Publication Cover
Natural Product Research
Formerly Natural Product Letters
Volume 36, 2022 - Issue 24
391
Views
4
CrossRef citations to date
0
Altmetric
Short Communications

Bixa orellana L. carotenoids: antiproliferative activity on human lung cancer, breast cancer, and cervical cancer cells in vitro

, , , & ORCID Icon
Pages 6421-6427 | Received 28 Sep 2021, Accepted 24 Jan 2022, Published online: 08 Feb 2022

References

  • Anantharaman A, Hemachandran H, Mohan S, Manikoth Ayyathan D, D TK, C GPD, Siva R. 2016. Induction of apoptosis by apocarotenoids in B16 melanoma cells through ROS-mediated mitochondrial-dependent pathway. J Funct Foods. 20(C):346–357.
  • Bautista ARPL, Moreira ELT, Batista MS, Miranda MS, Gomes ICS. 2004. Subacute toxicity assessment of annatto in rat. Food Chem Toxicol. 42(4):625–629.
  • Beydoun MA, Chen X, Jha K, Beydoun HA, Zonderman AB, Canas JA. 2019. Carotenoids, vitamin A, and their association with the metabolic syndrome: a systematic review and meta-analysis. Nutr Rev. 77(1):32–45.
  • Bouvier F, Dogbo O, Camara B. 2003. Biosynthesis of the food and cosmetic plant pigment bixin (annatto). Science. 300(5628):2089–2091.
  • Chisté RC, Yamashita F, Gozzo FC, Mercadante AZ. 2011. Simultaneous extraction and analysis by high performance liquid chromatography coupled to diode array and mass spectrometric detectors of bixin and phenolic compounds from annatto seeds. J Chromatogr A. 1218(1):57–63..
  • Cole SP, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, Kurz EU, Duncan AM, Deeley RG, et al. 1992. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 258(5088):1650–1654.
  • Ganesan P, Noda K, Manabe Y, Ohkubo T, Tanaka Y, Maoka T, Sugawara T, Hirata T. 2011. Siphonaxanthin, a marine carotenoid from green algae, effectively induces apoptosis in human leukemia (HL-60) cells. Biochim Biophys Acta. 1810(5):497–503.
  • Gao Y, Dorn P, Liu S, Deng H, Hall SRR, Peng R-W, Schmid RA, Marti TM. 2019. Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment. Cancer Cell Int. 19(1):317–331.
  • Giorgi A, De Marinis P, Granelli G, Chiesa LM, Panseri S. 2013. Secondary metabolite profile, antioxidant capacity, and mosquito repellent activity of Bixa orellana from Brazilian Amazon region. J Chem. 2013:1–10.
  • Gloria NF, Soares N, Brand C, Oliveira FL, Borojevic R, Teodoro AJ. 2014. Lycopene and beta-carotene induce cell-cycle arrest and apoptosis in human breast cancer cell lines. Anticancer Res. 34(3):1377–1386.
  • Hagiwara A, Imai N, Doi Y, Nabae K, Hirota T, Yoshino H, Kawabe M, Tsushima Y, Aoki H, Yasuhara K, et al. 2003. Absence of liver tumor promoting effects of annatto extract (norbixin), a natural carotenoid food color, in a medium-term liver carcinogenesis bioassay using male F344 rats. Cancer Lett. 199(1):9–17.
  • de Oliveira Júnior RG, Bonnet A, Braconnier E, Groult H, Prunier G, Beaugeard L, Grougnet R, da Silva Almeida JRG, Ferraz CAA, Picot L, et al. 2019. Bixin, an apocarotenoid isolated from Bixa orellana L., sensitizes human melanoma cells to dacarbazine-induced apoptosis through ROS-mediated cytotoxicity. Food Chem Toxicol. 125:549–561..
  • Kiokias S, Gordon MH. 2003. Antioxidant properties of annatto carotenoids. Food Chem. 83(4):523–529.
  • Kumar Y, Phaniendra A, Periyasamy L. 2018. Bixin triggers apoptosis of human Hep3B hepatocellular carcinoma cells: an insight to molecular and in silico approach. Nutr Cancer. 70(6):971–983.
  • Kurniawati PT, Soetjipto H, Limantara L. 2007. Antioxidant and antibacterial activities of bixin pigment from annatto (Bixa orellana L.) seeds. Indones J Chem. 7(1):88–92..
  • Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, Gargiulo G, Testa G, Cacciatore F, Bonaduce D, et al. 2018. Oxidative stress, aging, and diseases. Clin Interv Aging. 13:757–772.
  • Lin H, Hu B, He X, Mao J, Wang Y, Wang J, Zhang T, Zheng J, Peng Y, Zhang F, et al. 2020. Overcoming taxol-resistance in A549 cells: A comprehensive strategy of targeting P-gp transporter, AKT/ERK pathways, and cytochrome P450 enzyme CYP1B1 by 4-hydroxyemodin. Biochem Pharmacol. 171:113733.
  • Loeb LA, Loeb KR, Anderson JP. 2003. Multiple mutations and cancer. Proc Natl Acad Sci USA. 100(3):776–781.
  • Marelli M, Marzagalli M, Fontana F, Raimondi M, Moretti RM, Limonta P. 2019. Anticancer properties of tocotrienols: a review of cellular mechanisms and molecular targets. J Cell Physiol. 234(2):1147–1164.
  • Noppe H, Abuin Martinez S, Verheyden K, Van Loco J, Companyo Beltran R, De Brabander HF. 2009. Determination of bixin and norbixin in meat using liquid chromatography and photodiode array detection. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 26(1):17–24.
  • Ntohogian S, Gavriliadou V, Christodoulou E, Nanaki S, Lykidou S, Naidis P, Mischopoulou L, Barmpalexis P, Nikolaidis N, Bikiaris D, et al. 2018. Chitosan nanoparticles with encapsulated natural and UF-purified annatto and saffron for the preparation of UV protective cosmetic emulsions. Molecules. 23(9):2107.
  • Paula H. d, Pedrosa ML, Rossoni Júnior JV, Haraguchi FK, Santos R. C d, Silva ME. 2009. Effect of an aqueous extract of annatto (Bixa orellana) seeds on lipid profile and biochemical markers of renal and hepatic function in hipercholesterolemic rats. Braz Arch Biol Technol. 52(6):1373–1378.
  • Pierpaoli E, Viola V, Barucca A, Orlando F, Galli F, Provinciali M. 2013. Effect of annatto-tocotrienols supplementation on the development of mammary tumors in HER-2/neu transgenic mice. Carcinogenesis. 34(6):1352–1360.
  • Raddatz-Mota D, Pérez-Flores LJ, Carrari F, Mendoza-Espinoza JA, de León-Sánchez FD, Pinzón-López LL, Godoy-Hernández G, Rivera-Cabrera F. 2017. Achiote (Bixa orellana L.): a natural source of pigment and vitamin E. J Food Sci Technol. 54(6):1729–1741.
  • Rattanavipanon W, Nithiphongwarakul C, Sirisuwansith P, Chaiyasothi T, Thakkinstian A, Nathisuwan S, Pathomwichaiwat T. 2021. Effect of tomato, lycopene and related products on blood pressure: A systematic review and network meta-analysis. Phytomedicine. 88:153512.
  • Reith J, Gielen J. 1971. Properties of bixin and norbixin and the composition of Annatto extracts. J Food Science. 36(6):861–864.
  • Rivera-Madrid R, Aguilar-Espinosa M, Cárdenas-Conejo Y, Garza-Caligaris LE. 2016. Carotenoid derivates in achiote (Bixa orellana) seeds: synthesis and health promoting properties. Front Plant Sci. 7:1406.
  • Roehrs M, Conte L, da Silva DT, Duarte T, Maurer LH, de Carvalho JAM, Moresco RN, Somacal S, Emanuelli T. 2017. Annatto carotenoids attenuate oxidative stress and inflammatory response after high-calorie meal in healthy subjects. Food Res Int. 100(Pt 1):771–779.
  • Santos G, Almeida M, Antunes L, Bianchi M. 2016. Effect of bixin on DNA damage and cell death induced by doxorubicin in HL60 cell line. Hum Exp Toxicol. 35(12):1319–1327..
  • Scotter M. 2009. The chemistry and analysis of annatto food colouring: a review. Food Addit Contam Part A. 26(8):1123–1145..
  • Shin J, Song M-H, Oh J-W, Keum Y-S, Saini RK. 2020. Pro-oxidant actions of carotenoids in triggering apoptosis of cancer cells: A review of emerging evidence. Antioxidants. 9(6):532–517.
  • Song B, Liu K, Gao Y, Zhao L, Fang H, Li Y, Pei L, Xu Y. 2017. Lycopene and risk of cardiovascular diseases: A meta-analysis of observational studies. Mol Nutr Food Res. 61(9):1601009.
  • Souza LF, Pagno CH, Medeiros N. d S, Barbosa S, dos Santos PCP, Rios A, Achaval M, de Jong EV. 2016. The effect of the carotenoid bixin and annatto seeds on hematological markers and nephrotoxicity in rats subjected to chronic treatment with cisplatin. Rev Bras Farmacogn. 26(4):446–450.
  • Sowmya PR-R, Arathi BP, Vijay K, Baskaran V, Lakshminarayana R. 2017. Astaxanthin from shrimp efficiently modulates oxidative stress and allied cell death progression in MCF-7 cells treated synergistically with β-carotene and lutein from greens. Food Chem Toxicol. 106(Pt A):58–69.
  • Suparmi Limantara L, Prasetryo B. 2008. Natural food colourant from seed of kesumba (Bixa orellana L.). In: International Conference on Food Science and Technology the Challenge of Universal Food Quality and Safety Regime. pp p. 1–10.
  • Sznarkowska A, Kostecka A, Meller K, Bielawski KP. 2017. Inhibition of cancer antioxidant defense by natural compounds. Oncotarget. 8 (9):15996–16016.
  • Tibodeau JD, Isham CR, Bible KC. 2010. Annatto constituent cis-bixin has selective antimyeloma effects mediated by oxidative stress and associated with inhibition of thioredoxin and thioredoxin reductase. Antioxid Redox Signal. 13(7):987–997.
  • Tinoush B, Shirdel I, Wink M. 2020. Phytochemicals: potential lead molecules for MDR reversal. Front Pharmacol. 11:832.
  • Ventosa E. 2018. Bixa orellana (annatto). In: CABI.org. https://www.cabi.org/isc/datasheet/9242. Accessed August 22, 2021.
  • Wang Y, Cui R, Xiao Y, Fang J, Xu Q. 2015. Effect of carotene and lycopene on the risk of prostate cancer: A systematic review and dose-response meta-analysis of observational studies. PLoS One. 10(9):e0137427.
  • Xiao H, Zheng Y, Ma L, Tian L, Sun Q. 2021. Clinically-relevant ABC transporter for anti-cancer drug resistance. Front Pharmacol. 12:648407.
  • Xu L, Li H, Wang Y, Dong F, Wang H, Zhang S. 2014. Enhanced activity of doxorubicin in drug resistant A549 tumor cells by encapsulation of P-glycoprotein inhibitor in PLGA-based nanovectors . Oncol Lett. 7(2):387–392.
  • Zechmeister L. 1960. Cis-trans isomeric carotenoid pigments. Fort Chem Org Naturst. 18:224–349.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.