The use of vaginal progesterone as a maintenance therapy in women with arrested preterm labor: a double-blind placebo–randomized controlled trial

References

• WHO. WHO: recommended definitions, terminology and format for statistical tables related to the perinatal period and use of a new certificate for cause of perinatal deaths. Modifications recommended by FIGO as amended October 14, 1976. Acta Obstet Gynecol Scand. 1977;56(3):247–253.
   PubMed Web of Science ®Google Scholar
• Haram K, Mortensen JH, Wollen AL. Preterm delivery: an overview. Acta Obstet Gynecol Scand. 2003;82(8):687–704.
   PubMed Web of Science ®Google Scholar
• Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379(9832):2162–2172.
   PubMed Web of Science ®Google Scholar
• Callaghan WM, MacDorman MF, Rasmussen SA, et al. The contribution of preterm birth to infant mortality rates in the United States. Pediatrics. 2006;118(4):1566–1573.
   PubMed Web of Science ®Google Scholar
• Petrou S, Sach T, Davidson L. The long-term costs of preterm birth and low birth weight: results of a systematic review. Child Care Health Dev. 2001;27(2):97–115.
   PubMed Web of Science ®Google Scholar
• Birch M N, Frank Z, Caughey A B. Timing of Death and Rates of IVH, RDS, and NEC Among Infants With Neonatal Sepsis [27A]. Obstetrics & Gynecology. 2019;133(5):17S.
   Web of Science ®Google Scholar
• Armanian AM, Barekatain B, Sohrabi F, et al. The prevalence of complications of prematurity among 1000 newborns in Isfahan, Iran. Adv Biomed Res. 2019;8:12.
   PubMedGoogle Scholar
• Swamy GK, Ostbye T, Skjaerven R. Association of preterm birth with long-term survival, reproduction, and next-generation preterm birth. JAMA. 2008;299(12):1429–1436.
   PubMed Web of Science ®Google Scholar
• Carr DB, Clark AL, Kernek K, et al. Maintenance oral nifedipine for preterm labor: a randomized clinical trial. Am J Obstet Gynecol. 1999;181(4):822–827.
   PubMed Web of Science ®Google Scholar
• Dodd JM, Crowther CA, Dare MR, et al. Oral betamimetics for maintenance therapy after threatened preterm labour. Cochrane Database Syst Rev. 2006;1(1):CD003927.
   Google Scholar
• Han S, Crowther CA, Moore V. Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour. Cochrane Database Syst Rev. 2010;7:CD000940.
   Google Scholar
• Papatsonis DN, Flenady V, Liley HG. Maintenance therapy with oxytocin antagonists for inhibiting preterm birth after threatened preterm labour. Cochrane Database Syst Rev. 2009;1:CD005938.
   Google Scholar
• Baumbach J, Shi SQ, Shi L, et al. Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies. Am J Obstet Gynecol. 2012;206(3):254.e1–254.e5.
   PubMed Web of Science ®Google Scholar
• Zakar T, Mesiano S. How does progesterone relax the uterus in pregnancy? N Engl J Med. 2011;364(10):972–973.
   PubMed Web of Science ®Google Scholar
• Henderson D, Wilson T. Reduced binding of progesterone receptor to its nuclear response element after human labor onset. Am J Obstet Gynecol. 2001;185(3):579–585.
   PubMed Web of Science ®Google Scholar
• Schwartz N, Xue X, Elovitz MA, et al. Progesterone suppresses the fetal inflammatory response ex vivo. Am J Obstet Gynecol. 2009;201(2):211.e1–211.e9.
   PubMed Web of Science ®Google Scholar
• Czajkowski K, Sienko J, Mogilinski M, et al. Uteroplacental circulation in early pregnancy complicated by threatened abortion supplemented with vaginal micronized progesterone or oral dydrogesterone. Fertil Steril. 2007;87(3):613–618.
   PubMed Web of Science ®Google Scholar
• Garfield RE, Puri CP, Csapo AI. Endocrine, structural, and functional changes in the uterus during premature labor. Am J Obstet Gynecol. 1982;142(1):21–27.
   PubMed Web of Science ®Google Scholar
• Chanrachakul B, Broughton Pipkin F, Warren AY, et al. Progesterone enhances the tocolytic effect of ritodrine in isolated pregnant human myometrium. Am J Obstet Gynecol. 2005;192(2):458–463.
   PubMed Web of Science ®Google Scholar
• Ruddock NK, Shi S-Q, Jain S, et al. Progesterone, but not 17-alpha-hydroxyprogesterone caproate, inhibits human myometrial contractions. Am J Obstet Gynecol. 2008;199(4):391.e1–391.e7.
   PubMed Web of Science ®Google Scholar
• O’Brien JM, Ho SJ, Istwan NB, et al. Uterine activity in women receiving 17 α-hydroxyprogesterone caproate for the Prevention of preterm Birth: an observational study. Am J Perinatol. 2010;27(2):157–162.
   PubMed Web of Science ®Google Scholar
• Briery CM, Klauser CK, Martin RW, et al. The use of 17-hydroxy progesterone in women with arrested preterm labor: a randomized clinical trial. J Matern Fetal Neonatal Med. 2014;27(18):1892–1896.
   PubMed Web of Science ®Google Scholar
• Rozenberg P, Chauveaud A, Deruelle P, et al. Prevention of preterm delivery after successful tocolysis in preterm labor by 17 alpha-hydroxyprogesterone caproate: a randomized controlled trial. Am J Obstet Gynecol. 2012;206(3):206.e1–206.e9.
   PubMed Web of Science ®Google Scholar
• Romero R, Conde-Agudelo A, Da Fonseca E, et al. Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in singleton gestations with a short cervix: a meta-analysis of individual patient data. Am J Obstet Gynecol. 2018;218(2):161–180.
   PubMed Web of Science ®Google Scholar
• Norman JE, OPPTIMUM co-authors. Vaginal progesterone prophylaxis for preterm birth – Author’s reply. Lancet. 2016;388(10050):1160.
   PubMed Web of Science ®Google Scholar
• Dodd JM, Jones L, Flenady V, et al. Prenatal administration of progesterone for preventing preterm birth in women considered to be at risk of preterm birth. Cochrane Database Syst Rev. 2013;7(7):CD004947.
   Google Scholar
• Farine D, Mundle WR, Dodd J, et al. The use of progesterone for prevention of preterm birth. J Obstet Gynaecol Can. 2008;30(1):67–71.
   PubMedGoogle Scholar
• Arikan I, Barut A, Harma M, et al. Effect of progesterone as a tocolytic and in maintenance therapy during preterm labor. Gynecol Obstet Invest. 2011;72(4):269–273.
   PubMed Web of Science ®Google Scholar
• Martinez de Tejada B, Karolinski A, Ocampo MC, et al. Prevention of preterm delivery with vaginal progesterone in women with preterm labour (4P): randomised double-blind placebo-controlled trial. BJOG Int J Obstet Gynaecol. 2015;122(1):80–91.
   PubMed Web of Science ®Google Scholar
• Sharami SH, Shakiba M. Maintenance therapy by vaginal progesterone after threatened Idiopathic preterm Labor: a randomized placebo-controlled double-blind trial. Int J Fertil Steril. 2010;4(2):5–50.
   Web of Science ®Google Scholar
• Su LL, Samuel M, Chong YS. Progestational agents for treating threatened or established preterm labour. Cochrane Database Syst Rev. 2014;1:CD006770.
   Google Scholar
• Borna S, Sahabi N. Progesterone for maintenance tocolytic therapy after threatened preterm labour: a randomised controlled trial. Aust N Z J Obstet Gynaecol. 2008;48(1):58–63.
   PubMed Web of Science ®Google Scholar
• Choudhary M, Suneja A, Vaid NB, et al. Maintenance tocolysis with oral micronized progesterone for prevention of preterm birth after arrested preterm labor. Int J Gynaecol Obstet off Organ Int Fed Gynaecol Obstet. 2014;126(1):60–63.
   PubMed Web of Science ®Google Scholar
• Khorram O, Han G. Influence of progesterone on endometrial nitric oxide synthase expression. Fertil Steril. 2009;91(5 Suppl):2157–2162.
   PubMed Web of Science ®Google Scholar
• Garfield RE, Kannan MS, Daniel EE. Gap junction formation in myometrium: control by estrogens, progesterone, and prostaglandins. Am J Physiol. 1980;238(3):C81–C89.
   PubMedGoogle Scholar
• Perusquía M, Jasso-Kamel J. Influence of 5α- and 5β-reduced progestins on the contractility of isolated human myometrium at term. Life Sci. 2001;68(26):2933–2944.
   PubMed Web of Science ®Google Scholar
• Karteris E, Zervou S, Pang Y, et al. Progesterone signaling in human myometrium through two novel membrane G protein-coupled receptors: potential role in functional progesterone withdrawal at term. Mol Endocrinol. 2006;20(7):1519–1534.
   PubMedGoogle Scholar
• Merlino AA, Welsh TN, Tan H, et al. Nuclear progesterone receptors in the human pregnancy myometrium: evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A. J Clin Endocrinol Metab. 2007;92(5):1927–1933.
   PubMed Web of Science ®Google Scholar
• Nelson DB, McIntire DD, McDonald J, et al. 17-Alpha hydroxyprogesterone caproate did not reduce the rate of recurrent preterm birth in a prospective cohort study. Am J Obstet Gynecol. 2017;216(6):600.e1–600.e9.
   PubMed Web of Science ®Google Scholar
• Saccone G, Suhag A, Berghella V. 17-Alpha-hydroxyprogesterone caproate for maintenance tocolysis: a systematic review and metaanalysis of randomized trials. Am J Obstet Gynecol. 2015;213(1):16–22.
   PubMed Web of Science ®Google Scholar