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Natural Product Research
Formerly Natural Product Letters
Volume 38, 2024 - Issue 4
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Short Communication

Evaluation of the in vitro schistosomicidal, leishmanicidal, and trypanocidal activities of the capsaicin metabolite, Capsicum frutescens, and Capsicum baccatum extracts and of their analysis of the main constituents by HPLC/UV and CG/MS

Sandra Vaz Soares Martinsa Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilView further author information
,
Angélica Cristina Coelho Brittoa Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilView further author information
,
Marcos Gomide Tozzatia Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilView further author information
,
Lizandra Guidi Magalhãesa Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilORCID Iconhttps://orcid.org/0000-0003-2959-6752View further author information
ORCID Icon,
Márcio Luis Andrade e Silvaa Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilORCID Iconhttps://orcid.org/0000-0002-9442-4757View further author information
ORCID Icon,
Ana Helena Januárioa Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilView further author information
,
Patrícia Mendonça Paulettia Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilORCID Iconhttps://orcid.org/0000-0003-1831-0050View further author information
ORCID Icon,
Antônio Eduardo Miller Crottib Departamento de Química da Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto – USP, Franca, BrazilView further author information
,
Amanda Vargas dos Passosc Departamento de Química e Física, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo, Vitória, BrazilView further author information
,
Ester Gonçalves de Jesusc Departamento de Química e Física, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo, Vitória, BrazilView further author information
,
Amanda Diniz Peixotoc Departamento de Química e Física, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo, Vitória, BrazilView further author information
,
Gabriela dos Santos Medeirosc Departamento de Química e Física, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo, Vitória, BrazilView further author information
,
Mário F. C. Santosc Departamento de Química e Física, Centro de Ciências Exatas, Naturais e da Saúde, Universidade Federal do Espírito Santo, Vitória, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-1981-834XView further author information
ORCID Icon &
Wilson Roberto Cunhaa Grupo de Pesquisa em Produtos Naturais, Núcleo de Ciências Exatas e Tecnológica, Universidade de Franca, Franca, BrazilCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-1952-1944View further author information
ORCID Icon show all
Pages 679-684 | Received 28 Jul 2022, Accepted 26 Feb 2023, Published online: 10 Mar 2023

References

  • Abou-Elkhair R, Selim S, Hussein E. 2018. Effect of supplementing layer hen diet with phytogenic feed additives on laying performance, egg quality, egg lipid peroxidation and blood biochemical constituents. Anim Nutr. 4(4):394–400.
  • Antonio AS, Wiedemann LSM, Junior VV. 2018. The genus Capsicum: a phytochemical review of bioactive secondary metabolites. RSC Adv. 8(45):25767–25784.
  • Batiha GE, Alqahtani A, Ojo OA, Shaheen HM, Wasef L, Elzeiny M, Ismail M, Shalaby M, Murata T, Zaragoza-Bastida A, et al. 2020. Biological properties, bioactive constituents, and pharmacokinetics of some Capsicum spp. and capsaicinoids. IJMS. 21(15):5179.
  • Bustamante JM, Sanchez-Valdez F, Padilla AM, White B, Wang W, Tarleton RL. 2020. A modified drug regimen clears active and dormant trypanosomes in mouse models of Chagas disease. Sci Transl Med. 12(567):eabb7656.
  • De Araújo SC, De Mattos AC, Teixeira HF, Coelho PM, Nelson DL, De Oliveira MC. 2007. Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsions. Int J Pharm. 337(1-2):307–315.
  • De Oliveira Penido ML, Zech Coelho PM, De Mello RT, Piló- Veloso D, De Oliveira MC, Kusel JR, Nelson DL. 2008. Antischistosomal activity of aminoalkanethiols, aminoalkanethiosulfuric acids and the corresponding disulfides. Acta Trop. 108(2-3):249–255.
  • Gupta MK,Chiranjivi AK,Dutta T,Dubey VK,Rangan L. 2022. Synthesis and characterization of zinc derivatized 3, 5-dihydroxy 4’, 7-dimethoxyflavone and its anti leishmaniasis activity against Leishmania donovani. Biometals. 35(2):285–301. 10.1007/s10534-022-00364-x. 35141791
  • Ikeogu NM, Akaluka GN, Edechi CA, Salako ES, Onyilagha C, Barazandeh AF, Uzonna JE. 2020. Leishmania immunity: advancing immunotherapy and vaccine development. Microorganisms. 8(8):1201.
  • Mishra P, Colombe S, Paul N, Mlingi J, Tosiri I, Aristide C, Gao J, Kashangaki P, Nagai H, Kalluvya SE, et al. 2019. Insufficiency of annual praziquantel treatment to control Schistosoma mansoni infections in adult women: a longitudinal cohort study in rural Tanzania. PLoS Negl Trop Dis. 13(11):e0007844.
  • Moraes JD, Nascimento C, Lopes PO, Nakano E, Yamaguchi LF, Kato MJ, Kawano T. 2011. Schistosoma mansoni: in vitro schistosomicidal activity of piplartine. Exp Parasitol. 127(2):357–364.
  • Nadi MS, Fikri F, Purnama MTE. 2020. Determination of capsaicin levels in capsicum annum linn ethanolic extract using thin layer chromatography analysis. Drugs. 70(14):1831–1842.
  • Nakagawa H, Hiura A. 2006. Capsaicin, transient receptor potential (TRP) protein subfamilies and the particular relationship between capsaicin receptors and small primary sensory neurons. Anat Sci Int. 81(3):135–155.
  • Parry C, Wang YW, Lin SW, Barchenger DW. 2021. Reproductive compatibility in Capsicum is not necessarily reflected in genetic or phenotypic similarity between species complexes. PLoS ONE. 16(3):e0243689.
  • Pica-Mattoccia L, Cioli D. 2004. Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment. Int J Parasitol. 34(4):527–533.
  • Ozguven M, Yaldiz G. 2011. Capsaicin contents of different Capsicum (red peppers) populations and varieties. Adv Environ Biol 2011:1991–1996
  • Takikawa A, Abe K, Yamamoto M, Ishimaru S, Yasui M, Okubo Y, Yokoigawa K.. 2002. Antimicrobial activity of Nutmeg agaist Escherichia coli 0157. J Biosci Bioeng. 94:3315–3320.
  • Verjee MA. 2019. Schistosomiasis: still a cause of significant morbidity and mortality. Res Rep Trop Med. 10:153–163.

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