Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 22
237
Views
1
CrossRef citations to date
0
Altmetric
Short Communications

Nigellidine (Nigella sativa, black-cumin seed) docking to SARS CoV-2 nsp3 and host inflammatory proteins may inhibit viral replication/transcription and FAS-TNF death signal via TNFR 1/2 blocking

, , ORCID Icon, ORCID Icon, &
Pages 5817-5822 | Received 02 Sep 2021, Accepted 05 Dec 2021, Published online: 22 Dec 2021

References

  • Ahmad A, Husain A, Mujeeb M, Khan SA, Najmi AK, Siddique NA, Damanhouri ZA, Anwar F. 2013. A review on therapeutic potential of Nigella sativa: a miracle herb. Asian Pac J Trop Biomed. 3(5):337–352. PMID: 23646296; PMCID: PMC3642442.
  • Akram Khan M, Afzal M. 2016. Chemical composition of Nigella sativa Linn: part 2 recent advances. Inflammopharmacology. 24(2–3):67–79. Epub 2016 Apr 11. PMID: 27068721; PMCID: PMC4883276.
  • Ali Z, Ferreira D, Carvalho P, Avery MA, Khan IA. 2008. Nigellidine-4-O-sulfite, the first sulfated indazole-type alkaloid from the seeds of Nigella sativa . J Nat Prod. 71(6):1111–1112.
  • Chodorge M, Züger S, Stirnimann C, Briand C, Jermutus L, Grütter MG, Minter RR. 2012. A series of Fas receptor agonist antibodies that demonstrate an inverse correlation between affinity and potency. Cell Death Differ. 19(7):1187–1195.
  • Fararh KM, Atoji Y, Shimizu Y, Shiina T, Nikami H, Takewaki T. 2004. Mechanisms of the hypoglycaemic and immunopotentiating effects of Nigella sativa L. oil in streptozotocin-induced diabetic hamsters. Res Vet Sci. 77(2):123–129. PMID: 15196902.
  • https://www.worldometers.info/coronavirus/.
  • Lei J, Kusov Y, Hilgenfeld R. 2018. Nsp3 of coronaviruses: structures and functions of a large multi-domain protein. Antiviral Res. 149:58–74. Epub 2017 Nov 8. PMID: 29128390; PMCID: PMC7113668.
  • Locksley RM, Killeen N, Lenardo MJ. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell. 104(4):487–501. PMID: 11239407.
  • Maiti S, Banerjee A, Nazmeen A, Kanwar M, Das S. 2020. Active-site Molecular docking of Nigellidine with nucleocapsid- NSP2-MPro of COVID-19 and to human IL1R-IL6R and strong antioxidant role of Nigella-sativa in experimental rats [published online ahead of print, 2020 Sep 2]. J Drug Target. 2:1–23.Doi: 10.1080/1061186X.2020.1817040.
  • Mukai Y, Nakamura T, Yoshikawa M, Yoshioka Y, Tsunoda S, Nakagawa S, Yamagata Y, Tsutsumi Y. 2010. Solution of the structure of the TNF-TNFR2 complex. Sci Signal. 3(148):ra83–10. .
  • Naismith JH, Devine TQ, Brandhuber BJ, Sprang SR. 1995. Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor. J Biol Chem. 270(22):13303–13307. Doi:.
  • Prete M, Favoino E, Catacchio G, Racanelli V, Perosa F. 2020. SARS-CoV-2 inflammatory syndrome. Clinical features and rationale for immunological treatment. IJMS. 21(9):3377.ijms. 21093377. PMID: 32397684; PMCID: PMC7247005.
  • Santerre M, Arjona SP, Allen CN, Shcherbik N, Sawaya BE. 2021. Why do SARS-CoV-2 NSPs rush to the ER? [published online ahead of print, 2020 Sep 1]. J Neurol. 268(6):2013–2022. 10.1007/s00415-020-10197-8.
  • Varghese NJ, Epa C, Colman PM. 1995. Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase . Protein Sci. 4(6):1081–1087. PMID: 7549872. Doi: 10.1002/pro.5560040606.
  • Wang R, Zagariya A, Ang E, Ibarra-Sunga O, Uhal BD. 1999. Fas-induced apoptosis of alveolar epithelial cells requires ANG II generation and receptor interaction. Am J Physiol. 277(6):L1245–50. PMID: 10600897.
  • Zhang S-G, Liang C-G, Zhang W-H. 2018. Review recent advances in indazole-containing derivatives: synthesis and biological perspectives. Review. Molecules. 23(11):2783.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.