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COVID-19 vaccination hesitancy in pregnant and breastfeeding women and strategies to increase vaccination compliance: a systematic review and meta-analysis

ORCID Icon, ORCID Icon, , , & ORCID Icon
Pages 1443-1454 | Received 05 Apr 2022, Accepted 08 Jul 2022, Published online: 20 Jul 2022

References

  • Kourtis AP, Read JS, Jamieson DJ. Pregnancy and infection. N Engl J Med. 2014 Jun 5;370(23):2211–2218.
  • Sakala IG, Honda-Okubo Y, Fung J, et al. Influenza immunization during pregnancy: benefits for mother and infant. Hum Vaccin Immunother. 2016;Dec;12(12):3065–3071.
  • CDC. Guidelines for vaccinating pregnant women. Last updated: August 2016. [Accessed on 2022 Feb 10]. Available from: https://www.cdc.gov/vaccines/pregnancy/hcp-toolkit/guidelines.html
  • Marchand G, Patil AS, Masoud AT, et al. Systematic review and meta-analysis of COVID-19 maternal and neonatal clinical features and pregnancy outcomes up to June 3, 2021. AJOG Glob Rep. 2022 2;Feb(1):100049.
  • Di Toro F, Gjoka M, Di Lorenzo G, et al. Impact of COVID-19 on maternal and neonatal outcomes: a systematic review and meta-analysis. Clin Microbiol Infect. 2021 Jan;27(1):36–46.
  • CDC. COVID-19 vaccines while pregnant or breastfeeding. Last updated January 28, 2022. accessed on 2022 Feb 11. Available from: https://www.cdc.gov/coronavirus/2019-ncov/vaccines/recommendations/pregnancy.html.
  • Fu W, Sivajohan B, McClymont E, et al. Systematic review of the safety, immunogenicity, and effectiveness of COVID-19 vaccines in pregnant and lactating individuals and their infants. Int J Gynaecol Obstet. 2022 Mar;156(3):406–417.
  • Yan Z, Yang M, Lai CL. COVID-19 vaccinations: a comprehensive review of their safety and efficacy in special populations. Vaccines (Basel). 2021 Sep 28;9(10):1097.
  • Nir O, Schwartz A, Toussia-Cohen S, et al. Maternal-neonatal transfer of SARS-CoV-2 immunoglobulin G antibodies among parturient women treated with BNT162b2 messenger RNA vaccine during pregnancy. Am J Obstet Gynecol MFM. 2022 Jan;4(1): 100492.
  • Perl SH, Uzan-Yulzari A, Klainer H, et al. Youngster I. SARS-CoV-2-specific antibodies in breast milk after COVID-19 vaccination of breastfeeding women. JAMA. 2021 May 18;325(19):2013–2014.
  • Blakeway H, Prasad S, Kalafat E, et al. COVID-19 vaccination during pregnancy: coverage and safety. Am J Obstet Gynecol. 2022 Feb;226(2):236.e1–236.e14.
  • Stock SJ, Carruthers J, Calvert C, et al. SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland. Nat Med. 2022 Jan 13. Epub ahead of print. Erratum in: Nat Med. 2022 Feb 4. DOI:10.1038/s41591-021-01666-2
  • Má G-B, Gutiérrez-Calderón E, Pelcastre-Villafuerte BE, et al. Influenza vaccination hesitancy in five countries of South America. Confidence, complacency and convenience as determinants of immunization rates. PLoS One 2020 Dec 11 15(12):e0243833.
  • de Munter AC, Ruijs WLM, Ruiter RAC, et al. Decision-making on maternal pertussis vaccination among women in a vaccine-hesitant religious group: stages and needs. PLoS One. 2020 Nov 12;15(11):e0242261.
  • Martin S, Kilich E, Dada S, et al. “Vaccines for pregnant women … ?! Absurd” - Mapping maternal vaccination discourse and stance on social media over six months. Vaccine. 2020 Sep 29;38(42):6627–6637.
  • Bianchi FP, Stefanizzi P, Lattanzio S, et al. Attitude for vaccination prophylaxis among pregnant women: a cross-sectional study. Hum Vaccin Immunother. 2022 Feb;18:1–5.
  • Descamps A, Launay O, Bonnet C, et al. Seasonal influenza vaccine uptake and vaccine refusal among pregnant women in France: results from a national survey. Hum Vaccin Immunother. 2020 May 3;16(5):1093–1100.
  • Doraivelu K, Boulet SL, Biswas HH, et al. Predictors of tetanus, diphtheria, acellular pertussis and influenza vaccination during pregnancy among full-term deliveries in a medically underserved population. Vaccine. 2019 Sep 24;37(41):6054–6059.
  • Wales DP, Khan S, Suresh D, et al. Factors associated with Tdap vaccination receipt during pregnancy: a cross-sectional study. Public Health. 2020 Feb;179:38–44.
  • Wilson RJ, Paterson P, Jarrett C, et al. Understanding factors influencing vaccination acceptance during pregnancy globally: a literature review. Vaccine. 2015 Nov 25;33(47):6420–6429.
  • von Elm E, Altman DG, Egger M, et al. The Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344–349.
  • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.
  • Hosokawa Y, Okawa S, Hori A, et al. The prevalence of COVID-19 vaccination and vaccine hesitancy in pregnant women: an internet-based cross-sectional study in Japan. J Epidemiol. 2022 Jan; 29.
  • Huddleston HG, Jaswa EG, Lindquist KJ, et al. COVID-19 vaccination patterns and attitudes among American pregnant individuals. Am J Obstet Gynecol MFM. 2022 Jan;4(1): 100507.
  • Kiefer MK, Mehl R, Costantine MM, et al. Characteristics and perceptions associated with COVID-19 vaccination hesitancy among pregnant and postpartum individuals: a cross-sectional study. BJOG. 2022 Feb; 1.
  • Skirrow H, Barnett S, Bell S, et al. Women’s views on accepting COVID-19 vaccination during and after pregnancy, and for their babies: a multi-methods study in the UK. BMC Pregnancy Childbirth. 2022 Jan 14;22(1):33.
  • Sznajder KK, Kjerulff KH, Wang M, et al. Covid-19 vaccine acceptance and associated factors among pregnant women in Pennsylvania 2020. Prev Med Rep. 2022 Apr;26:101713.
  • Waring ME, Pagoto SL, Rudin LR, et al. Factors associated with mothers’ hesitancy to receive a COVID-19 vaccine. J Behav Med. 2022 Jan;4:1–6.
  • Aisyah R, Fitriyani F, Pambudi D. determinant factors involved in pregnant women’s willingness to receive Covid-19 vaccine. Interest [Internet]. 6 Jan.2022;231–239. [cited 2022 Feb 16]. Available from: http://jurnalinterest.com/index.php/int/article/view/362
  • Battarbee AN, Stockwell MS, Varner M, et al. Attitudes toward COVID-19 illness and COVID-19 vaccination among pregnant women: a cross-sectional multicenter study during August-December 2020. Am J Perinatol. 2022 Jan;39(1):75–83.
  • Carbone L, Mappa I, Sirico A, et al. Pregnant women’s perspectives on severe acute respiratory syndrome coronavirus 2 vaccine. Am J Obstet Gynecol MFM. 2021 Jul;3(4): 100352.
  • Ceulemans M, Foulon V, and Panchaud A, et al. Vaccine willingness and impact of the COVID-19 pandemic on women’s perinatal experiences and practices-A multinational, cross-sectional study covering the first wave of the pandemic. Int J Environ Res Public Health. 2021 Mar 24;18(7):3367.
  • Desai P, Kaur G, Dong F, et al. COVID-19 vaccine acceptance in pregnancy. Neonatol Today. 2021;16(7):11–15.
  • Gencer H, Özkan S, Vardar O, et al. The effects of the COVID 19 pandemic on vaccine decisions in pregnant women. Women Birth. 2021 May;19(21):S1871–5192.
  • Geoghegan S, Stephens LC, Feemster KA, et al. This choice does not just affect me.” Attitudes of pregnant women toward COVID-19 vaccines: a mixed-methods study. Hum Vaccin Immunother. 2021 Oct 3;17(10):3371–3376.
  • Goncu Ayhan S, Oluklu D, Atalay A, et al. COVID-19 vaccine acceptance in pregnant women. Int J Gynaecol Obstet. 2021 Aug;154(2):291–296.
  • Hailemariam S, Mekonnen B, Shifera N, et al. Predictors of pregnant women’s intention to vaccinate against coronavirus disease 2019: a facility-based cross-sectional study in southwest Ethiopia. SAGE Open Med. 2021 Aug 19;9:20503121211038454.
  • Hirshberg JS, Huysman BC, Oakes MC, et al. Offering onsite COVID-19 vaccination to high-risk obstetrical patients: initial findings. Am J Obstet Gynecol MFM. 2021 Nov;3(6): 100478.
  • Jayagobi PA, Ong C, Thai YK, et al. Perceptions and acceptance of COVID-19 vaccine among pregnant and lactating women in Singapore: a cross-sectional study. medRxiv. 2021;06:29.21259741.
  • Levy AT, Singh S, Riley LE, et al. Acceptance of COVID-19 vaccination in pregnancy: a survey study. Am J Obstet Gynecol MFM. 2021 Sep;3(5): 100399.
  • Mappa I, Luviso M, Distefano FA, et al. Women perception of SARS-CoV-2 vaccination during pregnancy and subsequent maternal anxiety: a prospective observational study. J Matern Fetal Neonatal Med. 2021 Apr;11:1–4.
  • Mohan S, Reagu S, Lindow S, et al. COVID-19 vaccine hesitancy in perinatal women: a cross sectional survey. J Perinat Med. 2021 Apr 28;49(6):678–685.
  • Mose A. Willingness to receive COVID-19 vaccine and its determinant factors among lactating mothers in Ethiopia: a cross-sectional study. Infect Drug Resist. 2021 Oct 14;14:4249–4259.
  • Nguyen LH, Hoang MT, Nguyen LD, et al. Acceptance and willingness to pay for COVID-19 vaccines among pregnant women in Vietnam. Trop Med Int Health. 2021 Oct;26(10):1303–1313.
  • Oluklu D, Goncu Ayhan S, Menekse Beser D, et al. Factors affecting the acceptability of COVID-19 vaccine in the postpartum period. Hum Vaccin Immunother. 2021 Nov 2;17(11):4043–4047.
  • Riad A, Jouzová A, Üstün B, et al. COVID-19 vaccine acceptance of Pregnant and lactating women (PLW) in Czechia: an analytical cross-sectional study. Int J Environ Res Public Health. 2021 Dec 19;18(24):13373.
  • Schaal NK, Zöllkau J, and Hepp P, et al. Pregnant and breastfeeding women’s attitudes and fears regarding the COVID-19 vaccination. Arch Gynecol Obstet. 2021 Oct;27:1–8.
  • Siegel MR, Lumbreras-Marquez MI, James K, et al. Perceptions and attitudes towards COVID-19 vaccination amongst pregnant and postpartum individuals. medRxiv. 2021;12:17.21267997.
  • Skjefte M, Ngirbabul M, and Akeju O, et al. COVID-19 vaccine acceptance among pregnant women and mothers of young children: results of a survey in 16 countries. Eur J Epidemiol. 2021 Feb;36(2):197–211.
  • Sutton D, D’Alton M, Zhang Y, et al. COVID-19 vaccine acceptance among pregnant, breastfeeding, and nonpregnant reproductive-aged women. Am J Obstet Gynecol MFM. 2021 Sep;3(5): 100403.
  • Tao L, Wang R, Han N, et al. Acceptance of a COVID-19 vaccine and associated factors among pregnant women in China: a multi-center cross-sectional study based on health belief model. Hum Vaccin Immunother. 2021 Aug 3;17(8):2378–2388.
  • Ransing R, Kukreti P, Raghuveer P, et al. A brief psycho-social intervention for COVID-19 vaccine hesitancy among perinatal women in low-and middle-income countries: need of the hour. Asian J Psychiatr. 2022 Jan;67:102929.
  • Anderson E, Brigden A, Davies A, et al. Maternal vaccines during the Covid-19 pandemic: a qualitative interview study with UK pregnant women. Midwifery. 2021 Sep;100:103062.
  • Chervenak FA, McCullough LB, Grünebaum A. Reversing physician hesitancy to recommend COVID-19 vaccination for pregnant patients. Am J Obstet Gynecol. 2021 Nov 8;S0002-9378(21):01210.
  • Daskalakis G, Pergialiotis V, Antsaklis P, et al. Healthcare workers’ attitudes about vaccination of pregnant women and those wishing to become pregnant. J Perinat Med. 2021 Dec; 7.
  • Deruelle P, Couffignal C, Sibiude J, et al. Prenatal care providers’ perceptions of the SARS-Cov-2 vaccine for themselves and for pregnant women.
  • Hayakawa S, Komine-Aizawa S, Takada K, et al. Anti-SARS-CoV-2 vaccination strategy for pregnant women in Japan. J Obstet Gynaecol Res. 2021 Jun;47(6):1958–1964.
  • Iacobucci G. Covid-19 and pregnancy: vaccine hesitancy and how to overcome it. BMJ. 2021 Nov;22(375):n2862.
  • Moodley J, Khaliq OP, Mkhize PZ. Misrepresentation about vaccines that are scaring women. Afr J Prim Health Care Fam Med. 2021 Jun 9;13(1):e1–e2.
  • Shook LL, Kishkovich TP, and Edlow AG. Countering COVID-19 Vaccine Hesitancy in Pregnancy: the “4 Cs.” Am J Perinatol. 2021 Oct;1055/a-1673-5546:19.
  • Knight M, Morris RK, Furniss J, et al. Include pregnant women in research-particularly covid-19 research. BMJ. 2020 Aug;25(370):m3305.
  • Perez MJ, Paul R, Raghuraman N, et al. Characterizing initial COVID-19 vaccine attitudes among pregnancy-capable healthcare workers. Am J Obstet Gynecol MFM. 2021 Dec;22 4(2):100557.
  • Samannodi M. COVID-19 vaccine acceptability among women who are pregnant or planning for pregnancy in Saudi Arabia: a cross-sectional study. Patient Prefer Adherence. 2021 Nov 23;15:2609–2618.
  • Stuckelberger S, Favre G, Ceulemans M, et al. SARS-CoV-2 vaccine willingness among pregnant and breastfeeding women during the first pandemic wave: a cross-sectional study in Switzerland. Viruses. 2021 Jun 22;13(7):1199.
  • Bradfield Z, Wynter K, Hauck Y, et al. COVID-19 vaccination perceptions and intentions of maternity care consumers and providers in Australia. PLoS One. 2021 Nov 15;16(11):e0260049.
  • Kansal N, Weaver K, Vasudevan, et al. Factors Increasing COVID-19 Vaccine Hesitancy Among Pregnant Women during a Global Pandemic. Am J Obstetrics & Ginecol. 2022 FEBRUARY 01;226(2):313–314.
  • Mark E, Rick AM, Demirci J, et al. Vaccination beliefs and attitudes of lactating women during the SARS-CoV2 pandemic. Am J Obstetrics & Ginecol. 2022 Jan 01;226(1):S678.
  • Saeb S, McCulloch J, Greene N, et al. The Childbirth Experience Survey (CBEX) and COVID-19: the ABCs of vaccine hesitancy in postpartum people. Am J Obstetrics & Ginecol. 2022 Jan 01;226(1):S227–S228.
  • Bianchi FP, Tafuri S. A public health perspective on the responsibility of mass media for the outcome of the anti-COVID-19 vaccination campaign: the AstraZeneca case. Ann Ig. 2022 Feb; 3.
  • Abba-Aji M, Stuckler D, Galea S, et al. Ethnic/racial minorities’ and migrants’ access to COVID-19 vaccines: a systematic review of barriers and facilitators. J Migr Health. 2022 Feb;18:100086.
  • Ayers CK, Kondo KK, Williams BE, et al. Disparities in H1N1 vaccination rates: a systematic review and evidence synthesis to inform COVID-19 vaccination efforts. J Gen Intern Med. 2021 Jun;36(6):1734–1745.
  • Lucyk K, Simmonds KA, Lorenzetti DL, et al. The association between influenza vaccination and socioeconomic status in high income countries varies by the measure used: a systematic review. BMC Med Res Methodol. 2019 Jul 17;19(1):153.
  • Adeyanju GC, Engel E, Koch L, et al. Determinants of influenza vaccine hesitancy among pregnant women in Europe: a systematic review. Eur J Med Res. 2021 Sep 28;26(1):116.
  • Biswas N, Mustapha T, Khubchandani J, Price JH. The Nature and. Extent of COVID-19 vaccination hesitancy in healthcare workers. J Community Health. 2021 Dec;46(6):1244–1251.
  • Hall CM, Northam H, Webster A, et al. Determinants of seasonal influenza vaccination hesitancy among healthcare personnel: an integrative review. J Clin Nurs. 2021 Oct; 29.
  • Bianchi FP, Vimercati L, Mansi F, et al. Compliance with immunization and a biological risk assessment of health care workers as part of an occupational health surveillance program: the experience of a university hospital in southern Italy. Am J Infect Control. 2020 Apr;48(4):368–374.
  • Januszek SM, Faryniak-Zuzak A, Barnaś E, et al. The approach of pregnant women to vaccination based on a COVID-19 systematic review. Medicina (Kaunas). 2021;57(9):977. Published 2021 Sep 17.
  • Truong J, Bakshi S, Wasim A, et al. What factors promote vaccine hesitancy or acceptance during pandemics? A systematic review and thematic analysis. Health Promot Int. 2022 Feb 17;37(1):daab105.
  • Bisset KA, Paterson P. Strategies for increasing uptake of vaccination in pregnancy in high-income countries: a systematic review. Vaccine. 2018 May 11;36(20):2751–2759.
  • Prospero E, Galmozzi S, Paris V, et al. Factors influencing refusing of flu vaccination among pregnant women in Italy: healthcare workers’ role. Influenza Other Respir Viruses. 2019 Mar;13(2):201–207.
  • Sturgis P, Brunton-Smith I, Jackson J. Trust in science, social consensus and vaccine confidence. Nat Hum Behav. 2021 Nov;5(11):1528–1534.
  • Muric G, Wu Y, Ferrara E. COVID-19 vaccine hesitancy on social media: building a public twitter data set of antivaccine content, vaccine misinformation, and conspiracies. JMIR Public Health Surveill. 2021 Nov 17;7(11):e30642.
  • Bianchi FP, Stefanizzi P, Spinelli G, et al. Immunization coverage among asplenic patients and strategies to increase vaccination compliance: a systematic review and meta-analysis. Expert Rev Vaccines. 2021 Mar;20(3):297–308.
  • Wake AD. The willingness to receive COVID-19 vaccine and its associated factors: “vaccination refusal could prolong the war of this pandemic” - A systematic review. Risk Manag Healthc Policy. 2021 Jun;21(14):2609–2623.
  • Sindoni A, Baccolini V, Adamo G, et al. Effect of the mandatory vaccination law on measles and rubella incidence and vaccination coverage in Italy (2013-2019). Hum Vaccin Immunother. 2021 Aug;4:1–10.
  • Chavan M, Qureshi H, Karnati S, et al. COVID-19 vaccination in pregnancy: the benefits outweigh the risks. J Obstet Gynaecol Can. 2021;43(7):814–816.
  • Giambi C, Fabiani M, D’Ancona F, et al. Parental vaccine hesitancy in Italy - Results from a national survey. Vaccine. 2018 Feb 1;36(6):779–787.
  • Signorelli C, Odone A, Conversano M, et al. Deaths after Fluad flu vaccine and the epidemic of panic in Italy. BMJ. 2015 Jan;14(350):h116.
  • Arghittu A, Dettori M, Dempsey E, et al. Health communication in COVID-19 Era: experiences from the Italian vaccinarsì network websites. Int J Environ Res Public Health. 2021 May 25;18(11):5642.
  • Denne SC. the pediatric policy council Including pregnant women in clinical research: time to overcome the barriers. Pediatr Res. 2019;86:554–555.
  • Strömmer S, Lawrence W, Rose T, et al. Improving recruitment to clinical trials during pregnancy: a mixed methods investigation. Soc Sci Med. 2018 Mar;200:73–82.
  • van der Graaf R, van der Zande ISE, den Ruijter HM, et al. Fair inclusion of pregnant women in clinical trials: an integrated scientific and ethical approach. Trials. 2018 Jan 29;19(1):78.
  • Bianchi DW, Kaeser L, Cernich AN. Involving pregnant individuals in clinical research on COVID-19 vaccines. JAMA. 2021 Mar 16;325(11):1041–1042.
  • Şahin D, Tanaçan A, Webster SN, et al. Pregnancy and COVID-19: prevention, vaccination, therapy, and beyond. Turk J Med Sci. 2021 Dec 17;51(SI–1):3312–3326.
  • Sahin D, Tanacan A, Anuk AT, et al. Comparison of clinical features and perinatal outcomes between pre-variant and post-variant periods in pregnant women with SARS-CoV-2: analysis of 1935 cases. Arch Gynecol Obstet. 2022 Mar;7:1–10.