Mediterranean shrubs as potential antioxidant sources

References

• Halliwell , B . 2006 . Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life . Plant Physiology , 141 ( 2 ) : 312 – 322 .
   PubMed Web of Science ®Google Scholar
• Cao , G , Sofic , E and Prior , RL . 1997 . Antioxidant and prooxidant behavior of flavonoids: Structure–activity relationships . Free Radical Biology and Medicine , 22 ( 5 ) : 749 – 760 .
   PubMed Web of Science ®Google Scholar
• Guo , Q , Zhao , B , Shen , S , Hou , J , Hu , J and Xin , W . 1999 . ESR study on the structure-antioxidant activity relationship of tea catechins and their epimers . Biochimica et Biophysica Acta (BBA) – General Subjects , 1427 ( 1 ) : 13 – 23 .
   PubMed Web of Science ®Google Scholar
• Rice-Evans , CA , Miller , NJ and Paganga , G . 1996 . Structure-antioxidant activity relationships of flavonoids and phenolic acids . Free Radical Biology and Medicine , 20 : 933 – 956 .
   PubMed Web of Science ®Google Scholar
• Sakar , MK , Berkman , MZ , Calis , I and Ruedi , P . 1991 . Constituents of Arbutus andrachne . Fitoterapia , 62 : 176 – 177 .
   Google Scholar
• Carcache-Blanco , EJ , Cuendet , M , Park , EJ , Su , BN , Rivero-Cruz , JF Farnsworth , NR . 2006 . Potential cancer chemopreventive agents from Arbutus unedo . Natural Product Research , 20 : 327 – 334 .
   PubMed Web of Science ®Google Scholar
• Ziyyat , A and Boussairi , EH . 1998 . Cardiovascular effects of Arbutus unedo L. in spontaneously hypertensive rats . Phytotherapy Research , 12 ( 2 ) : 110 – 113 .
   Web of Science ®Google Scholar
• Ziyyat , A , Mekhfi , H , Bnouham , M , Tahri , A , Legssyer , A Hoerter , J . 2002 . Arbutus unedo induces endothelium-dependent relaxation of the isolated rat aorta . Phytotherapy Research , 16 ( 6 ) : 572 – 575 .
   PubMed Web of Science ®Google Scholar
• Mekhfi , H , El Haouari , M , Legssyer , A , Bnouham , M , Aziz , M Atmani , F . 2004 . Platelet anti-aggregant property of some Moroccan medicinal plants . Journal of Ethnopharmacology , 94 ( 2–3 ) : 317 – 322 .
   PubMed Web of Science ®Google Scholar
• Mekhfi , H , ElHaouari , M , Bnouham , M , Aziz , M , Ziyyat , A and Legssyer , A . 2006 . Effects of extracts and Tannins from Arbutus unedo leaves on rat platelet aggregation . Phytotherapy Research. , 20 ( 2 ) : 135 – 139 .
   PubMed Web of Science ®Google Scholar
• Legssyer , A , Ziyyat , A , Mekhfi , H , Bnouham , M , Herrenknecht , C Roumy , V . 2004 . Tannins and catechin gallate mediate the vasorelaxant effect of Arbutus unedo on the rat isolated aorta . Phytotherapy Research , 18 ( 11 ) : 889 – 894 .
   PubMed Web of Science ®Google Scholar
• Lebreton , P and Bayet , C . 2002 . The physiological and biochemical variability of the strawberry tree Arbutus unedo L. (Ericaceae) . Acta Pharmaceutica , 52 : 83 – 90 .
   Google Scholar
• Kivcak , B and Mert , T . 2001 . Quantitative determination of [alpha]-tocopherol in Arbutus unedo by TLC-densitometry and colorimetry . Fitoterapia , 72 ( 6 ) : 656 – 661 .
   PubMed Web of Science ®Google Scholar
• Males , Z , Plazibat , M , Vundac , VB and Zuntar , I . 2006 . Qualitative and quantitative analysis of flavonoids of the strawberry tree –Arbutus unedo L. (Ericaceae) . Acta Pharmaceutica , 56 : 245 – 250 .
   PubMedGoogle Scholar
• Kivcak , B , Mert , T and Denizci , AA . 2001 . Antimicrobial activity of Arbutus unedo L. Fabad . Journal of Pharmaceutical Sciences , 26 : 125 – 128 .
   Google Scholar
• Thies , H and Sulc , D . 1950 . Arbutus unedo L. I. Determination of arbutin in the leaves of the strawberry tree . Pharmazie , 5 : 553 – 555 .
   PubMedGoogle Scholar
• Alarcao-E-Silva , M , Leitao , AEB , Azinheira , HG and Leitao , MCA . 2001 . The Arbutus berry: Studies on its color and chemical characteristics at two mature stages . Journal of Food Composition and Analysis , 14 ( 1 ) : 27 – 35 .
   Web of Science ®Google Scholar
• Ayaz , FA , Kucukislamoglu , M and Reunanen , M . 2000 . Sugar, non-volatile and phenolic acids composition of strawberry tree (Arbutus unedo L. var. ellipsoidea) fruits . Journal of Food Composition and Analysis , 13 ( 2 ) : 171 – 177 .
   Google Scholar
• Proliac , A and Raynaud , J . 1981 . Anthocyanin pigments of fruits of Arbutus unedo . Plantes Medicinales et Phytotherapia , 15 : 109 – 112 .
   Google Scholar
• Soufleros , EH , Mygdalia , SA and Natskoulis , P . 2005 . Production process and characterization of the traditional Greek fruit distillate “Koumaro” by aromatic and mineral composition . Journal of Food Composition and Analysis , 18 ( 7 ) : 699 – 716 .
   Web of Science ®Google Scholar
• Cabras , P , Angioni , A , Tuberoso , C , Floris , I , Reniero , F Guillou , C . 1999 . Homogentisic acid: A phenolic acid as a marker of strawberry-tree (Arbutus unedo) honey . Journal of Agricultural and Food Chemistry , 47 ( 10 ) : 4064 – 4067 .
   PubMed Web of Science ®Google Scholar
• Scanu , R , Spano , N , Panzanelli , A , Pilo , MI , Piu , PC Sanna , G . 2005 . Direct chromatographic methods for the rapid determination of homogentisic acid in strawberry tree (Arbutus unedo L.) honey . Journal of Chromatographic Science , 1090 ( 1–2 ) : 76 – 80 .
   Google Scholar
• Kontaxis , DG . 1997 . “ Caper ” . In Specialty and minor crops handbook , Oakland : The Small Farm Center UC DANR .
   Google Scholar
• Phillips , R and Foy , N . 1990 . Herbs , London : Pan Books Ltd. .
   Google Scholar
• Afsharypour , S , Jeiran , K and Jazy , AA . 1998 . First investigation of the flavour profile of the leaf, ripe fruit and root of Capparis spinosa var. mucronifolia from Iran . Pharmaceutica Acta Helvetiae , 72 : 307 – 309 .
   Google Scholar
• Brevard , H , Brambilla , M , Chaintreau , A , Marion , JP and Diserens , H . 1992 . Occurence of elemental sulphur in capers (Capparis spinosa L.) and first investigation of the flavour profile . Flavour and Fragrance Journal , 7 : 313 – 321 .
   Google Scholar
• Germano , MP , De Pasquale , R , D’Angelo , V , Catania , S , Silvari , V and Costa , C . 2002 . Evaluation of extracts and isolated fraction from Capparis spinosa L. buds as an antioxidant source . Journal of Agricultural and Food Chemistry , 50 ( 5 ) : 1168 – 1171 .
   PubMed Web of Science ®Google Scholar
• Fahey , JW and Talalay , P . 1999 . Antioxidant functions of sulforaphane: A potent inducer of phase II detoxication enzymes . Food and Chemical Toxicology , 37 : 973 – 979 .
   PubMed Web of Science ®Google Scholar
• Ahmed , ZF , Rizk , AM , Hammouda , FM and Sheif-El-Nasr , MM . 1972 . Glucosinolates of Egyptian Capparis species . Phytochemistry , 11 : 251 – 256 .
   Web of Science ®Google Scholar
• Daxenbichler , ME , Spencer , GF , Carlson , DG , Rose , GB , Brinker , AM and Powell , RG . 1991 . Glucosinolate composition of seeds from 297 species of wild plants . Phytochemistry , 30 ( 8 ) : 2623 – 2638 .
   Web of Science ®Google Scholar
• Matthaus , B and Ozcan , M . 2002 . Glucosinolate composition of young shoots and flower buds of capers (Capparis species) growing wild in Turkey . Journal of Agricultural and Food Chemistry , 50 ( 25 ) : 7323 – 7325 .
   PubMed Web of Science ®Google Scholar
• Matthaus , B and Ozcan , M . 2005 . Glucosinolates and fatty acid, sterol, and tocopherol composition of seed oils from Capparis spinosa var. spinosa and Capparis ovata Desf. var. canescens (Coss.) Heywood . Journal of Agricultural and Food Chemistry , 53 ( 18 ) : 7136 – 7141 .
   PubMed Web of Science ®Google Scholar
• Schraudolf , H . 1989 . Indole glucosinolates of Capparis spinosa . Phytochemistry , 88 : 259 – 260 .
   Google Scholar
• Bonina , F , Puglia , C , Ventura , D , Aquino , R , Tortora , S Sacchi , A . 2002 . In vitro antioxidant and in vivo photoprotective effects of a lyophilized extract of Capparis spinosa L. buds . Journal of Cosmetic Science , 53 : 321 – 335 .
   PubMed Web of Science ®Google Scholar
• Khanfar , MA , Sabri , SS , Zarga , MHA and Zeller , K-P . 2003 . The chemical constituents of Capparis spinosa of Jordanian origin . Natural Product Research , 17 ( 1 ) : 9 – 14 .
   PubMed Web of Science ®Google Scholar
• Giuffrida , D , Salvo , F , Ziino , M , Toscano , G and Dugo , G . 2002 . Initial investigation on some chemical constituents of capers (Capparis spinosa L.) from the island of Salina . Italian Journal of Food Science , 14 ( 1 ) : 25 – 33 .
   Web of Science ®Google Scholar
• Panico , AM , Cardile , V , Garufi , F , Puglia , C , Bonina , F and Ronsisvalle , G . 2005 . Protective effect of Capparis spinosa on chondrocytes . Life Sciences , 77 ( 20 ) : 2479 – 2488 .
   PubMed Web of Science ®Google Scholar
• Sharaf , M , El-Ansari , MA and Saleh , NAM . 2000 . Quercetin triglycoside from Capparis spinosa . Fitoterapia , 71 ( 1 ) : 46 – 49 .
   PubMed Web of Science ®Google Scholar
• Gadgoli , C and Mishra , SH . 1995 . Preliminary screening of Achillea millefolium, Cichorium intybus and Capparis spinosa for antihepatotoxic activity . Fitoterapia , 63 : 319 – 323 .
   Google Scholar
• Shirwaikar , A , Sreenivasan , KK , Krishnanand , BR and Vasanth , KA . 1996 . Chemical investigation and antihepatotoxic activity of the root bark of Capparis spinosa . Fitoterapia , 67 : 200 – 204 .
   Google Scholar
• el-Sissi , HI and el-Ansary , MA . 1967 . Tannins and polyphenolics of the leaves of Myrtus communis . Planta Medica , 15 : 41 – 51 .
   PubMed Web of Science ®Google Scholar
• Hayder , N , Abdelwahed , A , Kilani , S , Ben Ammar , R , Mahmoud , A Ghedira , K . 2004 . Anti-genotoxic and free-radical scavenging activities of extracts from (Tunisian) Myrtus communis . Mutation Research – Genetic Toxicology and Environmental Mutagenesis , 564 ( 1 ) : 89 – 95 .
   PubMed Web of Science ®Google Scholar
• Romani , A , Pinelli , P , Mulinacci , N , Vincieri , FF and Tattini , M . 1999 . Identification and quantitation of polyphenols in leaves of Myrtus communis L . Chromatographia , 49 ( 1–2 ) : 17 – 20 .
   Web of Science ®Google Scholar
• Romani , A , Coinu , R , Carta , S , Pinelli , P , Galardi , C Vincieri , FF . 2004 . Evaluation of antioxidant effect of different extracts of Myrtus communis L . Free Radical Research , 38 ( 1 ) : 97 – 103 .
   PubMed Web of Science ®Google Scholar
• Appendino , G , Bianchi , F , Minassi , A , Sterner , O , Ballero , M and Gibbons , S . 2002 . Oligomeric acylphloroglucinols from myrtle (Myrtus communis) . Journal of Natural Product Research , 65 ( 3 ) : 334 – 338 .
   PubMed Web of Science ®Google Scholar
• Appendino , G , Maxia , L , Bettoni , P , Locatelli , M , Valdivia , C Ballero , M . 2006 . Antibacterial galloylated alkylphloroglucinol glucosides from myrtle (Myrtus communis) . Journal of Natural Product Research , 69 ( 2 ) : 251 – 254 .
   PubMed Web of Science ®Google Scholar
• Feisst , C , Franke , L , Appendino , G and Werz , O . 2005 . Identification of molecular targets of the oligomeric nonprenylated acylphloroglucinols from Myrtus communis and their implication as anti-inflammatory compounds . Journal of Pharmacology and Experimental Therapeutics , 315 ( 1 ) : 389 – 396 .
   PubMed Web of Science ®Google Scholar
• Kashman , Y , Rotstein , A and Liftshitz , A . 1974 . The structure determination of two new acylphloroglucinols from Myrtus communis L . Tetrahedron , 30 : 991 – 997 .
   Web of Science ®Google Scholar
• Rosa , A , Deiana , M , Casu , V , Corona , G , Appendino , G Bianchi , F . 2003 . Antioxidant activity of oligomeric acylphloroglucinols from Myrtus communis L . Free Radical Research , 37 ( 9 ) : 1013 – 1019 .
   PubMed Web of Science ®Google Scholar
• Rotstein , A , Lifshitz , A and Kashman , Y . 1974 . Isolation and antibacterial activity of acylphloroglucinols from Myrtus communis . Antimicrobial Agricultural Chemistry , 6 : 539 – 542 .
   PubMed Web of Science ®Google Scholar
• Verotta , L . 2002 . Are acylphloroglucinols lead structures for the treatment of degenerative diseases? . Phytochemical Review , 1 ( 3 ) : 389 – 407 .
   Google Scholar
• Alamanni , MC and Cossu , M . 2004 . Radical scavenging activity and antioxidant activity of liquors of myrtle (Myrtus communis L.) berries and leaves . Italian Journal of Food Science , 16 ( 2 ) : 197 – 208 .
   Web of Science ®Google Scholar
• Martin-Lopez , T , Rubio , B , Villaescusa , L , Fernandez , L and Diaz , AM . 1999 . Polyphenolic compounds from pericarps of Myrtus communis . Pharmaceutical Biology (Formerly International Journal of Pharmacognosy) , 37 : 28 – 31 .
   Google Scholar
• Montoro , P , Tuberoso , CIG , Piacente , S , Perrone , A , De Feo , V Cabras , P . 2006 . Stability and antioxidant activity of polyphenols in extracts of Myrtus communis L. berries used for the preparation of myrtle liqueur . Journal of Pharmaceutical and Biomedical Analysis , 41 ( 5 ) : 1614 – 1619 .
   PubMed Web of Science ®Google Scholar
• Tuberoso , CIG , Melis , M , Angioni , A , Pala , M and Cabras , P . 2007 . Myrtle hydroalcoholic extracts obtained from different selections of Myrtus communis L . Food Chemistry , 101 ( 2 ) : 806 – 811 .
   Web of Science ®Google Scholar
• Barbera , G and Inglese , P . 1993 . La Coltura del Ficodindia , Bologna, , Italy : Edagricole .
   Google Scholar
• Barbera , G , Inglese , P and Pimienta-Barrios , E . 1995 . Agro-ecology, cultivation and uses of prickly pear . FAO Plant Produt. Protect. Pap. , 132
   Google Scholar
• Dominguez-Lopez , A . 1995 . Use of the fruits and stems of the prickly pear cactus (Opuntia spp.) into human food . Food Science and Technology International , 1 : 65 – 69 .
   Web of Science ®Google Scholar
• Muñoz-de-Chavez , M , Chavez , A , Valles , V and Roldan , JA . 1995 . “ The nopal: A plant of mainfold qualities ” . In World review of nutrition and dietetics , Edited by: Simopoulos , AP . Basel : Karger .
   Google Scholar
• Ramadan , MF and Morsel , MT . 2003 . Recovered lipids from prickly pear [Opuntia ficus-indica (L.) Mill.] peel: A good source of polyunsaturated fatty acids, natural antioxidant vitamins and sterols . Food Chemistry , 83 ( 3 ) : 447 – 456 .
   Web of Science ®Google Scholar
• Sawaya , WN , Khatchadourian , HA , Safi , WM and Al-Muhammad , HM . 1983 . Chemical characterization of prickly pear pulp, Opuntia ficus-indica, and the manufacturing of prickly pear jam . International Journal of Food Science and Technology , 18 ( 2 ) : 183 – 193 .
   Google Scholar
• Sepulveda , E and Saenz , C . 1990 . Caracteristicas quimicas y fisicas de pulpa de tuna (Opuntia ficus-indica) . Revista de Agroquimica y Tecnologia de Alimentos , 30 : 551 – 555 .
   Google Scholar
• Gurrieri , S , Miceli , L , Lanza , CM , Tomaselli , F , Bonomo , RP and Rizzarelli , E . 2000 . Chemical characterization of Sicilian prickly pear (Opuntia ficus-indica) and perspectives for the storage of its juice . Journal of Agricultural and Food Chemistry , 48 ( 11 ) : 5424 – 5431 .
   PubMed Web of Science ®Google Scholar
• Butera , D , Tesoriere , L , Di Gaudio , F , Bongiorno , A , Allegra , M Pintaudi , AM . 2002 . Antioxidant activities of Sicilian prickly pear (Opuntia ficus-indica) fruit extracts and reducing properties of its betalains: Betanin and indicaxanthin . Journal of Agricultural and Food Chemistry , 50 ( 23 ) : 6895 – 6901 .
   PubMed Web of Science ®Google Scholar
• Kanner , J , Harel , S and Granit , R . 2001 . Betalains – A new class of dietary cationized antioxidants . Journal of Agricultural and Food Chemistry , 49 ( 11 ) : 5178 – 5185 .
   PubMed Web of Science ®Google Scholar
• Strack , D , Vogt , T and Schliemann , W . 2003 . Recent advances in betalain research . Phytochemistry , 62 ( 3 ) : 247 – 269 .
   PubMed Web of Science ®Google Scholar
• Rein , E , Kharazmi , A and Winther , K . 2004a . A herbal remedy, Hyben Vital (stand. powder of a subspecies of Rosa canina fruits), reduces pain and improves general wellbeing in patients with osteoarthritis – a double-blind, placebo-controlled, randomised trial . Phytomedicine , 11 ( 5 ) : 383 – 391 .
   PubMed Web of Science ®Google Scholar
• Rein , E , Kharazmi , A and Winther , K . 2004b . A herbal remedy made from subspecies of rose-hip Rosa canina, reduces symptoms of knee and hip osteoarthritis . Osteoarthritis Cartilage , 12 ( 2 ) : 80 – 85 .
   Google Scholar
• Bond , H . 2004 . Multivitamins for HIV, fruit powder for osteoarthritis and kava for cheerfulness . The Pharmaceutical Journal , 273 : 857
   Google Scholar
• Winther , K , Apel , K and Thamsborg , G . 2005 . A powder made from seeds and shells of a rose-hip subspecies (Rosa canina) reduces symptoms of knee and hip osteoarthritis: A randomized, double-blind, placebo-controlled clinical trial . Scandinavian Journal of Rheumatology , 34 ( 4 ) : 302 – 308 .
   PubMed Web of Science ®Google Scholar
• Demir , F and Ozcan , M . 2001 . Chemical and technological properties of rose (Rosa canina L.) fruits grown wild in Turkey . Journal of Food Engineering , 47 ( 4 ) : 333 – 336 .
   Web of Science ®Google Scholar
• Kumarasamy , Y , Cox , PJ , Jaspars , M , Rashid , MA and Sarker , SD . 2003 . Bioactive flavonoid glycosides from the seeds of Rosa canina . Pharmaceutical Biology (Formerly International Journal of Pharmacognosy) , 41 : 237 – 242 .
   Web of Science ®Google Scholar
• Hodisan , T , Socaciu , C , Ropan , I and Neamtu , G . 1997 . Carotenoid composition of Rosa canina fruits determined by thin-layer chromatography and high-performance liquid chromatography . Journal of Pharmaceutics and Biomedical Analysis , 16 ( 3 ) : 521 – 528 .
   PubMed Web of Science ®Google Scholar
• Al-Sereiti , MR , Abu-Amer , KM and Sen , P . 1999 . Pharmacology of rosemary (Rosmarinus officinalis L.) and its therapeutic potentials . Indian Journal of Experimental Biology , 37 : 124 – 130 .
   PubMedGoogle Scholar
• Burton , GW and Ingold , KU . 1984 . β-Carotene: An unusual type of lipid antioxidant . Science , 224 : 569 – 573 .
   PubMed Web of Science ®Google Scholar
• Etter , SC . 2004 . Rosmarinus officinalis as an antioxidant . Journal of Herbs, Spices and Medicinal Plants , 11 : 121 – 159 .
   Google Scholar
• Fryer , MJ . 1992 . The antioxidant effects of thylacoid vitamin E (a-tocopherol) . Plant Cell and Environment , 15 : 381 – 393 .
   Web of Science ®Google Scholar
• Munne-Bosch , S and Alegre , L . 2000 . Changes in carotenoids, tocopherols and diterpenes during drought and recovery, and the biological significance of chlorophyll loss in Rosmarinus officinalis plants . Planta , 210 ( 6 ) : 925 – 931 .
   PubMed Web of Science ®Google Scholar
• Munne-Bosch , S and Alegre , L . 2003 . Drought-induced changes in the redox state of alpha-tocopherol, ascorbate, and the diterpene carnosic acid in chloroplasts of Labiatae species differing in carnosic acid contents . Plant Physiology , 131 ( 4 ) : 1816 – 1825 .
   PubMed Web of Science ®Google Scholar
• Smirnoff , N and Wheeler , GL . 2000 . Ascorbic acid in plants: Biosynthesis and function . Critical Reviews in Biochemistry Molecular Biology , 35 ( 4 ) : 291 – 314 .
   PubMed Web of Science ®Google Scholar
• Aeschbach , R , Philippossian , G and Richli , U . 1986 . Flavonoid glycosides from rosemary: Separation, isolation and identification . Bulletin of Liaision-Groupe Polyphenols , 13 : 56 – 58 .
   Google Scholar
• Cuvelier , M-E , Richard , H and Berset , C . 1996 . Antioxidative activity and phenolic composition of pilot-plant and commercial extracts of sage and rosemary . Journal of American Oil and Chemical Society , 73 ( 5 ) : 645 – 652 .
   Web of Science ®Google Scholar
• del Bano , MJ , Lorente , J , Castillo , J , Benavente-Garcia , O , del Rio , JA Ortuno , A . 2003 . Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity . Journal of Agricultural and Food Chemistry , 51 ( 15 ) : 4247 – 4253 .
   PubMed Web of Science ®Google Scholar
• Ho , CT , Wang , M , Wei , GJ , Huang , TC and Huang , MT . 2000 . Chemistry and antioxidative factors in rosemary and sage . BioFactors , 13 : 161 – 166 .
   PubMed Web of Science ®Google Scholar
• Okamura , N , Haraguchi , H , Hashimoto , K and Yagi , A . 1994 . Flavonoids in Rosmarinus officinalis leaves . Phytochemistry , 37 ( 5 ) : 1463 – 1466 .
   PubMed Web of Science ®Google Scholar
• Wenkert , E , Fuchs , A and McChensey , J . 1965 . Chemical artifacts from the family Labiatae . Journal of Organic Chemistry , 30 : 2932 – 2934 .
   Web of Science ®Google Scholar
• Lamaison , JL , Petijean-Freytet , C and Carnat , A . 1991 . Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid . Pharmaceutica Acta Helvetiae. , 66 : 185 – 188 .
   PubMedGoogle Scholar
• Moreno , S , Scheyer , T , Romano , CS and Vojnov , AA . 2006 . Antioxidant and antimicrobial activities of rosemary extracts linked to their polyphenol composition . Free Radical Research , 40 ( 2 ) : 223 – 231 .
   PubMed Web of Science ®Google Scholar
• Aruoma , OI , Halliwell , B , Aeschbach , R and Loligers , J . 1992 . Antioxidant and pro-oxidant properties of active rosemary constituents: Carnosol and carnosic acid . Xenobiotica , 22 : 257 – 268 .
   PubMed Web of Science ®Google Scholar
• Frankel , EN , Huang , SW , Aeschbach , R and Prior , E . 1996 . Antioxidant activity of a rosemary extract and its constituents, carnosic acid, carnosol, and rosmarinic acid, in bulk oil and oil-in-water emulsion . Journal of Agricultural and Food Chemistry , 44 ( 1 ) : 131 – 135 .
   Web of Science ®Google Scholar
• Haraguchi , H , Saito , T , Okamura , N and Yagi , A . 1995 . Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis . Planta Medica , 4 : 333 – 336 .
   Google Scholar
• Schwarz , K and Ternes , W . 1992 . Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis . Zeitschrift für Lebensmitteluntersuchung und – Forschung A , 195 ( 2 ) : 95 – 98 .
   PubMedGoogle Scholar
• Wellwood , CRL and Cole , RA . 2004 . Relevance of carnosic acid concentrations to the selection of rosemary, Rosmarinus officinalis L., accessions for optimization of antioxidant yield . Journal of Agricultural and Food Chemistry , 52 ( 20 ) : 6101 – 6107 .
   PubMed Web of Science ®Google Scholar
• Calabrese , V , Scapagnini , G , Catalano , C , Dinotta , F , Geraci , D and Morganti , P . 2000 . Biochemical studies of a natural antioxidant isolated from rosemary and its application in cosmetic dermatology . International Journal of Tissue Reactions - Experimental and Clinical Aspects , 22 ( 1 ) : 5 – 13 .
   PubMedGoogle Scholar
• Boyd , LC , Green , DP , Giesbrecht , FB and King , MF . 1993 . Inhibition of oxidative rancidity in frozen cooked fish flakes by tert-butylhydroquinone and rosemary extract . Journal of the Science of Food and Agriculture , 61 : 87 – 93 .
   Web of Science ®Google Scholar
• Chen , Q , Shi , H and Ho , C-T . 1992 . Effects of rosemary extracts and major constituents on lipid oxidation and soybean lipoxygenase activity . Journal of American Oil and Chemical Society , 69 ( 10 ) : 999 – 1002 .
   Web of Science ®Google Scholar
• Fernandez-Lopez , J , Sevilla , L , Sayas-Barbera , E , Navarro , C , Marin , F and Perez-Alvarez , JA . 2003 . Evaluation of the antioxidant potential of hyssop (Hyssopus officinalis L.) and rosemary (Rosmarinus officinalis L.) extracts in cooked pork meat . Journal of Food Science , 68 ( 2 ) : 660 – 664 .
   Web of Science ®Google Scholar
• Frutos , MJ and Hernandez-Herrero , JA . 2005 . Effects of rosemary extract (Rosmarinus officinalis) on the stability of bread with an oil, garlic and parsley dressing . Lwt-Food Science and Technology , 38 ( 6 ) : 651 – 655 .
   Web of Science ®Google Scholar
• Madsen , HL , Sorensen , B , Skibsted , LH and Bertelsen , G . 1998 . The antioxidative activity of summer savory (Satureja hortensis L.) and rosemary (Rosmarinus officinalis L.) in dressing stored exposed to light or in darkness . Food Chemistry , 63 ( 2 ) : 173 – 180 .
   Web of Science ®Google Scholar
• Man , YBC and Tan , CP . 1999 . Effects of natural and synthetic antioxidants on changes in refined, bleached, and deodorized palm olein during deep-fat frying of potato chips . Journal of American Oil and Chemical Society , 76 ( 3 ) : 331 – 339 .
   Web of Science ®Google Scholar
• Ostric-Matijasevic , B . 1963 . Application of antioxidant compounds of rosemary extracts to increase the stability of lard and meat . Revue Francaise des Corps Gras , 8–9 : 443 – 452 .
   Google Scholar
• Ozcan , M . 1999 . Antioxidant activity of rosemary (Rosmarinus officinalis L.) extracts on natural olive and sesame oils . Grasas Aceites , 50 ( 5 ) : 355 – 358 .
   Web of Science ®Google Scholar
• Ozcan , M . 2003 . Antioxidant activities of rosemary, sage, and sumac extracts and their combinations on stability of natural peanut oil . Journal of Medicinal Food , 6 ( 3 ) : 267 – 270 .
   PubMedGoogle Scholar
• Amin , A and Hamza , AA . 2005 . Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats . Life Science , 77 ( 3 ) : 266 – 278 .
   PubMed Web of Science ®Google Scholar
• Barlow , SM . 1990 . “ Toxicological aspects of antioxidants used as food additives ” . In Food antioxidants , Edited by: Hudson , BJF . London : Elsevier Applied Science .
   Google Scholar
• Huang , M-T , Ho , C-T , Wang , ZY , Ferraro , T , Lou , Y-R Stauber , K . 1994 . Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid . Cancer Research , 54 ( 3 ) : 701 – 708 .
   PubMed Web of Science ®Google Scholar
• Hui-Hui , Z , Peng-Fei , T , Kan , Z , Hui , W , Bao-Huai , W and Jing-Fen , L . 2001 . Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis . Acta Pharmacologica Sinica , 22 : 1094 – 1098 .
   PubMed Web of Science ®Google Scholar
• Joyeux , M , Rolland , A , Fleurentin , J , Mortier , F and Dorfman , P . 1990 . Tert-butyl hydroperoxide-induced injury in isolated rat hepatocytes: A model for studying anti-hepatotoxic crude drugs . Planta Medica , 2 : 171 – 174 .
   Google Scholar
• Offord , EA , Mace , K , Avanti , O and Pfeifer , AMA . 1997 . Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells . Cancer Letter , 114 : 275 – 281 .
   PubMed Web of Science ®Google Scholar
• Orhan , I , Aslan , S , Kartal , M , Sener , B and Baser , KHC . 2008 . Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes . Food Chemistry , 108 : 663 – 668 .
   PubMed Web of Science ®Google Scholar
• Sotelo-Felix , JI , Martinez-Fong , D , Muriel , P , Santillan , RL , Castillo , D and Yahuaca , P . 2002 . Evaluation of the effectiveness of Rosmarinus officinalis (Lamiaceae) in the alleviation of carbon tetrachloride-induced acute hepatotoxicity in the rat . Journal of Ethnopharmacology , 81 ( 2 ) : 145 – 154 .
   PubMed Web of Science ®Google Scholar
• Stefanovits-Bányai , E , Tulok , MH , Hegedus , A , Renner , C and Varga , IS . 2003 . Antioxidant effect of various rosemary (Rosmarinus officinalis L.) clones . Acta Biologica Szegediensis , 47 : 111 – 113 .
   Google Scholar
• Albu , S , Joyce , E , Paniwnyk , L , Lorimer , JP and Mason , TJ . 2004 . Potential for the use of ultrasound in the extraction of antioxidants from Rosmarinus officinalis for the food and pharmaceutical industry . Ultrasonic Sonochemistry , 11 ( 3–4 ) : 261 – 265 .
   PubMed Web of Science ®Google Scholar
• Bauman , D , Hadolin , M , Rizner-Hras , A and Knez , Z . 1999 . Supercritical fluid extraction of rosemary and sage antioxidants . Acta Alimentaria , 28 ( 1 ) : 15 – 28 .
   Web of Science ®Google Scholar
• Carvalho , RN , Moura , LS , Rosa , PTV and Meireles , MAA . 2005 . Supercritical fluid extraction from rosemary (Rosmarinus officinalis): Kinetic data, extract's global yield, composition, and antioxidant activity . Journal of Supercritical Fluids , 35 ( 3 ) : 197 – 204 .
   Web of Science ®Google Scholar
• Cavero , S , Jaime , L , Martin-Alvarez , PJ , Senorans , FJ , Reglero , G and Ibanez , E . 2005 . In vitro antioxidant analysis of supercritical fluid extracts from rosemary (Rosmarinus officinalis L.) . European Food Research and Technology , 221 ( 3–4 ) : 478 – 486 .
   Web of Science ®Google Scholar
• Ibanez , E , Kubatova , A , Senorans , FJ , Cavero , S , Reglero , G and Hawthorne , SB . 2003 . Subcritical water extraction of antioxidant compounds from rosemary plants . Journal of Agricultural and Food Chemistry , 51 ( 2 ) : 375 – 382 .
   PubMed Web of Science ®Google Scholar
• Benvenuti , S , Pellati , F , Melegari , M and Bertelli , D . 2004 . Polyphenols, anthocyanins, ascorbic acid, and radical scavenging activity of Rubus, Ribes, and Aronia . Journal of Food Science , 69 ( 3 ) : C164 – C169 .
   Web of Science ®Google Scholar
• Elisia , I , Hu , C , Popovich , DG and Kitts , DD . 2007 . Antioxidant assessment of an anthocyanin-enriched blackberry extract . Food Chemistry , 101 ( 3 ) : 1052 – 1058 .
   Web of Science ®Google Scholar
• Heinonen , IM , Meyer , AS and Frankel , EN . 1998 . Antioxidant activity of berry phenolics on human low-density lipoprotein and liposome oxidation . Journal of Agricultural and Food Chemistry , 46 ( 10 ) : 4107 – 4112 .
   Web of Science ®Google Scholar
• Kahkonen , MP , Hopia , AI and Heinonen , M . 2001 . Berry phenolics and their antioxidant activity . Journal of Agricultural and Food Chemistry , 49 ( 8 ) : 4076 – 4082 .
   PubMed Web of Science ®Google Scholar
• Moyer , RA , Hummer , KE , Finn , CE , Frei , B and Wrolstad , RE . 2002 . Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: Vaccinium, Rubus, and Ribes . Journal of Agricultural and Food Chemistry , 50 ( 3 ) : 519 – 525 .
   PubMed Web of Science ®Google Scholar
• Jiao , HJ and Wang , SY . 2000 . Correlation of antioxidant capacities to oxygen radical scavenging enzyme activities in blackberry . Journal of Agricultural and Food Chemistry , 48 ( 11 ) : 5672 – 5676 .
   PubMed Web of Science ®Google Scholar
• Hatano , T . 1995 . Constituents of natural medicines with scavenging effects on active oxygen species-tannins and related polyphenols . Natural Medicine , 49 : 357 – 363 .
   Google Scholar
• Okuda , T , Mori , K and Hayatsu , H . 1984 . Inhibitory effects of tannins on direct-agent mutagens . Chemical and Pharmaceutical Bulletin (Tokyo) , 32 : 3755 – 3758 .
   PubMed Web of Science ®Google Scholar
• Rapisarda , P , Tomaino , A , Lo Cascio , R , Bonina , F , De Pasquale , A and Saija , A . 1999 . Antioxidant effectiveness as influenced by phenolic content of fresh orange juices . Journal of Agricultural and Food Chemistry , 47 ( 11 ) : 4718 – 4723 .
   PubMed Web of Science ®Google Scholar
• Amakura , Y , Umino , Y , Tsuji , S and Tonogai , Y . 2000 . Influence of jam processing on the radical scavenging activity and phenolic content in berries . Journal of Agricultural and Food Chemistry , 48 ( 12 ) : 6292 – 6297 .
   PubMed Web of Science ®Google Scholar
• Urquiaga , I and Leighton , F . 2000 . Plant polyphenol antioxidants and oxidative stress . Biological Research , 33 : 55 – 64 .
   PubMed Web of Science ®Google Scholar
• Jovanovic , SV , Konya , K and Scaiano , JC . 1995 . Redox reactions of 3,5-di-tert-butyl-1,2-benzoquinone. Implications for reversal of paper yellowing . Canadian Journal of Chemistry , 73 : 1803 – 1810 .
   Web of Science ®Google Scholar
• Rescigno , A , Rinaldi , AC and Sanjust , E . 1998 . Some aspects of tyrosine secondary metabolism . Biochemical Pharmacology , 56 ( 9 ) : 1089 – 1096 .
   PubMed Web of Science ®Google Scholar
• Krinsky , NI and Yeum , KJ . 2003 . Carotenoid–radical interactions . Biochemical and Biophysical Research Communications , 305 ( 3 ) : 754 – 760 .
   PubMed Web of Science ®Google Scholar
• Mortensen , A , Skibsted , LH , Sampson , J , Rice-Evans , C and Everett , SA . 1997 . Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants . FEBS Letters , 418 ( 1–2 ) : 91 – 97 .
   PubMed Web of Science ®Google Scholar
• Mortensen , A , Skibsted , LH and Truscott , TG . 2001 . The interaction of dietary carotenoids with radical species . Archives of Biochemistry and Biophysics , 385 ( 1 ) : 13 – 19 .
   PubMed Web of Science ®Google Scholar
• Stahl , W and Sies , H . 1996 . Lycopene: A biologically important carotenoid for humans? . Archives of Biochemistry and Biophysics , 336 ( 1 ) : 1 – 9 .
   PubMed Web of Science ®Google Scholar
• Young , AJ and Lowe , GM . 2001 . Antioxidant and prooxidant properties of carotenoids . Archives of Biochemistry and Biophysics , 385 ( 1 ) : 20 – 27 .
   PubMed Web of Science ®Google Scholar
• Firuzi , O , Lacanna , A , Petrucci , R , Marrosu , G and Saso , L . 2005 . Evaluation of the antioxidant activity of flavonoids by “ferric reducing antioxidant power” assay and cyclic voltammetry . Biochimica et Biophysica Acta (BBA) – General Subjects , 1721 ( 1–3 ) : 174 – 184 .
   PubMed Web of Science ®Google Scholar
• Tepe , B . 2008 . Antioxidant potentials and rosmarinic acid levels of the methanolic extracts of Salvia virgata Jacq, Salvia staminea Montbret & Aucher ex Bentham and Salvia verbenaca L. from Turkey . Bioresource Technology , 99 ( 6 ) : 1584 – 1588 .
   PubMed Web of Science ®Google Scholar
• Munne-Bosch , S and Alegre , L . 2001 . Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary . Plant Physiology , 125 ( 2 ) : 1094 – 1102 .
   PubMed Web of Science ®Google Scholar
• Masuda , T , Inaba , Y and Takeda , Y . 2001 . Antioxidant mechanism of carnosic acid: Structural identification of two oxidation products . Journal of Agricultural and Food Chemistry , 49 ( 11 ) : 5560 – 5565 .
   PubMed Web of Science ®Google Scholar
• Masuda , T , Inaba , Y , Maekawa , T , Takeda , Y , Tamura , H and Yamaguchi , H . 2002 . Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant . Journal of Agricultural and Food Chemistry , 50 ( 21 ) : 5863 – 5869 .
   PubMed Web of Science ®Google Scholar
• Rinaldi , AC , Porcu , MC , Curreli , N , Rescigno , A , Finazziagro , A Pedersen , JZ . 1995 . Autoxidation of 4-methylcatechol: A model for the study of the biosynthesis of copper amine oxidases quinonoid cofactor . Biochemical and Biophysical Research Communications , 214 ( 2 ) : 559 – 567 .
   PubMed Web of Science ®Google Scholar
• Rinaldi , AC , Porcu , CM , Oliva , S , Curreli , N , Rescigno , A Sollai , F . 1998 . Biosynthesis of the topaquinone cofactor in copper amine oxidases – Evidence from model studies . European Journal of Biochemistry , 251 ( 1–2 ) : 91 – 97 .
   PubMedGoogle Scholar
• Sanjust , E , Rinaldi , AC , Rescigno , A , Porcu , MC , Alberti , G Rinaldi , A . 1995 . A hydroxyquinone with amine oxidase activity: Preparation and properties . Biochemical and Biophysical Research Communications , 208 ( 2 ) : 825 – 834 .
   PubMed Web of Science ®Google Scholar