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The Journal of Maternal-Fetal & Neonatal Medicine Volume 34, 2021 - Issue 7
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Original Articles

Phase-1 clinical study of tadalafil administered for selective fetal growth restriction in twin pregnancy

Shoichi MagawaFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9322-135X
ORCID Icon,
Masafumi NiiFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0001-5270-5182
ORCID Icon,
Hiroaki TanakaFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0002-1760-691X
ORCID Icon,
Fumi FuruhashiFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0002-5545-6086
ORCID Icon,
Shintaro MakiFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0001-9194-8013
ORCID Icon,
Michiko KuboFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0003-3493-8753
ORCID Icon,
Kayo TanakaFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0002-8373-1567
ORCID Icon,
Eiji KondoFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0001-9773-2520
ORCID Icon &
Tomoaki IkedaFaculty of Medicine, Department of Obstetrics and Gynecology, Mie University, Tsu, Mie, JapanORCID Iconhttps://orcid.org/0000-0003-1489-4810
ORCID Icon show all
Pages 1075-1082 | Received 28 Oct 2018, Accepted 23 May 2019, Published online: 10 Jun 2019

References

  • Kaufmann P , Black S , Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod. 2003;69(1):1–7.
  • Lewi L , Gucciardo L , Huber A , et al. Clinical outcome and placental characteristics of monochorionic diamniotic twin pairs with early- and late-onset discordant growth. Am J Obstet Gynecol. 2008;199(5):511.e1–511.e7.
  • Townsend R , Khalil A. Twin pregnancy complicated by selective growth restriction. Curr Opin Obstet Gynecol. 2016;28(6):485–491.
  • Kubo M , Tanaka H , Maki S , et al. Safety and dose-finding trial of tadalafil administered for fetal growth restriction: a phase-1 clinical study. J Obstet Gynaecol Res. 2017;43(7):1159–1168.
  • National Cancer Institute, Division of Cancer Treatment and Diagnosis . [Internet]. Bethesda (MD): NCI; Common terminology criteria for adverse events v4.0.; 2010, June 14 [Cited 2018 July 15]. Available from: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm#ctc_40.
  • Minakami H , Maeda T , Fujii T , et al. Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition. J Obstet Gynaecol Res. 2014;40(6):1469–1499.
  • Word RA , Cornwell TL. Regulation of cGMP-induced relaxation and cGMP-dependent protein kinase in rat myometrium during pregnancy. Am J Physiol. 1998;274(3):C748–C756.
  • Schneider F , Lutun P , Baldauf JJ , et al. Plasma cyclic GMP concentrations and their relationship with changes of blood pressure levels in pre-eclampsia. Acta Obstet Gynecol Scand. 1996;75(1):40–44.
  • Herraiz S , Pellicer B , Serra V , et al. Sildenafil citrate improves perinatal outcome in fetuses from pre-eclamptic rats. BJOG Int J Obstet Gynaecol. 2012;119(11):1394–1402.
  • Walton RB , Reed LC , Estrada SM , et al. Evaluation of sildenafil and tadalafil for reversing constriction of fetal arteries in a human placenta perfusion model. Hypertension. 2018;72(1):167–176.

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