Intra-amniotic infection and sterile intra-amniotic inflammation are associated with elevated concentrations of cervical fluid interleukin-6 in women with spontaneous preterm labor with intact membranes

References

• Romero R, Mazor M, Munoz H, et al. The preterm labor syndrome. Ann N Y Acad Sci. 1994;734:414–429.
   PubMed Web of Science ®Google Scholar
• Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010;362(6):529–535.
   PubMed Web of Science ®Google Scholar
• Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345(6198):760–765. 15
   PubMed Web of Science ®Google Scholar
• Romero R. The child is the father of the man. Prenat Neonat Med. 1996;1:8–11.
   Google Scholar
• Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG. 2006;113(Suppl.3):17–42.
   PubMed Web of Science ®Google Scholar
• Romero R. Prenatal medicine: the child is the father of the man. 1996. J Matern Fetal Neonatal Med. 2009;22(8):636–639.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC. The great obstetrical syndromes. J Matern Fetal Neonatal Med. 2009;22(8):633–635.
   PubMed Web of Science ®Google Scholar
• Brosens I, Pijnenborg R, Vercruysse L, et al. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204(3):193–201.
   PubMed Web of Science ®Google Scholar
• Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000-13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385(9966):430–440.
   PubMed Web of Science ®Google Scholar
• Murphy SL, Mathews TJ, Martin JA, et al. Annual summary of vital statistics: 2013–2014. Pediatrics. 2017;139(6):e20163239.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Romero R, Moon JB, et al. Clinical significance of intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 2001;185(5):1130–1136.
   PubMed Web of Science ®Google Scholar
• Romero R, Grivel JC, Tarca AL, et al. Evidence of perturbations of the cytokine network in preterm labor. Am J Obstet Gynecol. 2015;213(6):836 e1–836 e18.
   PubMed Web of Science ®Google Scholar
• Bhatti G, Romero R, Rice GE, et al. Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor. PLoS One. 2020;15(1):e0227881.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Chaiworapongsa T, et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72(5):458–474.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015;28(12):1394–1409.
   PubMed Web of Science ®Google Scholar
• Romero R, Miranda J, Chaiworapongsa T, et al. Sterile intra-amniotic inflammation in asymptomatic patients with a sonographic short cervix: prevalence and clinical significance. J Matern Fetal Neonatal Med. 2015;28(11):1343–1359.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Tarca AL, et al. Gasdermin D: evidence of pyroptosis in spontaneous preterm labor with sterile intra-amniotic inflammation or intra-amniotic infection. Am J Reprod Immunol. 2019;82(6):e13184.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Garcia-Flores V, et al. Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes†. Biol Reprod. 2019;100(5):1306–1318.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Panaitescu B, et al. Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation. Am J Reprod Immunol. 2018;80(5):e13049.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Galaz J, et al. Cellular immune responses in amniotic fluid of women with preterm labor and intra-amniotic infection or intra-amniotic inflammation. Am J Reprod Immunol. 2019;82(5):e13171.
   PubMed Web of Science ®Google Scholar
• Gomez-Lopez N, Romero R, Plazyo O, et al. Intra-amniotic administration of HMGB1 induces spontaneous preterm labor and birth. Am J Reprod Immunol. 2016;75(1):3–7.
   PubMed Web of Science ®Google Scholar
• Peiris HN, Romero R, Vaswani K, et al. Preterm labor is characterized by a high abundance of amniotic fluid prostaglandins in patients with intra-amniotic infection or sterile intra-amniotic inflammation. J Matern Fetal Neonatal Med. 2019;29:1–16.
   Google Scholar
• Motomura K, Romero R, Garcia-Flores V, et al. The alarmin interleukin-1α causes preterm birth through the NLRP3 inflammasome. Mol Hum Reprod. 2020;26(9):712–726.
   PubMed Web of Science ®Google Scholar
• Plazyo O, Romero R, Unkel R, et al. HMGB1 Induces an inflammatory response in the chorioamniotic membranes that is partially mediated by the inflammasome. Biol Reprod. 2016;95(6):130.
   PubMed Web of Science ®Google Scholar
• Friel LA, Romero R, Edwin S, et al. The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J Perinat Med. 2007;35(5):385–393.
   PubMed Web of Science ®Google Scholar
• Kim KW, Romero R, Park HS, et al. A rapid matrix metalloproteinase-8 bedside test for the detection of intraamniotic inflammation in women with preterm premature rupture of membranes. Am J Obstet Gynecol. 2007;197(3):292 e1–5.
   PubMed Web of Science ®Google Scholar
• Musilova I, Kutova R, Pliskova L, et al. Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLoS One. 2015;10(7):e0133929.
   PubMed Web of Science ®Google Scholar
• Bredeson S, Papaconstantinou J, Deford JH, et al. HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes. PLoS One. 2014;9(12):e113799.
   PubMed Web of Science ®Google Scholar
• Romero R, Chaiworapongsa T, Alpay Savasan Z, et al. Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1. J Matern Fetal Neonatal Med. 2011;24(12):1444–1455.
   PubMed Web of Science ®Google Scholar
• Jacobsson B, Mattsby-Baltzer I, Hagberg H. Interleukin-6 and interleukin-8 in cervical and amniotic fluid: relationship to microbial invasion of the chorioamniotic membranes. BJOG: Int J O&G. 2005;112(6):719–724.
   PubMed Web of Science ®Google Scholar
• Andrews WW, Hauth JC, Goldenberg RL, et al. Amniotic fluid interleukin-6: correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery. Am J Obstet Gynecol. 1995;173(2):606–612.
   PubMed Web of Science ®Google Scholar
• Rizzo G, Capponi A, Rinaldo D, et al. Interleukin-6 concentrations in cervical secretions identify microbial invasion of the amniotic cavity in patients with preterm labor and intact membranes. Am J Obstet Gynecol. 1996;175(4 Pt 1):812–817.
   PubMed Web of Science ®Google Scholar
• Holst RM, Mattsby-Baltzer I, Wennerholm UB, et al. Interleukin-6 and interleukin-8 in cervical fluid in a population of Swedish women in preterm labor: relationship to microbial invasion of the amniotic fluid, intra-amniotic inflammation, and preterm delivery. Acta Obstet Gynecol Scand. 2005;84(6):551–557.
   PubMed Web of Science ®Google Scholar
• van Baaren GJ, Vis JY, Wilms FF, et al. Predictive value of cervical length measurement and fibronectin testing in threatened preterm labor. Obstet Gynecol. 2014;123(6):1185–1192.
   PubMed Web of Science ®Google Scholar
• Fraunberger P, Pfeiffer M, Cremer P, et al. Validation of an automated enzyme immunoassay for Interleukin-6 for routine clinical use. Clin Chem Lab Med. 1998;36(10):797–801.
   PubMed Web of Science ®Google Scholar
• Musilova I, Andrys C, Holeckova M, et al. Interleukin-6 measured using the automated electrochemiluminescence immunoassay method for the identification of intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2020;33(11):1919–1926.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Romero R, Stepan M, et al. Antibiotic administration reduces the rate of intraamniotic inflammation in preterm prelabor rupture of the membranes. Am J Obstet Gynecol. 2020;223(1):114 e1–114 e20.
   PubMed Web of Science ®Google Scholar
• Kacerovsky M, Holeckova M, Stepan M, et al. Amniotic fluid glucose level in PPROM pregnancies: a glance at the old friend. J Matern Fetal Neonatal Med. 2020;24:1–13.
   Google Scholar
• Spacek R, Musilova I, Andrys C, et al. Extracellular granzyme A in amniotic fluid is elevated in the presence of sterile intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2020;10:1–10.
   Google Scholar
• Theis KR, Romero R, Motomura K, et al. Microbial burden and inflammasome activation in amniotic fluid of patients with preterm prelabor rupture of membranes. J Perinat Med. 2020;48(2):115–131.
   PubMed Web of Science ®Google Scholar
• Holst RM, Hagberg H, Wennerholm UB, et al. Prediction of spontaneous preterm delivery in women with preterm labor: analysis of multiple proteins in amniotic and cervical fluids. Obstet Gynecol. 2009;114(2 Pt 1):268–277.
   PubMed Web of Science ®Google Scholar
• Inglis SR, Jeremias J, Kuno K, et al. Detection of tumor necrosis factor-alpha, interleukin-6, and fetal fibronectin in the lower genital tract during pregnancy: relation to outcome. Am J Obstet Gynecol. 1994;171(1):5–10.
   PubMed Web of Science ®Google Scholar
• Lockwood CJ, Ghidini A, Wein R, et al. Increased interleukin-6 concentrations in cervical secretions are associated with preterm delivery. Am J Obstet Gynecol. 1994;171(4):1097–1102.
   PubMed Web of Science ®Google Scholar
• Goepfert AR, Goldenberg RL, Andrews WW, et al. The Preterm Prediction Study: association between cervical interleukin 6 concentration and spontaneous preterm birth. National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. Am J Obstet Gynecol. 2001;184(3):483–488.
   PubMed Web of Science ®Google Scholar
• Lange M, Chen FK, Wessel J, et al. Elevation of interleukin-6 levels in cervical secretions as a predictor of preterm delivery. Acta Obstet Gynecol Scand. 2003;82(4):326–329.
   PubMed Web of Science ®Google Scholar
• Kurkinen-Raty M, Ruokonen A, Vuopala S, et al. Combination of cervical interleukin-6 and -8, phosphorylated insulin-like growth factor-binding protein-1 and transvaginal cervical ultrasonography in assessment of the risk of preterm birth. BJOG. 2001;108(8):875–881.
   PubMedGoogle Scholar
• Brik M, Aguar M, Valiente A, et al. Cervical IL-6 and pIGFBP-1 and the prediction of neonatal outcome in symptomatic preterm labour. J Matern Fetal Neonatal Med. 2014;27(12):1241–1247.
   PubMed Web of Science ®Google Scholar