Challenges and opportunities for antimicrobial stewardship in resource-rich and resource-limited countries

References

• Sirijatuphat R, Sripanidkulchai K, Boonyasiri A, et al. Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteremia. PLoS One. 2018;13(1):e0190132.
   PubMed Web of Science ®Google Scholar
• O’Neill J. Review on antimicrobial resistance: tackling a crisis for the health and wealth of nations. London: Wellcome Trust and the UK Government; 2014. Available from: https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Tackling%20a%20crisis%20for%20the%20health%20and%20wealth%20of%20nations_1.pdf
   Google Scholar
• www.worldbank.org [internet]. Washington, DC: The World Bank Group; [cited 2019 June 18]. Available from: http://www.worldbank.org/en/topic/health/publication/drug-resistant-infections-a-threat-to-our-economic-future
   Google Scholar
• Infectious Diseases Society of America (IDSA), Spellberg B, Blaser M, et al. Combating antimicrobial resistance: policy recommendations to save lives. Clin Infect Dis. 2011;52 Suppl 5:S397–S428.
   PubMed Web of Science ®Google Scholar
• Tackling antimicrobial resistance (AMR) together. Working paper 1.0: multisectoral coordination. Geneva: World Health Organization; 2018. ( WHO/HWSI/AMR/2018.2).
   Google Scholar
• Global action plan on antimicrobial resistance. Geneva: World Health Organization; 2015. ( WHA68/2015/REC/1, Annex 3).
   Google Scholar
• Top ten threats to global health in 2019. World Health Organization [Internet]. [cited 2019 Jun 18]; Emergencies:[about 8 screens]. Available from: https://www.who.int/emergencies/ten-threats-to-global-health-in-2019
   Google Scholar
• Chung GW, Wu JE, Yeo CL, et al. Antimicrobial stewardship: a review of prospective audit and feedback systems and an objective evaluation of outcomes. Virulence. 2013;4(2):151–157.
   PubMed Web of Science ®Google Scholar
• Davey P, Marwick CA, Scott CL, et al. Interventions to improve antibiotic prescribing practices for hospital inpatients. Cochrane Database Syst Rev. 2017;2:CD003543.
   PubMed Web of Science ®Google Scholar
• Huijts SM, van Werkhoven CH, Boersma WG, et al. Guideline adherence for empirical treatment of pneumonia and patient outcome. treating pneumonia in the Netherlands. Neth J Med. 2013;71(10):502–507.
   PubMed Web of Science ®Google Scholar
• Pradelli J, Risso K, de Salvador FG, et al. Community-acquired pneumonia: impact of empirical antibiotic therapy without respiratory fluoroquinolones nor third-generation cephalosporins. Eur J Clin Microbiol Infect Dis. 2015;34(3):511–518.
   PubMed Web of Science ®Google Scholar
• Baur D, Gladstone BP, Burkert F, et al. Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and clostridium difficile infection: a systematic review and meta-analysis. Lancet Infect Dis. 2017;17(9):990–1001.
   PubMed Web of Science ®Google Scholar
• Schuts EC, Hulscher MEJL, Mouton JW, et al. Current evidence on hospital antimicrobial stewardship objectives: a systematic review and meta-analysis. Lancet Infect Dis. 2016;16(7):847–856.
   PubMed Web of Science ®Google Scholar
• Pulido MR, García-Quintanilla M, Martín-Peña R, et al. Progress on the development of rapid methods for antimicrobial susceptibility testing. J Antimicrob Chemother. 2013;68(12):2710–2717.
   PubMed Web of Science ®Google Scholar
• van Belkum A, Dunne WM Jr. Next-generation antimicrobial susceptibility testing. J Clin Microbiol. 2013;51(7):2018–2024.
   PubMed Web of Science ®Google Scholar
• Yong MK, Buising KL, Cheng AC, et al. Improved susceptibility of gram-negative bacteria in an intensive care unit following implementation of a computerized antibiotic decision support system. J Antimicrob Chemother. 2010;65(5):1062–1069.
   PubMed Web of Science ®Google Scholar
• Filice GA, Drekonja DM, Thurn JR, et al. Use of a computer decision support system and antimicrobial therapy appropriateness. Infect Control Hosp Epidemiol. 2013;34(6):558–565.
   PubMed Web of Science ®Google Scholar
• Hermsen ED, VanSchooneveld TC, Sayles H, et al. Implementation of a clinical decision support system for antimicrobial stewardship. Infect Control Hosp Epidemiol. 2012;33(4):412–415.
   PubMed Web of Science ®Google Scholar
• Oonsivilai M, Mo Y, Luangasanatip N, et al. Using machine learning to guide targeted and locally-tailored empiric antibiotic prescribing in a children’s hospital in Cambodia. Wellcome Open Res. 2018;3:131.
   PubMedGoogle Scholar
• WebResist (version 2.0) [ Computer software]. Location. Available from: http://www.webresist.org/
   Google Scholar
• Shiu J, Wang E, Tejani AM, et al. Continuous versus intermittent infusions of antibiotics for the treatment of severe acute infections. Cochrane Database Syst Rev. 2013;3:CD008481.
   PubMed Web of Science ®Google Scholar
• Dulhunty JM, Roberts JA, Davis JS, et al. A multicenter randomized trial of continuous versus intermittent β-lactam infusion in severe sepsis. Am J Respir Crit Care Med. 2015;192(11):1298–1305.
   PubMed Web of Science ®Google Scholar
• Abel Zur Wiesch P, Kouyos R, Abel S, et al. Cycling empirical antibiotic therapy in hospitals: meta-analysis and models. PLoS Pathog. 2014;10(6):e1004225.
   PubMed Web of Science ®Google Scholar
• van Duijn PJ, Bonten MJ. Antibiotic rotation strategies to reduce antimicrobial resistance in Gram-negative bacteria in European intensive care units: study protocol for a cluster-randomized crossover controlled trial. Trials. 2014;15:277.
   PubMed Web of Science ®Google Scholar
• Beardmore RE, Peña-Miller R, Gori F, et al. Antibiotic cycling and antibiotic mixing: which one best mitigates antibiotic resistance? Mol Biol Evol. 2017;34(4):802–817.
   PubMed Web of Science ®Google Scholar
• Cosgrove SE, Seo SK, Bolon MK, et al. Evaluation of postprescription review and feedback as a method of promoting rational antimicrobial use: a multicenter intervention. Infect Control Hosp Epidemiol. 2012;33(4):374–380.
   PubMed Web of Science ®Google Scholar
• Yeo CL, Chan DS, Earnest A, et al. Prospective audit and feedback on antibiotic prescription in an adult hematology-oncology unit in Singapore. Eur J Clin Microbiol Infect Dis. 2012;31(4):583–590.
   PubMed Web of Science ®Google Scholar
• Newland JG, Stach LM, De Lurgio SA, et al. Impact of a prospective-audit-with-feedback antimicrobial stewardship program at a children’s hospital. J Pediatric Infect Dis Soc. 2012;1(3):179–186.
   PubMedGoogle Scholar
• Takesue Y, Nakajima K, Ichiki K, et al. Impact of a hospital-wide programme of heterogeneous antibiotic use on the development of antibiotic-resistant gram-negative bacteria. J Hosp Infect. 2010;75(1):28–32.
   PubMed Web of Science ®Google Scholar
• Bal AM, Kumar A, Gould IM. Antibiotic heterogeneity: from concept to practice. Ann N Y Acad Sci. 2010;1213:81–91.
   PubMed Web of Science ®Google Scholar
• Quenot JP, Luyt CE, Roche N, et al. Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy. Ann Intensive Care. 2013;3(1):21.
   PubMed Web of Science ®Google Scholar
• Little P, Stuart B, Francis N, et al. Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial. Lancet. 2013;382(9899):1175–1182.
   PubMed Web of Science ®Google Scholar
• Aabenhus R, Jensen JU, Jørgensen KJ, et al. Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care. Cochrane Database Syst Rev. 2014;11:CD010130.
   PubMed Web of Science ®Google Scholar
• de Jong E, van Oers JA, Beishuizen A, et al. Efficacy and safety of procalcitonin guidance in reducing the duration of antibiotic treatment in critically ill patients: a randomised, controlled, open-label trial. Lancet Infect Dis. 2016;16(7):819–827.
   PubMed Web of Science ®Google Scholar
• Andriolo BN, Andriolo RB, Salomão R, et al. Effectiveness and safety of procalcitonin evaluation for reducing mortality in adults with sepsis, severe sepsis or septic shock. Cochrane Database Syst Rev. 2017;1:CD010959.
   PubMedGoogle Scholar
• Bouadma L, Luyt CE, Tubach F, et al. Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet. 2010;375(9713):463–474.
   PubMed Web of Science ®Google Scholar
• Keitel K, Kagoro F, Samaka J, et al. A novel electronic algorithm using host biomarker point-of-care tests for the management of febrile illnesses in Tanzanian children (e-POCT): a randomized, controlled non-inferiority trial. PLoS Med. 2017;14(10):e1002411.
   PubMed Web of Science ®Google Scholar
• Do NT, Ta NT, Tran NT, et al. Point-of-care C-reactive protein testing to reduce inappropriate use of antibiotics for non-severe acute respiratory infections in Vietnamese primary health care: a randomised controlled trial. Lancet Glob Health. 2016;4(9):e633–e641.
   PubMed Web of Science ®Google Scholar
• Althaus T, Greer RC, Swe MMM, et al. Effect of point-of-care C-reactive protein testing on antibiotic prescription in febrile patients attending primary care in Thailand and Myanmar: an open-label, randomised, controlled trial. Lancet Glob Health. 2019;7(1):e119–e131.
   PubMed Web of Science ®Google Scholar
• Peterson LR. Squeezing the antibiotic balloon: the impact of antimicrobial classes on emerging resistance. Clin Microbiol Infect. 2005;11 Suppl 5:4–16.
   PubMed Web of Science ®Google Scholar
• López-Lozano JM, Lawes T, Nebot C, et al. A nonlinear time-series analysis approach to identify thresholds in associations between population antibiotic use and rates of resistance. Nat Microbiol. 2019;4:1160–1172.
   PubMed Web of Science ®Google Scholar
• Lawes T, Lopez-Lozano JM, Nebot CA, et al. Effects of national antibiotic stewardship and infection control strategies on hospital-associated and community-associated meticillin-resistant staphylococcus aureus infections across a region of Scotland: a non-linear time-series study. Lancet Infect Dis. 2015;15(12):1438–1449.
   PubMed Web of Science ®Google Scholar
• Lawes T, Lopez-Lozano JM, Nebot CA, et al. Effect of a national 4C antibiotic stewardship intervention on the clinical and molecular epidemiology of clostridium difficile infections in a region of Scotland: a non-linear time-series analysis. Lancet Infect Dis. 2017;17(2):194–206.
   PubMed Web of Science ®Google Scholar
• Webber MA, Whitehead RN, Mount M, et al. Parallel evolutionary pathways to antibiotic resistance selected by biocide exposure. J Antimicrob Chemother. 2015;70(8):2241–2248.
   PubMed Web of Science ®Google Scholar
• Wand ME, Bock LJ, Bonney LC, et al. Mechanisms of increased resistance to chlorhexidine and cross-resistance to colistin following exposure of klebsiella pneumoniae clinical isolates to chlorhexidine. Antimicrob Agents Chemother. 2016;61(1):e01162–16.
   PubMed Web of Science ®Google Scholar
• Huang SS, Septimus E, Kleinman K, et al. Targeted versus universal decolonization to prevent ICU infection. N Engl J Med. 2013;368(24):2255–2265.
   PubMed Web of Science ®Google Scholar
• Allegranzi B, Zayed B, Bischoff P, et al. New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis. 2016;16(12):e288–e303.
   PubMedGoogle Scholar
• Oggioni MR, Coelho JR, Furi L, et al. Significant differences characterise the correlation coefficients between biocide and antibiotic susceptibility profiles in staphylococcus aureus. Curr Pharm Des. 2015;21(16):2054–2057.
   PubMed Web of Science ®Google Scholar
• Otter JA, Patel A, Cliff PR, et al. Selection for qacA carriage in CC22, but not CC30, methicillin-resistant staphylococcus aureus bloodstream infection isolates during a successful institutional infection control programme. J Antimicrob Chemother. 2013;68(5):992–999.
   PubMed Web of Science ®Google Scholar
• Lu Z, Chen Y, Chen W, et al. Characteristics of qacA/B-positive staphylococcus aureus isolated from patients and a hospital environment in China. J Antimicrob Chemother. 2015;70(3):653–657.
   PubMed Web of Science ®Google Scholar
• Rondeau C, Chevet G, Blanc DS, et al. Current molecular epidemiology of methicillin-resistant staphylococcus aureus in elderly French people: troublesome clones on the horizon. Front Microbiol. 2016;7:31.
   PubMed Web of Science ®Google Scholar
• Hijazi K, Mukhopadhya I, Abbott F, et al. Susceptibility to chlorhexidine amongst multidrug-resistant clinical isolates of staphylococcus epidermidis from bloodstream infections. Int J Antimicrob Agents. 2016;48(1):86–90.
   PubMed Web of Science ®Google Scholar
• Zamudio R, Oggioni MR, Gould IM, et al. Time for biocide stewardship? Nat Microbiol. 2019;4(5):732–733.
   PubMed Web of Science ®Google Scholar
• Mc Cay PH, Ocampo-Sosa AA, Fleming GT. Effect of subinhibitory concentrations of benzalkonium chloride on the competitiveness of pseudomonas aeruginosa grown in continuous culture. Microbiology. 2010;156(Pt 1):30–38.
   PubMedGoogle Scholar
• Buffet-Bataillon S, Tattevin P, Maillard JY, et al. Efflux pump induction by quaternary ammonium compounds and fluoroquinolone resistance in bacteria. Future Microbiol. 2016;11(1):81–92.
   PubMed Web of Science ®Google Scholar
• Gelband H, Miller-Petrie M, Pant S, et al. State of the world’s antibiotics, 2015. CDDEP: Washington, DC; 2015. Available from: https://cddep.org/publications/state_worlds_antibiotics_2015/
   Google Scholar
• Tóth H, Fésus A, Kungler-Gorácz O, et al. Utilization of vector autoregressive and linear transfer models to follow up the antibiotic resistance spiral in gram-negative bacteria from cephalosporin consumption to colistin resistance. Clin Infect Dis. 2018 [cited 2019 Jun 18];12. DOI:10.1093/cid/ciy1086
   Google Scholar
• Laxminarayan R, Sridhar D, Blaser M, et al. Achieving global targets for antimicrobial resistance. Science. 2016;353(6302):874–875.
   PubMed Web of Science ®Google Scholar
• Resistance Map. Center for disease dynamics, economics & policy. CDDEP: Washington, DC; 2017. Available from: https://cddep.org/partners/resistance-map/
   Google Scholar
• Klein EY, Van Boeckel TP, Martinez EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A. 2018;115(15):E3463–E3470.
   PubMed Web of Science ®Google Scholar
• Dragan V, Wei Y, Elligsen M, et al. Prophylactic antimicrobial therapy for acute aspiration pneumonitis. Clin Infect Dis. 2018;67(4):513–518.
   PubMed Web of Science ®Google Scholar
• Niël-Weise BS, van Den Broek PJ, Da Silva EM, et al. Urinary catheter policies for long-term bladder drainage. Cochrane Database Syst Rev. 2012;8:CD004201.
   Google Scholar
• Fisher H, Oluboyede Y, Chadwick T, et al. Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial. Lancet Infect Dis. 2018;18(9):957–968.
   PubMed Web of Science ®Google Scholar
• Selekman RE, Shapiro DJ, Boscardin J, et al. Uropathogen resistance and antibiotic prophylaxis: a meta-analysis. Pediatrics. 2018;142(1):e20180119.
   PubMed Web of Science ®Google Scholar
• uroweb.org [Internet]. European association of urology 2015; 2015 [cited 2019 Jun 18]. Available from: http://uroweb.org/wp-content/uploads/19-Urological-infections_LR2.pdf
   Google Scholar
• Dellinger RP, Levy MM, Rhodes A, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39(2):165–228.
   PubMed Web of Science ®Google Scholar
• Just say sepsis! A review of the process of care received by patients with sepsis. A report by the National Confidential Enquiry into Patient Outcome and Death 2015. London: The National Confidential Enquiry into Patient Outcome and Death; 2015. Available from: https://www.ncepod.org.uk/2015sepsis.html
   Google Scholar
• Thomas Z, Bandali F, Sankaranarayanan J, et al. A multicenter evaluation of prolonged empiric antibiotic therapy in adult ICUs in the united states. Crit Care Med. 2015;43(12):2527–2534.
   PubMed Web of Science ®Google Scholar
• Pouwels KB, Hopkins S, Llewelyn MJ, et al. Duration of antibiotic treatment for common infections in English primary care: cross sectional analysis and comparison with guidelines. BMJ. 2019;364:l440.
   PubMedGoogle Scholar
• Teshome BF, Vouri SM, Hampton N, et al. Duration of exposure to antipseudomonal β-lactam antibiotics in the critically ill and development of new resistance. Pharmacotherapy. 2019;39(3):261–270.
   PubMed Web of Science ®Google Scholar
• Garnacho-Montero J, Escoresca-Ortega A, Fernández-Delgado E. Antibiotic de-escalation in the ICU: how is it best done? Curr Opin Infect Dis. 2015;28(2):193–198.
   PubMed Web of Science ®Google Scholar
• Masterton RG. Antibiotic de-escalation. Crit Care Clin. 2011;27(1):149–162.
   PubMed Web of Science ®Google Scholar
• Paul M, Dickstein Y, Raz-Pasteur A. Antibiotic de-escalation for bloodstream infections and pneumonia: systematic review and meta-analysis. Clin Microbiol Infect. 2016;22(12):960–967.
   PubMed Web of Science ®Google Scholar
• Ambaras Khan R, Aziz Z. Antibiotic de-escalation in patients with pneumonia in the intensive care unit: a systematic review and meta-analysis. Int J Clin Pract. 2018;72(10):e13245.
   PubMed Web of Science ®Google Scholar
• Tiong JJ, Loo JS, Mai CW. Global antimicrobial stewardship: a closer look at the formidable implementation challenges. Front Microbiol. 2016;7:1860.
   PubMed Web of Science ®Google Scholar
• Collignon P, Beggs JJ, Walsh TR, et al. Anthropological and socioeconomic factors contributing to global antimicrobial resistance: a univariate and multivariable analysis. Lancet Planet Health. 2018;2(9):e398–e405.
   PubMedGoogle Scholar
• Ozawa S, Evans DR, Bessias S, et al. Prevalence and estimated economic burden of substandard and falsified medicines in low- and middle-income countries: a systematic review and meta-analysis. JAMA Network Open. 2018;1(4):e181662.
   PubMed Web of Science ®Google Scholar
• Alsan M, Schoemaker L, Eggleston K, et al. Out-of-pocket health expenditures and antimicrobial resistance in low-income and middle-income countries: an economic analysis. Lancet Infect Dis. 2015;15(10):1203–1210.
   PubMed Web of Science ®Google Scholar
• Morel CM, Mossialos E. Stoking the antibiotic pipeline. BMJ. 2010;340:c2115.
   PubMedGoogle Scholar
• Kelly R, Zoubiane G, Walsh D, et al. Public funding for research on antibacterial resistance in the JPIAMR countries, the European commission, and related European union agencies: a systematic observational analysis. Lancet Infect Dis. 2016;16(4):431–440.
   PubMed Web of Science ®Google Scholar
• Herrmann M. Monopoly pricing of an antibiotic subject to bacterial resistance. J Health Econ. 2010;29(1):137–150.
   PubMed Web of Science ®Google Scholar
• www.cdc.gov [Internet]. One health basics. Atlanta, GA: Centers for Disease Control and Prevention; 2018 [updated 2018 Nov 5; cited 2019 Jun 19]. Available from: https://www.cdc.gov/onehealth/basics/index.html
   Google Scholar
• www.fda.gov [Internet]. Guidance for industry: the judicious use of medically important antimicrobial drugs in food-producing animals. Silver Spring, MD:Food and Drug Administration, U. S., Department of Health and Human Services, Center for Veterinary Medicine; 2012. [updated 2018 Aug 24; cited 2019 Jun 19]. Available from: https://www.fda.gov/regulatory-information/search-fda-guidance-documents/cvm-gfi-209-judicious-use-medically-important-antimicrobial-drugs-food-producing-animals
   Google Scholar
• Collignon P, Powers JH, Chiller TM, et al. World health organization ranking of antimicrobials according to their importance in human medicine: a critical step for developing risk management strategies for the use of antimicrobials in food production animals. Clin Infect Dis. 2009;49(1):132–141.
   PubMed Web of Science ®Google Scholar
• Tang KL, Caffrey NP, Nóbrega DB, et al. Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis. Lancet Planet Health. 2017;1(8):e316–e327.
   PubMedGoogle Scholar
• Vanderhaeghen W, Dewulf J. Antimicrobial use and resistance in animals and human beings. Lancet Planet Health. 2017;1(8):e307–e308.
   PubMedGoogle Scholar
• Littmann J, Buyx A, Cars O. Antibiotic resistance: an ethical challenge. Int J Antimicrob Agents. 2015;46(4):359–361.
   PubMed Web of Science ®Google Scholar
• Parsonage B, Hagglund PK, Keogh L, et al. Control of antimicrobial resistance requires an ethical approach. Front Microbiol. 2017;8:2124.
   PubMed Web of Science ®Google Scholar
• Magouras I, Carmo LP, Stärk KDC, et al. Antimicrobial usage and -resistance in livestock: where should we focus? Front Vet Sci. 2017;4:148.
   PubMed Web of Science ®Google Scholar
• Berendsen BJ, Wegh RS, Memelink J, et al. The analysis of animal faeces as a tool to monitor antibiotic usage. Talanta. 2015;132:258–268.
   PubMed Web of Science ®Google Scholar
• Chen CE, Zhang H, Ying GG, et al. Passive sampling: a cost-effective method for understanding antibiotic fate, behaviour and impact. Environ Int. 2015;85:284–291.
   PubMed Web of Science ®Google Scholar
• UN Environment. Frontiers 2018/19: Emerging Issues of Environmental Concern. Nairobi, Kenya: UnitedNations Environment Programme; 2019. Available from: https://www.unenvironment.org/resources/frontiers-201819-emerging-issues-environmental-concern
   Google Scholar
• CDC. The core elements of human antibiotic stewardship programs in resource-limited settings: national and hospital levels. Atlanta, GA:US Department of Health and Human Services, CDC; 2018. Available from: https://www.cdc.gov/antibiotic-use/healthcare/implementation.html
   Google Scholar
• www.who.int [Internet]. Geneva: World Health Organization; [updated 2017 Jun 6; cited 2019 Jun 18]. Available from: https://www.who.int/news-room/detail/06-06-2017-who-updates-essential-medicines-list-with-new-advice-on-use-of-antibiotics-and-adds-medicines-for-hepatitis-c-hiv-tuberculosis-and-cancer
   Google Scholar
• Rzewuska M, Charani E, Clarkson JE, et al. Prioritizing research areas for antibiotic stewardship programmes in hospitals: a behavioural perspective consensus paper. Clin Microbiol Infect. 2019;25(2):163–168.
   PubMed Web of Science ®Google Scholar
• Arnold SR, Straus SE. Interventions to improve antibiotic prescribing practices in ambulatory care. Cochrane Database Syst Rev. 2005;4:CD003539.
   Google Scholar
• Ranji SR, Steinman MA, Shojania KG, et al. Interventions to reduce unnecessary antibiotic prescribing: a systematic review and quantitative analysis. Med Care. 2008;46(8):847–862.
   PubMed Web of Science ®Google Scholar
• Lee CR, Lee JH, Kang LW, et al. Educational effectiveness, target, and content for prudent antibiotic use. Biomed Res Int. 2015;2015:214021.
   PubMed Web of Science ®Google Scholar
• Filippini M, Ortiz LG, Masiero G. Assessing the impact of national antibiotic campaigns in Europe. Eur J Health Econ. 2013;14(4):587–599.
   PubMed Web of Science ®Google Scholar
• Curtis V, Schmidt W, Luby S. Hygiene: new hopes, new horizons. Lancet Infect Dis. 2011;11(4):312–321.
   PubMed Web of Science ®Google Scholar
• Jamhour A, El-Kheir A, Salameh P, et al. Antibiotic knowledge and self-medication practices in a developing country: a cross-sectional study. Am J Infect Control. 2017;45(4):384–388.
   PubMed Web of Science ®Google Scholar