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Short Communication

In-vitro hepatotoxic activity of mitragynine and paynantheine isolated from the leaves of Mitragyna speciosa Korth. (Kratom)

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Received 15 Apr 2024, Accepted 25 Jun 2024, Published online: 09 Jul 2024

References

  • Brown PN, Lund JA, Murch SJ. 2017. A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna Korth: implications for products sold as kratom. J Ethnopharmacol. 202:302–325. doi:10.1016/j.jep.2017.03.020.
  • Cinosi E, Martinotti G, Simonato P, Singh D, Demetrovics Z, Roman-Urrestarazu A, Bersani FS, Vicknasingam B, Piazzon G, Li J-H, et al. 2015. Following “the roots” of Kratom (Mitragyna speciosa): The evolution of an enhancer from a traditional use to increase work and productivity in Southeast Asia to a recreational psychoactive drug in Western countries. BioMed Res Int. 2015:1–11. doi:10.1155/2015/968786.
  • Domnic G, Jeng-Yeou Chear N, Abdul Rahman SF, Ramanathan S, Lo K-W, Singh D, Mohana-Kumaran N. 2021. Combinations of indole based alkaloids from Mitragyna speciosa (Kratom) and cisplatin inhibit cell proliferation and migration of nasopharyngeal carcinoma cell lines. J Ethnopharmacol. 279:114391. doi:10.1016/j.jep.2021.114391.
  • Farooq MU, Mumtaz MW, Mukhtar H, Rashid U, Akhtar MT, Raza SA, Nadeem M. 2020. UHPLC-QTOF-MS/MS based phytochemical characterization and anti-hyperglycemic prospective of hydro-ethanolic leaf extract of Butea monosperma. Sci Rep. 10(1):3530. doi:10.1038/s41598-020-60076-5.
  • Flores-Bocanegra L, Raja HA, Graf TN, Augustinović M, Wallace ED, Hematian S, Kellogg JJ, Todd DA, Cech NB, Oberlies NH. 2020. The chemistry of Kratom [Mitragyna speciosa]: Updated characterization data and methods to elucidate indole and oxindole alkaloids. J Nat Prod. 83(7):2165–2177. doi:10.1021/acs.jnatprod.0c00257.
  • Hassan Z, Muzaimi M, Navaratnam V, Yusoff NHM, Suhaimi FW, Vadivelu R, Vicknasingam BK, Amato D, Von Hörsten S, Ismail NIW, et al. 2013. From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Neurosci Biobehav Rev. 37(2):138–151. doi:10.1016/j.neubiorev.2012.11.012.
  • Kamble SH, León F, King TI, Berthold EC, Lopera-Londoño C, Siva Rama Raju K, Hampson AJ, Sharma A, Avery BA, McMahon LR, et al. 2020. Metabolism of a Kratom alkaloid metabolite in human plasma increases its opioid potency and efficacy. ACS Pharmacol Transl Sci. 3(6):1063–1068. doi:10.1021/acsptsci.0c00075.
  • Karunakaran T, Goh YS, Santhanam R, Murugaiyah V, Abu Bakar MH, Ramanathan S. 2022b. RP-HPLC-DAD analysis of mitragynine content in Mitragyna speciosa Korth. (Ketum) leaf extracts prepared using ultrasound assisted extraction technique and their cytotoxic2ty. Separations. 9(11):345. doi:10.3390/separations9110345.
  • Karunakaran T, Ngew KZ, Zailan AAD, Mian Jong VY, Abu Bakar MH. 2022a. The chemical and pharmacological properties of mitragynine and its diastereomers: an insight review. Front Pharmacol. 13:805986. doi:10.3389/fphar.2022.805986.
  • Krzywik J, Mozga W, Aminpour M, Janczak J, Maj E, Wietrzyk J, Tuszyński JA, Huczyński A. 2020. Synthesis, antiproliferative activity and molecular docking studies of novel doubly modified colchicine amides and sulfonamides as anticancer agents. Molecules. 25(8):1789. doi:10.3390/molecules25081789.
  • Matsumoto K, Mizowaki M, Suchitra T, Takayama H, Sakai S, Aimi N, Watanabe H. 1996. Antinociceptive action of mitragynine in mice: evidence for the involvement of supraspinal opioid receptors. Life Sci. 59(14):1149–1155. doi:10.1016/0024-3205(96)00432-8.
  • Mohd Shafiee MA, Muhamad Asri M, Alwi SS. 2021. Review on the in vitro cytotoxicity assessment in accordance to the International Organization for Standardization (ISO). Malays J Med Health Sci. 17:261–269.
  • Prevete E, Kuypers KPC, Theunissen EL, Esposito G, Ramaekers JG, Pasquini M, Corazza O. 2023. Clinical implications of Kratom (Mitragyna speciosa) Use: a literature review. Curr Addict Rep. 10(2):317–334. doi:10.1007/s40429-023-00478-3.
  • Takayama H. 2004. Chemistry and pharmacology of analgesic indole alkaloids from the Rubiaceous plant, Mitragyna speciosa. Chem Pharm Bull (Tokyo). 52(8):916–928. doi:10.1248/cpb.52.916.
  • Tanna RS, Cech NB, Oberlies NH, Rettie AE, Thummel KE, Paine MF. 2023. Translating Kratom-drug interactions: from bedside to bench and back. Drug Metab Dispos. 51(8):923–935. doi:10.1124/dmd.122.001005.

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