The association between in vitro fertilization and intracytoplasmic sperm injection treatment and the risk of congenital heart defects

References

• Hoorsan H, Mirmiran P, Chaichian S, et al. Congenital malformations in infants of mothers undergoing assisted reproductive technologies: A systematic review and meta-analysis study. J Prev Med Public Health. 2017;50(6):347–360.
   PubMedGoogle Scholar
• Steptoe PC, Edwards RG. Birth after the reimplantation of a human embryo. The Lancet. 1978;312(8085):366.
   Google Scholar
• Bi W-j, Cui L, Xiao Y-j, et al. Assessing cardiovascular remodelling in fetuses and infants conceived by assisted reproductive technologies: a prospective observational cohort study protocol. BMJ Open. 2019;9(10):e031452.
   PubMed Web of Science ®Google Scholar
• Kissin DM, Jamieson DJ, Barfield WD. Monitoring health outcomes of assisted reproductive technology. N Engl J Med. 2014;371(1):91–93.
   PubMed Web of Science ®Google Scholar
• Fortunato A, Tosti E. The impact of in vitro fertilization on health of the children: an update. Eur J Obstet Gynecol Reprod Biol. 2011;154(2):125–129.
   PubMed Web of Science ®Google Scholar
• Bahtiyar MO, Campbell K, Dulay AT, et al. Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased? A case–historical control study. Journal of Ultrasound in Medicine. 2010;29(6):917–922.
   PubMed Web of Science ®Google Scholar
• Jwa SC, Jwa J, Kuwahara A, et al. Male subfertility and the risk of major birth defects in children born after in vitro fertilization and intracytoplasmic sperm injection: a retrospective cohort study. BMC Pregnancy Childbirth. 2019;19(1):192.
   PubMedGoogle Scholar
• Saunders K, Spensley J, Munro J, et al. Growth and physical outcome of children conceived by in vitro fertilization. Pediatrics. 1996;97(5):688–692.
   PubMed Web of Science ®Google Scholar
• Hansen M, Kurinczuk JJ, Milne E, et al. Assisted reproductive technology and birth defects: a systematic review and meta-analysis. Hum Reprod Update. 2013;19(4):330–353.
   PubMed Web of Science ®Google Scholar
• Hansen M, Bower C, Milne E, et al. Assisted reproductive technologies and the risk of birth defects-a systematic review. Hum Reprod. 2005;20(2):328–338.
   PubMed Web of Science ®Google Scholar
• Davies MJ, Moore VM, Willson KJ, et al. Reproductive technologies and the risk of birth defects. N Engl J Med. 2012;366(19):1803–1813.
   PubMed Web of Science ®Google Scholar
• Kurinczuk JJ, Bower C. Birth defects in infants conceived by intracytoplasmic sperm injection: an alternative interpretation. BMJ. 1997;315(7118):1260–1265.
   PubMedGoogle Scholar
• Giorgione V, Parazzini F, Fesslova V, et al. Congenital heart defects in IVF/ICSI pregnancy: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;51(1):33–42.
   PubMed Web of Science ®Google Scholar
• Pontesilli M, Painter RC, Grooten IJ, et al. Subfertility and assisted reproduction techniques are associated with poorer cardiometabolic profiles in childhood. Reprod Biomed Online. 2015;30(3):258–267.
   PubMed Web of Science ®Google Scholar
• D'Souza SW, Rivlin E, Cadman J, et al. Children conceived by in vitro fertilisation after fresh embryo transfer. Arch Dis Child Fetal Neonatal Ed. 1997;76(2):F70–F74.
   PubMed Web of Science ®Google Scholar
• Wennerholm U, Hamberger L, Nilsson L, et al. Obstetric and perinatal outcome of children conceived from cryopreserved embryos. Hum Reprod. 1997;12(8):1819–1825.
   PubMed Web of Science ®Google Scholar
• Westergaard H, Tranberg Johansen A, Erb K, et al. Danish National In-Vitro Fertilization Registry 1994 and 1995: a controlled study of births, malformations and cytogenetic findings. Hum Reprod. 1999;14(7):1896–1902.
   PubMed Web of Science ®Google Scholar
• Sutcliffe A, Taylor B, Saunders K, et al. Outcome in the second year of life after in-vitro fertilisation by intracytoplasmic sperm injection: a UK case-control study. The Lancet. 2001;357(9274):2080–2084.
   PubMed Web of Science ®Google Scholar
• Anthony S, Buitendijk S, Dorrepaal C, et al. Congenital malformations in 4224 children conceived after IVF. Hum Reprod. 2002;17(8):2089–2095.
   PubMed Web of Science ®Google Scholar
• Isaksson R, Gissler M, Tiitinen A. Obstetric outcome among women with unexplained infertility after IVF: a matched case–control study. Hum Reprod. 2002;17(7):1755–1761.
   PubMed Web of Science ®Google Scholar
• Koivurova S, Hartikainen A-L, Gissler M, et al. Neonatal outcome and congenital malformations in children born after in-vitro fertilization. Hum Reprod. 2002;17(5):1391–1398.
   PubMed Web of Science ®Google Scholar
• Katalinic A, Rösch C, Ludwig M, German ICSI Follow-Up Study Group. Pregnancy course and outcome after intracytoplasmic sperm injection: a controlled, prospective cohort study. Fertil Steril. 2004;81(6):1604–1616.
   PubMed Web of Science ®Google Scholar
• Bonduelle M, Wennerholm U-B, Loft A, et al. A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod. 2005;20(2):413–419.
   PubMed Web of Science ®Google Scholar
• Källén B, Finnström O, Nygren KG, et al. In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Res A Clin Mol Teratol. 2005;73(3):162–169.
   PubMedGoogle Scholar
• Klemetti R, Gissler M, Sevón T, et al. Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil Steril. 2005;84(5):1300–1307.
   PubMed Web of Science ®Google Scholar
• Olson CK, Keppler-Noreuil KM, Romitti PA, et al. In vitro fertilization is associated with an increase in major birth defects. Fertil Steril. 2005;84(5):1308–1315.
   PubMed Web of Science ®Google Scholar
• Zhu JL, Basso O, Obel C, et al. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. BMJ. 2006;333(7570):679.
   PubMed Web of Science ®Google Scholar
• Buckett WM, Chian R-C, Holzer H, et al. Obstetric outcomes and congenital abnormalities after in vitro maturation, in vitro fertilization, and intracytoplasmic sperm injection. Obstetr Gynecol. 2007;110(4):885–891.
   PubMed Web of Science ®Google Scholar
• Knoester M, Helmerhorst FM, Vandenbroucke JP, et al.; Leiden Artificial Reproductive Techniques Follow-up Project (L-art-FUP). Perinatal outcome, health, growth, and medical care utilization of 5- to 8-year-old intracytoplasmic sperm injection singletons. Fertil Steril. 2008;89(5):1133–1146.
   PubMed Web of Science ®Google Scholar
• Desmyttere S, De Schepper J, Nekkebroeck J, et al. Two-year auxological and medical outcome of singletons born after embryo biopsy applied in preimplantation genetic diagnosis or preimplantation genetic screening. Hum Reprod. 2009;24(2):470–476.
   PubMed Web of Science ®Google Scholar
• El-Chaar D, Yang Q, Gao J, et al. Risk of birth defects increased in pregnancies conceived by assisted human reproduction. Fertil Steril. 2009;92(5):1557–1561.
   PubMed Web of Science ®Google Scholar
• Reefhuis J, Honein M, Schieve L, et al.; National Birth Defects Prevention Study. Assisted reproductive technology and major structural birth defects in the United States. Hum Reprod. 2009;24(2):360–366.
   PubMed Web of Science ®Google Scholar
• Halliday JL, Ukoumunne OC, Baker HG, et al. Increased risk of blastogenesis birth defects, arising in the first 4 weeks of pregnancy, after assisted reproductive technologies. Hum Reprod. 2010;25(1):59–65.
   PubMed Web of Science ®Google Scholar
• Källén B, Finnström O, Lindam A, et al. Congenital malformations in infants born after in vitro fertilization in Sweden. Birth Defects Res A Clin Mol Teratol. 2010;88(3):137–143.
   PubMed Web of Science ®Google Scholar
• Pinborg A, Loft A, Henningsen A-KA, et al. Infant outcome of 957 singletons born after frozen embryo replacement: the Danish National Cohort Study 1995–2006. Fertil Steril. 2010;94(4):1320–1327.
   PubMed Web of Science ®Google Scholar
• Wen SW, Leader A, White RR, et al. A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection. Euro J Obstetr Gynecol Reprod Biol. 2010;150(2):160–165.
   PubMed Web of Science ®Google Scholar
• Tararbit K, Houyel L, Bonnet D, et al. Risk of congenital heart defects associated with assisted reproductive technologies: a population-based evaluation. Eur Heart J. 2011;32(4):500–508.
   PubMed Web of Science ®Google Scholar
• Hansen M, Kurinczuk JJ, De Klerk N, et al. Assisted reproductive technology and major birth defects in Western Australia. Obstet Gynecol. 2012;120(4):852–863.
   PubMed Web of Science ®Google Scholar
• Kermani RM, Nedaeifard L, Nateghi MR, et al. Congenital anomalies in infants conceived by assisted reproductive techniques. Arch Iran Med. 2012;15(4):0–0.
   Web of Science ®Google Scholar
• Sagot P, Bechoua S, Ferdynus C, et al. Similarly increased congenital anomaly rates after intrauterine insemination and IVF technologies: a retrospective cohort study. Hum Reprod. 2012;27(3):902–909.
   PubMed Web of Science ®Google Scholar
• Farhangniya M, Rabori ED, Kermani RM, et al. Comparison of congenital abnormalities of infants conceived by assisted reproductive techniques versus infants with natural conception in Tehran. Int J Fertil Steril. 2013;7(3):217–224.
   PubMedGoogle Scholar
• Farhi A, Reichman B, Boyko V, et al. Congenital malformations in infants conceived following assisted reproductive technology in comparison with spontaneously conceived infants. J Matern Fetal Neonatal Med. 2013;26(12):1171–1179.
   PubMed Web of Science ®Google Scholar
• Fedder J, Loft A, Parner ET, et al. Neonatal outcome and congenital malformations in children born after ICSI with testicular or epididymal sperm: a controlled national cohort study. Human Reproduction. 2013;28(1):230–240.
   PubMed Web of Science ®Google Scholar
• Henriksson P, Westerlund E, Wallén H, et al. Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilisation: cross sectional study. BMJ. 2013;346(jan15 3):e8632–e8632.
   PubMedGoogle Scholar
• Kelley-Quon LI, Tseng C-H, Janzen C, et al. Congenital malformations associated with assisted reproductive technology: a California statewide analysis. J Pediatric Surg. 2013;48(6):1218–1224.
   PubMed Web of Science ®Google Scholar
• Tararbit K, Lelong N, Thieulin A-C, et al.; EPICARD Study Group. The risk for four specific congenital heart defects associated with assisted reproductive techniques: a population-based evaluation. Hum Reprod. 2013;28(2):367–374.
   PubMed Web of Science ®Google Scholar
• Udell JA, Lu H, Redelmeier DA. Long-term cardiovascular risk in women prescribed fertility therapy. J Am Coll Cardiol. 2013;62(18):1704–1712.
   PubMed Web of Science ®Google Scholar
• Bassiouny YA, Bayoumi YA, Gouda HM, et al. Is intracytoplasmic sperm injection (ICSI) associated with higher incidence of congenital anomalies? A single center prospective controlled study in Egypt. J Mater Fetal Neonatal Med. 2014;27(3):279–282.
   PubMed Web of Science ®Google Scholar
• Gutarra‐Vilchez R, Santamariña‐Rubio E, Salvador J, et al. Birth defects in medically assisted reproduction pregnancies in the city of Barcelona. Prenat Diagn. 2014;34(4):327–334.
   PubMed Web of Science ®Google Scholar
• Votava‐Smith JK, Glickstein JS, Simpson LL, et al. Comparison of method of conception in fetuses undergoing echocardiography at a tertiary referral center. Prenat Diagn. 2014;34(5):445–449.
   PubMed Web of Science ®Google Scholar
• Westerlund E, Brandt L, Hovatta O, et al. Incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization: a population-based cohort study from Sweden . Fertil Steril. 2014;102(4):1096–1102.
   PubMed Web of Science ®Google Scholar
• Farland LV, Grodstein F, Srouji SS, et al. Infertility, fertility treatment, and risk of hypertension. Fertil Steril. 2015;104(2):391–397.
   PubMed Web of Science ®Google Scholar
• Heisey AS, Bell EM, Herdt‐Losavio ML, et al. Surveillance of congenital malformations in infants conceived through assisted reproductive technology or other fertility treatments. Birth Defects Res A Clin Mol Teratol. 2015;103(2):119–126.
   PubMedGoogle Scholar
• Parazzini F, Cipriani S, Bulfoni G, et al. The risk of birth defects after assisted reproduction. J Assist Reprod Genet. 2015;32(3):379–385.
   PubMed Web of Science ®Google Scholar
• Seggers J, de Walle HE, Bergman JE, et al. Congenital anomalies in offspring of subfertile couples: a registry-based study in the northern Netherlands. Fertil Steril. 2015;103(4):1001–1010. e3.
   PubMed Web of Science ®Google Scholar
• Ben-Yaakov RD, Kessous R, Shoham-Vardi I, et al. Fertility treatments in women who become pregnant and carried to viability, and the risk for long-term maternal cardiovascular morbidity. Am J Perinatol. 2016;33(14):1388–1393.
   PubMed Web of Science ®Google Scholar
• Boulet SL, Kirby RS, Reefhuis J, et al.; States Monitoring Assisted Reproductive Technology (SMART) Collaborative. Assisted reproductive technology and birth defects among liveborn infants in Florida, Massachusetts, and Michigan, 2000-2010. JAMA Pediatr. 2016;170(6):e154934.
   PubMed Web of Science ®Google Scholar
• Ernstad EG, Bergh C, Khatibi A, et al. Neonatal and maternal outcome after blastocyst transfer: a population-based registry study. Am J Obstetr Gynecol. 2016;214(3):378.e1–e1-378. e10.
   PubMed Web of Science ®Google Scholar
• Setti PEL, Moioli M, Smeraldi A, et al. Obstetric outcome and incidence of congenital anomalies in 2351 IVF/ICSI babies. J Assist Reprod Genet. 2016;33(6):711–717.
   PubMed Web of Science ®Google Scholar
• Iwashima S, Ishikawa T, Itoh H. Reproductive technologies and the risk of congenital heart defects. Hum Fertil. 2017;20(1):14–21.
   PubMed Web of Science ®Google Scholar
• Schofield SJ, Doughty VL, Van Stiphout N, et al. Assisted conception and the risk of CHD: a case-control study. 2017.
   Google Scholar
• Patil AS, Nguyen C, Groff K, et al. Severity of congenital heart defects associated with assisted reproductive technologies: Case series and review of the literature. Birth Defects Res. 2018;110(8):654–661.
   PubMedGoogle Scholar
• Shiloh SR, Sheiner E, Wainstock T, et al. Long-term cardiovascular morbidity in children born following fertility treatment. J Pediatr. 2019;204:84–88. e2.
   PubMed Web of Science ®Google Scholar
• Bjorkman SH, Bjorkman KR, Sfakianaki AK, et al. Prevalence of clinically significant congenital heart defects in low-risk IVF pregnancies. Fertil Steril. 2019;112(3):e8.
   Web of Science ®Google Scholar
• Scherrer U, Rimoldi SF, Rexhaj E, et al. Systemic and pulmonary vascular dysfunction in children conceived by assisted reproductive technologies. Circulation. 2012;125(15):1890–1896.
   PubMed Web of Science ®Google Scholar
• Valenzuela-Alcaraz B, Crispi F, Bijnens B, et al. Assisted reproductive technologies are associated with cardiovascular remodeling in utero that persists postnatally. Circulation. 2013;128(13):1442–1450.
   PubMed Web of Science ®Google Scholar
• Zhou J, Liu H, Gu H-t, et al. Association of cardiac development with assisted reproductive technology in childhood: a prospective single-blind pilot study. Cell Physiol Biochem. 2014;34(3):988–1000.
   PubMedGoogle Scholar
• Liu H, Zhang Y, Gu H-T, et al. Association between assisted reproductive technology and cardiac alteration at age 5 years. JAMA Pediatr. 2015;169(6):603–605.
   PubMed Web of Science ®Google Scholar
• Von Arx R, Allemann Y, Sartori C, et al. Right ventricular dysfunction in children and adolescents conceived by assisted reproductive technologies. J Appl Physiol. 2015;118(10):1200–1206.
   PubMed Web of Science ®Google Scholar
• Lancaster P. Congenital malformations after in-vitro fertilization. Lancet. 1987;2(8572):1392–1393.
   PubMed Web of Science ®Google Scholar
• Ceelen M, van Weissenbruch MM, Vermeiden JP, et al. Cardiometabolic differences in children born after in vitro fertilization: follow-up study. J Clin Endocrinol Metabol. 2008;93(5):1682–1688.
   PubMed Web of Science ®Google Scholar
• Belva F, Roelants M, De Schepper J, et al. Blood pressure in ICSI-conceived adolescents. Hum Reprod. 2012;27(10):3100–3108.
   PubMed Web of Science ®Google Scholar
• Meister TA, Rimoldi SF, Soria R, et al. Association of assisted reproductive technologies with arterial hypertension during adolescence. J Am Coll Cardiol. 2018;72(11):1267–1274.
   PubMed Web of Science ®Google Scholar
• Scherrer U, Rexhaj E, Allemann Y, et al. Cardiovascular dysfunction in children conceived by assisted reproductive technologies. Eur Heart J. 2015;36(25):1583–1589.
   PubMed Web of Science ®Google Scholar
• Lie RT, Lyngstadaas A, Ørstavik KH, et al. Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis. Int J Epidemiol. 2005;34(3):696–701.
   PubMed Web of Science ®Google Scholar
• Hansen M, Kurinczuk JJ, Bower C, et al. The risk of major birth defects after intracytoplasmic sperm injection and in vitro fertilization. N Engl J Med. 2002;346(10):725–730.
   PubMed Web of Science ®Google Scholar
• Taitson PF, Kwong DD, Lima GCdA, et al. Incidence and anatomy of cardiac malformations in children con-ceived by assisted reproduction techniques–A review. 2014.
   Google Scholar
• Banker M, Arora P, Banker J, et al. Prevalence of structural birth defects in IVF-ICSI pregnancies resulting from autologous and donor oocytes in Indian sub-continent: results from 2444 births . Acta Obstet Gynecol Scand. 2019;98(6):715–721.
   PubMed Web of Science ®Google Scholar
• von Wolff M, Haaf T. In vitro fertilization technology and child health: risks. Mech Poss Conseq. Deutsches Ärzteblatt International. 2020;117(3):23.
   Google Scholar
• Aderibigbe OA, Ranzini AC. Is a Fetal Echocardiography Necessary in IVF-ICSI Pregnancies After Anatomic Survey? J Clin Ultrasound. 2020;48(6):307–311.
   PubMed Web of Science ®Google Scholar
• Guo X-Y, Liu X-M, Jin L, et al. Cardiovascular and metabolic profiles of offspring conceived by assisted reproductive technologies: a systematic review and meta-analysis. Fertil Steril. 2017;107(3):622–631. e5.
   PubMed Web of Science ®Google Scholar
• Dayan N, Filion KB, Okano M, et al. Cardiovascular risk following Fertility Therapy: Systematic Review and Meta-Analysis. J Am Coll Cardiol. 2017;70(10):1203–1213.
   PubMed Web of Science ®Google Scholar
• Zheng Z, Chen L, Yang T, et al. Multiple pregnancies achieved with IVF/ICSI and risk of specific congenital malformations: a meta-analysis of cohort studies. Reprod Biomed Online. 2018;36(4):472–482.
   PubMed Web of Science ®Google Scholar
• Park K, Wei J, Minissian M, et al. Adverse pregnancy conditions, infertility, and future cardiovascular risk: implications for mother and child. Cardiovasc Drugs Ther. 2015;29(4):391–401.
   PubMed Web of Science ®Google Scholar
• Sealey JE, Itskovitz-Eldor J, Rubattu S, et al. Estradiol-and progesterone-related increases in the renin-aldosterone system: studies during ovarian stimulation and early pregnancy. J Clin Endocrinol Metabol. 1994;79(1):258–264.
   PubMed Web of Science ®Google Scholar
• Brown MC, Best KE, Pearce MS, et al. Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis. Eur J Epidemiol. 2013;28(1):1–19.
   PubMed Web of Science ®Google Scholar
• Wen J, Jiang J, Ding C, et al. Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis. Fertil Steril. 2012;97(6):1331–1337. e4.
   PubMed Web of Science ®Google Scholar
• Rimm AA, Katayama AC, Diaz M, et al. A meta-analysis of controlled studies comparing major malformation rates in IVF and ICSI infants with naturally conceived children. J Assist Reprod Genet. 2004;21(12):437–443.
   PubMed Web of Science ®Google Scholar
• Germanakis I, Sifakis S. The impact of fetal echocardiography on the prevalence of liveborn congenital heart disease. Pediatr Cardiol. 2006;27(4):465–472.
   PubMed Web of Science ®Google Scholar
• Lacamara C, Ortega C, Villa S, et al. Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis. JBRA Assist Reprod. 2017;21(3):251–259.
   PubMed Web of Science ®Google Scholar
• Mainigi MA, Olalere D, Burd I, et al. Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014;90(2):1–9.
   Web of Science ®Google Scholar
• Jurema MW, Nogueira D. In vitro maturation of human oocytes for assisted reproduction. Fertil Steril. 2006;86(5):1277–1291.
   PubMed Web of Science ®Google Scholar
• Fleming T, Kwong W, Porter R, et al. 453 Eckert JJ. The embryo and its future. Biol Reprod. 2004;71(4):1046–1054. (454.
   PubMed Web of Science ®Google Scholar
• Padhee M, Zhang S, Lie S, et al. The periconceptional environment and cardiovascular disease: does in vitro embryo culture and transfer influence cardiovascular development and health? Nutrients. 2015;7(3):1378–1425.
   PubMed Web of Science ®Google Scholar
• London SN, Young D, Caldito G, et al. Clomiphene citrate-induced perturbations during meiotic maturation and cytogenetic abnormalities in mouse oocytes in vivo and in vitro. Fertil Steril. 2000;73(3):620–626.
   PubMed Web of Science ®Google Scholar
• Delimitreva S, Zhivkova R, Isachenko E, et al. Meiotic abnormalities in in vitro-matured marmoset monkey (Callithrix jacchus) oocytes: development of a non-human primate model to investigate causal factors. Hum Reprod. 2006;21(1):240–247.
   PubMed Web of Science ®Google Scholar
• Feng C, Wang L-Q, Dong M-Y, et al. Assisted reproductive technology may increase clinical mutation detection in male offspring. Fertil Steril. 2008;90(1):92–96.
   PubMed Web of Science ®Google Scholar
• Katari S, Turan N, Bibikova M, et al. DNA methylation and gene expression differences in children conceived in vitro or in vivo. Hum Mol Genet. 2009;18(20):3769–3778.
   PubMed Web of Science ®Google Scholar
• Van Montfoort A, Hanssen L, De Sutter P, et al. Assisted reproduction treatment and epigenetic inheritance. Hum Reprod Update. 2012;18(2):171–197.
   PubMed Web of Science ®Google Scholar
• De Rycke M, Liebaers I, Van Steirteghem A. Epigenetic risks related to assisted reproductive technologies: risk analysis and epigenetic inheritance. Hum Reprod. 2002;17(10):2487–2494.
   PubMed Web of Science ®Google Scholar
• Horsthemke B, Ludwig M. Assisted reproduction: the epigenetic perspective. Hum Reprod Update. 2005;11(5):473–482.
   PubMed Web of Science ®Google Scholar
• Rimoldi SF, Sartori C, Rexhaj E, et al. Vascular dysfunction in children conceived by assisted reproductive technologies: underlying mechanisms and future implications. Swiss Medical Weekly. 2014;144:w13973.
   PubMedGoogle Scholar
• Celermajer DS. Manipulating nature: might there be a cardiovascular price to pay for the miracle of assisted conception? Am Heart Assoc. 2012;125(15):1832–1834.
   Google Scholar