Advanced search
Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 10
Submit an article Journal homepage
151
Views
3
CrossRef citations to date
0
Altmetric
Short Communications

Cardioprotective potential of indol-3-carbinol against high salt induced myocardial stress and hypertrophy in Sprague dawley rats besides molecular docking on muscarinic receptor-2

Sudheer Akkirajua Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Anantapur, Andhra Pradesh, India
,
Somasekhar Reddy Kanalaa Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Anantapur, Andhra Pradesh, India
,
Sardip Khatria Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Anantapur, Andhra Pradesh, India
,
Vinay Kumar Kutagullaa Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Anantapur, Andhra Pradesh, IndiaCorrespondence[email protected] [email protected]
,
Vijayajyothi Mallelaa Department of Pharmacology, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Autonomous, Anantapur, Andhra Pradesh, India
&
Ramalingam Peramanb RERDS-Centre for Pharmaceutical Research, Raghavendra Institute of Pharmaceutical Education and Research (RIPER) Campus, Anantapur, Andhra Pradesh, IndiaCorrespondence[email protected] [email protected]
Pages 2610-2614 | Received 08 Dec 2020, Accepted 28 Mar 2021, Published online: 15 Apr 2021

References

  • Chang H, Wang M, Hsu C, Liu M, Chan M, Chen Y-H. 2011. 2 Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes. Int J Obes. 35(12):1530–1538.
  • Deng W, Zong J, Bian Z, Zhou H, Yuan Y, Zhang R, Guo H, Zhang Y, Shen D, Li H, et al. 2013. Indole-3-carbinol protects against pressure overload induced cardiac remodeling via activating AMPK-α. Mol Nutr Food Res. 57(9):1680–1687.
  • Dobrian AD, Schriver SD, Lynch T, Prewitt RL. 2003. Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity. Am J Physiol Renal Physiol. 285(4):619–628.
  • Dopona EP, Rocha VF, Furukawa LN, Oliveira IB, Heimann JC. 2019. Myocardial hypertrophy induced by high salt consumption is prevented by angiotensin II AT2 receptor agonist. Nutr Metab Cardiovasc Dis. 29(3):301–305.
  • Gomes PM, Sá RW, Aguiar GL, Paes MH, Alzamora AC, Lima WG, de Oliveira LB, Stocker SD, Antunes VR, Cardoso LM. 2017. Chronic high-sodium diet intake after weaning lead to neurogenic hypertension in adult Wistar rats. Sci Rep. 7(1):1–4.
  • Hasan H, Ismail H, El-Orfali Y, Khawaja G. 2018. Therapeutic benefits of Indole-3-Carbinol in adjuvant-induced arthritis and its protective effect against methotrexate induced-hepatic toxicity. BMC Complement Altern Med. 18(1):1–12.
  • Li B, Cong M, Zhu Y, Xiong Y, Jin W, Wan Y, Zhou Y, Ao Y, Wang H. 2017. Indole-3-carbinol induces apoptosis of hepatic stellate cells through K63 de-ubiquitination of RIP1 in rats. Cell Physiol Biochem. 41(4):1481–1490.
  • Li Y, Kong D, Ahmad A, Bao B, Sarkar FH. 2013. Antioxidant function of isoflavone and 3, 3′-diindolylmethane: are they important for cancer prevention and therapy? Antioxid Redox Signaling. 19(2):139–150.
  • Liu J-J, Huang N, Lu Y, Zhao M, Yu X-J, Yang Y, Yang Y-h, Zang W-J. 2015. Improving vagal activity ameliorates cardiac fibrosis induced by angiotensin II: in vivo and in vitro. Sci Rep. 5(1):1–13.
  • Luczak ED, Leinwand LA. 2009. Sex-based cardiac physiology. Annu Rev Physiol. 71:1–18.
  • Pradhan A, Maiti Choudhury S, Roy S. 2020. Evaluation of Indole-3-carbinol, a phenolic phytomedicine & its nanoformulation in cancer therapy [Doctoral dissertation]. Paschim Midnapore (India): Department of Human Physiology, Vidyasagar University.
  • Sukumaran V, Tsuchimochi H, Sonobe T, Waddingham MT, Shirai M, Pearson JT. 2020. Liraglutide treatment improves the coronary microcirculation in insulin resistant Zucker obese rats on a high salt diet. Cardiovasc Diabetol. 19(1):1–6.
  • Wang TT, Schoene NW, Milner JA, Kim YS. 2012. Broccoli-derived phytochemicals indole-3-carbinol and 3,3'-diindolylmethane exerts concentration-dependent pleiotropic effects on prostate cancer cells: comparison with other cancer preventive phytochemicals. Mol Carcinog. 51(3):244–256.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.