Antibiotic use in acute respiratory infections in under-fives in Uganda: findings and implications

References

• World Health Organization. Pneumonia factsheet. Geneva (Switzerland): WHO; 2013. Available from: http://www.who.int/mediacentre/factsheets/fs331/en/
   Google Scholar
• Bryce J, Boschi-Pinto C, Shibuya K, et al. WHO Child Health Epidemiology Reference Group: WHO estimates of the causes of death in children. Lancet. 2005;365:1147–1152.
   PubMed Web of Science ®Google Scholar
• Awad A, Eltayeb I, Matowe L, et al. Self-medication with antibiotics and antimalarials in the community of Khartoum State, Sudan. J Pharm Pharmaceut Sci. 2005;8(2):326–331.
   PubMed Web of Science ®Google Scholar
• Källander K, Hildenwall H, Waiswa P, et al. Delayed care seeking for fatal pneumonia in children aged under-five years in Uganda: a case-series study. Bull WHO. 2008;(2008(86):332–338.
   Google Scholar
• Källander K, Nsungwa-Sabiiti J, Balyeku A, et al. Home and community management of acute respiratory infections in children in eight Ugandan districts. Ann Trop Paediatr. 2005;25:283–291.
   PubMed Web of Science ®Google Scholar
• Uganda Bureau of Statistics. The population and housing census. Entebbe: Uganda Bureau of Statistics; 2002. Available from: http://www.ubos.org/onlinefiles/uploads/ubos/pdf%20documents/abstracts/Statistical%20Abstract%202002.pdf
   Google Scholar
• Acar JF, Kaplan EL, O’Brien TF. Monitoring and management of bacterial resistance to antimicrobial agents: a World Health Organization symposium. Clin Infect Dis. 1997;24:S1–S176.
   PubMed Web of Science ®Google Scholar
• Gonzales R, Malone DC, Maselli JH, et al. Excessive antibiotic use for acute respiratory infections in the United States. Clin Infect Dis. 2001;33:757–762.
   PubMed Web of Science ®Google Scholar
• Laxminarayan R, Matsoso P, Pant S, et al. Access to effective antimicrobials: a worldwide challenge. The Lancet. 2016;387:168–175.
   PubMed Web of Science ®Google Scholar
• Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014;5(6):229–241.
   PubMedGoogle Scholar
• Dyar OJ, Beović B, Vlahović-Palčevski V, et al. How can we improve antibiotic prescribing in primary care? Expert Rev Anti Infect Ther. 2016;14(4):403–413.
   PubMed Web of Science ®Google Scholar
• Rezal RS, Hassali MA, Alrasheedy AA, et al. Prescribing patterns for upper respiratory tract infections: a prescription-review of primary care practice in Kedah, Malaysia, and the implications. Expert Rev Anti Infect Ther. 2015;13(12):1547–1556.
   PubMed Web of Science ®Google Scholar
• Gabra M, Kisalu A, Hazemba O. Uganda assessment: drug management for childhood illness. Arlington (Virginia): Management Sciences for Health; 2000.
   Google Scholar
• Schellenberg JA, Victora CG, Mushi A, et al. Tanzania Integrated Management of Childhood Illness MCE Baseline Household Survey Study Group. Inequities among the very poor: health care for children in rural southern Tanzania. Lancet. 2003;361:561–566.
   PubMed Web of Science ®Google Scholar
• Chandani Y, Noel M, Pomeroy A, et al. Factors affecting availability of essential medicines among community health workers in Ethiopia, Malawi, and Rwanda: solving the last mile puzzle. Am J Trop Med Hyg. 2012;87(5 Suppl):120–126.
   PubMed Web of Science ®Google Scholar
• Diaz T, George AS, Rao SR, et al. Healthcare seeking for diarrhoea, malaria and pneumonia among children in four poor rural districts in Sierra Leone in the context of free health care: results of a cross-sectional survey. BMC Public Health. 2013;13:1571–12.
   Google Scholar
• Mosites EM, Matheson AI, Kern E, et al. Care-seeking and appropriate treatment for childhood acute respiratory illness: an analysis of Demographic and Health Survey and Multiple Indicators Cluster Survey datasets for high-mortality countries. BMC Public Health. 2014;14:446.
   PubMed Web of Science ®Google Scholar
• Mendelson M, Røttingen JR, Gopinathan U, et al. Maximising access to achieve appropriate human antimicrobial use in low-income and middle-income countries. Lancet. 2016;(2016(387):188–198.
   Web of Science ®Google Scholar
• Littrell M, Gatakaa G, Evance I, et al. Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countries. Malar J. 2011;10:327.
   PubMed Web of Science ®Google Scholar
• Ntambwe M, Luwombo I, Djurna O. Who sells drugs in rural Zaire? World Health Forum. 1994;15(1):62–63.
   PubMedGoogle Scholar
• Lufesi NN, Andrew M, Aursnes I, Deficient supplies of drugs for life threatening diseases in an African community. BMC Health Serv Res. 2007;7:86. Epub 2007/06/19.
   PubMed Web of Science ®Google Scholar
• Ding L, Sun Q, Sun W, et al. Antibiotic use in rural China: a cross sectional survey of knowledge, attitudes and self-reported practices among caregivers in Shandong province. BMC Infect Dis. 2015;15:576.
   PubMed Web of Science ®Google Scholar
• Faraha R, Lahoud N, Salameha P, et al. Antibiotic dispensation by Lebanese pharmacists: A comparison of higher and lower socio-economic levels. J Infect Public Health. 2015;8:37–46.
   PubMed Web of Science ®Google Scholar
• Kagoya HR, Kibuule D, Mitonga-Kabwebwe H, et al. Awareness of, responsiveness to and practice of patients’ rights at Uganda’s national referral hospital. Afr J Prim Health Care Fam Med. 2013;5(1):7. doi:10.4102/phcfm.v5i1.491.
   Google Scholar
• Vialle-Valentin CE, LeCates RF, Zhang F, et al. Treatment of Febrile illness with artemisinin combination therapy: prevalence and predictors in five African household surveys. J Pharm Policy Pract. 2015;8:1.
   PubMedGoogle Scholar
• Tumwikirize WA, Ekwaru PJ, Mohammed K, et al. Suppl: Management of acute respiratory infections in drug shops and private pharmacies in Uganda: a study of counter attendants’ knowledge and reported behaviour. East Afr Med J. 2004;S33–S40.
   Google Scholar
• Goodman C, Brieger W, Unwin A, et al. Medicine sellers and malaria treatment in sub-Saharan Africa: what do they do and how can their practice be improved? Am J Trop Med Hyg. 2007;77(6 Suppl):203–218.
   PubMed Web of Science ®Google Scholar
• Amito Florence P, Otim F, Okongo F, et al. The prevalence and antibiotics susceptibility pattern of Neisseria gonorrhoeae in patients attending OPD clinics at St. Mary’s Hospital Lacor Uganda. J Prev Med Hyg. 2012;53:186–189.
   PubMedGoogle Scholar
• Wafula FN, Mirit EN, Goodman CA. Examining characteristics, knowledge and regulatory practices of specialized drug shops in Sub-Saharan Africa: a systematic review of the literature. BMC Health Serv Res. 2012;12(223):1–18.
   PubMed Web of Science ®Google Scholar
• Mukanga D, Tiono AB, Anyorigiya T, et al. Integrated community case management of fever in children under five using rapid diagnostic tests and respiratory rate counting: a multi-country cluster randomized trial. Am J Trop Med Hyg. 2012;87(5 Suppl):21–29.
   PubMed Web of Science ®Google Scholar
• Mukonzo JK, Namuwenge PM, Okure G, et al. Over-the-counter suboptimal dispensing of antibiotics in Uganda. J Multidiscip Healthc. 2013;(2013(6):303–310.
   Google Scholar
• Seni J, Najjuka CF, Kateete DP, et al. Antibacterial resistance in hospitalized surgical patients: a silently emerging public health concern in Uganda. BMC Res Notes. 2013;6:298.
   PubMedGoogle Scholar
• Bebell LM, Muiru AN. (2014). Antibiotic use and emerging resistance—how can resource-limited countries turn the tide? Glob Heart. 2014 Sep;9(3):347–358.
   PubMedGoogle Scholar
• Kariuki S, Dougan G. Antibacterial resistance in sub-Saharan Africa: an underestimated emergency. Acad Sci. 2014 Sep;1323(1):43–55.
   PubMed Web of Science ®Google Scholar
• Nyquist AC, Gonzales R, Steiner JF, et al. Antibiotic prescribing for children with colds, upper respiratory tract infections, and bronchitis. JAMA. 1998;279(11):875–877.
   PubMed Web of Science ®Google Scholar
• Perez F, Hamady B, Dastagire SG, et al. The role of community health workers in improving child health programmes in Mali. BMC Int Health Hum Rights. 2009;9:28. doi:10.1186/1472-698X-9-28.
   PubMed Web of Science ®Google Scholar
• Webb C, Ngama M, Ngatia A, et al. Treatment failure among Kenyan children with severe pneumonia–a cohort study. Pediatr Infect Dis J. 2012;31(9):e152–e157.
   PubMed Web of Science ®Google Scholar
• World Health Organisation Improving the containment of antimicrobial resistance WHA; 2005 Available from http://www.searo.who.int/entity/medicines/topics/wha_58_27.pdf
   Google Scholar
• Lee GC, Reveles KR, Attridge RT, et al. Outpatient antibiotic prescribing in the United States: 2000 to 2010. BMC Med. 2014;12(1):96–98.
   PubMed Web of Science ®Google Scholar
• Lee ACC, Chandran A, Herbert HK, et al. Treatment of infections in young infants in low- and middle-income countries: a systematic review and meta-analysis of frontline health worker diagnosis and antibiotic access. PLoS Med. 2014;11(10):e1001741.
   PubMed Web of Science ®Google Scholar
• Leslie K Survey Sampling. New York (NY): Wiley; 1965 Available from: http://surveyanalysis.org/wiki/Design_Effects_and_Effective_Sample_Size
   Google Scholar
• Bennett S, Woods T, Liyanage WM, et al. A simplified general method for cluster-sample surveys of health in developing countries. World Health Stat Q. 1991;44:98–106.
   PubMedGoogle Scholar
• Republic of Uganda, Ministry of Health. Annual Health Sector report 2013/2014; 2014 Available from: http://www.nationalplanningcycles.org/sites/default/files/planning_cycle_repository/uganda/final_ahspr_2013_2014.pdf
   Google Scholar
• Integrated management of Childhood illnesses – IMCI ()World health organisation ISBN 92 4 154644 1. Available from: http://apps.who.int/iris/bitstream/10665/42939/1/9241546441.pdf
   Google Scholar
• Ocan M, Obuku EA, Bwanga F, et al. Household antimicrobial self-medication: a systematic review and meta-analysis of the burden, risk factors and outcomes in developing countries. BMC Public Health. 2015;15:742.
   PubMed Web of Science ®Google Scholar
• Parimi N, Pereira LMP, Prabhakar P. Caregivers’ practices, knowledge and beliefs of antibiotics in paediatric upper respiratory tract infections in Trinidad and Tobago: a cross-sectional study. BMC Fam Pract. 2004;5:28. doi:10.1186/1471-2296-5-28.
   PubMedGoogle Scholar
• Widayat A, Suryawati S, Crespigny CD, et al. Self-medication with antibiotics in Yogyakarta City Indonesia: a cross sectional population-based Survey. BMC Res Notes. 2011;4:491.
   PubMedGoogle Scholar
• Sikolia DN, Mwololo K, Cherop H, et al..The prevalence of acute respiratory infections and the associated risk factors: a study of children under five years of age in Kibera Lindi Village, Nairobi, Kenya. J Natl Institute Public Health. 2002;51(1):2002.
   Google Scholar
• WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC classification and DDD assignment; 2014 Available from: http://www.whocc.no/filearchive/publications/1_2013guidelines.pdf
   Google Scholar
• Republic of Uganda. Uganda Clinical guidelines – National guidelines for managing common conditions; 2012 Available from: http://apps.who.int/medicinedocs/documents/s21741en/s21741en.pdf
   Google Scholar
• Republic of Uganda. National Antiretroviral treatment and care guidelines for adultds, adolescents and children; 2008 http://www.who.int/hiv/amds/uganda_moh_treatment_guidelines.pdf
   Google Scholar
• Chenge MF, Van der Vennet J, Luboya NO, et al. Health-seeking behaviour in the city of Lubumbashi, Democratic Republic of the Congo: results from a cross-sectional household survey. BMC Health Serv Res. 2014;14:173.
   PubMed Web of Science ®Google Scholar
• Lam TP, Wun YT, Lam KF, et al. Differences in antibiotic use between patients with and without a regular doctor in Hong Kong. BMC Pharmacol Toxicol. 2015;16:40.
   PubMed Web of Science ®Google Scholar