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Natural Product Research
Formerly Natural Product Letters
Volume 33, 2019 - Issue 21
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Research Articles

Synthesis, structural elucidation and biological evaluations of new guanidine-containing terpenoids as anticancer agents

Gheorghe DucaInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova;
,
Aculina AricuInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova; Correspondence[email protected]
,
Kaleria KuchkovaInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova;
,
Elena SecaraInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova;
,
Alic BarbaInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova;
,
Ion DragalinInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova;
,
Nicon UngurInstitute of Chemistry, Laboratory of Chemistry of Natural and Biologically Active Compounds, Academy of Sciences of Moldova, Chisinau, Republic of Moldova;
&
Gabriella SpenglerDepartment of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, Szeged, Hungary
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Pages 3052-3056 | Received 14 Apr 2018, Accepted 17 Aug 2018, Published online: 16 Nov 2018

References

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  • Berlinck RGS, Romminger S. 2016. The chemistry and biology of guanidine natural products. Nat Prod Rep. 33(3):456–490.
  • Carbone M, Ciavatta ML, Mathieu V, Ingels A, Kiss R, Pascale P, Mollo E, Ungur N, Guo Y-W, Gavagnin M. 2017. Marine terpenoid diacylguanidines: structure, synthesis, and biological evaluation of naturally occurring actinofide and synthetic analogues. J Nat Prod. 80(5):1339–1346.
  • Das BC, Mahalingam SM, Mohapatra P. 2009. Design and synthesis of guanidine – containing novel retinoids. Tetrahedron Lett. 50(42):5860–5863.
  • Kuchkova K, Aricu A, Secara E, Barba A, Vlad P, Ungur N, Tuchilus C, Shova S, Zbancioc G, Mangalagiu II. 2014. Design, synthesis, and antimicrobial activity of some novel homodrimane sesquiterpenoids with diazine skeleton. Med Chem Res. 23(3):1559–1568.
  • Kuchkova KI, Aricu AN, Barba AN, Sekara ES, Vlad PF, Ungur ND. 2014. Synthesis of 12-amino-11-dihomodrimane sesquiterpenoids from norambreinolide. Chem Nat Compd. 50(3):458–461.
  • Kuchkova KI, Aricu AN, Secara ES, Barba AN, Dragalin IP, Vlad PF, Ungur ND. 2014. Synthesis of 13-amino-14,15-dinorlabd-8(9)-ene from sclareol. Russ Chem Bull, International Edition. 63:1–3.
  • Kuchkova KI, Arycu AN, Sekara ES, Barba AN, Vlad PF, Makaev FZ, Mel’nik E, Kravtsov VK. 2015. Synthesis and structure of homodrimane sesquiterpenoids containing 1.2.4-triazole and carbazole rings. Chem Nat Compd. 51(4):684–688.
  • Mo S, Krunic A, Pegan SD, Franzblau SG, Orjala J. 2009. An antimicrobial guanidine – bearing sesterterpene from cultured cyanobacterium Scytonema sp. J Nat Prod. 72(11):2043–2045.
  • Zarraga M, Zarraga AM, Rodriguez B, Perez C, Paz C, Paz P, Sanhueza C. 2008. Synthesis of a new nitrogenated drimane derivative with antifungal activity. Tetrahedron Lett. 49(32):4775–4776.

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