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Original Articles

Effects of antibiotic therapy in women with the amniotic fluid “sludge” at 15–24 weeks of gestation on pregnancy outcomes

Pages 3016-3027 | Received 25 Jun 2018, Accepted 07 Jan 2019, Published online: 27 Jan 2019

References

  • Romero R, Miranda J, Chaiworapongsa T, et al. A novel molecular microbiologic technique for the rapid diagnosis of microbial invasion of the amniotic cavity and intra-amniotic infection in preterm labor with intact membranes. Am J Reprod Immunol. 2014;71(4):330–358.
  • Romero R, Espinoza J, Gonçalves LF, et al. The role of inflammation and infection in preterm birth. Semin Reprod Med. 2007;25(1):021–039.
  • Romero R, Miranda J, Kusanovic JP, et al. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques. J Perinat Med. 2015;43(1):19–36.
  • Madan I, Romero R, Kusanovic JP, et al. The frequency and clinical significance of intra-amniotic infection and/or inflammation in women with placenta previa and vaginal bleeding: an unexpected observation. J Perinat Med. 2010;38(3):275–279.
  • Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001;29(7):1303–1310.
  • Pustotina OA, Bubnova NI, Yezhova LS. Clinicomorphological evaluation of fetoplacental complex athydramnios and oligohydramnios of infectious genesis (in Russian). Obstet Gynecol. 2008;N2:19–22.
  • Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345(6198):760–765.
  • Boggess KA, Moss K, Madianos P, et al. Fetal immune response to oral pathogens and risk of preterm birth. Am J Obstet Gynecol. 2005;193(3 Pt 2):1121–1126.
  • Bearfield C, Davenport ES, Sivapathasundaram V, et al. Possible association between amniotic fluid micro-organism infection and microflora in the mouth. BJOG. 2002;109(5):527–533.
  • Kim CJ, Romero R, Chaemsaithong P, et al. Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance. Am J Obstet Gynecol. 2015;213(4 Suppl):S29–S52.
  • Gomez-Lopez N, Romero R, Xu Y, et al. Neutrophil extracellular traps in the amniotic cavity of women with intra-amniotic infection: A new mechanism of host defense. Reprod Sci. 2017;24(8):1139–1153.
  • Gomez-Lopez N, Romero R, Garcia-Flores V, et al. Amniotic fluid neutrophils can phagocytize bacteria: a mechanism for microbial killing in the amniotic cavity. Am J Reprod Immunol. 2017;78(4):e12723.
  • Oh KJ, Kim SM, Hong JS, et al. Twenty-four percent of patients with clinical chorioamnionitis in preterm gestations have no evidence of either culture-proven intraamniotic infection or intraamniotic inflammation. Am J Obstet Gynecol. 2017;216(6):604.e1–604.e11.
  • Roberts DJ, Celi AC, Riley LE, et al. Acute histologic chorioamnionitis at term: nearly always noninfectious. PLoS One. 2012;7(3):e31819.
  • Pustotina OA. Clinical, histological and cytological criteria for diagnosis of intrauterine infection and prediction infectious complications in the mother and the newborn (in Russian) [thesis for a MD in medical sciences]. 143 pp; 1999.
  • Pustotina OA. Clinical and pathogenetic substantiation of obstetric management of oligohydramnios and hydramnios the amniotic fluid volume pathology (in Russian) [thesis for PhD in medical sciences]. 237 pp; 2006.
  • Chen GY, Nuñez G. Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol. 2010;10(12):826–837.
  • Romero R, Miranda J, Chaiworapongsa T, et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72(5):458–474.
  • Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015;28(12):1394–1409.
  • Romero R, Miranda J, Chaiworapongsa T, et al. Sterile intra- amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance. J Matern Fetal Neonatal Med. 2015;28(11):1343–1359.
  • Gardella C, Riley DE, Hitti J, et al. Identification and sequencing of bacterial rDNAs in culture-negative amniotic fluid from women in premature labor. Am J Perinatol. 2004;21(6):319–323.
  • Romero R, Schaudinn C, Kusanovic JP, et al. Detection of a microbial biofilm in intraamniotic infection. Am J Obstet Gynecol. 2008;198(1):135.e1–135.e5.
  • Davies D. Understanding biofilm resistance to antibacterial agents. Nat Rev Drug Discov. 2003;2(2):114–122.
  • Espinoza J, Gonçalves LF, Romero R, et al. The prevalence and clinical significance of amniotic fluid “sludge” in patients with preterm labor and intact membranes. Ultrasound Obstet Gynecol. 2005;25(4):346–352.
  • Romero R, Kusanovic JP, Espinoza J, et al. What is amniotic fluid “sludge”? Ultrasound Obstet Gynecol. 2007;30(5):793–798.
  • Paules C, Moreno E, Gonzales A, et al. Amniotic fluid sludge as a marker of intra-amniotic infection and histological chorioamnionitis in cervical insufficiency: a report of four cases and literature review. J Matern Fetal Neonatal Med. 2016;29(16):2681–2684.
  • Kusanovic JP, Romero R, Espinoza J, et al. Clinical significance of the presence of amniotic fluid “sludge” in asymptomatic high-risk patients for spontaneous preterm delivery. Ultrasound Obstet Gynecol. 2007;30(5):706–714.
  • Nakayama T, Kikuchi A, Okuno T, et al. Enlarging amniotic fluid “sludge” in preterm labor associated with severe course of sepsis and recurrent tension pneumothorax in the infant. J Med Ultrason. 2012;39(3):187–192.
  • Simonsen KA, Anderson-Berry AL, Delair SF, et al. Early-onset neonatal sepsis. Clin Microbiol Rev. 2014;27(1):21–47.
  • Kusanovic JP, Espinoza J, Romero R, et al. Clinical significance of the presence of amniotic fluid “sludge” in asymptomatic patients at high risk for spontaneous preterm delivery. Ultrasound Obstet Gynecol. 2007;30(5):706–714.
  • Fuchs F, Boucoiran I, Picard A, et al. Impact of amniotic fluid “sludge” on the risk of preterm delivery. J Matern Fetal Neonatal Med. 2015;28(10):1176–1180.
  • Hatanaka AR, Mattar R, Kawanami TEN, et al. Amniotic fluid “sludge” is an independent risk factor for preterm delivery. J Matern Fetal Neonatal Med. 2016;29(1):120–125.
  • Adanir I, Ozyuncu O, Gokmen Karasu AF, et al. Amniotic fluid “sludge”; prevalence and clinical significance of it in asymptomatic patients at high risk for spontaneous preterm delivery. J Matern Fetal Neonatal Med. 2018;31(2):135–140.
  • Vaisbuch E, Romero R, Erez O, et al. Clinical significance of early (<20 weeks) vs. late (20–24 weeks) detection of sonographic short cervix in asymptomatic women in the mid-trimester. Ultrasound Obstet Gynecol. 2010;36(4):471–481.
  • Sperling RS, Newton E, Gibbs RS. Intraamniotic infection in low-birth-weight infants. J Infect Dis. 1988;157(1):113–117.
  • Kusanovic JP, Romero R, Martinovic C, et al. Transabdominal collection of amniotic fluid “sludge” and identification of Candida albicans intra-amniotic infection. J Matern Fetal Neonatal Med. 2018;31(10):1279–1284.
  • Lee JH, Romero R, Kim SM, et al. A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM. J Matern Fetal Neonatal Med. 2016;29(17):2727–2737.
  • Hassan S, Romero R, Hendler I, et al. A sonographic short cervix as the only clinical manifestation of intra-amniotic infection. J Perinatal Med. 2006;34(1):13–19.
  • Khalifeh A, Berghella V. Universal cervical length screening in singleton gestations without a previous preterm birth: ten reasons why it should be implemented. Am J Obstet Gynecol. 2016;214(5):603.e1–603.e5.
  • Mella MT, Berghella V. Prediction of preterm birth: cervical sonography. Semin Perinatol. 2009;33(5):317–324.
  • Hassan SS, Romero R, Vidyadhari D, et al. Vaginal progesterone reduces the rate of preterm birth in women with a sonographic short cervix: a multicenter, randomized, double-blind, placebo-controlled trial. Ultrasound Obstet Gynecol. 2011;38(1):18–31.
  • Myers KM, Feltovich H, Mazza E, et al. The mechanical role of the cervix in pregnancy. J Biomech. 2015;48(9):1511–1523.
  • Fonseca EB, Celik E, Parra M, et al. Progesterone and the risk of preterm birth among women with a short cervix. N Engl J Med. 2007;357(5):462–469.
  • Romero R, Nicolaides KH, Conde-Agudelo A, et al. Vaginal progesterone decreases preterm birth ≤34 weeks of gestation in women with a singleton pregnancy and a short cervix: an updated meta-analysis including data from the OPPTIMUM study. Ultrasound Obstet Gynecol. 2016;48(3):308–317.
  • Norman JE, Marlow N, Messow CM, et al. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. Lancet. 2016;387(10033):2106–2116.
  • Kuon RJ, Garfield RE. Actions of progestins for the inhibition of cervical ripening and uterine contractions to prevent preterm birth. Facts Views Vis Obgyn. 2012;4(2):110–119.
  • Baumbach J, Shi SQ, Shi L, et al. Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. Am J Obstet Gynecol. 2012;206(3):254.e1–254.e5.
  • Pustotina OA. Effectiveness of dydrogesterone, 17-OH progesterone and micronized progesterone in prevention of preterm birth in women with a short cervix. J Matern Fetal Neonat Med. 2018;31(14):1830–1838.
  • De La Cochetière MF, Durand T, Lepage P, et al. Resilience of the dominant human fecal microbiota upon short-course antibiotic challenge. J Clin Microbiol. 2005;43(11):5588–5592.
  • Rakoff-Nahoum S, Kong Y, Kleinstein SH, et al. Analysis of gene-environment interactions in postnatal development of the mammalian intestine. Proc Natl Acad Sci USA. 2015;112(7):1929–1936.
  • Gomez de Agüero M, Ganal-Vonarburg SC, Fuhrer T, et al. The maternal microbiota drives early postnatal innate immune development. Science. 2016;351(6279):1296–1302.
  • Myhre R, Brantsaeter AL, Myking S, et al. Intake of probiotic food and risk of spontaneous preterm delivery. Am J Clin Nutr. 2011;93(1):151–157.
  • Yeganegi M, Watson CS, Martins A, et al. Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm labor. Am J Obstet Gynecol. 2009;200(5):532.e1–532.e8.
  • Renthal NE, Williams KC, Mendelson CR. MicroRNAs–mediators of myometrial contractility during pregnancy and labour. Nat Rev Endocrinol. 2013;9(7):391–401.
  • Mahendroo M. Cervical remodeling in term and preterm birth: insights from an animal model. Reproduction. 2012;143(4):429–438.
  • Ireland DJ, Kemp MW, Miura Y, et al. Intra-amniotic pharmacological blockade of inflammatory signalling pathways in an ovine chorioamnionitis model. Mol Hum Reprod. 2015;21(5):479–489.
  • Ng PY, Ireland DJ, Keelan JA. Drugs to block cytokine signaling for the prevention and treatment of inflammation-induced preterm birth. Front Immunol. 2015;6:166.
  • Lamont RF. Advances in the prevention of infection-related preterm birth. Front Immunol. 2015;6:566.

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