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Review

Novel approaches to decrease inappropriate ambulatory antibiotic use

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Pages 511-521 | Received 31 Mar 2019, Accepted 18 Jun 2019, Published online: 05 Jul 2019

References

  • Sanchez GV, Fleming-Dutra KE, Roberts RM, et al. Core elements of outpatient antibiotic stewardship. MMWR Recomm Rep. 2016;65(6):1–12.
  • Chua KP, Fischer MA, Linder JA. Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based cross sectional study. BMJ. 2019;364:k5092.
  • Havers FP, Hicks LA, Chung JR, et al. Outpatient antibiotic prescribing for acute respiratory infections during influenza seasons. Jama Network Open. 2018;1(2):e180243.
  • Fleming-Dutra KE, Hersh AL, Shapiro DJ, et al. Prevalence of inappropriate antibiotic prescriptions among US ambulatory care visits, 2010–2011. JAMA. 2016;315(17):1864–1873.
  • Smieszek T, Pouwels KB, Dolk FCK, et al. Potential for reducing inappropriate antibiotic prescribing in English primary care. J Antimicrob Chemother. 2018;73(suppl_2):ii36–ii43.
  • Gulliford MC, Prevost AT, Charlton J, et al. Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial. BMJ. 2019;364:l236.
  • The White House. National action plan for combating antibiotic-resistant bacteria. US Department of Health and Human Services. March 2015. [cited 2019 Mar 15]. Available from: https://www.cdc.gov/drugresistance/pdf/national_action_plan_for_combating_antibotic-resistant_bacteria.pdf.
  • Shehab N, Patel PR, Srinivasan A, et al. Emergency department visits for antibiotic-associated adverse events. Clin Infect Dis. 2008;47(6):735–743.
  • Lessa FC, Winston LG, McDonald LC. Emerging infections program CdST. Burden of Clostridium difficile infection in the United States. N Engl J Med. 2015;372(24):2369–2370.
  • Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. 2013. US Department of Health and Human Services. [cited 2019 Mar 15]. Available from: https://www.cdc.gov/drugresistance/pdf/ar-threats-2013-508.pdf
  • White AT, Clark CM, Sellick JA, et al. Antibiotic stewardship targets in the outpatient setting. Am J Infect Control. 2019 Mar 9. pii: S0196-6553(19)30071-9. doi: 10.1016/j.ajic.2019.01.027. [Epub ahead of print].
  • Centers for Disease Control and Prevention. Outpatient antibiotic prescriptions - United States. 2015. Available fromhttps://www.cdc.gov/antibiotic-use/community/pdfs/Annual-Report-2015.pdf.
  • Walker AJ, Curtis HJ, Goldacre B. Impact of Chief Medical Officer activity on prescribing of antibiotics in England: an interrupted time series analysis. J Antimicrob Chemother. 2019;74(4):1133–1136.
  • Bou-Antoun S, Costelloe C, Honeyford K, et al. Age-related decline in antibiotic prescribing for uncomplicated respiratory tract infections in primary care in England following the introduction of a national financial incentive (the Quality Premium) for health commissioners to reduce use of antibiotics in the community: an interrupted time series analysis. J Antimicrob Chemother. 2018;73(10):2883–2892.
  • Dolk FCK, Pouwels KB, Smith DRM, et al. Antibiotics in primary care in England: which antibiotics are prescribed and for which conditions? J Antimicrob Chemother. 2018;73(suppl_2):ii2–ii10.
  • Molstad S, Lofmark S, Carlin K, et al. Lessons learnt during 20 years of the Swedish strategic programme against antibiotic resistance. Bull World Health Organ. 2017;95(11):764–773.
  • Hicks LA, Bartoces MG, Roberts RM, et al. US outpatient antibiotic prescribing variation according to geography, patient population, and provider specialty in 2011. Clin Infect Dis. 2015;60(9):1308–1316.
  • King LM, Bartoces M, Fleming-Dutra KE, et al. Changes in US outpatient antibiotic prescriptions from 2011–2016. Clin Infect Dis. 2019.
  • US Foodand Drug. Administration. FDA drug safety communication: FDAupdates warnings for oral and injectable fluoroquinolone antibiotics due to disabling side effects. US Department of Health and Human Services, FDA; 2016. Available from: https://www.fda.gov/Drugs/DrugSafety/ucm511530.htm.
  • Baillargeon J, Holmes HM, Lin YL, et al. Concurrent use of warfarin and antibiotics and the risk of bleeding in older adults. Am J Med. 2012;125(2):183–189.
  • Ray WA, Murray KT, Hall K, et al. Azithromycin and the risk of cardiovascular death. N Engl J Med. 2012;366(20):1881–1890.
  • Daneman N, Guttmann A, Wang X, et al. The association of hospital prevention processes and patient risk factors with the risk of Clostridium difficile infection: a population-based cohort study. BMJ Qual Saf. 2015;24(7):435–443.
  • Bartlett JG. Antibiotic-associated diarrhea. Clin Infect Dis. 1992;15(4):573–581.
  • Zaura E, Brandt BW, Teixeira de Mattos MJ, et al. Same exposure but two radically different responses to antibiotics: resilience of the salivary microbiome versus long-term microbial shifts in feces. MBio. 2015;6(6):e01693–01615.
  • Boursi B, Mamtani R, Haynes K, et al. The effect of past antibiotic exposure on diabetes risk. Eur J Endocrinol. 2015;172(6):639–648.
  • Hviid A, Svanstrom H, Frisch M. Antibiotic use and inflammatory bowel diseases in childhood. Gut. 2011;60(1):49–54.
  • Hviid A, Svanstrom H. Antibiotic use and type 1 diabetes in childhood. Am J Epidemiol. 2009;169(9):1079–1084.
  • Moore M, Little P, Rumsby K, et al. Effect of antibiotic prescribing strategies and an information leaflet on longer-term reconsultation for acute lower respiratory tract infection. Br J Gen Pract. 2009;59(567):728–734.
  • Little P, Williamson I, Warner G, et al. Open randomised trial of prescribing strategies in managing sore throat. BMJ. 1997;314(7082):722–727.
  • Meeker D, Linder JA, Fox CR, et al. Effect of behavioral interventions on inappropriate antibiotic prescribing among primary care practices: a randomized clinical trial. JAMA. 2016;315(6):562–570.
  • Olesen SW, Barnett ML, MacFadden DR, et al. Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011–15: observational study. BMJ. 2018;362:k3155.
  • Sanchez GV, Roberts RM, Albert AP, et al. Effects of knowledge, attitudes, and practices of primary care providers on antibiotic selection, United States. Emerg Infect Dis. 2014;20(12):2041–2047.
  • Dempsey PP, Businger AC, Whaley LE, et al. Primary care clinicians’ perceptions about antibiotic prescribing for acute bronchitis: a qualitative study. BMC Fam Pract. 2014;15:194.
  • Hay AD. Antibiotic prescribing in primary care. BMJ. 2019;364:l780.
  • Persell SD, Friedberg MW, Meeker D, et al. Use of behavioral economics and social psychology to improve treatment of acute respiratory infections (BEARI): rationale and design of a cluster randomized controlled trial [1RC4AG039115-01]–study protocol and baseline practice and provider characteristics. BMC Infect Dis. 2013;13:290.
  • Deschepper R, Grigoryan L, Lundborg CS, et al. Are cultural dimensions relevant for explaining cross-national differences in antibiotic use in Europe? BMC Health Serv Res. 2008;8:123.
  • McKay R, Mah A, Law MR, et al. Systematic review of factors associated with antibiotic prescribing for respiratory tract infections. Antimicrob Agents Chemother. 2016;60(7):4106–4118.
  • Petersen I, Johnson AM, Islam A, et al. Protective effect of antibiotics against serious complications of common respiratory tract infections: retrospective cohort study with the UK General Practice Research Database. BMJ. 2007;335(7627):982.
  • Linder JA. Moving the mean with feedback: insights from behavioural science. NPJ Prim Care Respir Med. 2016;26:16018.
  • Hallsworth M, Chadborn T, Sallis A, et al. Provision of social norm feedback to high prescribers of antibiotics in general practice: a pragmatic national randomised controlled trial. Lancet. 2016;387(10029):1743–1752.
  • Persell SD, Doctor JN, Friedberg MW, et al. Behavioral interventions to reduce inappropriate antibiotic prescribing: a randomized pilot trial. BMC Infect Dis. 2016;16:373.
  • Linder JA, Meeker D, Fox CR, et al. Effects of behavioral interventions on inappropriate antibiotic prescribing in primary care 12 months after stopping interventions. JAMA. 2017;318(14):1391–1392.
  • Meeker D, Knight TK, Friedberg MW, et al. Nudging guideline-concordant antibiotic prescribing: a randomized clinical trial. JAMA Intern Med. 2014;174(3):425–431.
  • Mangione-Smith R, McGlynn EA, Elliott MN, et al. Parent expectations for antibiotics, physician-parent communication, and satisfaction. Arch Pediatr Adolesc Med. 2001;155(7):800–806.
  • MacGeorge EL, Smith RA, Caldes EP, et al. Toward reduction in antibiotic use for pediatric otitis media: predicting parental compliance with “Watchful waiting” advice. J Health Commun. 2017;22(11):867–875.
  • Mangione-Smith R, Zhou C, Robinson JD, et al. Communication practices and antibiotic use for acute respiratory tract infections in children. Ann Fam Med. 2015;13(3):221–227.
  • Fleming-Dutra KE, Mangione-Smith R, Hicks LA. How to prescribe fewer unnecessary antibiotics: talking points that work with patients and their families. Am Fam Physician. 2016;94(3):200–202.
  • Drekonja DM, Filice GA, Greer N, et al. Antimicrobial stewardship in outpatient settings: a systematic review. Infect Control Hosp Epidemiol. 2015;36(2):142–152.
  • Cals JW, Butler CC, Hopstaken RM, et al. Effect of point of care testing for C reactive protein and training in communication skills on antibiotic use in lower respiratory tract infections: cluster randomised trial. BMJ. 2009;338:b1374.
  • Cals JW, de Bock L, Beckers PJ, et al. Enhanced communication skills and C-reactive protein point-of-care testing for respiratory tract infection: 3.5-year follow-up of a cluster randomized trial. Ann Fam Med. 2013;11(2):157–164.
  • Little P, Stuart B, Francis N, et al. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. Lancet. 2013;382(9899):1175–1182.
  • Little P, Stuart B, Francis N, et al. Antibiotic prescribing for acute respiratory tract infections 12 months after communication and CRP training: a randomized trial. Ann Fam Med. 2019;17(2):125–132.
  • Anthierens S, Tonkin-Crine S, Cals JW, et al. Clinicians’ views and experiences of interventions to enhance the quality of antibiotic prescribing for acute respiratory tract infections. J Gen Intern Med. 2015;30(4):408–416.
  • Bekkers MJ, Simpson SA, Dunstan F, et al. Enhancing the quality of antibiotic prescribing in primary care: qualitative evaluation of a blended learning intervention. BMC Fam Pract. 2010;11:34.
  • Yardley L, Douglas E, Anthierens S, et al. Evaluation of a web-based intervention to reduce antibiotic prescribing for LRTI in six European countries: quantitative process analysis of the GRACE/INTRO randomised controlled trial. Implement Sci. 2013;8:134.
  • O’Sullivan JW, Harvey RT, Glasziou PP, et al. Written information for patients (or parents of child patients) to reduce the use of antibiotics for acute upper respiratory tract infections in primary care. Cochrane Database Syst Rev. 2016;11:CD011360.
  • Ivers NM, Grimshaw JM, Jamtvedt G, et al. Growing literature, stagnant science? Systematic review, meta-regression and cumulative analysis of audit and feedback interventions in health care. J Gen Intern Med. 2014;29(11):1534–1541.
  • Bright TJ, Wong A, Dhurjati R, et al. Effect of clinical decision-support systems: a systematic review. Ann Intern Med. 2012;157(1):29–43.
  • Ranji SR, Steinman MA, Shojania KG, et al. Interventions to reduce unnecessary antibiotic prescribing: a systematic review and quantitative analysis. Med Care. 2008;46(8):847–862.
  • Linder JA, Schnipper JL, Tsurikova R. et al. Documentation-based clinical decision support to improve antibiotic prescribing for acute respiratory infections in primary care: a cluster randomised controlled trial. Inform Prim Care. 2009;17(4):231–240.
  • Gonzales R, Steiner JF, Lum A, et al. Decreasing antibiotic use in ambulatory practice: impact of a multidimensional intervention on the treatment of uncomplicated acute bronchitis in adults. JAMA. 1999;281(16):1512–1519.
  • Butler CC, Simpson SA, Dunstan F, et al. Effectiveness of multifaceted educational programme to reduce antibiotic dispensing in primary care: practice based randomised controlled trial. BMJ. 2012;344:d8173.
  • Loeb M, Brazil K, Lohfeld L, et al. Effect of a multifaceted intervention on number of antimicrobial prescriptions for suspected urinary tract infections in residents of nursing homes: cluster randomised controlled trial. BMJ. 2005;331(7518):669.
  • Linder JA. Antibiotic prescribing for acute respiratory infections–success that’s way off the mark: comment on “A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis”. JAMA Intern Med. 2013;173(4):273–275.
  • Gerber JS, Prasad PA, Fiks AG, et al. Durability of benefits of an outpatient antimicrobial stewardship intervention after discontinuation of audit and feedback. JAMA. 2014;312(23):2569–2570.
  • Gonzales R, Anderer T, McCulloch CE, et al. A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis. JAMA Intern Med. 2013;173(4):267–273.
  • Finkelstein JA, Huang SS, Kleinman K, et al. Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts. Pediatrics. 2008;121(1):e15–23.
  • Metlay JP, Camargo CA Jr., MacKenzie T, et al. Cluster-randomized trial to improve antibiotic use for adults with acute respiratory infections treated in emergency departments. Ann Emerg Med. 2007;50(3):221–230.
  • Briel M, Schuetz P, Mueller B, et al. Procalcitonin-guided antibiotic use vs a standard approach for acute respiratory tract infections in primary care. Arch Intern Med. 2008;168(18):2000–2007; discussion 2007–2008.
  • Burkhardt O, Ewig S, Haagen U, et al. Procalcitonin guidance and reduction of antibiotic use in acute respiratory tract infection. Eur Respir J. 2010;36(3):601–607.
  • van Vugt SF, Broekhuizen BD, Lammens C, et al. Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ. 2013;346:f2450.
  • Huang DT, Yealy DM, Filbin MR, et al. Procalcitonin-guided use of antibiotics for lower respiratory tract infection. N Engl J Med. 2018;379(3):236–249.
  • Oppong R, Smith RD, Little P, et al. Cost-effectiveness of internet-based training for primary care clinicians on antibiotic prescribing for acute respiratory tract infections in Europe. J Antimicrob Chemother. 2018;73(11):3189–3198.
  • Morgan DJ, Malani P, Diekema DJ. Diagnostic stewardship-leveraging the laboratory to improve antimicrobial use. JAMA. 2017;318(7):607–608.
  • Messacar K, Parker SK, Todd JK, et al. Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J Clin Microbiol. 2017;55(3):715–723.
  • Lieberthal AS, Carroll AE, Chonmaitree T, et al. The diagnosis and management of acute otitis media. Pediatrics. 2013;131(3):e964–999.
  • Spurling GK, Del Mar CB, Dooley L, et al. Delayed antibiotic prescriptions for respiratory infections. Cochrane Database Syst Rev. 2017;9:CD004417.
  • Linder JA, Friedberg MW. Mixed diagnoses and mixed messages. JAMA Intern Med. 2016;176(5):718–719.
  • Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis executive summary. Otolaryngol Head Neck Surg. 2015;152(4):598–609.
  • Harris AM, Hicks LA, Qaseem A. High value care task force of the American College of P, for the Centers for Disease C, Prevention. Appropriate antibiotic use for acute respiratory tract infection in adults: advice for high-value care from the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2016;164(6):425–434.
  • Shulman ST, Bisno AL, Clegg HW, et al. Clinical practice guideline for the diagnosis and management of group A streptococcal pharyngitis: 2012 update by the Infectious Diseases Society of America. Clin Infect Dis. 2012;55(10):1279–1282.
  • Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical practice guidelines by the infectious diseases society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis. 2019;68(6):895–902.
  • Hwang TJ, Gibbs KA, Podolsky SH, et al. Antimicrobial stewardship and public knowledge of antibiotics. Lancet Infect Dis. 2015;15(9):1000–1001.
  • Palms DL, Hicks LA, Bartoces M, et al. Comparison of antibiotic prescribing in retail clinics, urgent care centers, emergency departments, and traditional ambulatory care settings in the United States. JAMA Intern Med. 2018;178(9):1267–1269.
  • Riedle BN, Polgreen LA, Cavanaugh JE, et al. Phantom prescribing: examining the frequency of antimicrobial prescriptions without a patient visit. Infect Control Hosp Epidemiol. 2017;38(3):273–280.
  • Mundkur ML, Franklin J, Huybrechts KF, et al. Changes in outpatient use of antibiotics by adults in the United States, 2006–2015. Drug Saf. 2018;41(12):1333–1342.
  • Gulliford MC, Dregan A, Moore MV, et al. Continued high rates of antibiotic prescribing to adults with respiratory tract infection: survey of 568 UK general practices. BMJ Open. 2014;4(10):e006245.

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