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Natural Product Research
Formerly Natural Product Letters
Volume 29, 2015 - Issue 18
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Short Communication

Pistagremic acid, a novel β-secretase enzyme (BACE1) inhibitor from Pistacia integerrima Stewart

Abdur RaufInstitute of Chemical Sciences, University of Peshawar, Peshawar25120, KPK, PakistanCorrespondence[email protected] [email protected]
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,
Ghias UddinInstitute of Chemical Sciences, University of Peshawar, Peshawar25120, KPK, PakistanView further author information
,
Ajmal KhanH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi75270, PakistanView further author information
,
Bina S. SiddiquiH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi75270, PakistanView further author information
,
Mohammad ArfanInstitute of Chemical Sciences, University of Peshawar, Peshawar25120, KPK, PakistanView further author information
,
Kourosh DalvandiDr. Panjwani Centre for Molecular Medicine and Drug Research, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi75270, PakistanView further author information
&
Taibi Ben HaddaLaboratoire Chimie Matériaux, FSO, Université Mohammed Premier, Oujda60000, MoroccoView further author information
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Pages 1735-1738 | Received 31 Oct 2014, Accepted 06 Dec 2014, Published online: 15 Jan 2015

References

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  • Rauf A, Uddin G, Latif A, Muhammad N. 2014. Pistagremic Acid, a novel antimicrobial and antioxidant isolated from Pistacia integerrima. Chem Nat Compd. 50:97–99.
  • Rauf A, Uddin G, Siddiqui BS, Khan A, Khan H, Arfan M, Wadood A. 2014. In-vivo antinociceptive, anti-inflammatory and antipyretic activity of pistagremic acid isolated from Pistacia integerrima. Phytomedicine. 21:1509–1515.
  • Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R. 1999. β-Secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 286:735–741.
  • Wolfe MS. 2008. γ-Secretase inhibition and modulation for Alzheimer's disease. Curr Alzheimer Res. 5:158–164.

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