216
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Intra-amniotic infection and sterile intra-amniotic inflammation in women with preterm labor with intact membranes are associated with a higher rate of Ureaplasma species DNA presence in the cervical fluid

, , , , , , , , & show all
Pages 7344-7352 | Received 16 May 2021, Accepted 21 Jun 2021, Published online: 08 Jul 2021

References

  • Romero R, Mazor M, Munoz H, et al. The preterm labor syndrome. Ann N Y Acad Sci. 1994;734:414–429.
  • Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med. 2010;362(6):529–535.
  • Romero R, Dey SK, Fisher SJ. Preterm labor: one syndrome, many causes. Science. 2014;345(6198):760–765.
  • Romero R. The child is the father of the man. Prenat Neonat Med. 1996;1:8–11.
  • Romero R, Espinoza J, Kusanovic JP, et al. The preterm parturition syndrome. BJOG. 2006;113(Suppl. 3):17–42.
  • Romero R. Prenatal medicine: the child is the father of the man. 1996. J Matern Fetal Neonatal Med. 2009;22(8):636–639.
  • Di Renzo GC. The great obstetrical syndromes. J Matern Fetal Neonatal Med. 2009;22(8):633–635.
  • Brosens I, Pijnenborg R, Vercruysse L, et al. The “Great Obstetrical Syndromes“ are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204(3):193–201.
  • Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385(9966):430–440.
  • Murphy SL, Mathews TJ, Martin JA, et al. Annual summary of vital statistics: 2013–2014. Pediatrics. 2017;139(6):e20163239.
  • Romero R, Miranda J, Chaiworapongsa T, et al. Prevalence and clinical significance of sterile intra-amniotic inflammation in patients with preterm labor and intact membranes. Am J Reprod Immunol. 2014;72(5):458–474.
  • Stranik J, Kacerovsky M, Andrys C, et al. Intra-amniotic infection and sterile intra-amniotic inflammation are associated with elevated concentrations of cervical fluid interleukin-6 in women with spontaneous preterm labor with intact membranes. J Matern Fetal Neonatal Med. 2021;7:1–9.
  • Stranik J, Kacerovsky M, Soucek O, et al. IgGFc-binding protein in pregnancies complicated by spontaneous preterm delivery: a retrospective cohort study. Sci Rep. 2021;11(1):6107.
  • Motomura K, Romero R, Galaz J, et al. RNA sequencing reveals distinct immune responses in the chorioamniotic membranes of women with preterm labor and microbial or sterile intra-amniotic inflammation. Infect Immun. 2021;89(5):e00819-20.
  • Friel LA, Romero R, Edwin S, et al. The calcium binding protein, S100B, is increased in the amniotic fluid of women with intra-amniotic infection/inflammation and preterm labor with intact or ruptured membranes. J Perinat Med. 2007;35(5):385–393.
  • Kim KW, Romero R, Park HS, et al. A rapid matrix metalloproteinase-8 bedside test for the detection of intraamniotic inflammation in women with preterm premature rupture of membranes. Am J Obstet Gynecol. 2007;197(3):292.e1–292e5.
  • Romero R, Miranda J, Chaemsaithong P, et al. Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2015;28(12):1394–1409.
  • Musilova I, Kutova R, Pliskova L, et al. Intraamniotic inflammation in women with preterm prelabor rupture of membranes. PLOS One. 2015;10(7):e0133929.
  • Bredeson S, Papaconstantinou J, Deford JH, et al. HMGB1 promotes a p38MAPK associated non-infectious inflammatory response pathway in human fetal membranes. PLOS One. 2014;9(12):e113799.
  • Romero R, Chaiworapongsa T, Alpay Savasan Z, et al. Damage-associated molecular patterns (DAMPs) in preterm labor with intact membranes and preterm PROM: a study of the alarmin HMGB1. J Matern Fetal Neonatal Med. 2011;24(12):1444–1455.
  • Jacobsson B, Mattsby-Baltzer I, Hagberg H. Interleukin-6 and interleukin-8 in cervical and amniotic fluid: relationship to microbial invasion of the chorioamniotic membranes. BJOG. 2005;112(6):719–724.
  • Andrews WW, Hauth JC, Goldenberg RL, et al. Amniotic fluid interleukin-6: correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery. Am J Obstet Gynecol. 1995;173(2):606–612.
  • Donders GGG, Ruban K, Bellen G, et al. Mycoplasma/ureaplasma infection in pregnancy: to screen or not to screen. J Perinat Med. 2017;45(5):505–515.
  • Gonzalez Bosquet E, Gene A, Ferrer I, et al. Value of endocervical ureaplasma species colonization as a marker of preterm delivery. Gynecol Obstet Invest. 2006;61(3):119–123.
  • Miyoshi Y, Suga S, Sugimi S, et al. Vaginal Ureaplasma urealyticum or Mycoplasma hominis and preterm delivery in women with threatened preterm labor. J Matern Fetal Neonatal Med. 2020;4:1–6.
  • Mitsunari M, Yoshida S, Deura I, et al. Cervical Ureaplasma urealyticum colonization might be associated with increased incidence of preterm delivery in pregnant women without prophlogistic microorganisms on routine examination. J Obstet Gynaecol Res. 2005;31(1):16–21.
  • Musilova I, Pliskova L, Kutova R, et al. Ureaplasma species and Mycoplasma hominis in cervical fluid of pregnancies complicated by preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2016;29(1):1–7.
  • van Baaren GJ, Vis JY, Wilms FF, et al. Predictive value of cervical length measurement and fibronectin testing in threatened preterm labor. Obstet Gynecol. 2014;123(6):1185–1192.
  • Fraunberger P, Pfeiffer M, Cremer P, et al. Validation of an automated enzyme immunoassay for interleukin-6 for routine clinical use. Clin Chem Lab Med. 1998;36(10):797–801.
  • Liu CM, Aziz M, Kachur S, et al. BactQuant: an enhanced broad-coverage bacterial quantitative real-time PCR assay. BMC Microbiol. 2012;12(1):56.
  • Kacerovsky M, Pliskova L, Bolehovska R, et al. Lactobacilli-dominated cervical microbiota in women with preterm prelabor rupture of membranes. Pediatr Res. 2020;87(5):952–960.
  • Musilova I, Andrys C, Holeckova M, et al. Interleukin-6 measured using the automated electrochemiluminescence immunoassay method for the identification of intra-amniotic inflammation in preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2020;33(11):1919–1926.
  • Larsen B, Hwang J. Mycoplasma, Ureaplasma, and adverse pregnancy outcomes: a fresh look. Infect Dis Obstet Gynecol. 2010;2010:521921.
  • Sprong KE, Mabenge M, Wright CA, et al. Ureaplasma species and preterm birth: current perspectives. Crit Rev Microbiol. 2020;46(2):169–181.
  • Breugelmans M, Vancutsem E, Naessens A, et al. Association of abnormal vaginal flora and Ureaplasma species as risk factors for preterm birth: a cohort study. Acta Obstet Gynecol Scand. 2010;89(2):256–260.
  • Cobo T, Vergara A, Collado MC, et al. Characterization of vaginal microbiota in women with preterm labor with intra-amniotic inflammation. Sci Rep. 2019;9(1):18963.
  • Kwak DW, Hwang HS, Kwon JY, et al. Co-infection with vaginal Ureaplasma urealyticum and Mycoplasma hominis increases adverse pregnancy outcomes in patients with preterm labor or preterm premature rupture of membranes. J Matern Fetal Neonatal Med. 2014;27(4):333–337.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.