Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 27, 2013 - Issue 20
Submit an article Journal homepage
267
Views
13
CrossRef citations to date
0
Altmetric
Research Article

Two new vinblastine-type N-oxide alkaloids from Catharanthus roseus

Wei-Ku ZhangDepartment of Pharmacology, Institute of Clinical Medical Sciences, China–Japan Friendship Hospital, Beijing, 100029, People's Republic of China
,
Jie-Kun XuSchool of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing, 100029, People's Republic of China
,
Hai-Yan TianInstitute of Traditional Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China
,
Lei WangInstitute of Traditional Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China
,
Xiao-Qi ZhangInstitute of Traditional Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China
,
Xu-Zhi XiaoInstitute of Traditional Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China
,
Ping LiDepartment of Pharmacology, Institute of Clinical Medical Sciences, China–Japan Friendship Hospital, Beijing, 100029, People's Republic of ChinaCorrespondence[email protected] [email protected]
&
Wen-Cai YeInstitute of Traditional Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, 510632, People's Republic of China;Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, People's Republic of China
 show all
Pages 1911-1916 | Received 07 Jan 2013, Accepted 02 Mar 2013, Published online: 27 Apr 2013

REFERENCES

  • Akino J, Pierre F, Bernard B. 1998. A new structural class of bisindole alkaloids from the seeds of Catharanthus roseus: vingramine and methylvingramine. J Org Chem. 63:7162–7167.
  • Brossi A. 1990. The alkaloids. New York: Academic Press. p. 1–240.
  • Chuang TH, Lee SJ, Yang C-W, Wu P-L. 2006. Expedient synthesis and structure–activity relationships of phenanthroindolizidine and phenanthroquinolizidine alkaloids. Org Biomol Chem. 4:860–867.
  • Cordell GA. 1983. Intoduction to alkaloids: a biogenic approach. New York: Wiley-Interscience. p.1–3.
  • Dorman DE, Paschal JW. 1976. Carbon-13 NMR spectroscopy. Comparison of the spectra of some dimeric Catharanthus alkaloids and their derivatives. Org Magn Res. 8:413–418.
  • El-Sayed A, Handy GA, Cordell GA. 1983. Catharanthus alkaloids, XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N′b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus. J Nat Prod. 46:517–527.
  • Kuehne ME, Bornmann WG. 1989. Syntheses of 20′-deoxyvinblastine, 20′-deoxyleurosidine, 20′-deoxyvincovaline, 20′-epi-20′-deoxyvincovaline, and 20′-deoxyvincristine and its 20′-epimer through racemic and enantioselectively generated intermediates. New syntheses of D/E-cis- and -trans-ψ-vincadifformines and D/E-cis- and -trans-20-epi-ψ-vincadifformine. J Org Chem. 54:3407–3420.
  • Manske RHF, Rodrigo RGA. 1981. The alkaloids: chemistry and physiology. New York: Academic Press. p. 1–296.
  • Mauri L, András N. 1982. The synthesis of bis-indole alkaloids and their derivatives. Tetrahedron. 38:223–243.
  • Mukhopadhyay S, Cordell GA. 1981. Catharanthus alkaloids. XXXV. Isolation of leurosidine N(-oxide from Catharanthus roseus. J Nat Prod. 44:611–613.
  • Sápi J, Matasiot G. 1995. The alkaloids: noniridoid bisindole alkaloids. London: Academic Press. p. 173–226.
  • Taylor WI, Farnsworth NR. 1975. The Catharanthus alkaloids. New York: Dekker. p. 9–236.
  • Van der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R. 2004. The Catharanthus alkaloids: pharmacognosy and biotechnology. Curr Med Chem. 11:607–628.
  • Wang C-H, Wang G-C, Wang Y, Zhang X-Q, Huang X-J, Ye W-C. 2012. Three new monomeric indole alkaloids from the roots of Catharanthus roseus. J Asian Nat Prod Res. 14:249–255.
  • Wang C-H, Wang G-C, Wang Y, Zhang X-Q, Huang X-J, Zhang D-M, Chen M-F, Ye W-C. 2012. Cytotoxic dimeric indole alkaloids from Catharanthus roseus. Fitoterapia. 83:765–769.
  • Wang G-C, Zhong X-Z, Zhang D-M, Wang Y, Zhang X-Q, Jiang R-W, Li Y-L, Wang J, Yao X-S, Ye W-C. 2011. Two pairs of epimeric indole alkaloids from Catharanthus roseus. Planta Med. 77:1739–1741.
  • Zhang W-K, Xu J-K, Tian H-Y, Wang L, Zhang X-Q, Xiao X-Z, Li P, Ye W-C. 2013. Further bisindole alkaloids from Catharanthus roseus and their cytotoxicity. Heterocycles. 87:627–636.
  • Zhong X-Z, Wang G-C, Wang Y, Zhang X-Q, Ye W-C. 2010. Monomeric indole alkaloids from the aerial parts of Catharanthus roseus. Yao Xue Xue Bao. 45:471–474.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.