Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 35, 2021 - Issue 19
467
Views
9
CrossRef citations to date
0
Altmetric
Research Articles

Synthesis, molecular modelling studies of indolyl chalcone derivatives and their antimalarial activity evaluation

, , , , , , & ORCID Icon show all
Pages 3261-3268 | Received 19 Jun 2019, Accepted 14 Nov 2019, Published online: 04 Dec 2019

References

  • Bhagat S, Sharma R, Sawant DM, Sharma L, Chakraborti AKJ. 2006. LiOH.H2O as a novel dual activation catalyst for highly efficient and easy synthesis of 1,3-diaryl-2-propenones by Claisen-Schmidt condensation under mild conditions. J Mol Catal A Chem. 244(1-2):20.
  • Brinner KM, Powles MA, Schmatz DM, Ellman JA. 2005. Potent 4-aminopiperidine based antimalarial agents. Bioorg Med Chem Lett. 15(2):345–348.
  • Butcher GA, Sinden RE, Curtis C. 2000. Malaria: new ideas, old problems, new technologies. Parasitol Today. 16(2):43.
  • Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, et al. 2001. Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 2. Bioorg Med Chem Lett. 11(2):113–117.
  • Delarue S, Girault S, Maes L, Debreu-Fontaine MA, Labaeïd M, Grellier P, Sergheraert C. 2001. Synthesis and in vitro and in vivo antimalarial activity of new 4-anilinoquinolines. J Med Chem. 44(17):2827–2833.
  • Enserink M. 2000. Malaria researchers wait for industry to join fight. Science. 287(5460):1956.
  • Gardner MJ, Shallom SJ, Carlton JM, Salzberg SL, Nene V, Shoaibi A, Ciecko A, Lynn J, Rizzo M, Weaver B. 2000. Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Nature. 419(6906):531–534.
  • Gaur R, Cheema HS, Kumar Y, Singh SP, Yadav DK, Darokar MP, Khan F, Bhakuni RS. 2015. In vitro antimalarial activity and molecular modeling studies of novel artemisinin derivatives. RSC Adv. 5(59):47959–47974.
  • Gaur R, Gupta VK, Pal A, Darokar MP, Bhakuni RS, Kumar B. 2015. Synthesis of novel chalcone derivatives as potential inhibitor of multidrug resistance efflux pumps in clinical isolates of methicillin resistant S. aureus: novel agents for combination therapy. RSC Adv. 5(8):5830–5845.
  • Gaur R, Thakur JP, Yadav DK, Kapkoti DK, Verma RK, Gupta N, Khan F, Saikia D, Bhakuni RS. 2015. Synthesis, antitubercular activity, and molecular modelling studies of analogues of isoliquiritigenin and liquiritigenin, bioactive components from Glycyrrhiza glabra. Med Chem Res. 24(9):3494–3503.
  • Gaur R, Yadav DK, Kumar S, Darokar MP, Khan F, Bhakuni RS. 2015. Molecular modelling based synthesis and in vitro evaluation of anticancer activity of indolyl chalcones. Curr Top Med Chem. 15(11):1003–1012.
  • Gaur R, Yadav KS, Verma RK, Yadav NP, Bhakuni RS. 2014. In vivo anti-diabetic activity of derivatives of isoliquiritigenin and liquiritigenin. Phytomedicine. 21(4):415–422.
  • Geneva: World Health Organization. 2015. Strategy for malaria elimination in the GMS (2015–2030). http://www.wpro.who.int/mvp/documents/strat_mal_elim_gms/en/.
  • Jeong T-S, Soon Kim K, An S-J, Cho K-H, Lee S, Song Lee W. 2004. Novel 3,5-diarylpyrazolines as human acyl-CoA:cholesterolacyltransferase inhibitors. Bioorg Med Chem Lett. 14(11):2715.
  • Klayman DL. 1985. Qinghaosu (artemisinin): an antimalarial drug from China. Science. 228(4703):1049–1055.
  • Kumar A, Katiyar SB, Agarwal A, Chauhan PMS. 2003a. Perspective in antimalarial chemotherapy. Curr Med Chem. 10(13):1137.
  • Kumar A, Katiyar SB, Agarwal A, Chauhan PMS. 2003b. Current trends in antimalarial chemotherapy. Drugs Fut. 28(3):243.
  • Lecaille F, Kaleta J, Brömme D. 2002. Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design. Chem Rev. 102(12):4459–4488.
  • Lipinski CA, Lombardo F, Dominy B, Feeney P. 2001. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 46(1-3):3–26.
  • Luo XD, Shen CC. 1987. The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives. Med Res Rev. 7(1):29–52.
  • Makler MT, Hinrichs D. 1993. Measurement of the lactate dehydrogenase activity of Plasmodium falciparum as an assessment of parasitemia. Am J Trop Med Hyg. 48(2):205–210.
  • Naß J, Efferth T. 2019. Development of artemisinin resistance in malaria therapy. Pharmacol Res. 146:104275.
  • Pandey KC, Wang SX, Sijwali PS, Lau AL, McKerrow JH, Rosenthal PJ. 2005. The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci USA. 102(26):9138–9143.
  • Rarey M, Kramer B, Lengauer T, Klebe G. 1996. A fast flexible docking method using an incremental construction algorithm. J Mol Biol. 261(3):470–489.
  • Rastelli G, Sirawaraporn W, Sompornpisut P, Vilaivan T, Kamchonwongpaisan S, Quarrell R, Lowe G, Thebtaranonth Y, Yuthavong Y. 2000. Interaction of pyrimethamine, cycloguanil, WR99210 and their analogues with Plasmodium falciparum dihydrofolate reductase: structural basis of antifolate resistance. Bioorg Med Chem. 8(5):1117–1128.
  • Ryckebusch A, Deprez-Poulain R, Debreu-Fontaine M-A, Vandaele R, Mouray E, Grellier P, Sergheraert C. 2003. Synthesis and antimalarial evaluation of new 1,4-bis(3-aminopropyl) piperazine derivatives. Bioorg Med Chem Lett. 13(21):3783–3787.
  • Shrivastava SK, Chauhan PMS. 2001. Present trends and future strategy in chemotherapy of malaria. Curr Med Chem. 8:1535.
  • Singh SB, Zink DL, Polishook JD, Dombrowski AW, Darkin-Rattray SJ, Schmatz DM, Goetz MA. 1996. Apicidins: novel cyclic tetrapeptides as coccidiostats and antimalarial agents from Fusarium pallidoroseum. Tetrahedron Lett. 37(45):8077–8080.
  • Srinivasan B, Johnson TE, Lad R, Xing C. 2009. Structure-activity relationship studies of chalcone leading to 3-hydroxy-4,3',4',5'-tetramethoxychalcone and its analogues as potent nuclear factor kappa B inhibitors and their anticancer activities. J Med Chem. 52(22):7228.
  • Ursos LMB, Roepe PD. 2002. Chloroquine resistance in the malarial parasite, Plasmodium falciparum. Med Res Rev. 22(5):465–491.
  • World Malaria Report. 2018.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.