithelial-derived IL-25. J Immunol Epub 2010 Sep 20. PMID: 20855881. 2010;185(8): 4681–4690.
  • Graham BS, Bunton LA, Wright PF et al., Role of T lymphocyte subsets in the pathogenesis of primary infection and rechallenge with respiratory syncytial virus in mice. J Clin Invest PMID: 1909350; PMCID: PMC295511. 1991;88(3): 1026–1033.
  • Liu J, Haddad EK, Marceau J et al., A numerically subdominant cd8 t cell response to matrix protein of respiratory syncytial virus controls infection with limited immunopathology. PLoS Pathog PMID: 26943673; PMCID: PMC4778879. 2016;12(3): e1005486.
  • Morabito KM, Ruckwardt TR, Redwood AJ, et al. Intranasal administration of RSV antigen-expressing MCMV elicits robust tissue-resident effector and effector memory CD8+ T cells in the lung. Mucosal Immunol. 2017. 10(2):545–554. Epub 2016 May 25. PMID: 27220815; PMCID: PMC5123975.
  • Olson MR, Hartwig SM, Varga SM. The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia. J Immunol. PMID: 19017987; PMCID: PMC2587004. 2008;181(11):7958–7968.
  • Cannon MJ, Openshaw PJ, Askonas BA. Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. J Exp Med. PMID: 3262705; PMCID: PMC2189034. 1988;168(3):1163–1168.
  • Schmidt ME, Knudson CJ, Hartwig SM et al., Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection. PLoS Pathog PMID: 29293660; PMCID: PMC5766251. 2018;14(1): e1006810.
  • Kinnear E, Lambert L, McDonald JU, et al. Erratum: airway T cells protect against RSV infection in the absence of antibody. Mucosal Immunol. 2018. Jan. 11(1):290. Epub 2017 Aug 30. Erratum for: Mucosal Immunol. 2018 Jan; 11( 1): 249-256. PMID: 28853440.
  • Welliver TP, Reed JL, Welliver RC.Respiratory syncytial virus and influenza virus infections: observations from tissues of fatal infant cases. Pediatr Infect Dis J. 2008. 27. 10 Suppl): S92-6. PMID: 18820587.
  • Singleton R, Etchart N, Hou S, et al. Inability to evoke a long-lasting protective immune response to respiratory syncytial virus infection in mice correlates with ineffective nasal antibody responses. J Virol. 2003;77(21):11303–11311. PMID: 14557616; PMCID: PMC229280.
  • Habibi MS, Jozwik A, Makris S, et al. Mechanisms of severe acute influenza consortium investigators. impaired antibody-mediated protection and defective iga b-cell memory in experimental infection of adults with respiratory syncytial virus. Am J Respir Crit Care Med. 2015;191(9):1040–1049. PMID: 25730467; PMCID: PMC4435460.
  • Piedra PA, Hause AM, Aideyan L, et al. Respiratory syncytial virus (RSV): neutralizing antibody, a correlate of immune protection. Ra T, Pa J, editors. Human respiratory syncytial virus. Springer: New York. 2016. Vol. 1442. 77–91.
  • Hall CB, Walsh EE, Long CE, et al. Immunity to and frequency of reinfection with respiratory syncytial virus. J Infect Dis. 1991;163(4):693–698.
  • Groothuis JR, Simoes E, Levin MJ, et al. Prophylactic administration of respiratory syncytial virus immune globulin to high-risk infants and young children. N Engl J Med. 1993;329(21):1524–1530.
  • Falsey AR, Walsh EE. Relationship of serum antibody to risk of respiratory syncytial virus infection in elderly adults. J Infect Dis. 1998;177(2):463–466.
  • Glezen WP, Paredes A, Allison JE, et al. Risk of respiratory syncytial virus infection for infants from low-income families in relationship to age, sex, ethnic group, and maternal antibody level. J Pediatr. 1981;98(5):708–715. PMID: 7229749.
  • Glenn GM, Smith G, Fries L et al., Safety and immunogenicity of a Sf9 insect cell-derived respiratory syncytial virus fusion protein nanoparticle vaccine. Vaccine Epub 2012 Nov 12. PMID: 23153449. 2013;31(3): 524–532.
  • Fries L, Shinde V, Stoddard JJ et al., Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults. Immun Ageing PMID: 28413427; PMCID: PMC5389002. 2017;14(1): 8.
  • Glenn GM, Fries LF, Thomas DN et al., A randomized, blinded, controlled, dose-ranging study of a respiratory syncytial virus recombinant fusion (f) nanoparticle vaccine in healthy women of childbearing age. J Infect Dis Epub 2015 Aug 10. PMID: 26259809. 2016;213(3): 411–422.
  • August A, Glenn GM, Kpamegan E et al., A Phase 2 randomized, observer-blind, placebo-controlled, dose-ranging trial of aluminum-adjuvanted respiratory syncytial virus F particle vaccine formulations in healthy women of childbearing age. Vaccine Epub 2017 Jun 1. PMID: 28579233. 2017;35(30): 3749–3759.
  • Muňoz FM, Swamy GK, Hickman SP, et al. Safety and immunogenicity of a respiratory syncytial virus fusion (f) protein nanoparticle vaccine in healthy third-trimester pregnant women and their infants. J Infect Dis. 2019;220(11):1802–1815. PMID: 31402384.
  • Eberhardt CS, Blanchard-Rohner G, Lemaître B et al., Maternal immunization earlier in pregnancy maximizes antibody transfer and expected infant seropositivity against pertussis. Clin Infect Dis PMID: 26797213 PMCID: PMC4787611. 2016;62(7): 829–836.
  • Abu Raya B, Srugo I, Kessel A, et al. The effect of timing of maternal tetanus, diphtheria, and acellular pertussis (Tdap) immunization during pregnancy on newborn pertussis antibody levels - A prospective study. Vaccine. 2014;32(44):5787–5793. PMID: 25173476.
  • Madhi SA, Polack FP, Piedra PA, et al. Prepare study group. respiratory syncytial virus vaccination during pregnancy and effects in infants. N Engl J Med. PMID: 32726529; PMCID: PMC7299433. 2020;383(5):426–439.

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