Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 16
460
Views
10
CrossRef citations to date
0
Altmetric
Short Communications

In vivo anxiolytic and in vitro anti-inflammatory activities of water-soluble extract (WSE) of Nigella sativa (L.) seeds

ORCID Icon, , ORCID Icon, ORCID Icon, , , , , , , , ORCID Icon, ORCID Icon & show all
Pages 2793-2798 | Received 28 Jun 2019, Accepted 31 Aug 2019, Published online: 03 Oct 2019

References

  • Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. 2013. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 3(5):337–352.
  • Beheshti F, Hosseini M, Khazaei M. 2016. Neuropharmacological effects of Nigella sativa. Avicenna J Phytomed. 6(1):104–116.
  • Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL. 1997. GABAA, NMDA and AMPA receptors: a developmentally regulatedmenage a trois'. Trends Neurosci. 20(11):523–529.
  • Bourgou S, Pichette A, Marzouk B, Legault J. 2012. Antioxidant, anti‐inflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (black cumin) plant parts. J Food Biochem. 36(5):539–546.
  • Calcaterra NE, Barrow JC. 2014. Classics in chemical neuroscience: diazepam (valium). ACS Chem Neurosci. 5(4):253–260.
  • Christian CA, Herbert AG, Holt RL, Peng K, Sherwood KD, Pangratz-Fuehrer S, Rudolph U, Huguenard JR. 2013. Endogenous positive allosteric modulation of GABAA receptors by diazepam binding inhibitor. Neuron. 78(6):1063–1074.
  • Ferrarese C, Appollonio I, Bianchi G, Frigo M, Marzorati C, Pecora N, Perego M, Pierpaoli C, Frattola L. 1993. Benzodiazepine receptors and diazepam binding inhibitor: a possible link between stress, anxiety and the immune system. Psychoneuroendocrino. 18(1):3–22.
  • Gardes J, Michineau S, Pizard A, Alhenc-Gelas F, Rajerison RM. 2008. Aspirin inhibits human bradykinin B2 receptor ligand binding function. Biochem Pharmacol. 75(9):1807–1816.
  • Ghannadi A, Hajhashemi V, Jafarabadi H. 2005. An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. J Med Food. 8(4):488–493.
  • Gholamnezhad Z, Havakhah S, Boskabady MH. 2016. Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: a review. J Ethnopharmacol. 190:372–386.
  • Gilhotra N, Dhingra D. 2011. Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. Pharmacol Rep. 63(3):660–669.
  • Gryglewski RJ. 2008. Prostacyclin among prostanoids. Pharmacol Rep. 60(1):3–11.
  • Hosseini M, Khoshdast S, Rastegar M, Kahdouee S, Rakhshandeh H, Zakeri S, Yousefian FT, Vafaee F, Ghorbani F, Kazemi S. 2012. The effects of Nigella sativa hydro-alcoholic extract and thymoquinone on lipopolysaccharide-induced depression like behavior in rats. J Pharm Bioall Sci. 4(3):219–225.
  • Kadam D, Lele SS. 2017. Extraction, characterization and bioactive properties of Nigella sativa seedcake. J Food Sci Technol. 54(12):3936–3947.
  • Kazemi M. 2014. Phytochemical composition, antioxidant, anti-inflammatory and antimicrobial activity of Nigella sativa L. essential oil. J Essent Oil Bear Pl. 17(5):1002–1011.
  • Leelaprakash G, Dass SM. 2011. Invitro anti-inflammatory activity of methanol extract of Enicostemma axillare. Int J Drug Dev Res. 3:189–196.
  • Maghsoudi H, Haj-Allahyari S. 2018. Anti-inflammatory effect of alcoholic extract of Nigella sativa L on bovine fibroblast-like synoviocyte and THP-1. Int J Cont Res Rev. 9:20181–20191.
  • Majdalawieh AF, Fayyad MW. 2015. Immunomodulatory and anti-inflammatory action of Nigella sativa and thymoquinone: a comprehensive review. Int Immunopharmacol. 28(1):295–304.
  • Nakanishi S. 1992. Molecular diversity of glutamate receptors and implications for brain function. Sci. 258(5082):597–603.
  • Nergiz C, Ötleş S. 1993. Chemical composition of Nigella sativa L. seeds. Food Chem. 48(3):259–261.
  • Nutt DJ, Malizia AL. 2001. New insights into the role of the GABA A–benzodiazepine receptor in psychiatric disorder. Br J Psychiatry. 179(5):390–396.
  • Paez Espinosa EV, Murad JP, Khasawneh FT. 2012. Aspirin: pharmacology and clinical applications. Thromb. 2012:1–15.
  • Pin JP, Duvoisin R. 1995. The metabotropic glutamate receptors: structure and functions. Neuropharmacol. 34(1):1–26.
  • Ramadan MF. 2007. Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. Int J Food Sci Tech. 42(10):1208–1218.
  • Raza M, El-Hadiyah TM, Al-Shabanah OA. 2007. Nigella sativa seed constituents and anxiety relief in experimental models. J Herbs Spices Med Plants. 12(1-2):153–164.
  • Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJP, Ecker GF, Ernst M. 2012. Diazepam-bound GABA A receptor models identify new benzodiazepine binding-site ligands. Nat Chem Biol. 8(5):455–464.
  • Shrivastava RM, Agrawal RC, Parveen ZEBA. 2011. A review on therapeutic applications of Nigella sativa. J Chem Chem Sci. 1:241–248.
  • Trigui I, Yaich H, Sila A, Cheikh-Rouhou S, Bougatef A, Blecker C, Attia H, Ayadi MA. 2018. Physicochemical properties of water-soluble polysaccharides from black cumin seeds. Int J Biol Macromol. 117:937–946.
  • Zacharias-Millward N, Menter DG, Davis JS, Lichtenberger L, Hawke D, Hawk E, Millward S. 2017. Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention. Cancer Metastasis Rev. 36:289–303.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.