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Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 16
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Research Articles

Anti-aging derivatives of cycloastragenol produced by biotransformation

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Pages 2685-2690 | Received 24 Jun 2019, Accepted 16 Aug 2019, Published online: 09 Sep 2019

References

  • Agzamova MA, Isaev MI. 1995. Astragalus triterpene glycosides and their genins. I. Structures of cycloapigenin and cycloalpioside. Chem Nat Compd. 31(5):589–595.
  • Debeleç-Bütüner B, Öztürk MB, Tağ Ö, Akgün IH, Yetik-Anacak G, Bedir E, Korkmaz KS. 2018. Cycloartane-type sapogenol derivatives inhibit NF-κB activation as chemopreventive strategy for inflammation-induced prostate carcinogenesis. Steroids. 135:9–20.
  • Feng LM, Ji S, Qiao X, Li ZW, Lin XH, Ye M. 2015. Biocatalysis of cycloastragenol by Syncephalastrum racemosum and Alternaria alternate to discover anti-aging derivatives. Adv Synth Catal. 357(8):1928–1940.
  • Jung Y, Jerng U, Lee S. 2016. A systematic review of anticancer effects of Radix astragali. Chin J Integr Med. 22(3):225–236.
  • Lin HJ, Jiang BC, Chen C, Song Y, Yang M, Huang HL, Chen GT. 2019. Microbial transformation of the anti-aging agent cycloastragenol by Mucor racemosus. Nat Prod Res. 33(21): 3103–3108.
  • Liu T, Liao JX, Hu Y, Tu YH, Sun JS. 2017. Synthetic access toward cycloastragenol glycosides. J Org Chem. 82(8):4170–4178.
  • Lou YM, Guo ZZ, Zhu YF, Zhang GY, Wang Y, Qi XX, Lu LL, Liu ZQ, Wu JJ. 2019. Astragali radix and its main bioactive compounds activate the Nrf2-mediated signaling pathway to induce P-glycoprotein and breast cancer resistance protein. J Ethnopharmacol. 228:82–91.
  • Shi J, Zheng L, Lin ZF, Hou CQ, Liu WQ, Yan TM, Zhu LJ, Wang Y, Lu LL, Liu ZQ. 2015. Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC-MS/MS. J Ethnopharmacol. 169:183–194.
  • Sun C, Jiang M, Zhang L, Yang J, Zhang G, Du B, Ren Y, Li X, Yao J. 2017. Cycloastragenol mediates activation and proliferation suppression in concanavalin A-induced mouse lymphocyte pan-activation model. Immunopharmacol Immunotoxicol. 39(3):131–139.
  • Valenzuela HF, Fuller T, Edwards J, Finger D, Molgora B. 2009. Cycloastragenol extends T cell proliferation by increasing telomerase activity. J Immunol. 18:9030.
  • Yang WZ, Ye M, Huang FX, He WN, Guo DA. 2012. Biocatalysis of cycloastragenol by filamentous fungi to produce unexpected triterpenes. Adv Synth Catal. 354(2–3):527–539.

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