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Review

Vascular endothelial growth factor gene polymorphisms and pregnancy

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Pages 371-378 | Received 04 Aug 2008, Accepted 19 Nov 2008, Published online: 21 Jul 2009

References

  • Ferrara N, Houck K, Jakeman L, Leung D W. Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocr Rev 1992; 13: 18–32
  • Vincenti V, Cassano C, Rocchi M, Persico G. Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation 1996; 93: 1493–1495
  • Ferrara N, Gerber H P, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669–676
  • Harry L E, Paleolog E M. From the cradle to the clinic: VEGF in developmental, physiological, and pathological angiogenesis. Birth Defects Res C Embryo Today 2003; 69: 363–374
  • Vuorela P, Helske S, Hornig C, Alitalo K, Weich H, Halmesmaki E. Amniotic fluid – soluble vascular endothelial growth factor receptor-1 in preeclampsia. Obstet Gynecol 2000; 95: 353–357
  • Anthony F W, Evans P W, Wheeler T, Wood P J. Variation in detection of VEGF in maternal serum by immunoassay and the possible influence of binding proteins. Ann Clin Biochem 1997; 34: 276–280
  • Zygmunt M, Herr F, Munstedt K, Lang U, Liang O D. Angiogenesis and vasculogenesis in pregnancy. Eur J Obstet Gynecol Reprod Biol 2003; 110(Suppl. 1)S10–218
  • te Velde E A, Exalto N, Hesseling P, van der Linden H C. First trimester development of human chorionic villous vascularization studied with CD34 immunohistochemistry. Hum Reprod 1997; 12: 1577–1581
  • Sharkey A M, Charnock-Jones D S, Boocock C A, Brown K D, Smith S K. Expression of mRNA for vascular endothelial growth factor in human placenta. J Reprod Fertil 1993; 99: 609–615
  • Geva E, Ginzinger D G, Zaloudek C J, Moore D H, Byrne A, Jaffe R B. Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2. J Clin Endocrinol Metab 2002; 87: 4213–4224
  • Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997; 18: 4–25
  • Dvorak H F, Brown L F, Detmar M, Dvorak A M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 1995; 146: 1029–1039
  • Jelkmann W. Pitfalls in the measurement of circulating vascular endothelial growth factor. Clin Chem 2001; 47: 617–623
  • Ahmed A, Li X F, Dunk C, Whittle M J, Rushton D I, Rollason T. Colocalisation of vascular endothelial growth factor and its Flt-1 receptor in human placenta. Growth Factors 1995; 12: 235–243
  • Shiraishi S, Nakagawa K, Kinukawa N, Nakano H, Sueishi K. Immunohistochemical localization of vascular endothelial growth factor in the human placenta. Placenta 1996; 17: 111–121
  • Vuorela P, Hatva E, Lymboussaki A, Kaipainen A, Joukov V, Persico M G, Alitalo K, Halmesmaki E. Expression of vascular endothelial growth factor and placenta growth factor in human placenta. Biol Reprod 1997; 56: 489–494
  • Cooper J C, Sharkey A M, McLaren J, Charnock-Jones D S, Smith S K. Localization of vascular endothelial growth factor and its receptor, flt, in human placenta and decidua by immunohistochemistry. J Reprod Fertil 1995; 105: 205–213
  • Marvin K W, Keelan J A, Eykholt R L, Sato T A, Mitchell M D. Expression of angiogenic and neurotrophic factors in the human amnion and choriodecidua. Am J Obstet Gynecol 2002; 187: 728–734
  • Baker P N, Krasnow J, Roberts J M, Yeo K T. Elevated serum levels of vascular endothelial growth factor in patients with preeclampsia. Obstet Gynecol 1995; 86: 815–821
  • Roberts J M, Taylor R N, Musci T J, Rodgers G M, Hubel C A, McLaughlin M K. Preeclampsia: an endothelial cell disorder. Am J Obstet Gynecol 1989; 161: 1200–1204
  • Galazios G, Papazoglou D, Giagloglou K, Vassaras G, Koutlaki N, Maltezos E. Umbilical cord serum vascular endothelial growth factor (VEGF) levels in normal pregnancies and in pregnancies complicated by preterm delivery or pre-eclampsia. Int J Gynaecol Obstet 2004; 85: 6–11
  • Goldberg M A, Schneider T J. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin. J Biol Chem 1994; 269: 4355–4359
  • Tsurumi Y, Murohara T, Krasinski K, Chen D, Witzenbichler B, Kearney M, Couffinhal T, Isner J M. Reciprocal relation between VEGF and NO in the regulation of endothelial integrity. Nat Med 1997; 3: 879–886
  • Fernandez-Patron C, Radomski M W, Avidge S T. Vascular matrix metalloproteinase-2 cleaves big endothelin-1 yielding a novel vasoconstrictor. Circ Res 1999; 85: 906–911
  • Arngrimsson R, Bjornsson H, Geirsson R T. Analysis of different inheritance patterns in preeclampsia/eclampsia syndrome. Hypertens Pregnancy 1995; 14: 27–38
  • Chesley L C, Cooper D W. Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. Br J Obstet Gynaecol 1986; 93: 898–908
  • Hayman R, Brockelsby J, Kenny L, Baker P. Preeclampsia: the endothelium, circulating factor(s) and vascular endothelial growth factor. J Soc Gynecol Invest 1999; 6: 3–10
  • Papazoglou D, Galazios G, Koukourakis M I, Panagopoulos I, Kontomanolis E N, Papatheodorou K, Maltezos E. Vascular endothelial growth factor gene polymorphisms and pre-eclampsia. Mol Hum Reprod 2004; 10: 321–324
  • Shim J Y, Jun J K, Jung B K, Kim S H, Won H S, Lee P R, Kim A. Vascular endothelial growth factor gene +936C/T polymorphism is associated with preeclampsia in Korean women. Am J Obstet Gynecol 2007; 197: 271–274
  • Kim Y J, Park B H, Park H, Jung S C, Pang M G, Ryu H M, Lee K S, Eom S M, Park H Y. No association of the genetic polymorphisms of endothelial nitric oxide synthase, dimethylarginine dimethylaminohydrolase, and vascular endothelial growth factor with preeclampsia in Korean populations. Twin Res Hum Genet 2008; 11: 77–83
  • Kupferminc M J, Daniel Y, Englender T, Baram A, Many A, Jaffa A J, Gull I, Lessing J B. Vascular endothelial growth factor is increased in patients with preeclampsia. Am J Reprod Immunol 1997; 38: 302–306
  • Hunter A, Aitkenhead M, Caldwell C, McCracken G, Wilson D, McClure N. Serum levels of vascular endothelial growth factor in preeclamptic and normotensive pregnancy. Hypertension 2000; 36: 965–969
  • Maynard S E, Min J Y, Merchan J, Lim K H, Li J, Mondal S, Libermann T A, Morgan J P, Sellke F W, Stillman I E, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest 2003; 111: 649–658
  • Lyall F, Greer I A, Boswell F, Fleming R. Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia. Br J Obstet Gynaecol 1997; 104: 223–228
  • Koga K, Osuga Y, Yoshino O, Hirota Y, Ruimeng X, Hirata T, Takeda S, Yano T, Tsutsumi O, Taketani Y. Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia. J Clin Endocrinol Metab 2003; 88: 2348–2351
  • Ranheim T, Staff A C, Henriksen T. VEGF mRNA is unaltered in decidual and placental tissues in preeclampsia at delivery. Acta Obstet Gynecol Scand 2001; 80: 93–98
  • Lachmeijer A M, Dekker G A, Pals G, Aarnoudse J G, ten Kate L P, Arngrimsson R. Searching for preeclampsia genes: the current position. Eur J Obstet Gynecol Reprod Biol 2002; 105: 94–113
  • Renner W, Kotschan S, Hoffmann C, Obermayer-Pietsch B, Pilger E. A common 936C/T mutation in the gene for vascular endothelial growth factor is associated with vascular endothelial growth factor plasma levels. J Vasc Res 2000; 37: 443–448
  • Livingston J C, Chin R, Haddad B, McKinney E T, Ahokas R, Sibai B M. Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia. Am J Obstet Gynecol 2000; 183: 1554–1557
  • Madazli R, Aydin S, Uludag S, Vildan O, Tolun N. Maternal plasma levels of cytokines in normal and preeclamptic pregnancies and their relationship with diastolic blood pressure and fibronectin levels. Acta Obstet Gynecol Scand 2003; 82: 797–802
  • Galazios G, Papazoglou D, Giagloglou K, Vassaras G, Maltezos E, Anastasiadis P. Interleukin-6 levels in umbilical artery serum in normal and abnormal pregnancies. Int J Gynaecol Obstet 2002; 78: 147–151
  • Polliotti B M, Fry A G, Saller D N, Mooney R A, Cox C, Miller R K. Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia. Obstet Gynecol 2003; 101: 1266–1274
  • Romero R, Avila C, Santhanam U, Sehgal P B. Amniotic fluid interleukin 6 in preterm labor. Association with infection. J Clin Invest 1990; 85: 1392–1400
  • Ong S, Lash G, Baker P N. Angiogenesis and placental growth in normal and compromised pregnancies. Baillieres Best Pract Res Clin Obstet Gynaecol 2000; 14: 969–980
  • Silver R M, Schwinzer B, McGregor J A. Interleukin-6 levels in amniotic fluid in normal and abnormal pregnancies: preeclampsia, small-for-gestational-age fetus, and premature labor. Am J Obstet Gynecol 1993; 169: 1101–1105
  • Carlini L, Somigliana E, Rossi G, Veglia F, Busacca M, Vignali M. Risk factors for spontaneous preterm birth: a Northern Italian multicenter case-control study. Gynecol Obstet Invest 2002; 53: 174–180
  • Fedrick J, Anderson A B. Factors associated with spontaneous pre-term birth. Br J Obstet Gynaecol 1976; 83: 342–350
  • Aveyard P, Cheng K K, Manaseki S, Gardosi J. The risk of preterm delivery in women from different ethnic groups. BJOG 2002; 109: 894–899
  • Migone A, Emanuel I, Mueller B, Daling J, Little R E. Gestational duration and birthweight in white, black and mixed-race babies. Paediatr Perinat Epidemiol 1991; 5: 378–391
  • Rudnik-Schoneborn S, Nicholson G A, Morgan G, Rohrig D, Zerres K. Different patterns of obstetric complications in myotonic dystrophy in relation to the disease status of the fetus. Am J Med Genet 1998; 80: 314–321
  • Brown K R, England K M, Goss K L, Snyder J M, Acarregui M J. VEGF induces airway epithelial cell proliferation in human fetal lung in vitro. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1001–L1010
  • Kasahara Y, Tuder R M, Taraseviciene-Stewart L, Le Cras T D, Abman S, Hirth P K, Waltenberger J, Voelkel N F. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J Clin Invest 2000; 106: 1311–1319
  • Papazoglou D, Galazios G, Koukourakis M I, Kontomanolis E N, Maltezos E. Association of -634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm delivery. Acta Obstet Gynecol Scand 2004; 83: 461–465
  • Watson C J, Webb N J, Bottomley M J, Brenchley P E. Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine 2000; 12: 1232–1235
  • Regan L. Overview of recurrent miscarriage. Gynaecol Forum 1998; 3: 3–7
  • Li T C, Makris M, Tomsu M, Tuckerman E, Laird S. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update 2002; 8: 463–481
  • Wilcox A J, Weinberg C R, O'Connor J F, Baird D D, Schlatterer J P, Canfield R E, Armstrong E G, Nisula B C. Incidence of early loss of pregnancy. N Engl J Med 1988; 319: 189–194
  • Vuorela P, Carpen O, Tulppala M, Halmesmaki E. VEGF, its receptors and the tie receptors in recurrent miscarriage. Mol Hum Reprod 2000; 6: 276–282
  • Meegdes B H, Ingenhoes R, Peeters L L, Exalto N. Early pregnancy wastage: relationship between chorionic vascularization and embryonic development. Fertil Steril 1988; 49: 216–220
  • Vailhe B, Dietl J, Kapp M, Toth B, Arck P. Increased blood vessel density in decidua parietalis is associated with spontaneous human first trimester abortion. Hum Reprod 1999; 14: 1628–1634
  • Papazoglou D, Galazios G, Papatheodorou K, Liberis V, Papanas N, Maltezos E, Maroulis G B. Vascular endothelial growth factor gene polymorphisms and idiopathic recurrent pregnancy loss. Fertil Steril 2005; 83: 959–963
  • Coulam C B, Jeyendran R S. Vascular endothelial growth factor gene polymorphisms and recurrent pregnancy loss. Am J Reprod Immunol 2008; 59: 301–305
  • Goodman C, Jeyendran R S, Coulam C B. Vascular endothelial growth factor gene polymorphism and implantation failure. Reprod Biomed Online 2008; 16: 720–723
  • Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380: 435–439
  • Ferrara N, Carver-Moore K, Chen H, Dowd M, Lu L, O'Shea K S, Powell-Braxton L, Hillan K J, Moore M W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996; 380: 439–442
  • Laudenbach V, Fontaine R H, Medja F, Carmeliet P, Hicklin D J, Gallego J, Leroux P, Marret S, Gressens P. Neonatal hypoxic preconditioning involves vascular endothelial growth factor. Neurobiol Dis 2007; 26: 243–252
  • Sivakumar V, Lu J, Ling E A, Kaur C. Vascular endothelial growth factor and nitric oxide production in response to hypoxia in the choroid plexus in neonatal brain. Brain Pathol 2008; 18: 71–85
  • Compernolle V, Brusselmans K, Acker T, Hoet P, Tjwa M, Beck H, Plaisance S, Dor Y, Keshet E, Lupu F, et al. Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice. Nat Med 2002; 8: 702–710
  • Spalding S J, Hennon T, Dohar J, Arkachaisri T. Neonatal lupus erythematosus complicated by mucocutaneous and visceral hemangiomas. Lupus 2007; 16: 904–907

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