Are genetic variations in IL-1β and IL-6 cytokines associated with the risk of pre-eclampsia? Evidence from a systematic review and meta-analysis

References

• Ananth CV, Keyes KM, Wapner RJ. Pre-eclampsia rates in the United States, 1980–2010: age-period-cohort analysis. BMJ. 2013;347:f6564.
   PubMed Web of Science ®Google Scholar
• Omani-Samani R, Ranjbaran M, Amini P, et al. Adverse maternal and neonatal outcomes in women with preeclampsia in Iran. J Matern Fetal Neonat Med. 2019;32(2):212–216.
   PubMed Web of Science ®Google Scholar
• Souza JP, Gülmezoglu AM, Vogel J, et al. Moving beyond essential interventions for reduction of maternal mortality (the WHO Multicountry Survey on Maternal and Newborn Health): a cross-sectional study. Lancet. 2013;381(9879):1747–1755.
   PubMed Web of Science ®Google Scholar
• Das UN. Cytokines, angiogenic, and antiangiogenic factors and bioactive lipids in preeclampsia. Nutrition. 2015;31(9):1083–1095.
   PubMed Web of Science ®Google Scholar
• Hod T, Cerdeira AS, Karumanchi SA. Molecular mechanisms of preeclampsia. Cold Spring Harb Perspect Med. 2015;5(10):a023473.
   PubMed Web of Science ®Google Scholar
• Mol BW, Roberts CT, Thangaratinam S, et al. Pre-eclampsia. Lancet. 2016;387(10022):999–1011.
   PubMed Web of Science ®Google Scholar
• Marusic J, Prusac IK, Tomas SZ, et al. Expression of inflammatory cytokines in placentas from pregnancies complicated with preeclampsia and HELLP syndrome. J Matern Fetal Neonat Med. 2013;26(7):680–685.
   PubMed Web of Science ®Google Scholar
• Redman C, Sargent I. Pre-eclampsia, the placenta and the maternal systemic inflammatory response—a review. Placenta. 2003;24:S21–S27.
   PubMed Web of Science ®Google Scholar
• Pinheiro MB, Martins-Filho OA, Mota AP, et al. Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state. Cytokine. 2013;62(1):165–173.
   PubMed Web of Science ®Google Scholar
• Tosun M, Celik H, Avci B, et al. Maternal and umbilical serum levels of interleukin-6, interleukin-8, and tumor necrosis factor-α in normal pregnancies and in pregnancies complicated by preeclampsia. J Matern Fetal Neonat Med. 2010;23(8):880–886.
   PubMed Web of Science ®Google Scholar
• Gharesi-Fard B, Mobasher-Nejad F, Nasri F. The expression of T-helper associated transcription factors and cytokine genes in pre-eclampsia. Iran J Immunol. 2016;13(4):296–308.
   PubMed Web of Science ®Google Scholar
• Tok A, Seyithanoğlu M, Ozer A, et al. The serum level of soluble CXCL16 is increased in preeclampsia and associated with hepatic/renal damage. J Matern Fetal Neonat Med. 2021;34(9):1435–1436.
   PubMed Web of Science ®Google Scholar
• Kalinderis M, Papanikolaou A, Kalinderi K, et al. Elevated serum levels of interleukin-6, interleukin-1beta and human chorionic gonadotropin in pre-eclampsia. Am J Reprod Immunol. 2011;66(6):468–475.
   PubMed Web of Science ®Google Scholar
• Daher S, Sass N, Oliveira LG, et al. Cytokine genotyping in preeclampsia. Am J Reprod Immunol. 2006;55(2):130–135.
   PubMed Web of Science ®Google Scholar
• Freitas NAd, Santiago LTC, Kurokawa CS, et al. Effect of preeclampsia on human milk cytokine levels. J Matern Fetal Neonat Med. 2019;32(13):2209–2213.
   PubMed Web of Science ®Google Scholar
• Greer IA, Lyall F, Perera T, et al. Increased concentrations of cytokines interleukin-6 and interleukin-1 receptor antagonist in plasma of women with preeclampsia: a mechanism for endothelial dysfunction? Obstet Gynecol. 1994;84(6):937–940.
   PubMed Web of Science ®Google Scholar
• Bidwell J, Keen L, Gallagher G, et al. Cytokine gene polymorphism in human disease: on-line databases. Genes Immun. 1999;1(1):3.
   PubMed Web of Science ®Google Scholar
• Chen P, Gong Y, Pu Y, et al. Association between polymorphisms in IL-27 gene and pre-eclampsia. Placenta. 2016;37:61–64.
   PubMed Web of Science ®Google Scholar
• Ghasemi M, Kashani E, Fayyaz A, et al. Interleukin-1 alpha variation is associated with the risk of developing preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2015;193:75–78.
   PubMed Web of Science ®Google Scholar
• Liu Q, Gao F, Liu X, et al. Investigations into the association between polymorphisms in the interleukin-10 gene and risk of early-onset preeclampsia. Genet Mol Res. 2015;14(4):19323–19328.
   PubMed Web of Science ®Google Scholar
• Wang H, Guo M, Liu F, et al. Role of IL-17 variants in preeclampsia in Chinese Han women. PLOS One. 2015;10(10):e0140118.
   PubMed Web of Science ®Google Scholar
• Chen H, Wilkins LM, Aziz N, et al. Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context. Hum Mol Genet. 2006;15(4):519–529.
   PubMed Web of Science ®Google Scholar
• El-Omar EM, Carrington M, Chow WH, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404(6776):398–402.
   PubMed Web of Science ®Google Scholar
• Huang S, Chen CP, Schatz F, et al. Pre‐eclampsia is associated with dendritic cell recruitment into the uterine decidua. J Pathol. 2008;214(3):328–336.
   PubMed Web of Science ®Google Scholar
• Koçyıgıt Y, Atamer Y, Atamer A, et al. Changes in serum levels of leptin, cytokines and lipoprotein in pre-eclamptic and normotensive pregnant women. Gynecol Endocrinol. 2004;19(5):267–273.
   PubMed Web of Science ®Google Scholar
• Wang J, Huang Y, Huang Y, et al. Effect of lipoxin A4 on IL-1β production of monocytes and its possible mechanism in severe preeclampsia. J Huazhong Univ Sci Technol Med Sci. 2010;30(6):767–770.
   PubMed Web of Science ®Google Scholar
• Rinehart BK, Terrone DA, Lagoo-Deenadayalan S, et al. Expression of the placental cytokines tumor necrosis factor alpha, interleukin 1beta, and interleukin 10 is increased in preeclampsia. Am J Obstet Gynecol. 1999;181(4):915–920.
   PubMed Web of Science ®Google Scholar
• Amash A, Holcberg G, Sapir O, et al. Placental secretion of interleukin-1 and interleukin-1 receptor antagonist in preeclampsia: effect of magnesium sulfate. J Interferon Cytokine Res. 2012;32(9):432–441.
   PubMed Web of Science ®Google Scholar
• Lockwood CJ, Oner C, Uz YH, et al. Matrix metalloproteinase 9 (MMP9) expression in preeclamptic decidua and MMP9 induction by tumor necrosis factor alpha and interleukin 1 beta in human first trimester decidual cells. Biol Reprod. 2008;78(6):1064–1072.
   PubMed Web of Science ®Google Scholar
• Clark J, Boswell F, Greer IA. The neutrophil and preeclampsia. Semin Reprod Endocrinol. 1998;16(1):57–64..
   Google Scholar
• Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens. 1991;4(8):700–708.
   Google Scholar
• Hu M, Yu Z, Luo D, et al. Association between-174G > C polymorphism in the IL-6 promoter region and the risk of obesity: a meta-analysis. Medicine. 2018;97(33):e11773.
   PubMed Web of Science ®Google Scholar
• Benyo DF, Smarason A, Redman CW, et al. Expression of inflammatory cytokines in placentas from women with preeclampsia. J Clin Endocrinol Metabol. 2001;86(6):2505–2512.
   PubMed Web of Science ®Google Scholar
• Jonsson Y, Rubèr M, Matthiesen L, et al. Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J Reprod Immunol. 2006;70(1–2):83–91.
   PubMed Web of Science ®Google Scholar
• Korn T, Mitsdoerffer M, Croxford AL, et al. IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc Natl Acad Sci USA. 2008;105(47):18460–18465.
   PubMed Web of Science ®Google Scholar
• Sutton CE, Lalor SJ, Sweeney CM, et al. Interleukin-1 and IL-23 induce innate IL-17 production from γδ T cells, amplifying Th17 responses and autoimmunity. Immunity. 2009;31(2):331–341.
   PubMed Web of Science ®Google Scholar
• Meisser A, Cameo P, Islami D, et al. Effects of interleukin-6 (IL-6) on cytotrophoblastic cells. Mol Hum Reprod. 1999;5(11):1055–1058.
   PubMed Web of Science ®Google Scholar
• Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta‐analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10.
   PubMedGoogle Scholar
• Huedo-Medina TB, Sánchez-Meca J, Marín-Martínez F, et al. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods. 2006;11(2):193–206.
   PubMed Web of Science ®Google Scholar
• Egger M, Smith GD, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315(7109):629–634.
   PubMed Web of Science ®Google Scholar
• Ali SM, Khalil RA. Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy. Expert Opin Ther Targets. 2015;19(11):1495–1515.
   PubMed Web of Science ®Google Scholar
• Bellos I, Karageorgiou V, Kapnias D, et al. The role of interleukins in preeclampsia: a comprehensive review. Am J Reprod Immunol. 2018;80(6):e13055.
   PubMed Web of Science ®Google Scholar
• Equils O, Kellogg C, McGregor J, et al. The role of the IL-1 system in pregnancy and the use of IL-1 system markers to identify women at risk for pregnancy complications. Biol Reprod. 2020;103(4):684–694.
   PubMed Web of Science ®Google Scholar
• Thakoordeen S, Moodley J, Naicker T. Candidate gene, genome-wide association and bioinformatic studies in pre-eclampsia: a review. Curr Hypertens Rep. 2018;20(10):91.
   PubMed Web of Science ®Google Scholar
• Staines-Urias E, Paez MC, Doyle P, et al. Genetic association studies in pre-eclampsia: systematic meta-analyses and field synopsis. Int J Epidemiol. 2012;41(6):1764–1775.
   PubMed Web of Science ®Google Scholar
• Xie C, Yao MZ, Liu JB, et al. A meta-analysis of tumor necrosis factor-alpha, interleukin-6, and interleukin-10 in preeclampsia. Cytokine. 2011;56(3):550–559.
   PubMed Web of Science ®Google Scholar
• Glotov AS, Vashukova YS, Glotov OS, et al. Study of the population frequencies of gene polymorphisms, associated with preeclampsia. Russ J Genet Appl Res. 2014;4(5):388–396.
   Google Scholar
• Pfab T, Chen Y-P, Slowinski T, et al. Impact of genes related to immune tolerance and inflammation (tumour necrosis factor-α, interleukin-6) on blood pressure, protein excretion and oedema in pregnancy. J Hypertens. 2005;23(12):2187–2191.
   PubMed Web of Science ®Google Scholar
• Wu W, Yang H, Feng Y, et al. Polymorphisms in inflammatory mediator genes and risk of preeclampsia in Taiyuan, China. Reprod Sci. 2017;24(4):539–547.
   PubMed Web of Science ®Google Scholar
• Goddard KA, Tromp G, Romero R, et al. Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes. Hum Hered. 2007;63(1):1–16.
   PubMed Web of Science ®Google Scholar
• Hefler LA, Tempfer CB, Gregg AR. Polymorphisms within the interleukin-1 beta gene cluster and preeclampsia. Obstet Gynecol. 2001;97(5 Pt 1):664–668.
   PubMed Web of Science ®Google Scholar
• Lachmeijer AM, Nosti-Escanilla MP, Bastiaans EB, et al. Linkage and association studies of IL1B and IL1RN gene polymorphisms in preeclampsia. Hypertens Pregnancy. 2002;21(1):23–38.
   PubMed Web of Science ®Google Scholar
• Pontillo A, Reis EC, Bricher PN, et al. NLRP1 L155H polymorphism is a risk factor for preeclampsia development. Am J Reprod Immunol. 2015;73(6):577–581.
   PubMed Web of Science ®Google Scholar
• Kang L, Chen C-H, Yu C-H, et al. Interleukin-1β gene is not associated with preeclampsia in Taiwanese. Taiwan J Obstet Gynecol. 2012;51(2):240–244.
   PubMed Web of Science ®Google Scholar
• Wang X, Jiang F, Liang Y, et al. Interleukin-1beta-31C/T and -511T/C polymorphisms were associated with preeclampsia in Chinese Han population. PLOS One. 2014;9(9):e106919.
   PubMed Web of Science ®Google Scholar
• Andraweera PH, Dekker GA, Jayasekara RW, et al. Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women. J Matern Fetal Neonat Med. 2016;29(7):1072–1076.
   PubMed Web of Science ®Google Scholar
• Freeman DJ, McManus F, Brown EA, et al. Short- and long-term changes in plasma inflammatory markers associated with preeclampsia. Hypertension. 2004;44(5):708–714.
   PubMed Web of Science ®Google Scholar
• Nasr AS, El Azizy HM, Hassan S, et al. Interleukin-1β-gene polymorphisms in preeclamptic Egyptian women. Middle East Fertil Soc J. 2017;22(4):285–289.
   Web of Science ®Google Scholar
• Mohajertehran F, Afshari JT, Rezaieyazdi Z, et al. Association of single nucleotide polymorphisms in the human tumor necrosis factor-α and interleukin 1-β genes in patients with pre-eclampsia. Iran J Allergy Asthma Immunol. 2012;11(3):224–229.
   PubMed Web of Science ®Google Scholar
• Leme Galvão LP, Menezes FE, Mendonca C, et al. Analysis of association of clinical aspects and IL1B tagSNPs with severe preeclampsia. Hypertens Pregnancy. 2016;35(1):112–122.
   PubMed Web of Science ®Google Scholar
• Tavakkol Afshari Z, Rahimi HR, Ehteshamfar SM, et al. Tumor necrosis factor-α and interleukin-1-β polymorphisms in pre-eclampsia. Iran J Immunol. 2016;13(4):309–316.
   PubMed Web of Science ®Google Scholar
• Fan D, Wang Y, Liu X, et al. Polymorphisms in interleukin-6 and interleukin-10 may be associated with risk of preeclampsia. Genet Mol Res. 2017;16(1).
   Web of Science ®Google Scholar
• Hamid HM, Abdalla SE, Sidig M, et al. Association of VEGFA and IL1β gene polymorphisms with preeclampsia in Sudanese women. Mol Genet Genomic Med. 2020;8(3):e1119.
   PubMed Web of Science ®Google Scholar
• Valencia Villalvazo EY, Canto-Cetina T, Romero Arauz JF, et al. Analysis of polymorphisms in interleukin-10, interleukin-6, and interleukin-1 receptor antagonist in Mexican-Mestizo women with pre-eclampsia. Genet Test Mol Biomarkers. 2012;16(11):1263–1269.
   PubMed Web of Science ®Google Scholar
• de Lima TH, Sass N, Mattar R, et al. Cytokine gene polymorphisms in preeclampsia and eclampsia. Hypertens Res. 2009;32(7):565–569.
   PubMed Web of Science ®Google Scholar
• Stonek F, Hafner E, Metzenbauer M, et al. Absence of an association of tumor necrosis factor (TNF)-alpha G308A, interleukin-6 (IL-6) G174C and interleukin-10 (IL-10) G1082A polymorphism in women with preeclampsia. J Reprod Immunol. 2008;77(1):85–90.
   PubMed Web of Science ®Google Scholar
• Harmon QE, Engel SM, Wu MC, et al. Polymorphisms in inflammatory genes are associated with term small for gestational age and preeclampsia. Am J Reprod Immunol. 2014;71(5):472–484.
   PubMed Web of Science ®Google Scholar
• Pinheiro MB, Gomes KB, Ronda CR, et al. Severe preeclampsia: association of genes polymorphisms and maternal cytokines production in Brazilian population. Cytokine. 2015;71(2):232–237.
   PubMed Web of Science ®Google Scholar
• Vural P, Degirmencioglu S, Saral NY, et al. Tumor necrosis factor α, interleukin-6 and interleukin-10 polymorphisms in preeclampsia. J Obstet Gynaecol Res. 2010;36(1):64–71.
   PubMed Web of Science ®Google Scholar
• Stonek F, Metzenbauer M, Hafner E, et al. Interleukin 6-174 G/C promoter polymorphism and pregnancy complications: results of a prospective cohort study in 1626 pregnant women. Am J Reprod Immunol. 2008;59(4):347–351.
   PubMed Web of Science ®Google Scholar
• Saarela T, Hiltunen M, Helisalmi S, et al. Polymorphisms of interleukin-6, hepatic lipase and calpain-10 genes, and preeclampsia. Eur J Obstet Gynecol Reprod Biol. 2006;128(1–2):175–179.
   PubMed Web of Science ®Google Scholar
• Khadhim MM, Kaduim NMK, Sawadi SM. Polymorphisms of the IL1-BETA-511T/C gene in pregnant women complicated with pre-eclampsia. Iraq Med J. 2017;1(4):88–93.
   Google Scholar
• Puppala M, Kalpana VL, Anuradha A, et al. Association of tumor necrosis factor-alpha and interleukin-6 gene polymorphisms with preeclampsia. Int J Bioassays. 2016;5(02):4774–4778.
   Google Scholar
• Bayoumy NM, Al-Sharaidh AS, Babay ZH, et al. The role of interleukin-6 promoter polymorphism -174G/C in Saudi women with hypertensive disorders of pregnancy. Saudi Med J. 2013;34(7):689–694.
   PubMed Web of Science ®Google Scholar
• Bombell S, McGuire W. Cytokine polymorphisms in women with recurrent pregnancy loss: meta‐analysis. Aust N Z J Obstet Gynaecol. 2008;48(2):147–154.
   PubMed Web of Science ®Google Scholar
• Chen L, Zhang Z, Huang J, et al. Association between rs1800795 polymorphism in the interleukin-6 gene and the risk of polycystic ovary syndrome: a meta-analysis. Medicine. 2018;97(29):e11558.
   PubMed Web of Science ®Google Scholar
• Goussalya D, Jancy MS, Jemi AA, et al. Association of Interleukin 6 and insulin resistance gene polymorphism with polycystic ovarian syndrome: a meta-analysis. Meta Gene. 2020;24:100675.
   Web of Science ®Google Scholar
• Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33(3):130–137.
   Google Scholar
• Xiao J, Yin Y, Gao Y, et al. The increased maternal serum levels of IL-6 are associated with the severity and onset of preeclampsia. Cytokine. 2012;60(3):856–860.
   PubMed Web of Science ®Google Scholar
• Lee YH, Bae S-C, Choi SJ, et al. The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis. Inflamm Res. 2012;61(7):665–671.
   PubMed Web of Science ®Google Scholar
• LaMarca B, Brewer J, Wallace K. IL-6-induced pathophysiology during pre-eclampsia: potential therapeutic role for magnesium sulfate? Int J Interferon Cytokine Mediat Res. 2011;2011(3):59.
   PubMedGoogle Scholar
• Sharma A, Satyam A, Sharma JB. Leptin, IL‐10 and inflammatory markers (TNF‐α, IL‐6 and IL‐8) in pre‐eclamptic, normotensive pregnant and healthy non‐pregnant women. Am J Reprod Immunol. 2007;58(1):21–30.
   PubMed Web of Science ®Google Scholar
• Takacs P, Green KL, Nikaeo A, et al. Increased vascular endothelial cell production of interleukin-6 in severe preeclampsia. Am J Obstet Gynecol. 2003;188(3):740–744.
   PubMed Web of Science ®Google Scholar
• Zhang M, Xu J, Bao X, et al. Association between genetic polymorphisms in interleukin genes and recurrent pregnancy loss – a systematic review and meta-analysis. PLOS One. 2017;12(1):e0169891.
   PubMed Web of Science ®Google Scholar
• Agrawal S, Parveen F, Faridi R, et al. Interleukin-1 gene cluster variants and recurrent pregnancy loss among North Indian women: retrospective study and meta-analysis. Reprod Biomed Online. 2012;24(3):342–351.
   PubMed Web of Science ®Google Scholar
• Romero R, Gotsch F, Pineles B, et al. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev. 2007;65(Suppl. 3):S194–S202.
   PubMedGoogle Scholar
• Luppi P, Deloia JA. Monocytes of preeclamptic women spontaneously synthesize pro-inflammatory cytokines. Clin Immunol. 2006;118(2–3):268–275.
   PubMed Web of Science ®Google Scholar
• Lockwood CJ, Matta P, Krikun G, et al. Regulation of monocyte chemoattractant protein-1 expression by tumor necrosis factor-alpha and interleukin-1beta in first trimester human decidual cells: implications for preeclampsia. Am J Pathol. 2006;168(2):445–452.
   PubMed Web of Science ®Google Scholar