Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 34, 2020 - Issue 18
Submit an article Journal homepage
280
Views
11
CrossRef citations to date
0
Altmetric
Short Communications

Silymarin, a polyphenolic flavonoid impede Plasmodium falciparum growth through interaction with heme

Pooja Rani MinaMolecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, U.P., India;
,
Yogesh KumarMetabolic & Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, U.P., India;
,
Ajeet Kumar VermaMolecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, U.P., India;
,
Feroz KhanMetabolic & Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, U.P., India;
,
Sudeep TandonChemical Processing Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, India
,
Anirban PalMolecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, U.P., India;
&
Mahendra Pandurang DarokarMolecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow, U.P., India; Correspondence[email protected] [email protected]
ORCID Iconhttp://orcid.org/0000-0002-4397-5516
ORCID Icon show all
Pages 2647-2651 | Received 20 Aug 2018, Accepted 09 Nov 2018, Published online: 19 Jan 2019

References

  • Aft RL, Mueller G. 1984. Hemin-mediated oxidative degradation of proteins. Journal of Biological Chemistry. 10;259(1):301–5.
  • Atamna H, Ginsburg H. 1995. Heme degradation in the presence of glutathione. A proposed mechanism to account for the high levels of non-heme iron found in the membranes of hemoglobinopathic red blood cells. J Biol Chem. 270(42):24876–24883.
  • Bathurst I, Hentschel C. 2006. Medicines for Malaria Venture: sustaining antimalarial drug development. Trends Parasitol. 22(7):301–307.
  • Bohle DS, Kosar AD, Stephens PW. 2002. Phase homogeneity and crystal morphology of the malaria pigment β-hematin. Acta Crystallogr D Biol Crystallogr. 58(10):1752–1756.
  • Egan TJ. 2002. Four aspartic proteases occur in the Plasmodium falciparum food vacuole. Trends in parasitology. 18(4):150.
  • Huy NT, Mizunuma K, Kaur K, Nhien NTT, Jain M, Uyen DT, Harada S, Jain R, Kamei K. 2007. 2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization. Antimicrobial Agents Chemother. 51(8):2842–2847.
  • Hogan FS, Krishnegowda NK, Mikhailova M, Kahlenberg MS. 2007. Flavonoid, silibinin, inhibits proliferation and promotes cell-cycle arrest of human colon cancer. J Surg Res. 143(1):58–65.
  • Kumar S, Guha M, Choubey V, Maity P, Srivastava K, Puri SK, Bandyopadhyay U. 2008. Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen species. Free Radic Biol Med. 44(4):602–613.
  • Kroll DJ, Shaw HS, Oberlies NH. 2007. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther. 6(2):110–119.
  • Lamikanra AA, Theron M, Kooij TW, Roberts DJ. 2009. Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors. PloS ONE. 4(12):e8446.
  • Le Bonniec S, Deregnaucourt C, Redeker V, Banerjee R, Grellier P, Goldberg DE, Schrével J. 1999. Plasmepsin II, an acidic hemoglobinase from the plasmodium falciparum food vacuole, is active at neutral pH on the host erythrocyte membrane skeleton. J Biol Chem. 274(20):14218–14223.
  • Maknitikul S, Luplertlop N, Chaisri U, Maneerat Y, Ampawong S. 2018. Featured Article: Immunomodulatory effect of hemozoin on pneumocyte apoptosis via CARD9 pathway, a possibly retarding pulmonary resolution. Exp Biol Med. 243(5):395–407.
  • Mullié C, Jonet A, Dassonville-Klimpt A, Gosmann G, Sonnet P. 2010. Inhibitory effect of ursolic acid derivatives on hydrogen peroxide-and glutathione-mediated degradation of hemin: A possible additional mechanism of action for antimalarial activity. Exp Parasitol. 125(3):202–207.
  • Ncokazi KK, Egan TJ. 2005. A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds. Anal Biochem. 338(2):306–319. 15
  • Pradhan S, Girish C. 2006. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian Journal of Medical Research. 124(5):491–504.
  • Ortiz S, Dali-Yahia K, Vasquez-Ocmin P, Grougnet R, Grellier P, Michel S, Maciuk A, Boutefnouchet S. 2017. Heme-binding activity of methoxyflavones from Pentzia monodiana Maire (Asteraceae). Fitoterapia. 118:1–5.
  • Sarkar S, Siddiqui AA, Saha SJ, De R, Mazumder S, Banerjee C, Iqbal MS, Nag S, Adhikari S, Bandyopadhyay U. 2016. Antimalarial activity of small-molecule benzothiazole hydrazones. Antimicrob Agents Chemother. 60(7):4217–4228.
  • Singh SV, Manhas A, Kumar Y, Mishra S, Shanker K, Khan F, Srivastava K, Pal A. 2017. Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action. Biomed Pharmacother. 89:761–771.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.